Bloom Syndrome

An autosomal recessive disorder characterized by telangiectatic ERYTHEMA of the face, photosensitivity, DWARFISM and other abnormalities, and a predisposition toward developing cancer. The Bloom syndrome gene (BLM) encodes a RecQ-like DNA helicase.

Synonym
Bloom-Torre-Machacek Syndrome
Congenital Telangiectatic Erythema
Bloom Syndrome
Bloom's Syndrome

Excerpt	Reference
"Bloom's syndrome is characterized by a high sister chromatid exchange (SCE) frequency, the basis for which is not yet understood."	( Heartlein, MW; Latt, SA; Tsuji, H, 1987)
"Bloom syndrome is evidently an example of homozygosity for a recessive mutation occurring in nature."	( Alhadeff, B; Siniscalco, M, 1984)
"Bloom syndrome is an autosomal recessive genetic disease."	( Kennedy, AR; Nagasawa, H; Radner, BS, 1984)
"Bloom's syndrome is a rare autosomal recessive disorder characterized by genomic instability and predisposition to cancer."	( Bohr, VA; Brosh, RM; Cooper, MP; Hickson, ID; Karow, JK; Kenny, MK; Kureekattil, RP; Li, JL, 2000)
"Bloom syndrome is a disorder of profound and early cancer predisposition in which cells become hypermutable, exhibit high frequency of sister chromatid exchanges, and show increased micronuclei."	( Campbell, JL; Imamura, O, 2003)
"Bloom's syndrome is a rare autosomal recessive genetic disorder characterized by chromosomal aberrations, genetic instability, and cancer predisposition, all of which may be the result of abnormal signal transduction during DNA damage recognition."	( Celeste, A; Chen, J; Halazonetis, TD; Harris, CC; Linke, SP; Nussenzweig, A; Pedeux, R; Robles, AI; Sengupta, S; Sinogeeva, NI; Ward, IM; Zhang, R, 2004)
"Bloom's syndrome is a hereditary cancer-predisposition disorder resulting from mutations in the BLM gene."	( Bernstein, DA; Bohr, VA; Chan, KL; Garcia, PL; Hickson, ID; Janscak, P; Keck, JL; Ralf, C; Vindigni, A; Wu, L, 2005)
"Bloom Syndrome is an autosomal recessive cancer-prone disorder caused by mutations in the BLM gene."	( Ali, AM; Andreassen, PR; Busygina, V; Du, CH; Fan, Q; Meetei, AR; Raynard, S; Singh, TR; Sung, P, 2008)
"Bloom's syndrome is an autosomal recessive genome-instability disorder associated with a predisposition to cancer, premature aging and developmental abnormalities."	( Bertrand, JA; Bordas, R; Charlton, PA; Golec, JM; Legris, V; Pollard, JR; Reaper, PM; Swan, MK; Tanner, A; Vial, S, 2014)

Excerpt	Reference
"Cells from patients with Bloom syndrome, a cancer-prone disorder with cutaneous photosensitivity and spontaneous chromosome breakage, exhibit an abnormally increased number of sister-chromatid exchanges following treatment with 5-bromodeoxyuridine (BrdU)."	( Kerrigan, D; Kraemer, KH; Pommier, Y; Rünger, TM, 1991)
"The two Bloom's syndrome cell lines and 46BR cells had a nearly normal ability to reseal breaks resulting from gamma irradiation or treatment with xanthine plus xanthine oxidase."	( Nocentini, S, 1995)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	49 (33.33)	23.3326
1990's	39 (26.53)	12.5806
2000's	42 (28.57)	18.1394
2010's	14 (9.52)	28.8240
2020's	3 (2.04)	9.53

Drug	Relationship Strength	Studies	Trials
phosphoserine	low	1	0
adenine	low	1	0
cytosine	low	1	0
pyruvaldehyde	low	1	0
nickel	low	1	0
niacin	low	1	0
thymine	low	1	0
uracil	low	1	0
xanthine	low	1	0
3-aminobenzamide	low	3	0
bisbenzimidazole	low	3	0
caffeine	low	2	0
carmustine	low	1	0
chloroquine	low	1	0
stallimycin	low	1	0
fluorouracil	low	2	0
ethidium	low	2	0
hydroxyurea	low	13	0
nocodazole	low	1	0
methyl methanesulfonate	low	5	0
netropsin	low	1	0
w 7	low	1	0
mitomycin	low	4	0
prednisolone	low	1	0
estriol	low	1	0
thymidine	low	4	0
floxuridine	low	3	0
prednisone	low	1	0
dichlororibofuranosylbenzimidazole	low	1	0
alanine	low	1	0
serine	low	2	0
4-nitroquinoline-1-oxide	low	4	0
lysine	low	2	0
adenosine diphosphate	low	2	0
bromodeoxyuridine	low	25	0
edetic acid	low	1	0
adenosine monophosphate	low	2	0
ethyl methanesulfonate	low	3	0
methionine	low	1	0
colchicine	low	1	0
cycloheximide	low	2	0
cytarabine	low	1	0
histidine	low	2	0
threonine	low	2	0
dimethyl sulfate	low	1	0
glyoxal	low	1	0
nitrilotriacetic acid	low	1	0
acridines	low	1	0
pyrimidine	low	1	0
luminol	low	1	0
ethylnitrosourea	low	1	0
deoxycytidine	low	4	0
paraquat	low	2	0
camptothecin	low	5	0
deuterium	low	1	0
deuterium oxide	low	1	0
tetradecanoylphorbol acetate	low	3	0
etoposide	low	9	0
ibacitabine	low	1	0
glutathione disulfide	low	1	0
pyrimidine dimers	low	1	0
fangchinoline	low	1	0
methotrexate	low	1	0
xylose	medium	1	1
phorbols	low	2	0
hydroxyl radical	low	1	0
demecolcine	low	2	0
puromycin	low	1	0
n-formylmethionine leucyl-phenylalanine	low	2	0
trichostatin a	low	1	0
tretinoin	low	1	0
dactinomycin	low	1	0
aphidicolin	low	6	0
bromodeoxycytidine	low	1	0
isomethyleugenol	low	2	0
thioguanine anhydrous	low	1	0
phosphothreonine	low	1	0
zinostatin	low	1	0
cysteine	low	1	0
mocetinostat	low	1	0
calcimycin	low	1	0
nad	low	1	0
oligonucleotides	low	4	0
phosphatidylcholines	low	1	0
1-palmitoyl-2-(6-(n-(7-nitrobenz)-2-oxa-1,3-diazol-4-yl)aminocaproyl)phosphatidylcholine	low	1	0
tetracycline	low	1	0
nickel nitrilotriacetic acid	low	1	0
epidermal growth factor	low	1	0
antipain	low	1	0
deoxyguanosine	low	3	0
guanine	low	4	0
hypoxanthine	low	1	0
allopurinol	low	1	0
methylnitronitrosoguanidine	low	3	0
8-hydroxy-2'-deoxyguanosine	low	2	0

Protein Targets (987)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	18	0	0	18
Chain A, HADH2 protein	6	0	0	6
Chain B, HADH2 protein	6	0	0	6
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
Chain A, Ferritin light chain	9	0	0	9
Chain A, Cruzipain	5	0	0	5
aldehyde dehydrogenase 1 family, member A1	23	0	0	23
cytochrome P450 2D6 isoform 1	3	0	0	3
cytochrome P450 2C9 precursor	4	0	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
lamin isoform A-delta10	14	0	0	14
Poly [ADP-ribose] polymerase 2	0	1	0	1
Poly [ADP-ribose] polymerase 1	0	2	0	2
Poly [ADP-ribose] polymerase 1	0	1	0	1
Histamine H2 receptor	6	1	0	7
Transporter	0	1	0	1
ATP-dependent phosphofructokinase	13	0	0	13
Chain A, Avidin	0	0	2	2
Chain A, Avidin	0	0	2	2
Chain B, Avidin	0	0	2	2
thioredoxin reductase	14	0	0	14
TDP1 protein	32	0	0	32
Microtubule-associated protein tau	12	0	0	12
Smad3	9	0	0	9
alpha-galactosidase	3	0	0	3
flap endonuclease 1	8	0	0	8
DNA polymerase iota isoform a (long)	10	0	0	10
DNA topoisomerase 2-alpha	0	3	1	10
Acetylcholinesterase	0	3	0	3
Chain A, MTA/SAH nucleosidase	0	1	0	1
Chain A, Ribosome-inactivating protein alpha-trichosanthin	0	0	1	1
Chain A, Ricin A chain	0	0	1	1
Chain A, Ribosome-inactivating protein 3	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
Chain A, Phenylethanolamine N-methyltransferase	0	0	1	1
RAR-related orphan receptor gamma	21	0	0	21
AR protein	31	0	0	31
nuclear receptor subfamily 1, group I, member 3	18	0	0	18
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
glucocorticoid receptor [Homo sapiens]	27	0	0	27
estrogen-related nuclear receptor alpha	31	0	0	31
pregnane X nuclear receptor	16	0	0	16
estrogen nuclear receptor alpha	32	0	0	32
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	13	0	0	13
nuclear factor erythroid 2-related factor 2 isoform 2	19	0	0	19
heat shock protein beta-1	3	0	0	3
importin subunit beta-1 isoform 1	3	0	0	3
snurportin-1	3	0	0	3
tumor susceptibility gene 101 protein	1	0	0	1
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
Voltage-dependent calcium channel gamma-2 subunit	18	0	0	18
Bile salt export pump	0	16	0	16
Cyclin-dependent kinase 1	0	1	0	1
Heat shock protein HSP 90-beta	0	2	1	4
Glutamate receptor 2	18	0	0	18
Xanthine dehydrogenase/oxidase	0	5	0	5
TAR DNA-binding protein 43	6	0	0	6
Protein mono-ADP-ribosyltransferase PARP15	0	1	0	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	2	0	2
ATPase family AAA domain-containing protein 5	12	0	0	12
Ataxin-2	15	0	0	15
Chain A, Heat Shock Protein 90	0	0	1	1
Chain A, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain B, GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE	0	0	1	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, EOSINOPHIL-DERIVED NEUROTOXIN	0	1	0	1
Chain A, Myosin Ie Heavy Chain	0	0	1	1
Chain A, Preprotein translocase secA	0	0	1	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Phosphoribosylformylglycinamidine synthase	0	1	0	1
Chain A, nucleoside diphosphate kinase A	0	0	1	1
Chain B, nucleoside diphosphate kinase A	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain D, DNA polymerase III subunit gamma	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3	0	0	1	1
Chain A, Kinesin-like protein KIF11	0	1	0	1
regulator of G-protein signaling 4	7	0	0	7
HPr kinase/phosphorylase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
ATP-dependent molecular chaperone HSP82	0	0	0	1
Heat shock protein HSP 90-alpha	0	1	1	3
2-dehydropantoate 2-reductase	0	2	2	4
Heat shock 70 kDa protein 1A	0	1	1	2
Endoplasmic reticulum chaperone BiP	0	0	1	1
Heat shock cognate 71 kDa protein	0	0	1	1
Pyruvate kinase PKM	0	0	0	1
Pyruvate kinase PKLR	0	0	0	1
Endoplasmin	0	0	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
5'-nucleotidase	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Delta-type opioid receptor	0	1	1	2
Kappa-type opioid receptor	0	0	1	1
Endoplasmin	0	1	1	2
P2Y purinoceptor 2	0	0	2	2
Phosphatidylinositol 4-kinase alpha	0	2	0	2
P2X purinoceptor 1	0	0	1	1
P2Y purinoceptor 1	0	0	2	2
P2Y purinoceptor 1	0	0	2	2
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 4	0	0	1	1
P2X purinoceptor 5	0	0	1	1
P2X purinoceptor 6	0	0	1	1
P2X purinoceptor 3	0	0	1	1
Inositol monophosphatase 1	4	0	0	4
Heat shock protein 75 kDa, mitochondrial	0	1	0	1
P2Y purinoceptor 6	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	2
P2Y purinoceptor 11	0	0	2	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	2
P2Y purinoceptor 12	0	0	1	1
Sensor protein kinase WalK	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	2	0	2
P2X purinoceptor 2	0	0	1	1
Chain A, Glycogen Phosphorylase B	0	0	1	1
Chain B, Glycogen Phosphorylase B	0	0	1	1
Chain A, ADP-dependent glucokinase	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, Ribonuclease pancreatic	0	1	0	1
Chain A, phosphodiesterase-nucleotide pyrophosphatase	0	1	0	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain B, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
Chain A, GLYCOGEN PHOSPHORYLASE B	0	0	1	1
euchromatic histone-lysine N-methyltransferase 2	22	0	0	22
v-jun sarcoma virus 17 oncogene homolog (avian)	14	0	0	14
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
2'-deoxynucleoside 5'-phosphate N-hydrolase 1	0	1	0	1
5'-AMP-activated protein kinase subunit beta-2	0	0	1	1
Transient receptor potential cation channel subfamily M member 2	0	1	0	1
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
L-lactate dehydrogenase A chain	0	1	1	2
Adenylate kinase isoenzyme 1	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	0	0	1
Fructose-1,6-bisphosphatase 1	0	1	0	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	1
Cytochrome P450 2C9	0	5	2	7
Proto-oncogene tyrosine-protein kinase Src	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
5'-nucleotidase	0	0	0	1
Choline O-acetyltransferase	0	1	0	1
Adenylate kinase 2, mitochondrial	0	1	0	2
GTP:AMP phosphotransferase AK3, mitochondrial	0	0	0	1
Adenosine receptor A1	0	3	2	7
Adenylate kinase isoenzyme 1	0	1	0	2
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Adenylate kinase 2, mitochondrial	0	0	0	1
Glycine--tRNA ligase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Adenosine deaminase-like protein	0	0	0	1
Protease	0	1	1	2
Histamine H3 receptor	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	1	1
5'-AMP-activated protein kinase subunit beta-1	0	0	2	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	8	0	0	8
Carbonic anhydrase 1	0	1	0	4
Carbonic anhydrase 2	0	2	1	7
Alanine racemase, biosynthetic	0	0	0	1
5-hydroxytryptamine receptor 1D	0	0	0	2
Glutamate receptor ionotropic, NMDA 1	0	1	0	3
Proton-coupled amino acid transporter 1	0	2	0	2
Adenosine deaminase	0	0	0	1
Carbonic anhydrase 4	0	0	0	2
interleukin 8	10	0	0	10
thyroid stimulating hormone receptor	11	0	0	11
estrogen receptor 2 (ER beta)	13	0	0	13
progesterone receptor	14	0	0	14
IDH1	13	0	0	13
Bloom syndrome protein isoform 1	11	0	0	11
transcriptional regulator ERG isoform 3	3	0	0	3
thyroid hormone receptor beta isoform 2	20	0	0	20
ras-related protein Rab-9A	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	22	0	0	22
geminin	25	0	0	25
survival motor neuron protein isoform d	14	0	0	14
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	15
Polyphenol oxidase 2	0	2	0	2
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	4
Cellular tumor antigen p53	21	0	0	21
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Adenosine receptor A2a	0	4	3	8
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	5
Purine nucleoside phosphorylase	0	0	1	1
Canalicular multispecific organic anion transporter 1	0	15	0	16
Shiga toxin subunit A	0	2	0	2
Histamine H3 receptor	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	5	0	0	5
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	7	0	0	7
huntingtin isoform 2	7	0	0	7
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase beta	0	1	0	1
DNA polymerase beta	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase alpha catalytic subunit	0	1	1	2
DNA polymerase delta catalytic subunit	0	1	0	1
DNA polymerase catalytic subunit	0	1	0	1
DNA polymerase subunit gamma-1	0	1	0	1
DNA polymerase lambda	0	1	0	1
Luciferase	6	0	0	6
nonstructural protein 1	4	0	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
DNA topoisomerase 1	0	5	1	11
DNA topoisomerase 2-beta	0	1	1	10
pregnane X receptor	8	0	0	8
ATAD5 protein, partial	12	0	0	12
retinoic acid nuclear receptor alpha variant 1	24	0	0	24
retinoid X nuclear receptor alpha	16	0	0	16
bromodomain adjacent to zinc finger domain 2B	3	0	0	3
arylsulfatase A	5	0	0	5
nuclear receptor subfamily 1, group I, member 2	5	0	0	5
cellular tumor antigen p53 isoform a	9	0	0	9
Nuclear hormone receptor family member daf-12	0	0	1	1
chromobox protein homolog 1	17	0	0	17
serine/threonine-protein kinase mTOR isoform 1	6	0	0	6
oxysterols receptor LXR-beta isoform 1	0	0	1	1
urokinase-type plasminogen activator precursor	9	0	0	9
plasminogen precursor	9	0	0	9
urokinase plasminogen activator surface receptor precursor	9	0	0	9
peripheral myelin protein 22	12	0	0	12
muscarinic acetylcholine receptor M1	6	0	0	6
Thymidine kinase, cytosolic	0	5	0	8
Thymidine phosphorylase	0	0	0	3
Thymidylate kinase	0	2	0	2
Nuclear receptor ROR-gamma	6	1	1	8
Spike glycoprotein	7	1	2	10
Thymidine kinase	0	0	0	3
Thymidylate kinase	0	2	0	2
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Glycogen phosphorylase, liver form	0	0	1	1
Chain A, Chitinase	0	1	0	1
phosphopantetheinyl transferase	8	0	0	8
GLS protein	5	0	0	5
GLI family zinc finger 3	19	0	0	19
farnesoid X nuclear receptor	12	0	0	12
thyroid stimulating hormone receptor	5	0	0	5
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
thyroid hormone receptor beta isoform a	11	0	0	11
DNA polymerase beta	2	0	0	2
nuclear receptor ROR-gamma isoform 1	11	0	0	11
DNA polymerase kappa isoform 1	7	0	0	7
lethal factor (plasmid)	8	0	0	8
Potassium channel subfamily K member 2	0	0	1	1
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	1	0	1
Cholinesterase	0	2	0	2
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Replicase polyprotein 1ab	0	2	2	4
Adenosine receptor A3	0	5	0	5
Replicase polyprotein 1ab	0	3	2	5
Amine oxidase [flavin-containing] A	0	2	0	2
Adenosine receptor A1	0	2	0	4
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Adenosine receptor A2b	0	3	0	4
Adenosine receptor A2a	0	3	0	6
Vasopressin V2 receptor	0	0	0	1
Serine/threonine-protein kinase mTOR	0	2	0	2
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	1	0	1
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	1
Chitotriosidase-1	0	1	0	1
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	2	3
Endochitinase B1	0	1	0	1
Muscarinic acetylcholine receptor	0	0	0	1
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	2
Guanine deaminase	0	2	0	3
Chain A, Putative fructose-1,6-bisphosphate aldolase	6	0	0	6
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
acid sphingomyelinase	2	0	0	2
endonuclease IV	5	0	0	5
glp-1 receptor, partial	7	0	0	7
ClpP	2	0	0	2
electroneutral potassium-chloride cotransporter KCC2	0	0	1	1
Fumarate hydratase	8	0	0	8
USP1 protein, partial	8	0	0	8
TSHR protein	1	0	0	1
apical membrane antigen 1, AMA1	3	0	0	3
polyprotein	8	0	0	8
67.9K protein	16	0	0	16
glucocerebrosidase	4	0	0	4
Parkin	2	0	0	2
LacZ protein (plasmid)	0	0	1	1
XBP1	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	4	0	0	4
hexokinase-4 isoform 1	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
peripheral myelin protein 22 isoform 1	6	0	0	6
type-1 angiotensin II receptor	0	1	0	1
D(1A) dopamine receptor	1	0	0	1
vitamin D3 receptor isoform VDRA	8	0	0	8
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	2	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	2	0	0	2
glucokinase regulatory protein	1	0	0	1
mitogen-activated protein kinase 1	3	0	0	3
serine/threonine-protein kinase PLK1	2	0	0	2
apelin receptor	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
DNA damage-inducible transcript 3 protein	0	1	0	1
Vpr	3	0	0	3
