Lupus Erythematosus Panniculitis

A type of lupus erythematosus characterized by deep dermal or subcutaneous nodules, most often on the head, face, or upper arms. It is generally chronic and occurs most often in women between the ages of 20 and 45.

Synonyms(5)

Synonym
Lupus Profundus
Lupus Panniculitis
Lupus Erythematosus Panniculitis
Lupus Erythematosus Profundus
Panniculitis, Lupus Erythematosus

Research Excerpts

Overview

Excerpt	Reference
"Lupus panniculitis is a rare variant of cutaneous lupus erythematosus."	( Lübke, S; Meurer, M; Ruzicka, T; Schirren, CG; Süss, R, 1994)
"Lupus panniculitis is an unusual immunological disease that characteristically affects the subcutaneous fat and occurs in 2% of patients with systemic lupus erythematosus."	( Clotet, M; Gómez, A; Lerma, E; Sabaté, JM; Salinas, T; Torrubia, S, 2006)
"Lupus erythematosus panniculitis is a rare disease characterized by deep subcutaneous nodules, most commonly localized on the upper limbs and face."	( Alessi, E; Caputo, R; Marzano, AV; Tanzi, C, 2005)
"Lupus profundus is classically of benign course with only cutaneous involvement, but it may sometimes be a sign of systemic lupus and in rare cases may be associated with severe complications."	( Bathelier, E; Blanc-Lasserre, K; Geffroy, D; Kanitakis, J; Labeille, B; Truchot, F; Zenone, T, 2006)

Context

Excerpt	Reference
"Lupus panniculitis has been reported to occur with a frequency of 2-3% in patients with lupus erythematosus (LE)."	( Callen, JP; Morgan, KW, 2001)
"The lupus panniculitis has generally a favorable prognosis."	( Azzabi, S; Ben Hassine, L; Fathallah, L; Fazâa, B; Haddad, A; Hamza, M; Khalfallah, N; Kooli, C, 2003)

Treatment

Excerpt	Reference
"We diagnosed the case as lupus erythematosus profundus, and successfully treated her with 20 mg/day prednisolone."	( Akashi, R; Ishiguro, N; Kawashima, M; Tsuzaka, S, 2012)

Research

Studies (70)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	1 (1.43)	23.3326
1990's	10 (14.29)	12.5806
2000's	20 (28.57)	18.1394
2010's	31 (44.29)	28.8240
2020's	8 (11.43)	9.53

Drug	Relationship Strength	Studies
quinacrine	low	1
salicylic acid	low	8
lactic acid	low	2
thiosulfates	low	1
1-anilino-8-naphthalenesulfonate	low	1
aspirin	low	1
azathioprine	low	3
chloroquine	low	4
cimetidine	low	1
dapsone	low	6
hydroxychloroquine	low	21
indomethacin	low	1
thalidomide	low	5
prednisolone	low	14
prednisone	low	9
mannitol	low	1
triamcinolone acetonide	low	1
methylprednisolone	low	2
cladribine	low	1
sodium thiosulfate	low	1
triamcinolone	low	1
diltiazem	low	2
propiconazole	low	1
methotrexate	low	5
lenalidomide	low	1
tacrolimus	low	3
mycophenolic acid	low	1
clobetasol	low	1
gadolinium dtpa	low	1
mocetinostat	low	1
cellulose	low	1
warfarin	low	1
transforming growth factor beta	low	1
cyclosporine	low	4
eye	low	1

