Page last updated: 2024-09-28

Bovine Leukemia

A lymphoid neoplastic disease in cattle caused by the bovine leukemia virus. Enzootic bovine leukosis may take the form of lymphosarcoma, malignant lymphoma, or leukemia but the presence of malignant cells in the blood is not a consistent finding.

Synonyms(9)

Synonym
Lymphosarcoma, Bovine
Bovine Lymphoma
Enzootic Bovine Leukosis
Leukosis, Bovine
Bovine Leukemia
Bovine Lymphosarcoma
Bovine Leukosis
Lymphoma, Bovine
Leukemia, Bovine

Research Excerpts

Research

Studies (50)

TimeframeStudies, This Condition (%)All Conditions %
pre-19901 (2.00)23.3326
1990's15 (30.00)12.5806
2000's16 (32.00)18.1394
2010's12 (24.00)28.8240
2020's6 (12.00)9.53
DrugIndicatedRelationship StrengthStudiesTrials
adenine0low10
cytosine0low10
formaldehyde0low20
pteridines0low10
uracil0low10
valproic acid0low10
indomethacin0low10
prednisolone0low10
alanine0low10
bromodeoxyuridine0low10
tyrosine0low10
lactose0medium11
pyrroles0low10
fluorescein-5-isothiocyanate0low10
dihydrostreptomycin sulfate0low10
gold0low10
trolamine salicylate0low20
tetradecanoylphorbol acetate0low10
propiconazole0low10
didodecyl n-(alpha-trimethylammonioacetyl)glutamate0low10
glycogen0low10
retinol0low10
1,2-dilauroylphosphatidylcholine0low10
sodium dodecyl sulfate0low20
dinoprostone0low20
cysteine0low30
phosphorus0medium11
1,2-dielaidoylphosphatidylethanolamine0low10
1,2-dioleoyloxy-3-(trimethylammonium)propane0low10
sq-233770low10
mocetinostat0low10
acid phosphatase0low10
phosphatidylcholines0low10
gs-96200low10
transforming growth factor beta0low20
sybr green i0low10
agar0low40
caseins0medium11
guanine0low10
concanavalin a0low20

Protein Targets (418)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
thioredoxin reductase2002
ATAD5 protein, partial2002
GLS protein1001
TDP1 protein8008
regulator of G-protein signaling 42002
67.9K protein2002
Parkin2002
bromodomain adjacent to zinc finger domain 2B3003
IDH13003
euchromatic histone-lysine N-methyltransferase 24004
nuclear factor erythroid 2-related factor 2 isoform 24004
huntingtin isoform 21001
ras-related protein Rab-9A2002
serine/threonine-protein kinase mTOR isoform 13003
urokinase-type plasminogen activator precursor2002
plasminogen precursor2002
urokinase plasminogen activator surface receptor precursor2002
survival motor neuron protein isoform d2002
D(1A) dopamine receptor1001
Ataxin-26006
ATP-dependent phosphofructokinase1001
Chain A, MTA/SAH nucleosidase0101
Chain A, Ribosome-inactivating protein alpha-trichosanthin0011
Chain A, Ricin A chain0011
Chain A, Ribosome-inactivating protein 30011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
Chain A, Phenylethanolamine N-methyltransferase0011
RAR-related orphan receptor gamma110011
AR protein9009
nuclear receptor subfamily 1, group I, member 35005
cytochrome P450 family 3 subfamily A polypeptide 45005
glucocorticoid receptor [Homo sapiens]8008
estrogen-related nuclear receptor alpha100010
pregnane X nuclear receptor6006
estrogen nuclear receptor alpha130013
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a6006
heat shock protein beta-14004
importin subunit beta-1 isoform 11001
snurportin-11001
tumor susceptibility gene 101 protein1001
GTP-binding nuclear protein Ran isoform 11001
lamin isoform A-delta103003
Voltage-dependent calcium channel gamma-2 subunit6006
Bile salt export pump0505
Cyclin-dependent kinase 10101
Heat shock protein HSP 90-beta0101
Glutamate receptor 26006
Xanthine dehydrogenase/oxidase0101
TAR DNA-binding protein 433003
Protein mono-ADP-ribosyltransferase PARP150101
Leucine-rich repeat serine/threonine-protein kinase 20202
ATPase family AAA domain-containing protein 55005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE3003
Carbonic anhydrase 10002
Carbonic anhydrase 20002
Alanine racemase, biosynthetic0001
5-hydroxytryptamine receptor 1D0001
Glutamate receptor ionotropic, NMDA 1 0102
Proton-coupled amino acid transporter 10101
Adenosine deaminase0001
Carbonic anhydrase 40001
interleukin 84004
pregnane X receptor4004
Microtubule-associated protein tau4004
aldehyde dehydrogenase 1 family, member A12002
progesterone receptor5005
retinoic acid nuclear receptor alpha variant 17007
retinoid X nuclear receptor alpha8008
arylsulfatase A2002
nuclear receptor subfamily 1, group I, member 22002
cellular tumor antigen p53 isoform a1001
Nuclear hormone receptor family member daf-120011
chromobox protein homolog 12002
thyroid hormone receptor beta isoform 26006
oxysterols receptor LXR-beta isoform 10011
geminin6006
peripheral myelin protein 224004
muscarinic acetylcholine receptor M11001
Thymidine kinase, cytosolic0101
Thymidine phosphorylase0001
Thymidylate kinase0101
Nuclear receptor ROR-gamma4004
Spike glycoprotein3003
Thymidine kinase0001
Thymidylate kinase0101
GLI family zinc finger 37007
Deoxycytidine kinase0001
Chain A, Cruzipain4004
SMAD family member 25005
SMAD family member 35005
thyroid stimulating hormone receptor3003
farnesoid X nuclear receptor5005
thyroid stimulating hormone receptor3003
activating transcription factor 62002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
prostaglandin E2 receptor EP2 subtype1001
vitamin D3 receptor isoform VDRA5005
mitogen-activated protein kinase 13003
nuclear factor erythroid 2-related factor 2 isoform 17007
Solute carrier family 22 member 20001
Solute carrier family 22 member 1 0001
Multidrug resistance-associated protein 40203
Solute carrier organic anion transporter family member 1A50001
Cellular tumor antigen p538008
Cytochrome P450 3A40213
Prostaglandin E2 receptor EP3 subtype0202
Prostaglandin E2 receptor EP4 subtype0202
Prostaglandin E2 receptor EP1 subtype0213
Prostaglandin E2 receptor EP1 subtype0202
Prostaglandin E2 receptor EP4 subtype0213
Prostaglandin F2-alpha receptor0011
Prostaglandin E2 receptor EP4 subtype0112
Prostaglandin E2 receptor EP3 subtype0213
Prostaglandin E2 receptor EP2 subtype0213
Prostacyclin receptor0213
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 60102
Solute carrier family 22 member 70002
Prostaglandin E2 receptor EP2 subtype0202
Prostaglandin E2 receptor EP2 subtype0112
Solute carrier family 22 member 200101
Solute carrier family 22 member 80102
Solute carrier family 22 member 60101
Solute carrier family 22 member 70001
Solute carrier organic anion transporter family member 2A10001
Solute carrier family 22 member 110001
Solute carrier organic anion transporter family member 1B20001
Solute carrier family 22 member 70001
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
endonuclease IV1001
Bloom syndrome protein isoform 11001
peripheral myelin protein 22 isoform 12002
D(1A) dopamine receptor1001
hypoxia-inducible factor 1 alpha subunit4004
peroxisome proliferator-activated receptor delta5005
peroxisome proliferator activated receptor gamma6006
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
thyrotropin-releasing hormone receptor1001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
Histone H2A.x1001
cytochrome P450 2D62002
Toll-like receptor 80012
Toll-like receptor 70012
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
Chain A, membrane-associated prostaglandin E synthase-20101
Chain A, 2-oxoglutarate Oxygenase1001
Luciferase3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)1001
estrogen receptor 2 (ER beta)3003
EWS/FLI fusion protein2002
G2002
glucocerebrosidase1001
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)3003
aryl hydrocarbon receptor3003
cytochrome P450 2D6 isoform 11001
cytochrome P450 2C9 precursor1001
thyroid hormone receptor beta isoform a4004
DNA polymerase iota isoform a (long)3003
nuclear receptor ROR-gamma isoform 14004
DNA polymerase kappa isoform 12002
M-phase phosphoprotein 81001
neuropeptide S receptor isoform A1001
Prostaglandin-H2 D-isomerase0101
Prostaglandin E synthase0101
ATP-binding cassette sub-family C member 30202
Solute carrier family 22 member 60101
Prostaglandin G/H synthase 1 0102
Prostaglandin G/H synthase 2 0102
3',5'-cyclic-AMP phosphodiesterase 0101
Solute carrier organic anion transporter family member 2B1 0202
Cytochrome c oxidase subunit 20101
Epidermal growth factor receptor0101
Phospholipase A2, major isoenzyme0101
Interferon beta3003
HLA class I histocompatibility antigen, B alpha chain 2002
Albumin0112
Prostaglandin G/H synthase 10203
Procathepsin L0101
ATP-dependent translocase ABCB10101
Neuronal acetylcholine receptor subunit alpha-40101
Interleukin-80101
Androgen receptor0213
Neuronal acetylcholine receptor subunit beta-20101
Polyunsaturated fatty acid 5-lipoxygenase0102
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member B10101
Aldo-keto reductase family 1 member C40101
Prostaglandin G/H synthase 10101
Prostaglandin G/H synthase 10101
Sodium-dependent dopamine transporter0101
Sodium- and chloride-dependent GABA transporter 10101
Thromboxane-A synthase 0101
Adenosine receptor A10102
Serum paraoxonase/arylesterase 10101
Indoleamine 2,3-dioxygenase 10101
Caspase-10001
Nitric oxide synthase, inducible0101
Adenosine receptor A2a0102
Substance-P receptor0101
Sodium- and chloride-dependent GABA transporter 20101
Sodium- and chloride-dependent GABA transporter 30101
Multidrug resistance-associated protein 1 0101
Bifunctional epoxide hydrolase 20202
Prostaglandin G/H synthase 20314
Prostaglandin G/H synthase 2 0101
Peroxisome proliferator-activated receptor gamma0011
Aldo-keto reductase family 1 member C30202
Histamine H2 receptor2002
Sodium- and chloride-dependent betaine transporter0101
C-X-C chemokine receptor type 30101
Aldo-keto reductase family 1 member C2 0101
Guanine nucleotide-binding protein G2002
Prostaglandin D2 receptor 0202
Solute carrier organic anion transporter family member 1A30101
Prostaglandin G/H synthase 20202
Lactoylglutathione lyase0101
Aldo-keto reductase family 1 member C10101
Prostaglandin G/H synthase 20102
Potassium voltage-gated channel subfamily H member 20202
Uracil nucleotide/cysteinyl leukotriene receptor0101
Sigma intracellular receptor 20101
Rho-associated protein kinase 20101
Prostaglandin G/H synthase 1 0101
Nicotinate phosphoribosyltransferase0101
Inositol hexakisphosphate kinase 12002
Canalicular multispecific organic anion transporter 10202
Multidrug and toxin extrusion protein 10101
Dehydrogenase/reductase SDR family member 90101
P2Y purinoceptor 120101
Solute carrier organic anion transporter family member 1B30202
Cytosolic phospholipase A2 gamma0101
Prostaglandin D2 receptor 20112
Solute carrier organic anion transporter family member 1B10202
cytochrome P450 2C9, partial2002
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, Lectin0011
Chain A, ERYTHRINA CRISTA-GALLI LECTIN0011
Chain A, ERYTHRINA CRISTA-GALLI LECTIN0011
Chain A, cellulase0011
Chain A, cellulase0011
Chain A, Galectin-30011
Chain A, Anti-tumor lectin0101
Galectin-30101
Galectin-90011
Galectin-80011
Beta-galactoside-binding lectin0101
Galectin-10113
Galectin-30112
Galectin-30113
Galectin-70011
Alpha 1,4 galactosyltransferase0001
PPM1D protein1001
Histone deacetylase 30404
Nuclear receptor corepressor 10101
Integrin beta-10101
Leukotriene A-4 hydrolase0101
Cytochrome P450 2D60101
Integrin alpha-40101
Cytochrome P450 2C190101
Histone deacetylase 40303
Histone deacetylase 10404
Histone deacetylase 70303
Histone deacetylase 20404
Histone deacetylase 11 0303
Histone deacetylase 80303
Histone deacetylase 60303
Histone deacetylase 50303
Nuclear receptor corepressor 20101
luciferase0001
v-jun sarcoma virus 17 oncogene homolog (avian)2002
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Glucocorticoid receptor0218
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Glycine receptor subunit alpha-10202
Corticosteroid-binding globulin0101
Mineralocorticoid receptor 0213
Cytochrome P450 2C9 0101
Glutamine synthetase0011
Androgen receptor0101
Glycine receptor subunit beta0202
Glycine receptor subunit alpha-20202
Glycine receptor subunit alpha-30202
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20101
Estrogen receptor beta0202
Chain A, Beta-lactamase1001
Chain A, Ferritin light chain1001
glp-1 receptor, partial1001
phosphopantetheinyl transferase2002
nonstructural protein 11001
heat shock protein HSP 90-alpha isoform 20001
Polyunsaturated fatty acid lipoxygenase ALOX15B1001
heat shock protein 90, putative0001
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR0011
acetylcholinesterase1001
15-lipoxygenase, partial1001
USP1 protein, partial2002
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
potassium voltage-gated channel subfamily H member 2 isoform d2002
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
cytochrome P450 3A4 isoform 11001
Gamma-aminobutyric acid receptor subunit pi1001
Retinol-binding protein 40011
Beta-lactoglobulin0011
Amyloid-beta precursor protein0101
Gamma-aminobutyric acid receptor subunit beta-11001
Gamma-aminobutyric acid receptor subunit delta1001
Gamma-aminobutyric acid receptor subunit gamma-21001
Gamma-aminobutyric acid receptor subunit alpha-51001
Gamma-aminobutyric acid receptor subunit alpha-31001
Gamma-aminobutyric acid receptor subunit gamma-11001
Gamma-aminobutyric acid receptor subunit alpha-21001
Gamma-aminobutyric acid receptor subunit alpha-41001
Gamma-aminobutyric acid receptor subunit gamma-31001
Gamma-aminobutyric acid receptor subunit alpha-61001
Alpha-synuclein0101
Gamma-aminobutyric acid receptor subunit alpha-11001
Gamma-aminobutyric acid receptor subunit beta-31001
Gamma-aminobutyric acid receptor subunit beta-21001
Disintegrin and metalloproteinase domain-containing protein 171001
GABA theta subunit1001
Gamma-aminobutyric acid receptor subunit epsilon1001
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
alpha-galactosidase1001
histone acetyltransferase KAT2A isoform 11001
lethal factor (plasmid)1001
Peroxisome proliferator-activated receptor alpha1001
Serine/threonine-protein kinase D30011
Protein kinase C gamma type0112
Protein kinase C beta type0112
Luciferin 4-monooxygenase0011
Protein kinase C alpha type0112
Beta-1 adrenergic receptor0101
Protein kinase C eta type0011
Protein kinase C iota type0011
Protein kinase C epsilon type0112
Protein kinase C theta type0011
Protein kinase C zeta type0011
Protein kinase C delta type0112
Serine/threonine-protein kinase D10011
Ras guanyl-releasing protein 30011
Chain A, CHORISMATE MUTASE0101
Chain A, TYROSYL-tRNA SYNTHETASE0011
Polyphenol oxidase 20001
Carbonic anhydrase 120001
Plasma kallikrein0001
Carbonic anhydrase 30001
Carbonic anhydrase 40001
Carbonic anhydrase 60001
Carbonic anhydrase 5A, mitochondrial0001
Carbonic anhydrase0001
Carbonic anhydrase 70001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2A 0001
Glutamate receptor ionotropic, NMDA 2B0001
Glutamate receptor ionotropic, NMDA 2C0001
Large neutral amino acids transporter small subunit 10101
SLC16A10 protein0001
Carbonic anhydrase 90001
Carbonic anhydrase 0001
Carbonic anhydrase-like protein, putative0001
Carbonic anhydrase0001
Carbonic anhydrase0001
Glutamate receptor ionotropic, NMDA 2D0001
Carbonic anhydrase 0001
Tubulin--tyrosine ligase0101
Glutamate receptor ionotropic, NMDA 3B0001
Monocarboxylate transporter 100001
Carbonic anhydrase 150001
Taste receptor type 2 member 140001
Glutamate receptor ionotropic, NMDA 3A0001
Carbonic anhydrase 140001
Carbonic anhydrase 5B, mitochondrial0001
Chain A, Uracil-DNA Glycosylase0101
Protein cereblon0202
Cocaine esterase0101
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0101
Aldo-keto reductase family 1 member B10101
Cytochrome P450 2A60101
Tissue factor0101
Aldo-keto reductase family 1 member A10101
UDP-glucuronosyltransferase 2B70102
UDP-glucuronosyltransferase 1-60001
Liver carboxylesterase 10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member A10101
Aldo-keto reductase family 1 member B70101
Sigma non-opioid intracellular receptor 10101
Polyamine deacetylase HDAC100202
NAD-dependent protein deacylase sirtuin-5, mitochondrial0101
Histone deacetylase 90202
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]