| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347059 | CD47-SIRPalpha protein protein interaction - Alpha assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347045 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot counterscreen GloSensor control cell line | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347410 | qHTS for inhibitors of adenylyl cyclases using a fission yeast platform: a pilot screen against the NCATS LOPAC library | 2019 | Cellular signalling, 08, Volume: 60 | A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504836 | Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in human glioma: Validation | 2002 | The Journal of biological chemistry, Apr-19, Volume: 277, Issue:16
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. |
| AID1347151 | Optimization of GU AMC qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347083 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347049 | Natriuretic polypeptide receptor (hNpr1) antagonism - Pilot screen | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347086 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588349 | qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay | | | |
| AID588378 | qHTS for Inhibitors of ATXN expression: Validation | | | |
| AID1347057 | CD47-SIRPalpha protein protein interaction - LANCE assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347082 | qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal | 2020 | Antiviral research, 01, Volume: 173 | A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity. |
| AID1347058 | CD47-SIRPalpha protein protein interaction - HTRF assay qHTS validation | 2019 | PloS one, , Volume: 14, Issue:7
| Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. |
| AID1347050 | Natriuretic polypeptide receptor (hNpr2) antagonism - Pilot subtype selectivity assay | 2019 | Science translational medicine, 07-10, Volume: 11, Issue:500
| Inhibition of natriuretic peptide receptor 1 reduces itch in mice. |
| AID1347405 | qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS LOPAC collection | 2020 | ACS chemical biology, 07-17, Volume: 15, Issue:7
| High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle. |
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID169315 | Central dopamine receptor stimulation was accessed by rat rotation after oral administration of 20.3 umol/kg after 2 hr (in vivo) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID65250 | Binding affinity was determined by measuring the ability to displace [125I]N-(p-aminophenethyl)-spiroperidol from Dopamine receptor D2 in rat caudate (in vitro) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID61494 | Binding affinity using [125 I] SCH 23982 radioligand competitive binding assay on dopamine receptor D1 | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID227611 | Intrinsic activity measured relative to dopamine on D1C(R) receptor | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID220912 | Binding affinity towards beta-1 adrenergic receptor using [3H]iodocyanopindolol as radioligand in competitive binding assay | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID65429 | Binding affinity for dopamine receptor D2 | 1991 | Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
| Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands. |
| AID169325 | Central dopamine receptor stimulation was accessed by rat rotation after subcutaneous administration of 4.1 umol/kg after 2 hr (in vivo) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID34290 | In vitro inhibition of dopamine stimulated adenylate cyclase; na = 'not applicable' | 1991 | Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
| Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands. |
| AID196584 | Evaluated for the maximum stimulation of adenylate cyclase in rat striatal tissue with respect to the maximum stimulation caused by dopamine | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. |
| AID61501 | Binding affinity was determined by measuring the ability to displace [125I]SCH-23982 from Dopamine receptor D1 in rat caudate (in vitro) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID63042 | Formation of cAMP on Dopamine receptor D1 in vitro in carp retina | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID227609 | Intrinsic activity relative to dopamine at D-2 receptor. | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID169319 | Central dopamine receptor stimulation was accessed by rat rotation after subcutaneous administration of 1.02 umol/kg after 2 hr (in vivo) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID168043 | Rat rotation experiments were conducted to evaluate rational behavior of the rats by administering at a dose of 2.0 umol/kg subcutaneously | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID65110 | Binding affinity using [3H]-spiperone radioligand competitive binding assay against dopamine receptor D2 | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID63043 | Percent intrinsic activity as formation of cAMP on Dopamine receptor D1 in vitro in carp retina | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID37091 | Binding affinity towards alpha-2 adrenergic receptor using [3H]rauwolscine as radioligand in competitive binding assay | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID169322 | Central dopamine receptor stimulation was accessed by rat rotation after subcutaneous administration of 2.03 umol/kg after 2 hr (in vivo) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID4756 | Binding affinity towards 5-hydroxytryptamine 1C receptor using [125 I]-SCH23982 as radioligand in competitive binding assay | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID61248 | Percent intrinsic activity was determined by measuring the formation of cAMP on Dopamine receptor D2 in vitro in rat intermediate lobe | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID61220 | Formation of cAMP on Dopamine receptor D2 in vitro in rat intermediate lobe | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID63375 | Concentration required to inhibit 50% dopamine receptor D1 using cell free homogenate of rat striatum | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID61010 | Effective concentration was determined for the adenylate cyclase activity in rat striatal tissue as a measure of Dopamine receptor D1 functional activity | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. |
| AID218672 | Binding affinity towards alpha-1 adrenergic receptor using [3H]prazosin as radioligand in competitive binding assay | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID169320 | Central dopamine receptor stimulation was accessed by rat rotation after subcutaneous administration of 1.2 umol/kg after 2 hr (in vivo) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID168035 | Rat rotation experiments were conducted to evaluate rational behavior of the rats by administering at a dose of 1.0 umol/kg subcutaneously | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID169317 | Central dopamine receptor stimulation was accessed by rat rotation after subcutaneous administration of 0.20 umol/kg after 2 hr (in vivo) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID4010 | Binding affinity towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand in competitive binding assay | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID61219 | Concentration required to inhibit 50% dopamine receptor D2 in a cell free homogenate of intermediate lobe of pituitary gland | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID64779 | Affinity towards Dopamine receptor D2 was evaluated in rat striatal membrane using [3H]spiperone as radioligand | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. |
| AID63041 | Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retina | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID169318 | Central dopamine receptor stimulation was accessed by rat rotation after subcutaneous administration of 0.41 umol/kg after 2 hr (in vivo) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID168032 | Rat rotation experiments were conducted to evaluate rational behavior of the rats by administering at a dose of 0.2 umol/kg subcutaneously | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID61345 | Affinity towards Dopamine receptor D1 was evaluated in rat striatal membrane using [3H]SCH-23,390 as radioligand | 1996 | Journal of medicinal chemistry, Jan-05, Volume: 39, Issue:1
| Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. |
| AID169316 | Central dopamine receptor stimulation was accessed by rat rotation after oral administration of 40.6 umol/kg after 2 hr (in vivo) | 1990 | Journal of medicinal chemistry, Nov, Volume: 33, Issue:11
| (1R,3S)-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-3-phenyl-1H-2-benzopyran: a potent and selective D1 agonist. |
| AID227613 | Intrinsic activity measured relative to dopamine on D1C(S) receptor | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID61513 | Binding affinity for dopamine receptor D1 | 1991 | Journal of medicinal chemistry, Oct, Volume: 34, Issue:10
| Synthesis and pharmacological evaluation of 1-(aminomethyl)-3,4-dihydro-5-hydroxy-1H-2-benzopyrans as dopamine D1 selective ligands. |
| AID5152 | Binding affinity towards 5-hydroxytryptamine 2- receptor using [3H]ketanserin as radioligand in competitive binding assay | 1991 | Journal of medicinal chemistry, Aug, Volume: 34, Issue:8
| Synthesis and dopaminergic activity of 3-substituted 1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyrans: characterization of an auxiliary binding region in the D1 receptor. |
| AID1345718 | Human D1 receptor (Dopamine receptors) | 2005 | Pharmacology, biochemistry, and behavior, Nov, Volume: 82, Issue:3
| Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors. |
| AID1345879 | Human D5 receptor (Dopamine receptors) | 2005 | Pharmacology, biochemistry, and behavior, Nov, Volume: 82, Issue:3
| Differences between A 68930 and SKF 82958 could suggest synergistic roles of D1 and D5 receptors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |