Page last updated: 2024-12-08

dipfluzine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

dipfluzine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID146001
MeSH IDM0180717

Synonyms (7)

Synonym
dipfluzine
1-butanone, 4-(4-(diphenylmethyl)-1-piperazinyl)-1-(4-fluorophenyl)-
4-(4-(diphenylmethyl)-1-piperazinyl)-1-(4-fluorophenyl)-1-butanone
4-(4-benzhydrylpiperazin-1-yl)-1-(4-fluorophenyl)butan-1-one
89223-80-3
DTXSID90237580
1-diphenylmethyl-4-[3-(4-fluorobenzoyl)propyl] piperazine

Research Excerpts

Overview

Dipfluzine (Dip) is a promising candidate for the treatment of cerebral vascular diseases. It has 5 metabolites in rat urine and liver microsomes, but their biological activity is still unknown.

ExcerptReferenceRelevance
"Dipfluzine (Dip) is a promising candidate for the treatment of cerebral vascular diseases and has 5 metabolites (M1∼M5) in rat urine and liver microsomes, but their biological activity is still unknown."( Vasodilation activity of dipfluzine metabolites in isolated rat basilar arteries and their underlying mechanisms.
Guo, W; He, C; Li, S; Wang, H; Wang, T; Wang, X; Wang, Y, 2020
)
1.58
"Dipfluzine (Dip) is a novel diphenylpiperazine calcium channel blocker first synthesized in China. "( Effect of dipfluzine on platelet aggregation and thrombus formation.
He, RR; Wang, YL, 1994
)
2.13
"Dipfluzine (Dip) is a novel calcium antagonist first developed by Department of Chemistry, Beijing University. "( Selective vasodilatory effect of dipfluzine on vertebral artery in anesthetized dogs.
He, RR; Wang, YL, 1993
)
2.01
"Dipfluzine (Dip) is a new derivative of cinnarizine (Cin) first developed by Department of Chemistry, Beijing University. "( Acute toxicity of dipfluzine and its effects on isolated vascular smooth muscle.
Fu, SX; Jin, S; Li, YS; Wang, YL, 1990
)
2.06

Toxicity

ExcerptReferenceRelevance
" The acute iv LD50 of Dip and Cin in mice were 37 and 36 mg/kg, respectively."( Acute toxicity of dipfluzine and its effects on isolated vascular smooth muscle.
Fu, SX; Jin, S; Li, YS; Wang, YL, 1990
)
0.61

Pharmacokinetics

ExcerptReferenceRelevance
" The technique was successfully applied to a pharmacokinetic study of Dip and its metabolites after a single oral administration of Dip (20 mg/kg) to rats."( Pharmacokinetic evaluation of dipfluzine and its three metabolites in rat plasma using liquid chromatography-mass spectrometry.
Guo, W; Li, J; Shi, X; Wang, W; Xiong, C, 2014
)
0.69

Bioavailability

ExcerptReferenceRelevance
" To investigate the feasibility of the co-crystal for improving solubility and a faster dissolution rate in vitro and evaluate the bioavailability and tissue distribution of co-crystal in vivo."( Preparation, characterization, and evaluation of dipfluzine-benzoic acid co-crystals with improved physicochemical properties.
Lin, Y; Wang, J; Yang, C; Yang, H, 2014
)
0.66
" The co-crystal solubility, the rate of drug dissolution and the relative bioavailability were approximately 500 times, five times and double that of dipfluzine, respectively."( Preparation, characterization, and evaluation of dipfluzine-benzoic acid co-crystals with improved physicochemical properties.
Lin, Y; Wang, J; Yang, C; Yang, H, 2014
)
0.86
" Furthermore, the increased relative bioavailability of co-crystal indicated the potential use in further clinical study."( Preparation, characterization, and evaluation of dipfluzine-benzoic acid co-crystals with improved physicochemical properties.
Lin, Y; Wang, J; Yang, C; Yang, H, 2014
)
0.66
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's6 (26.09)18.2507
2000's9 (39.13)29.6817
2010's6 (26.09)24.3611
2020's2 (8.70)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other23 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]