Page last updated: 2024-10-24

formation of radial glial scaffolds

Definition

Target type: biologicalprocess

The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:15157725]

Radial glial scaffolds are critical structures in the developing vertebrate brain that provide a framework for neuronal migration and differentiation. They are specialized glial cells that extend long, radial processes from the ventricular zone, the innermost layer of the developing brain, to the pial surface, the outermost layer. These processes serve as guiding tracks for migrating neurons, allowing them to reach their final destinations in the brain.

The formation of radial glial scaffolds begins during early embryogenesis with the specification of radial glial progenitors from the neuroepithelium. These progenitors undergo asymmetric cell division, giving rise to both a radial glial cell and a neuroblast. The radial glial cell retains its progenitor potential and continues to divide, while the neuroblast migrates away from the ventricular zone along the radial glial process to become a mature neuron.

The radial glial process itself is a complex structure that is composed of a variety of proteins, including microtubules, actin filaments, and intermediate filaments. These cytoskeletal components provide structural support and facilitate the transport of molecules along the process. The radial glial process also expresses cell adhesion molecules, such as integrins and cadherins, which mediate interactions between the radial glia and migrating neurons.

As the brain develops, the radial glial scaffold undergoes a number of changes. For example, the number of radial glial cells increases during the period of active neurogenesis, and the length of the radial glial processes increases as the brain grows. In addition, the radial glial scaffold can be remodeled in response to environmental cues, such as changes in the concentration of growth factors or the presence of other cells.

The formation and maintenance of the radial glial scaffold is essential for normal brain development. Disruptions in radial glial function can lead to a variety of neurodevelopmental disorders, including microcephaly, lissencephaly, and polymicrogyria. These disorders are characterized by abnormal brain size, structure, or function.

In summary, radial glial scaffolds play a critical role in brain development by providing a framework for neuronal migration and differentiation. They are dynamic structures that are regulated by a variety of factors, including cell division, cytoskeletal dynamics, and cell-cell interactions. Disruptions in radial glial function can lead to severe neurodevelopmental disorders.'
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Proteins (1)

ProteinDefinitionTaxonomy
Integrin beta-1An integrin beta-1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:P05556]Homo sapiens (human)

Compounds (17)

CompoundDefinitionClassesRoles
haloperidolhaloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.

Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol
antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
1,3-ditolylguanidine1,3-ditolylguanidine: structure given in first source; a selective ligand for the sigma binding sites in the braintoluenes
tirofibantirofiban : A member of the class of piperidines that is L-tyrosine in which a hydrogen attached to the amino group is replaced by a butylsulfonyl group and in which the hydrogen attached to the phenolic hydroxy group is replaced by a 4-(piperidin-4-yl)butyl group.

Tirofiban: Tyrosine analog and PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX antagonist that inhibits PLATELET AGGREGATION and is used in the treatment of ACUTE CORONARY SYNDROME.
L-tyrosine derivative;
piperidines;
sulfonamide
anticoagulant;
fibrin modulating drug;
platelet glycoprotein-IIb/IIIa receptor antagonist
arginyl-glycyl-aspartic acidarginyl-glycyl-aspartic acid: amino acid sequence of basic unit of widespread cellular recognition systemoligopeptide
arginyl-glycyl-aspartyl-serinearginyl-glycyl-aspartyl-serine: corresponds to cell attachment site of fibronectin; located near carboxyl-terminal region of alpha-chain of fibrinogen; inhibits platelet aggregation & fibrinogen binding to activated platelets
glycyl-arginyl-glycyl-aspartyl-serineglycyl-arginyl-glycyl-aspartyl-serine: synthetic peptide from fibronectins; inhibits experimental metastasis of murine melanoma cells
d-arg-gly-asp-trparginyl-glycyl-aspartyl-tryptophan: a synthetic RGD-containing peptide
l 738167L 738167: structure in first source
cilengitideCilengitide: an alphaVbeta3 integrin antagonist that paralyzes cancer cellsoligopeptide
l 734217L 734217: fibrinogen receptor antagonist; structure given in first source
cyclopaminepiperidinesglioma-associated oncogene inhibitor
arginyl-glycyl-aspartyl-phenylalanine
cyclic(arg-gly-asp-d-phe-val)
mk-0429
mocetinostatmocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).

mocetinostat: undergoing phase II clinical trials for treatment of cancer
aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline
antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
tr 14035N-(2,6-dichlorobenzoyl)-4-(2',6'-bismethoxyphenyl)phenylalanine: TR-14035 is the (L)-isomer; an antagonist of both alpha4beta1 and beta7 integrins; structure in first source
bio 1211BIO 1211: integrin alpha4beta1 inhibitor; structure in first source