dipfluzine: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
ID Source | ID |
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PubMed CID | 146001 |
MeSH ID | M0180717 |
Synonym |
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dipfluzine |
1-butanone, 4-(4-(diphenylmethyl)-1-piperazinyl)-1-(4-fluorophenyl)- |
4-(4-(diphenylmethyl)-1-piperazinyl)-1-(4-fluorophenyl)-1-butanone |
4-(4-benzhydrylpiperazin-1-yl)-1-(4-fluorophenyl)butan-1-one |
89223-80-3 |
DTXSID90237580 |
1-diphenylmethyl-4-[3-(4-fluorobenzoyl)propyl] piperazine |
Dipfluzine (Dip) is a promising candidate for the treatment of cerebral vascular diseases. It has 5 metabolites in rat urine and liver microsomes, but their biological activity is still unknown.
Excerpt | Reference | Relevance |
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"Dipfluzine (Dip) is a promising candidate for the treatment of cerebral vascular diseases and has 5 metabolites (M1∼M5) in rat urine and liver microsomes, but their biological activity is still unknown." | ( Vasodilation activity of dipfluzine metabolites in isolated rat basilar arteries and their underlying mechanisms. Guo, W; He, C; Li, S; Wang, H; Wang, T; Wang, X; Wang, Y, 2020) | 1.58 |
"Dipfluzine (Dip) is a novel diphenylpiperazine calcium channel blocker first synthesized in China. " | ( Effect of dipfluzine on platelet aggregation and thrombus formation. He, RR; Wang, YL, 1994) | 2.13 |
"Dipfluzine (Dip) is a novel calcium antagonist first developed by Department of Chemistry, Beijing University. " | ( Selective vasodilatory effect of dipfluzine on vertebral artery in anesthetized dogs. He, RR; Wang, YL, 1993) | 2.01 |
"Dipfluzine (Dip) is a new derivative of cinnarizine (Cin) first developed by Department of Chemistry, Beijing University. " | ( Acute toxicity of dipfluzine and its effects on isolated vascular smooth muscle. Fu, SX; Jin, S; Li, YS; Wang, YL, 1990) | 2.06 |
Excerpt | Reference | Relevance |
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" The acute iv LD50 of Dip and Cin in mice were 37 and 36 mg/kg, respectively." | ( Acute toxicity of dipfluzine and its effects on isolated vascular smooth muscle. Fu, SX; Jin, S; Li, YS; Wang, YL, 1990) | 0.61 |
Excerpt | Reference | Relevance |
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" The technique was successfully applied to a pharmacokinetic study of Dip and its metabolites after a single oral administration of Dip (20 mg/kg) to rats." | ( Pharmacokinetic evaluation of dipfluzine and its three metabolites in rat plasma using liquid chromatography-mass spectrometry. Guo, W; Li, J; Shi, X; Wang, W; Xiong, C, 2014) | 0.69 |
Excerpt | Reference | Relevance |
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" To investigate the feasibility of the co-crystal for improving solubility and a faster dissolution rate in vitro and evaluate the bioavailability and tissue distribution of co-crystal in vivo." | ( Preparation, characterization, and evaluation of dipfluzine-benzoic acid co-crystals with improved physicochemical properties. Lin, Y; Wang, J; Yang, C; Yang, H, 2014) | 0.66 |
" The co-crystal solubility, the rate of drug dissolution and the relative bioavailability were approximately 500 times, five times and double that of dipfluzine, respectively." | ( Preparation, characterization, and evaluation of dipfluzine-benzoic acid co-crystals with improved physicochemical properties. Lin, Y; Wang, J; Yang, C; Yang, H, 2014) | 0.86 |
" Furthermore, the increased relative bioavailability of co-crystal indicated the potential use in further clinical study." | ( Preparation, characterization, and evaluation of dipfluzine-benzoic acid co-crystals with improved physicochemical properties. Lin, Y; Wang, J; Yang, C; Yang, H, 2014) | 0.66 |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 6 (26.09) | 18.2507 |
2000's | 9 (39.13) | 29.6817 |
2010's | 6 (26.09) | 24.3611 |
2020's | 2 (8.70) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 23 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |