Escherichia coli Meningitis

A form of gram-negative meningitis that tends to occur in neonates, in association with anatomical abnormalities (which feature communication between the meninges and cutaneous structures) or as OPPORTUNISTIC INFECTIONS in association with IMMUNOLOGIC DEFICIENCY SYNDROMES. In premature neonates the clinical presentation may be limited to ANOREXIA; VOMITING; lethargy; or respiratory distress. Full-term infants may have as additional features FEVER; SEIZURES; and bulging of the anterior fontanelle. (From Menkes, Textbook of Child Neurology, 5th ed, pp398-400)

Synonym
Escherichia coli Meningitis
Meningitis, Escherichia coli

Excerpt	Reference
"Neonatal Escherichia coli meningitis is a serious disease with high mortality and poor outcome."	( Brinkmann, G; Hellwege, HH; Kaczmarek, D; Kammler, G; Sonntag, J, 2004)
"Escherichia coli meningitis is an important cause of mortality and morbidity, and a key contributing factor is our incomplete understanding of the pathogenesis of E."	( Kim, KS; Pearce, D; Zhu, L, 2010)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	4 (6.35)	23.3326
1990's	0 (0.00)	12.5806
2000's	26 (41.27)	18.1394
2010's	30 (47.62)	28.8240
2020's	3 (4.76)	9.53

Drug	Relationship Strength	Studies
citric acid, anhydrous	low	1
lactic acid	low	6
indole	low	1
melatonin	low	1
niacinamide	low	1
nitrates	low	1
nitrites	low	1
3-aminobenzamide	low	1
7-nitroindazole	low	1
pimagedine	low	1
aztreonam	low	1
baclofen	low	1
ciprofloxacin	low	3
gentamicin	low	2
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one	low	1
memantine	low	2
ofloxacin	low	1
chloramphenicol	low	1
galactose	low	1
ampicillin	low	3
mannitol	low	2
shikimic acid	low	1
indazoles	low	1
thiazoles	low	1
malondialdehyde	low	1
vancomycin	low	1
streptomycin	low	3
phenyl acetate	low	2
glutamic acid	low	1
amoxicillin	low	1
etoposide	low	1
amikacin	low	1
ng-nitroarginine methyl ester	low	1
cephalosporin c	low	4
telmisartan	low	1
nicotine	low	1
gefitinib	low	1
aerobactin	low	2
beta-lactams	low	1
levofloxacin	low	1
moxifloxacin	low	1
meropenem	low	4
yersiniabactin	low	1
fosfomycin	low	1
phenyl-n-tert-butylnitrone	low	1
sphingosine	low	1
dinoprostone	low	2
montelukast	low	2
sphingosine 1-phosphate	low	1
deamino arginine vasopressin	low	1
cysteine	low	1
cefepime	low	1
cefotaxime	low	3
selenocysteine	low	1
dizocilpine maleate	low	1
ppi-0903	low	1
mocetinostat	low	1
losartan potassium	low	1
dextrothyroxine	low	1
ro13-9904	low	7
interleukin-8	low	1
oxytetracycline, anhydrous	low	1
cyclic gmp	low	1
2,4-diaminohypoxanthine	low	1
bis(3',5')-cyclic diguanylic acid	low	1
colibactin	low	1

Protein Targets (1,314)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1	0	1	0	1
Chain A, Proto-oncogene serine/threonine-protein kinase Pim-1	0	1	0	1
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	10	0	0	10
Chain A, Cruzipain	7	0	0	7
Chain A, Methyltransferase Wbdd	0	1	0	1
thioredoxin reductase	14	0	0	14
15-lipoxygenase, partial	1	0	0	1
ATAD5 protein, partial	4	0	0	4
NFKB1 protein, partial	3	0	0	3
TDP1 protein	15	0	0	15
Thrombopoietin	1	0	0	1
aldehyde dehydrogenase 1 family, member A1	13	0	0	13
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	2	0	0	2
thyroid stimulating hormone receptor	3	0	0	3
regulator of G-protein signaling 4	8	0	0	8
EWS/FLI fusion protein	10	0	0	10
67.9K protein	3	0	0	3
Parkin	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	14	0	0	14
cytochrome P450 2D6 isoform 1	3	0	0	3
cellular tumor antigen p53 isoform a	2	0	0	2
cytochrome P450 2C19 precursor	2	0	0	2
cytochrome P450 2C9 precursor	3	0	0	3
chromobox protein homolog 1	8	0	0	8
flap endonuclease 1	6	0	0	6
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	6	0	0	6
M-phase phosphoprotein 8	3	0	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	2	1	4
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha	0	1	0	1
Serine/threonine-protein kinase PLK4	0	1	1	2
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	1	1	2
Gamma-aminobutyric acid receptor subunit pi	6	2	0	8
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Bromodomain-containing protein 4	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Integrin beta-3	2	0	1	3
Cytochrome P450 1A2	0	5	0	5
Integrin alpha-IIb	2	0	1	3
Neuronal acetylcholine receptor subunit alpha-4	1	3	2	7
Serine/threonine-protein kinase pim-1	0	1	1	2
Neuronal acetylcholine receptor subunit beta-2	1	3	2	7
Gamma-aminobutyric acid receptor subunit beta-1	6	2	0	8
Gamma-aminobutyric acid receptor subunit delta	6	2	0	8
Gamma-aminobutyric acid receptor subunit gamma-2	6	2	1	9
Casein kinase II subunit alpha'	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	6	2	0	8
Gamma-aminobutyric acid receptor subunit alpha-3	6	2	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	6	2	0	8
Gamma-aminobutyric acid receptor subunit alpha-2	6	2	0	8
Proteinase-activated receptor 1	0	0	0	1
Bromodomain-containing protein 2	0	1	0	1
Phosphatidylinositol 3-kinase regulatory subunit alpha	0	1	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	6	2	0	8
Gamma-aminobutyric acid receptor subunit gamma-3	6	2	0	8
Gamma-aminobutyric acid receptor subunit alpha-6	6	2	0	8
Sodium-dependent serotonin transporter	0	3	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Type-1 angiotensin II receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	4	0	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	3	1	5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	2	1	5
Serine/threonine-protein kinase mTOR	0	2	1	3
Serine/threonine-protein kinase mTOR	0	1	0	1
Histamine H2 receptor	4	0	0	4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	1	4
Glycogen synthase kinase-3 beta	0	1	1	2
D(1A) dopamine receptor	1	0	0	1
Serine/threonine-protein kinase PLK1	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-1	6	2	1	9
Gamma-aminobutyric acid receptor subunit beta-3	6	2	0	8
Gamma-aminobutyric acid receptor subunit beta-2	6	2	1	9
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	1	2
DNA-dependent protein kinase catalytic subunit	0	3	0	3
Mu-type opioid receptor	0	2	0	2
Serine-protein kinase ATM	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	3	0	3
Serine/threonine-protein kinase ATR	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
Bromodomain-containing protein 3	0	1	0	1
Serine/threonine-protein kinase pim-3	0	1	1	2
Phosphoinositide 3-kinase regulatory subunit 5	0	1	0	1
GABA theta subunit	6	2	0	8
Gamma-aminobutyric acid receptor subunit epsilon	6	2	0	8
Serine/threonine-protein kinase PLK3	0	2	1	3
Serine/threonine-protein kinase PLK2	0	1	1	2
ATP-dependent phosphofructokinase	8	0	0	8
Chain A, Beta-lactamase	4	0	0	4
RAR-related orphan receptor gamma	7	0	0	7
GLS protein	4	0	0	4
Bloom syndrome protein isoform 1	6	0	0	6
lethal factor (plasmid)	5	0	0	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	12	0	0	12
Chain A, Ferritin light chain	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	8	0	0	8
lamin isoform A-delta10	11	0	0	11
Poly [ADP-ribose] polymerase 2	0	2	0	2
Poly [ADP-ribose] polymerase 1	0	3	0	3
Poly [ADP-ribose] polymerase 1	0	1	0	1
Transporter	0	3	1	5
endonuclease IV	3	0	0	3
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
nuclear receptor ROR-gamma isoform 1	1	0	0	1
geminin	16	0	0	16
muscleblind-like protein 1 isoform 1	2	0	0	2
muscarinic acetylcholine receptor M1	2	0	0	2
neuropeptide S receptor isoform A	3	0	0	3
Aromatase	0	2	0	2
Amine oxidase [flavin-containing] A	0	1	1	2
Nitric oxide synthase, endothelial	0	2	0	2
Nitric oxide synthase, endothelial	0	3	0	4
Nitric oxide synthase, brain	0	5	0	6
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	3	0	3
Nitric oxide synthase, inducible	0	3	0	4
Nitric oxide synthase, endothelial	0	1	0	1
estrogen nuclear receptor alpha	15	0	0	15
peripheral myelin protein 22	5	0	0	5
histone acetyltransferase KAT2A isoform 1	7	0	0	7
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	16
Bile salt export pump	0	18	0	18
Canalicular multispecific organic anion transporter 1	0	13	0	14
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
AR protein	15	0	0	15
apical membrane antigen 1, AMA1	4	0	0	4
Beta-lactamase	0	0	0	2
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	3	0	0	3
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	8	0	0	8
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
DNA polymerase kappa isoform 1	4	0	0	4
Bile salt export pump	0	3	0	3
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	4
Cytochrome P450 2C9	0	4	0	4
Beta-lactamase	0	0	0	4
Kappa-type opioid receptor	0	0	0	3
Solute carrier family 15 member 1	0	5	0	5
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	4
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Solute carrier family 15 member 2	0	4	0	4
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Beta-lactamase	0	0	0	3
acid sphingomyelinase	2	0	0	2
GLI family zinc finger 3	14	0	0	14
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
farnesoid X nuclear receptor	7	0	0	7
Beta-lactamase	0	1	0	3
Beta-lactamase	0	0	0	4
Metallo-beta-lactamase type 2	0	0	1	5
Metallo-beta-lactamase VIM-11	0	0	0	4
Metallo-beta-lactamase VIM-2	0	0	0	4
Beta-lactamase	0	0	0	4
Metallo-beta-lactamase	0	0	0	4
Beta-lactamase	0	1	0	3
thyroid hormone receptor beta isoform 2	10	0	0	10
DNA polymerase beta	5	0	0	5
Carbonic anhydrase 1	0	4	0	5
Carbonic anhydrase 2	0	4	0	5
60 kDa heat shock protein, mitochondrial	0	2	0	2
Beta-lactamase OXA-7	0	0	0	1
Spike glycoprotein	5	0	0	5
10 kDa heat shock protein, mitochondrial	0	2	0	2
Angiopoietin-1 receptor	0	0	2	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Thiosulfate sulfurtransferase	0	2	0	2
Metallo-beta-lactamase VIM-13	0	0	0	4
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	3
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
60 kDa chaperonin	0	2	0	2
Metallo-beta-lactamase	0	0	0	4
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	1	4
10 kDa chaperonin	0	2	0	2
Metallo-b-lactamase	0	0	0	4
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	3
Histamine H3 receptor	0	0	0	3
Beta-lactamase class B VIM-2	0	0	1	5
Beta-lactamase VIM-1	0	0	0	4
phosphopantetheinyl transferase	5	0	0	5
activating transcription factor 6	7	0	0	7
D(1A) dopamine receptor	2	0	0	2
Gamma-aminobutyric acid type B receptor subunit 2	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 2	0	2	0	2
Gamma-aminobutyric acid type B receptor subunit 1	0	2	1	3
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
Stimulator of interferon genes protein	0	0	1	1
Stimulator of interferon genes protein	0	0	2	2
RocR	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-19	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 5	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase TEM	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	3
Beta-lactamase	0	0	0	2
BlaVIM-1	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 6	0	1	0	1
Albumin	0	0	3	3
Beta-lactamase	0	0	0	1
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 7	0	1	0	2
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 8	0	1	0	1
Solute carrier family 22 member 7	0	1	0	2
interleukin 8	3	0	0	3
estrogen-related nuclear receptor alpha	11	0	0	11
pregnane X nuclear receptor	7	0	0	7
G	4	0	0	4
cytochrome P450 2D6	6	0	0	6
peroxisome proliferator activated receptor gamma	4	0	0	4
vitamin D (1,25- dihydroxyvitamin D3) receptor	3	0	0	3
aryl hydrocarbon receptor	8	0	0	8
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
heat shock protein beta-1	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 1	10	0	0	10
streptokinase A precursor	0	0	5	5
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Interferon beta	4	0	0	4
HLA class I histocompatibility antigen, B alpha chain	4	0	0	4
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Cellular tumor antigen p53	7	0	0	7
Cytochrome P450 3A4	0	6	1	7
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Inositol hexakisphosphate kinase 1	4	0	0	4
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	4	0	0	4
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	2	0	3
DNA gyrase subunit A	0	3	0	7
DNA gyrase subunit B	0	3	0	7
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	2	0	3
Cytochrome P450 2D6	0	3	0	3
DNA topoisomerase 2-alpha	0	2	2	13
DNA gyrase subunit A	0	2	0	3
Cytochrome P450 2C19	0	3	0	3
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	3	0	5
DNA gyrase subunit A	0	4	0	6
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	2
Potassium voltage-gated channel subfamily H member 2	0	8	0	10
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	3	0	0	3
nuclear receptor subfamily 1, group I, member 3	7	0	0	7
glucocorticoid receptor [Homo sapiens]	6	0	0	6
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	3	0	0	3
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
Proto-oncogene tyrosine-protein kinase Src	0	2	1	3
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	1	0	2
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	2	0	2
Alpha-ketoglutarate-dependent dioxygenase FTO	0	2	0	2
Phosphodiesterase	0	1	0	1
Multidrug resistance-associated protein 5	0	0	0	1
Vasopressin V2 receptor	0	1	1	2
Oxytocin receptor	0	0	1	1
Vasopressin V1a receptor	0	1	1	2
Vasopressin V1b receptor	0	1	1	2
Translocator protein	0	1	0	1
Vasopressin V2 receptor	0	1	1	2
Microtubule-associated protein tau	6	0	0	6
nonstructural protein 1	1	0	0	1
glucocerebrosidase	2	0	0	2
peripheral myelin protein 22 isoform 1	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	6	0	0	6
mitogen-activated protein kinase 1	4	0	0	4
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
retinoid X nuclear receptor alpha	7	0	0	7
thyroid stimulating hormone receptor	4	0	0	4
prostaglandin E2 receptor EP2 subtype	1	0	0	1
vitamin D3 receptor isoform VDRA	6	0	0	6
Solute carrier family 22 member 2	0	0	0	2
Solute carrier family 22 member 1	0	1	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Glutamate receptor ionotropic, NMDA 1	0	5	1	7
Glutamate receptor ionotropic, NMDA 2A	0	5	1	7
Glutamate receptor ionotropic, NMDA 2B	0	5	1	7
Glutamate receptor ionotropic, NMDA 2C	0	5	1	7
Glutamate receptor ionotropic, NMDA 2D	0	5	1	7
Glutamate receptor ionotropic, NMDA 3B	0	5	1	7
Glutamate receptor ionotropic, NMDA 3A	0	5	1	7
glp-1 receptor, partial	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
caspase 7, apoptosis-related cysteine protease	3	0	0	3
progesterone receptor	3	0	0	3
peroxisome proliferator-activated receptor delta	2	0	0	2
caspase-3	3	0	0	3
LMP1 [Human herpesvirus 4]	0	0	0	1
v-jun sarcoma virus 17 oncogene homolog (avian)	4	0	0	4
Histone H2A.x	3	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Voltage-dependent calcium channel gamma-2 subunit	3	0	0	3
Prothrombin	0	0	1	2
Regulatory protein E2	0	0	1	1
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	1	6
DNA topoisomerase 1	0	1	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
DNA topoisomerase 2	0	0	0	1
Glutamate receptor 2	3	2	1	6
ATP-dependent translocase ABCB1	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Serum paraoxonase/arylesterase 1	0	2	0	2
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	2	9
Tubulin beta-2B chain	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
ATPase family AAA domain-containing protein 5	2	0	0	2
Ataxin-2	2	0	0	2
Solute carrier organic anion transporter family member 1B3	0	4	0	4
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
UDP-N-acetylglucosamine 1-carboxyvinyltransferase	0	1	0	1
USP1 protein, partial	5	0	0	5
IDH1	3	0	0	3
importin subunit beta-1 isoform 1	2	0	0	2
snurportin-1	2	0	0	2
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
Leukotriene C4 synthase	0	0	1	1
acetylcholinesterase	2	0	0	2
Fumarate hydratase	1	0	0	1
estrogen receptor 2 (ER beta)	4	0	0	4
polyprotein	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	3	0	0	3
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
epidermal growth factor receptor isoform a precursor	1	1	0	2
tyrosine-protein kinase Yes	1	0	0	1
Bone morphogenetic protein receptor type-1B	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase 25	0	0	1	1
ATP-dependent RNA helicase DDX3X	0	0	1	1
Pyridoxal kinase	0	0	1	1
Citron Rho-interacting kinase	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Aurora kinase A	0	0	1	1
Cyclin-G-associated kinase	0	1	1	2
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Ephrin type-B receptor 6	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 3	0	0	1	1
Mitogen-activated protein kinase 13	0	0	1	1
3-phosphoinositide-dependent protein kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 2	0	0	1	1
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	1	1
NUAK family SNF1-like kinase 1	0	0	1	1
Dynamin-like 120 kDa protein, mitochondrial	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Tyrosine-protein kinase JAK2	0	0	1	1
Rho-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase ULK1	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	1	1
Ribosomal protein S6 kinase alpha-5	0	0	1	1
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	1	1
Ribosomal protein S6 kinase alpha-4	0	0	1	1
Serine/threonine-protein kinase 16	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Serine/threonine-protein kinase 10	0	0	1	1
Serine/threonine-protein kinase D3	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Structural maintenance of chromosomes protein 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 6	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	1	1
Serine/threonine-protein kinase LATS1	0	0	1	1
Serine/threonine-protein kinase PAK 4	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
Tyrosine-protein kinase ABL1	0	1	1	2
Epidermal growth factor receptor	0	3	2	5
RAF proto-oncogene serine/threonine-protein kinase	0	0	1	1
Receptor tyrosine-protein kinase erbB-2	0	1	1	2
High affinity nerve growth factor receptor	0	0	1	1
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	1	1
ADP/ATP translocase 2	0	0	1	1
Cytochrome P450 2E1	0	1	0	1
Protein kinase C beta type	0	0	1	1
Insulin receptor	0	1	1	2
Tyrosine-protein kinase Lck	0	0	1	1
Tyrosine-protein kinase Fyn	0	1	1	2
Cyclin-dependent kinase 1	0	1	1	2
Glycogen phosphorylase, liver form	0	0	1	1
Tyrosine-protein kinase Fes/Fps	0	0	1	1
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	1	1
Tyrosine-protein kinase Lyn	0	0	1	1
Proto-oncogene tyrosine-protein kinase receptor Ret	0	1	1	2
Insulin-like growth factor 1 receptor	0	0	1	1
Signal recognition particle receptor subunit alpha	0	0	1	1
Cytochrome c1, heme protein, mitochondrial	0	0	1	1
Hepatocyte growth factor receptor	0	0	1	1
Tyrosine-protein kinase HCK	0	1	1	2
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Platelet-derived growth factor receptor beta	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Quinolone resistance protein NorA	0	1	0	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Serine/threonine-protein kinase A-Raf	0	0	1	1
Cytochrome P450 2C8	0	2	0	2
Mast/stem cell growth factor receptor Kit	0	0	1	1
Glycogen phosphorylase, brain form	0	0	1	1
Breakpoint cluster region protein	0	0	1	1
Fibroblast growth factor receptor 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Cyclin-dependent kinase 4	0	0	1	1
ADP/ATP translocase 3	0	0	1	1
Inosine-5'-monophosphate dehydrogenase 2	0	0	1	1
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	1	1
Insulin receptor-related protein	0	0	1	1
Serine/threonine-protein kinase B-raf	0	1	1	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	1	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	1	3
Platelet-derived growth factor receptor alpha	0	0	1	1
Tyrosine-protein kinase Fer	0	0	1	1
Protein kinase C alpha type	0	0	1	1
cAMP-dependent protein kinase catalytic subunit alpha	0	0	1	1
Vascular endothelial growth factor receptor 1	0	0	1	1
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Ras-related protein Rab-6A	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Fibroblast growth factor receptor 2	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	1	1	2
Multifunctional protein ADE2	0	0	1	1
Fibroblast growth factor receptor 4	0	0	1	1
Fibroblast growth factor receptor 3	0	0	1	1
cAMP-dependent protein kinase catalytic subunit gamma	0	0	1	1
cAMP-dependent protein kinase catalytic subunit beta	0	0	1	1
Ferrochelatase, mitochondrial	0	0	1	1
Ribosomal protein S6 kinase beta-1	0	0	1	1
Tyrosine-protein kinase JAK1	0	0	1	1
Sodium-dependent dopamine transporter	0	1	0	1
Protein kinase C eta type	0	0	1	1
Cyclin-dependent kinase 2	0	1	1	2
Beta-adrenergic receptor kinase 1	0	0	1	1
Cruzipain	0	1	0	1
Probable ATP-dependent RNA helicase DDX6	0	0	1	1
Activin receptor type-2A	0	0	1	1
Mitogen-activated protein kinase 3	0	0	1	1
MAP/microtubule affinity-regulating kinase 3	0	0	1	1
Deoxycytidine kinase	0	0	1	1
Mitogen-activated protein kinase 1	0	0	1	1
Ephrin type-A receptor 2	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Ephrin type-B receptor 2	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Non-receptor tyrosine-protein kinase TYK2	0	0	1	1
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	1	1
Heme oxygenase 2	0	0	1	1
Tyrosine-protein kinase receptor UFO	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
S-adenosylmethionine synthase isoform type-2	0	0	1	1
DnaJ homolog subfamily A member 1	0	0	1	1
RAC-alpha serine/threonine-protein kinase	0	1	1	2
RAC-beta serine/threonine-protein kinase	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Dual specificity protein kinase TTK	0	0	1	1
DNA replication licensing factor MCM4	0	0	1	1
Prostaglandin G/H synthase 2	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 3	0	0	1	1
Vascular endothelial growth factor receptor 2	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 2	0	0	1	1
Receptor-type tyrosine-protein kinase FLT3	0	0	1	1
Bone morphogenetic protein receptor type-1A	0	0	1	1
Activin receptor type-1B	0	0	1	1
TGF-beta receptor type-1	0	0	1	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
TGF-beta receptor type-2	0	0	1	1
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	1	1
Glycine--tRNA ligase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 8	0	1	0	1
Protein kinase C iota type	0	0	1	1
Exosome RNA helicase MTR4	0	0	1	1
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase Tec	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
Tyrosine-protein kinase ABL2	0	0	1	1
Tyrosine-protein kinase FRK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Tyrosine-protein kinase SYK	0	0	1	1
26S proteasome regulatory subunit 6B	0	0	1	1
Mitogen-activated protein kinase 8	0	0	1	1
Mitogen-activated protein kinase 9	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 3	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0	0	1	1
Casein kinase I isoform alpha	0	1	1	2
Casein kinase I isoform delta	0	0	1	1
MAP kinase-activated protein kinase 2	0	0	1	1
Cyclin-dependent kinase 8	0	0	1	1
Elongation factor Tu, mitochondrial	0	0	1	1
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	1	1
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	1	1
Dual specificity protein kinase CLK1	0	0	1	1
Dual specificity protein kinase CLK2	0	0	1	1
Dual specificity protein kinase CLK3	0	0	1	1
Glycogen synthase kinase-3 alpha	0	0	1	1
Cyclin-dependent kinase 7	0	0	1	1
Cyclin-dependent kinase 9	0	0	1	1
Ras-related protein Rab-27A	0	0	1	1
Tyrosine-protein kinase Blk	0	0	1	1
Interleukin-1 receptor-associated kinase 1	0	0	1	1
Ribosomal protein S6 kinase alpha-3	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek2	0	0	1	1
Serine/threonine-protein kinase Nek3	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	1	1	2
Dual specificity mitogen-activated protein kinase kinase 6	0	0	1	1
Death-associated protein kinase 1	0	0	1	1
LIM domain kinase 1	0	0	1	1
LIM domain kinase 2	0	0	1	1
Mitogen-activated protein kinase 12	0	0	1	1
Mitogen-activated protein kinase 10	0	0	1	1
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 3	0	0	1	1
Ephrin type-A receptor 5	0	0	1	1
Ephrin type-B receptor 4	0	1	1	2
Ephrin type-B receptor 1	0	0	1	1
Ephrin type-A receptor 4	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	1	1
Adenosine kinase	0	0	2	2
Beta-secretase 1	0	1	0	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Ras-related protein Rab-10	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Actin-related protein 3	0	0	1	1
Actin-related protein 2	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
GTP-binding nuclear protein Ran	0	0	1	1
Tubulin alpha-1A chain	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Casein kinase I isoform gamma-2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase 3	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Cyclin-dependent kinase 6	0	0	1	1
Cyclin-dependent-like kinase 5	0	0	1	1
Cyclin-dependent kinase 16	0	0	1	1
Cyclin-dependent kinase 17	0	0	1	1
ATP-dependent 6-phosphofructokinase, platelet type	0	0	1	1
Synaptic vesicular amine transporter	0	1	0	1
Protein kinase C epsilon type	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Transcription factor p65	0	1	0	1
Protein kinase C theta type	0	0	1	1
Activin receptor type-1	0	0	1	1
Macrophage-stimulating protein receptor	0	0	1	1
Focal adhesion kinase 1	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	0	1	1
Tyrosine-protein kinase BTK	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Activated CDC42 kinase 1	0	0	1	1
Epithelial discoidin domain-containing receptor 1	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	0	1	1
Serine/threonine-protein kinase 4	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	1	1
Serine/threonine-protein kinase PAK 1	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 5	0	0	1	1
Mitogen-activated protein kinase 7	0	0	1	1
Serine/threonine-protein kinase PAK 2	0	0	1	1
Serine/threonine-protein kinase 3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 1	0	0	1	1
cGMP-dependent protein kinase 2	0	0	1	1
Integrin-linked protein kinase	0	0	1	1
Rho-associated protein kinase 1	0	0	1	1
Non-receptor tyrosine-protein kinase TNK1	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	1	1
Activin receptor type-2B	0	0	1	1
Bone morphogenetic protein receptor type-2	0	0	1	1
Protein-tyrosine kinase 6	0	0	1	1
cGMP-dependent protein kinase 1	0	0	1	1
Cyclin-dependent kinase 13	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	1	1
Protein-tyrosine kinase 2-beta	0	0	1	1
Maternal embryonic leucine zipper kinase	0	0	1	1
Structural maintenance of chromosomes protein 1A	0	0	1	1
Chromodomain-helicase-DNA-binding protein 4	0	0	1	1
Peroxisomal acyl-coenzyme A oxidase 1	0	0	1	1
Serine/threonine-protein kinase D1	0	0	1	1
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	1	1	2
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Ephrin type-A receptor 7	0	0	1	1
Delta(24)-sterol reductase	0	0	1	1
Ribosomal protein S6 kinase alpha-1	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Myosin light chain kinase, smooth muscle	0	0	1	1
Mitogen-activated protein kinase 11	0	0	1	1
Serine/threonine-protein kinase STK11	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
Serine/threonine-protein kinase N1	0	0	1	1
Serine/threonine-protein kinase N2	0	0	1	1
Mitogen-activated protein kinase 14	0	1	1	2
Calcium/calmodulin-dependent protein kinase type IV	0	0	1	1
Mitogen-activated protein kinase kinase kinase 11	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Discoidin domain-containing receptor 2	0	0	1	1
AP2-associated protein kinase 1	0	0	1	1
Myosin light chain kinase 3	0	0	1	1
Uncharacterized aarF domain-containing protein kinase 5	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Putative heat shock protein HSP 90-beta 2	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase MRCK alpha	0	0	1	1
Serine/threonine-protein kinase MRCK gamma	0	0	1	1
Acyl-CoA dehydrogenase family member 10	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Serine/threonine-protein kinase ULK3	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Uncharacterized protein FLJ45252	0	0	1	1
Acyl-CoA dehydrogenase family member 11	0	0	1	1
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	1	1
Serine/threonine-protein kinase MARK2	0	0	1	1
Serine/threonine-protein kinase TAO1	0	0	1	1
STE20-related kinase adapter protein alpha	0	0	1	1
Myosin-14	0	0	1	1
AarF domain-containing protein kinase 1	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
ATP-dependent RNA helicase DDX42	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
MAP kinase-activated protein kinase 5	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	1	1
Mitogen-activated protein kinase 15	0	0	1	1
Serine/threonine-protein kinase Nek9	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Serine/threonine-protein kinase Nek7	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
ATP-dependent RNA helicase DDX1	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Aurora kinase B	0	0	1	1
MAP/microtubule affinity-regulating kinase 4	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Serine/threonine-protein kinase Nek1	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	1	1
EKC/KEOPS complex subunit TP53RK	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 5	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Mitogen-activated protein kinase kinase kinase 3	0	0	1	1
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Nucleolar GTP-binding protein 1	0	0	1	1
Serine/threonine-protein kinase D2	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
NUAK family SNF1-like kinase 2	0	0	1	1
RNA cytidine acetyltransferase	0	0	1	1
Serine/threonine-protein kinase SIK2	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
STE20-like serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase TAO3	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
dCTP pyrophosphatase 1	0	0	1	1
Dual specificity protein kinase CLK4	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
Casein kinase I isoform gamma-1	0	0	1	1
Serine/threonine-protein kinase PAK 6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Phenylalanine--tRNA ligase beta subunit	0	0	1	1
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	1	1
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	1	1
Interleukin-1 receptor-associated kinase 4	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Mitogen-activated protein kinase kinase kinase 20	0	0	1	1
Cyclin-dependent kinase 12	0	0	1	1
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
Serine/threonine-protein kinase 26	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	1	1
Phosphatidylinositol 4-kinase beta	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
Serine/threonine-protein kinase TBK1	0	0	1	1
Septin-9	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Ribosomal protein S6 kinase alpha-6	0	0	1	1
TRAF2 and NCK-interacting protein kinase	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
Serine/threonine-protein kinase TAO2	0	0	1	1
Long-chain-fatty-acid--CoA ligase 5	0	0	1	1
ALK tyrosine kinase receptor	0	0	1	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	2	1	3
SRSF protein kinase 3	0	0	1	1
Serine/threonine-protein kinase ICK	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
RAC-gamma serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase SIK3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 2	0	0	1	1
Thyroid hormone receptor-associated protein 3	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	1	1
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 3	0	0	1	1
Serine/threonine-protein kinase MRCK beta	0	0	1	1
Interleukin-1 receptor-associated kinase 3	0	0	1	1
Serine/threonine-protein kinase 24	0	0	1	1
Casein kinase I isoform gamma-3	0	0	1	1
Mitogen-activated protein kinase kinase kinase 4	0	0	1	1
Chain A, GLUTAMATE RECEPTOR SUBUNIT 2	0	1	0	1
Chain A, Glutamate Receptor Subunit 2	0	1	0	1
Chain B, Glutamate Receptor Subunit 2	0	1	0	1
Chain A, Slr1257 protein	0	0	1	1
Chain A, Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	0	1	0	1
beta-2 adrenergic receptor	1	0	0	1
Metabotropic glutamate receptor 8	0	2	0	2
Metabotropic glutamate receptor 6	0	1	1	3
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Excitatory amino acid transporter 4	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutathione reductase, mitochondrial	0	2	0	2
Bifunctional aspartokinase/homoserine dehydrogenase 1	0	1	0	1
Glutamate receptor 1	0	2	1	3
Glutamate receptor 3	0	2	1	3
Glutamate receptor 4	0	2	1	3
Glutamate receptor ionotropic, kainate 1	0	2	1	3
Metabotropic glutamate receptor 1	0	2	1	3
Metabotropic glutamate receptor 2	0	0	1	1
Metabotropic glutamate receptor 3	0	0	1	1
Metabotropic glutamate receptor 4	0	1	1	2
Metabotropic glutamate receptor 5	0	0	1	1
Metabotropic glutamate receptor 6	0	0	1	1
Metabotropic glutamate receptor 7	0	0	1	1
Glutamate receptor ionotropic, kainate 1	0	1	1	2
Metabotropic glutamate receptor 5	0	1	1	3
Glutamate receptor ionotropic, kainate 2	0	2	1	3
Glutamate receptor 1	0	2	1	3
Glutamate receptor 2	0	2	1	3
Glutamate receptor 3	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	2	0	2
Excitatory amino acid transporter 1	0	2	0	3
Excitatory amino acid transporter 2	0	2	0	3
Excitatory amino acid transporter 3	0	2	0	3
Metabotropic glutamate receptor 8	0	0	1	1
Glutamate receptor 4	0	2	1	3
Excitatory amino acid transporter 3	0	0	0	1
Glutamate racemase	0	0	0	1
Metabotropic glutamate receptor 8	0	1	1	2
Fatty-acid amide hydrolase 1	0	3	0	3
Glutamate receptor ionotropic, kainate 4	0	2	0	2
Glutamate carboxypeptidase 2	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, kainate 2	0	1	1	2
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Metabotropic glutamate receptor 1	0	1	1	3
Metabotropic glutamate receptor 2	0	1	1	3
Metabotropic glutamate receptor 7	0	1	1	3
Metabotropic glutamate receptor 3	0	1	1	3
Metabotropic glutamate receptor 4	0	1	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, kainate 5	0	1	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Glutamate receptor ionotropic, kainate 5	0	2	0	2
Glutamate racemase	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, CELL DIVISION PROTEIN KINASE 2	0	1	0	1
Chain A, Cell Division Protein Kinase 2	0	1	0	1
DNA repair and recombination protein RadA	0	0	1	1
Heat shock protein HSP 90-alpha	0	0	1	1
G2/mitotic-specific cyclin-B1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	0	1	1
Cyclin-A2	0	1	0	1
Cyclin-A1	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	5	0	0	5
Phenol oxidase	0	1	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	2	2
Endolysin	0	0	1	1
Integrin beta-2	0	0	1	1
Intercellular adhesion molecule 1	0	0	1	1
Trp operon repressor	0	0	1	1
Integrin alpha-L	0	0	1	1
Carbonic anhydrase 4	0	3	0	3
Carbonic anhydrase 6	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
CAAX prenyl protease 2 isoform 2	0	0	0	1
Tubulin beta-4A chain	0	1	0	1
Tubulin beta chain	0	1	0	1
Tubulin alpha-3C chain	0	1	0	1
Tubulin alpha-1B chain	0	1	0	1
Tubulin alpha-4A chain	0	1	0	1
Tubulin beta-4B chain	0	1	0	1
DNA primase	0	1	0	1
Tubulin beta-3 chain	0	1	0	1
Tubulin beta-2A chain	0	1	0	1
Tubulin beta-8 chain	0	1	0	1
Tubulin alpha-3E chain	0	1	0	1
Tubulin alpha-1A chain	0	1	0	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Tubulin alpha-1C chain	0	1	0	1
Tubulin beta-6 chain	0	1	0	1
Tubulin beta-2B chain	0	1	0	1
Tubulin beta-1 chain	0	1	0	1
Smad3	2	0	0	2
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
TAR DNA-binding protein 43	3	0	0	3
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
ClpP	1	0	0	1
ras-related protein Rab-9A	1	0	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Myeloperoxidase	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 2C11	0	1	0	1
Acetylcholinesterase	0	2	0	2
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Nociceptin receptor	0	1	0	1
Alpha-1A adrenergic receptor	0	4	0	4
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear receptor ROR-gamma	2	0	0	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Cytochrome P450 1B1	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Histamine H3 receptor	0	1	0	1
huntingtin isoform 2	1	0	0	1
Acetylcholinesterase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	3	2	6
Neuronal acetylcholine receptor subunit beta-4	0	3	2	6
Neuronal acetylcholine receptor subunit alpha-6	0	3	2	6
5-hydroxytryptamine receptor 7	0	1	0	1
Cholinesterase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
Beta-lactamase	0	0	0	1
PPM1D protein	1	0	0	1
Histone deacetylase 3	0	2	0	2
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	2	0	2
Histone deacetylase 11	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	2
Aldo-keto reductase family 1 member B1	0	3	0	3
Alpha-2A adrenergic receptor	0	3	0	3
Adenosine receptor A3	0	2	0	2
Muscarinic acetylcholine receptor M1	0	2	0	2
Beta-3 adrenergic receptor	0	2	0	2
Alpha-1B adrenergic receptor	0	3	0	3
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
Substance-K receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Thromboxane-A synthase	0	1	0	1
D(3) dopamine receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Leukotriene C4 synthase	0	1	0	1
Cysteinyl leukotriene receptor 1	0	1	0	1
Cysteinyl leukotriene receptor 2	0	1	0	1
Cysteinyl leukotriene receptor 1	0	2	1	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Replicase polyprotein 1ab	0	1	0	1
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
arylsulfatase A	3	0	0	3
Neutrophil elastase	0	2	0	2
Collagenase 3	0	2	0	2
Chain A, NAD-dependent deacetylase	0	1	0	1
NAD-dependent histone deacetylase SIR2	0	1	0	1
Coagulation factor VII	0	1	0	1
Tissue factor	0	1	0	1
Cytochrome P450 3A5	0	1	0	1
NAD-dependent protein deacetylase HST2	0	1	0	1
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
NAD(+) hydrolase SARM1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-2	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	0	1
NAD-dependent protein deacetylase sirtuin-1	0	1	0	1
NAD-dependent protein deacetylase sirtuin-3, mitochondrial	0	1	0	1
NAD-dependent protein deacylase sirtuin-5, mitochondrial	0	1	0	1
NAD-dependent protein deacetylase	0	1	0	1
5-hydroxytryptamine receptor 3E	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3B	0	1	0	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Cytochrome P450 2A6	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	2	2	5
Neuronal acetylcholine receptor subunit beta-3	0	2	2	5
Translocator protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-5	0	2	2	5
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Muscarinic acetylcholine receptor M4	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Delta-type opioid receptor	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	4
Neuronal acetylcholine receptor subunit alpha-9	0	2	2	5
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
5-hydroxytryptamine receptor 3A	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Inositol monophosphatase 1	1	0	0	1
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-7	0	2	2	5
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Solute carrier family 22 member 1	0	1	0	1
5-hydroxytryptamine receptor 3D	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
5-hydroxytryptamine receptor 3C	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-10	0	2	2	5
Solute carrier family 22 member 2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Carbonic anhydrase	0	2	0	2
Sodium/iodide cotransporter	0	1	0	1
Carbonic anhydrase 15	0	2	0	2
STE24	0	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
thioredoxin glutathione reductase	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
transcriptional regulator ERG isoform 3	1	0	0	1
microphthalmia-associated transcription factor isoform 9	0	1	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
phosphoglycerate kinase	1	0	0	1
Retinoid isomerohydrolase	0	1	0	1
Retinoid isomerohydrolase	0	1	0	1
Retinoid isomerohydrolase	0	1	0	1
Albumin	0	0	1	1
Complement C1s subcomponent	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Chain A, Shikimate kinase	0	0	1	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Chain A, 3-phosphoshikimate 1-carboxyvinyltransferase	0	1	0	1
Luciferase	2	0	0	2
alpha-galactosidase	1	0	0	1
C-X-C chemokine receptor type 5 isoform 1	0	1	0	1
ubiquitin-conjugating enzyme E2 N	0	1	0	1
C-C chemokine receptor type 6	0	1	0	1
apelin receptor	0	1	0	1
bcl-2-related protein A1	0	1	0	1
Endoglycoceramidase II	0	0	0	1
Protein kinase C alpha type	0	1	0	1
Estrogen receptor	0	0	1	1
Protein kinase C delta type	0	1	0	1
Protein kinase C epsilon type	0	1	0	1
Protein kinase C zeta type	0	1	0	1
cAMP-dependent protein kinase catalytic subunit alpha	0	1	0	1
Protein kinase C gamma type	0	1	0	1
Protein kinase C beta type	0	1	0	1
Estrogen receptor beta	0	0	1	1
Protein kinase C eta type	0	1	0	1
Sphingosine kinase 2	0	1	0	1
Sphingosine kinase 1	0	1	0	1
Protein kinase C theta type	0	1	0	1
Sphingosine 1-phosphate receptor 2	0	1	1	2
Sphingosine 1-phosphate receptor 4	0	1	1	2
Sphingosine 1-phosphate receptor 1	0	1	1	2
Sodium-dependent serotonin transporter	0	1	1	2
Sphingosine 1-phosphate receptor 3	0	1	1	2
Sphingosine 1-phosphate receptor 5	0	1	1	2
Protein-arginine deiminase type-4	0	2	0	2
eyes absent homolog 2 isoform a	1	0	0	1
Angiotensin-converting enzyme	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Thromboxane A2 receptor	0	0	0	1
Peroxisome proliferator-activated receptor alpha	0	0	1	1
Glycine receptor subunit alpha-1	0	0	1	1
Type-1 angiotensin II receptor	0	1	0	2
Peroxisome proliferator-activated receptor delta	0	0	1	1
Peroxisome proliferator-activated receptor gamma	0	1	1	2
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Type-2 angiotensin II receptor	0	1	0	1
Guanine nucleotide-binding protein G	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Peroxisome proliferator-activated receptor delta	0	1	1	2
Peroxisome proliferator-activated receptor alpha	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Escherichia coli Meningitis

Synonyms(2)

Research Excerpts

Overview

Research

Studies (63)

Protein Targets (1,314)

Escherichia coli Meningitis

Synonyms(2)

Research Excerpts

Overview

Research

Studies (63)

Drugs Studied (75)

Protein Targets (1,314)