Page last updated: 2024-12-06
3-pyridyl pinacidil
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
3-pyridyl pinacidil: RN refers to cpd without isomeric designation [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 43347 |
| CHEMBL ID | 75172 |
| SCHEMBL ID | 9456838 |
| MeSH ID | M0226154 |
Synonyms (10)
| Synonym |
|---|
| ly-222675 |
| CHEMBL75172 |
| 2-cyano-3-(3-pyridyl)-1-(1,2,2-trimethylpropyl)guanidine |
| 3-pyridyl pinacidil |
| guanidine, 2-cyano-3-(3-pyridyl)-1-(1,2,2-trimethylpropyl)- |
| 1-cyano-2-(3,3-dimethylbutan-2-yl)-3-pyridin-3-ylguanidine |
| SCHEMBL9456838 |
| 60560-07-8 |
| DTXSID10975992 |
| n''-cyano-n-(3,3-dimethylbutan-2-yl)-n'-pyridin-3-ylguanidine |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (11)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID29396 | Ionisation constant (pKa2) due to proton loss from the pyridine ring | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Structure-activity studies of potassium channel opening in pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas. |
| AID1148549 | Toxicity in po dosed mouse assessed as mortality after 7 days | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and hypotensive activity of N-alkyl-N"-cyano-N'-pyridylguanidines. |
| AID1148550 | Hypotensive activity in po dosed spontaneously hypertensive Wistar-Okamoto rat assessed as dose required to cause 30 mmHg fall of blood pressure administered for 5 days | 1978 | Journal of medicinal chemistry, Aug, Volume: 21, Issue:8 | Synthesis and hypotensive activity of N-alkyl-N"-cyano-N'-pyridylguanidines. |
| AID197347 | Concentration required to cause 15% increase in [86Rb+] efflux from rat portal vein. | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Structure-activity studies of potassium channel opening in pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas. |
| AID193409 | Maximum percent fall in Systolic blood pressure (SBP) was measured in anesthetized normotensive rat for 30 mins after intravenous (iv) injection at 0.03 mg/kg dose | 1994 | Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1 | Novel potassium channel openers: synthesis and pharmacological evaluation of new N-(substituted-3-pyridyl)-N'-alkylthioureas and related compounds. |
| AID190149 | The hypotensive activity expressed as rating of therapeutic index (MED/LD50 <1/200). | 1980 | Journal of medicinal chemistry, Jan, Volume: 23, Issue:1 | Adaptive least-squares method applied to structure--activity correlation of hypotensive N-alkyl-N''-cyano-N'-pyridylguanidines. |
| AID193410 | Maximum percent fall in Systolic blood pressure (SBP) was measured in anesthetized normotensive rat for 30 mins after intravenous (iv) injection at 0.1 mg/kg dose | 1994 | Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1 | Novel potassium channel openers: synthesis and pharmacological evaluation of new N-(substituted-3-pyridyl)-N'-alkylthioureas and related compounds. |
| AID29374 | Ionisation constant (pKa1) due to protonation of the pyridyl ring | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Structure-activity studies of potassium channel opening in pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas. |
| AID197525 | Concentration required to cause 50% inhibition of spontaneous activity in rat portal vein | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Structure-activity studies of potassium channel opening in pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas. |
| AID197345 | Negative logarithm of the concentration causing a 100% inhibition of spontaneous mechanical activity in rat portal vein is determined in vitro | 1994 | Journal of medicinal chemistry, Jan-07, Volume: 37, Issue:1 | Novel potassium channel openers: synthesis and pharmacological evaluation of new N-(substituted-3-pyridyl)-N'-alkylthioureas and related compounds. |
| AID493017 | Wombat Data for BeliefDocking | 1992 | Journal of medicinal chemistry, Jun-12, Volume: 35, Issue:12 | Structure-activity studies of potassium channel opening in pinacidil-type cyanoguanidines, nitroethenediamines, thioureas, and ureas. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.38
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.38) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||