Protein Targets (576)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	2	0	0	2
thioredoxin reductase	9	0	0	9
USP1 protein, partial	6	0	0	6
TDP1 protein	17	0	0	17
vitamin D3 receptor isoform VDRA	5	0	0	5
importin subunit beta-1 isoform 1	3	0	0	3
flap endonuclease 1	4	0	0	4
serine/threonine-protein kinase PLK1	1	0	0	1
snurportin-1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase eta isoform 1	2	0	0	2
DNA polymerase iota isoform a (long)	7	0	0	7
urokinase-type plasminogen activator precursor	3	0	0	3
plasminogen precursor	3	0	0	3
urokinase plasminogen activator surface receptor precursor	3	0	0	3
geminin	14	0	0	14
DNA polymerase kappa isoform 1	7	0	0	7
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	1	2	3
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
AR protein	21	0	0	21
glucocorticoid receptor [Homo sapiens]	17	0	0	17
estrogen nuclear receptor alpha	24	0	0	24
peroxisome proliferator activated receptor gamma	10	0	0	10
ATP-binding cassette sub-family C member 3	0	15	0	15
Multidrug resistance-associated protein 4	0	15	0	17
Bile salt export pump	0	19	0	19
Cellular tumor antigen p53	17	0	0	17
Thromboxane-A synthase	0	2	0	2
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostacyclin receptor	0	1	1	2
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Canalicular multispecific organic anion transporter 1	0	15	0	15
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	8	0	0	8
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	4	0	0	4
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	6	0	0	6
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	5	0	0	5
GLS protein	2	0	0	2
aldehyde dehydrogenase 1 family, member A1	7	0	0	7
thyroid stimulating hormone receptor	4	0	0	4
hypothetical protein, conserved	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
EWS/FLI fusion protein	10	0	0	10
retinoic acid nuclear receptor alpha variant 1	10	0	0	10
estrogen-related nuclear receptor alpha	19	0	0	19
cytochrome P450 2D6	7	0	0	7
glucocerebrosidase	3	0	0	3
peroxisome proliferator-activated receptor delta	9	0	0	9
Rac1 protein	0	0	1	1
IDH1	7	0	0	7
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	12	0	0	12
Bloom syndrome protein isoform 1	5	0	0	5
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	4	0	0	4
muscarinic acetylcholine receptor M1	3	0	0	3
lethal factor (plasmid)	2	0	0	2
Prostaglandin-H2 D-isomerase	0	2	0	2
Solute carrier family 22 member 6	0	5	0	5
Prostaglandin G/H synthase 1	0	2	0	3
Prostaglandin G/H synthase 2	0	2	0	3
Epidermal growth factor receptor	0	2	0	2
Carbonic anhydrase 1	0	4	0	4
Carbonic anhydrase 2	0	4	1	5
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	3	1	0	4
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	4	0	5
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	3	1	0	4
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Adenosine receptor A1	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Substance-P receptor	0	2	0	2
Prostaglandin G/H synthase 2	0	6	1	7
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	5	0	0	5
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	6	1	0	7
Prostaglandin G/H synthase 2	0	4	0	4
Rho-associated protein kinase 2	0	2	0	2
Nicotinate phosphoribosyltransferase	0	3	0	3
Solute carrier family 22 member 20	0	3	0	3
Solute carrier family 22 member 6	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	2	1	3
Sigma non-opioid intracellular receptor 1	0	0	1	1
Chain A, Ferritin light chain	4	0	0	4
acetylcholinesterase	4	0	0	4
phosphopantetheinyl transferase	4	0	0	4
RAR-related orphan receptor gamma	10	0	0	10
SMAD family member 2	6	0	0	6
ATAD5 protein, partial	5	0	0	5
Fumarate hydratase	3	0	0	3
SMAD family member 3	6	0	0	6
GLI family zinc finger 3	11	0	0	11
Microtubule-associated protein tau	4	0	0	4
thioredoxin glutathione reductase	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	6	0	0	6
retinoid X nuclear receptor alpha	13	0	0	13
farnesoid X nuclear receptor	7	0	0	7
pregnane X nuclear receptor	10	0	0	10
G	7	0	0	7
polyprotein	3	0	0	3
P53	1	0	0	1
arylsulfatase A	5	0	0	5
aryl hydrocarbon receptor	7	0	0	7
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
thyroid stimulating hormone receptor	2	0	0	2
activating transcription factor 6	5	0	0	5
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	4	0	0	4
peripheral myelin protein 22 isoform 1	3	0	0	3
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	4	0	0	4
thyroid hormone receptor beta isoform 2	11	0	0	11
heat shock protein beta-1	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
peripheral myelin protein 22	5	0	0	5
survival motor neuron protein isoform d	6	0	0	6
cytochrome P450 3A4 isoform 1	6	0	0	6
M-phase phosphoprotein 8	5	0	0	5
muscleblind-like protein 1 isoform 1	6	0	0	6
lamin isoform A-delta10	13	0	0	13
Gamma-aminobutyric acid receptor subunit pi	6	0	0	6
Bile salt export pump	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	6	0	0	6
Interferon beta	11	0	0	11
HLA class I histocompatibility antigen, B alpha chain	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit delta	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-2	6	0	0	6
Glutamate receptor 2	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-1	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-2	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-4	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit alpha-6	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-3	6	0	0	6
Gamma-aminobutyric acid receptor subunit beta-2	6	0	0	6
GABA theta subunit	6	0	0	6
Inositol hexakisphosphate kinase 1	7	0	0	7
ATPase family AAA domain-containing protein 5	10	0	0	10
Ataxin-2	12	0	0	12
Gamma-aminobutyric acid receptor subunit epsilon	6	0	0	6
Protein-arginine deiminase type-4	0	2	0	2
cytochrome P450 2C9, partial	7	0	0	7
PPM1D protein	4	0	0	4
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	2	3
Dihydrofolate reductase	0	2	0	2
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	1	2	3
Major prion protein	0	0	2	2
Amyloid-beta precursor protein	0	1	0	1
Histidine-rich protein PFHRP-II	0	2	0	3
Procathepsin L	0	2	2	4
Muscarinic acetylcholine receptor M2	0	5	0	5
Muscarinic acetylcholine receptor M4	0	4	0	4
Cytochrome P450 3A4	0	7	0	8
Muscarinic acetylcholine receptor M5	0	4	0	4
Alpha-2A adrenergic receptor	0	4	0	4
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Replicase polyprotein 1ab	0	2	2	4
Spike glycoprotein	0	1	0	1
Replicase polyprotein 1ab	0	3	2	5
Muscarinic acetylcholine receptor M1	0	4	0	4
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2B adrenergic receptor	0	4	0	4
Alpha-2C adrenergic receptor	0	4	0	4
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	4	0	4
Serine/threonine-protein kinase mTOR	0	2	0	2
Beta-secretase 1	0	1	0	1
Spike glycoprotein	4	1	2	7
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	6	0	6
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Angiotensin-converting enzyme 2	0	1	2	3
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
progesterone receptor	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
alpha-galactosidase	2	0	0	2
cytochrome P450 2C19 precursor	1	0	0	1
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
Solute carrier family 22 member 1	0	3	0	3
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	1	4
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	5	0	5
Potassium-transporting ATPase alpha chain 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Histamine H2 receptor	0	4	0	4
Histamine H1 receptor	0	0	2	2
Histamine H2 receptor	4	2	1	7
Potassium-transporting ATPase subunit beta	0	1	0	1
Cytochrome P450 2J2	0	4	0	4
Aldehyde oxidase	0	2	0	2
Solute carrier family 22 member 6	0	3	0	4
Solute carrier family 22 member 1	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
Solute carrier family 22 member 8	0	4	0	6
Multidrug and toxin extrusion protein 1	0	2	0	2
Histamine H4 receptor	0	1	0	1
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
glp-1 receptor, partial	4	0	0	4
Smad3	3	0	0	3
67.9K protein	6	0	0	6
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
huntingtin isoform 2	2	0	0	2
tyrosine-protein kinase Yes	1	0	0	1
nuclear receptor ROR-gamma isoform 1	6	0	0	6
relaxin receptor 1 isoform 1	1	0	0	1
bcl-2-like protein 11 isoform 1	0	0	1	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Adenosine receptor A3	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
Rap guanine nucleotide exchange factor 3	1	0	0	1
Glutathione S-transferase P	0	1	0	1
Alpha-tocopherol transfer protein	0	0	1	1
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase	0	1	0	1
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
cytochrome P450 2C9 precursor	2	0	0	2
Dihydrofolate reductase	0	3	0	3
5-hydroxytryptamine receptor 6	0	1	0	1
estrogen receptor 2 (ER beta)	8	0	0	8
regulator of G-protein signaling 4	2	0	0	2
D(1A) dopamine receptor	2	0	0	2
histone acetyltransferase KAT2A isoform 1	4	0	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1D	0	2	0	2
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 4 subunit alpha	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	2	0	2
Potassium voltage-gated channel subfamily A member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Sodium channel protein type 9 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Sodium channel protein type 11 subunit alpha	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	0	3
Sodium channel protein type 8 subunit alpha	0	1	0	1
Sodium channel protein type 10 subunit alpha	0	1	0	1
Genome polyprotein	0	1	0	1
Alpha-1D adrenergic receptor	0	4	0	4
Cyclic GMP-AMP synthase	0	2	0	2
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Chain A, Cruzipain	1	0	0	1
Luciferase	1	0	0	1
hypoxia-inducible factor 1 alpha subunit	4	0	0	4
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	5	0	0	5
Parkin	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
cytochrome P450 2D6 isoform 1	1	0	0	1
thyroid hormone receptor beta isoform a	4	0	0	4
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
neuropeptide S receptor isoform A	1	0	0	1
Prostaglandin E synthase	0	1	0	1
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Phospholipase A2, major isoenzyme	0	1	0	1
Albumin	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Interleukin-8	0	1	0	1
Androgen receptor	0	2	1	3
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	2	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Caspase-1	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Solute carrier family 22 member 7	0	0	0	2
Sigma intracellular receptor 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	3	0	3
Cereblon isoform 4	0	3	0	3
Bromodomain-containing protein 4	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	2
Breakpoint cluster region protein	0	0	0	1
DNA-binding protein Ikaros	0	0	1	4
DNA damage-binding protein 1	0	2	1	3
Protein cereblon	0	4	2	9
Zinc finger protein Aiolos	0	0	1	1
potassium voltage-gated channel subfamily H member 2 isoform d	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
TAR DNA-binding protein 43	5	0	0	5
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	2	0	0	2
ClpP	1	0	0	1
15-lipoxygenase, partial	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
chromobox protein homolog 1	5	0	0	5
transcriptional regulator ERG isoform 3	1	0	0	1
DNA polymerase beta	1	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
caspase-1 isoform alpha precursor	1	0	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	2	2
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Caspase-7	1	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
nonstructural protein 1	2	0	0	2
nuclear receptor subfamily 1, group I, member 2	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Glucocorticoid receptor	0	10	2	17
Glycine receptor subunit alpha-1	0	10	0	10
Androgen receptor	0	3	0	3
Glycine receptor subunit beta	0	10	0	10
Glycine receptor subunit alpha-2	0	10	0	10
Glycine receptor subunit alpha-3	0	10	0	10
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Cytochrome P450 2C19	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Glutamate receptor 1	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor 4	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	0	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Alpha-synuclein	1	0	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
pregnane X receptor	2	0	0	2
Chain A, Beta-lactamase	3	0	0	3
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
heat shock protein 90, putative	0	0	0	1
N	0	1	0	1
NPYLR7B	0	0	1	1
NPC intracellular cholesterol transporter 1 precursor	1	0	0	1
cystic fibrosis transmembrane conductance regulator	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
Glutathione reductase, mitochondrial	0	1	0	1
Major prion protein	0	1	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
DNA-directed RNA polymerase subunit alpha	0	1	0	1
DNA-directed RNA polymerase subunit omega	0	1	0	1
DNA-directed RNA polymerase subunit beta'	0	1	0	1
DNA-directed RNA polymerase subunit beta	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Phospholipase A2, membrane associated	0	1	0	1
Acidic phospholipase A2 2	0	1	0	1
Acetylcholinesterase	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
Trypanothione reductase	0	2	0	2
D(3) dopamine receptor	0	2	0	2
D(1A) dopamine receptor	1	0	0	1
Aldehyde oxidase 1	0	1	0	1
Cholinesterase	0	1	0	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
Carbonic anhydrase 12	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Carbonic anhydrase 3	0	1	0	1
Stromelysin-1	0	0	1	1
Tyrosine-protein phosphatase YopH	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Cystathionine gamma-lyase	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase 9	0	1	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
NFKB1 protein, partial	1	0	0	1
procathepsin L isoform 1 preproprotein	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Protease	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

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