histone acetyltransferase KAT2A isoform 1	6	0	0	6
streptokinase A precursor	0	0	2	2
neuropeptide S receptor isoform A	3	0	0	3
Rap guanine nucleotide exchange factor 3	1	0	0	1
Amyloid-beta precursor protein	2	4	0	6
Alpha-synuclein	3	3	0	6
D(1A) dopamine receptor	3	0	0	3
Guanine nucleotide-binding protein G	1	0	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	2
heat shock protein 90, putative	0	0	0	2
DNA topoisomerase	0	1	0	1
15-lipoxygenase, partial	3	0	0	3
NFKB1 protein, partial	3	0	0	3
PPM1D protein	8	0	0	8
Thrombopoietin	5	0	0	5
EWS/FLI fusion protein	13	0	0	13
putative alpha-glucosidase	1	0	0	1
hemoglobin subunit beta	3	0	0	3
cytochrome P450 2C19 precursor	3	0	0	3
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
cytochrome P450 3A4 isoform 1	8	0	0	8
M-phase phosphoprotein 8	3	0	0	3
muscleblind-like protein 1 isoform 1	4	0	0	4
relaxin receptor 1 isoform 1	1	0	0	1
Gamma-aminobutyric acid receptor subunit pi	8	0	0	8
Telomerase reverse transcriptase	0	1	0	1
Serine/threonine-protein kinase Chk1	0	0	1	1
Histone deacetylase 3	0	5	0	7
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	0	0	2
DNA ligase	0	2	0	2
Interferon beta	14	0	0	14
Integrin beta-3	3	1	0	4
Integrin alpha-IIb	3	1	0	4
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-1	8	0	0	8
Gamma-aminobutyric acid receptor subunit delta	8	0	0	8
Gamma-aminobutyric acid receptor subunit gamma-2	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-5	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-3	8	0	0	8
Gamma-aminobutyric acid receptor subunit gamma-1	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-2	8	0	0	8
Type-2 restriction enzyme BamHI	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	8	0	0	8
Gamma-aminobutyric acid receptor subunit gamma-3	8	0	0	8
Gamma-aminobutyric acid receptor subunit alpha-6	8	0	0	8
Somatostatin receptor type 1	0	1	0	1
Somatostatin receptor type 2	0	1	0	1
Somatostatin receptor type 4	0	1	0	1
Somatostatin receptor type 3	0	1	0	1
Somatostatin receptor type 5	0	1	0	1
5-hydroxytryptamine receptor 2B	0	6	0	6
Type-2 restriction enzyme HindIII	0	1	0	1
Histone deacetylase 4	0	4	1	8
Ribonuclease pancreatic	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	8	0	0	8
Gamma-aminobutyric acid receptor subunit beta-3	8	0	0	8
Gamma-aminobutyric acid receptor subunit beta-2	8	0	0	8
DNA topoisomerase 1	0	1	0	2
Histone deacetylase 1	0	5	2	9
DNA topoisomerase 1	0	1	0	1
Integrase	0	3	0	3
Histone deacetylase 7	0	4	0	6
GABA theta subunit	8	0	0	8
Histone deacetylase 2	0	5	1	8
DNA topoisomerase type IB small subunit	0	0	1	1
Polyamine deacetylase HDAC10	0	3	0	5
Histone deacetylase 11	0	4	0	6
Histone deacetylase 8	0	4	0	6
Gamma-aminobutyric acid receptor subunit epsilon	8	0	0	8
Tyrosyl-DNA phosphodiesterase 1	0	2	0	2
Histone deacetylase 6	0	4	1	7
Histone deacetylase 9	0	3	0	5
Histone deacetylase 5	0	4	0	6
cytochrome P450 2D6	3	0	0	3
peroxisome proliferator activated receptor gamma	15	0	0	15
Bile salt export pump	0	2	0	2
Glutathione reductase, mitochondrial	0	3	0	3
Glutathione reductase	0	1	0	1
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
Spike glycoprotein	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Transmembrane protease serine 2	0	1	2	3
Dihydrofolate reductase	0	2	0	2
Riboflavin-binding protein	0	0	1	1
Major prion protein	0	0	1	1
Histidine-rich protein PFHRP-II	0	1	0	2
Procathepsin L	0	1	2	3
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Cytochrome P450 3A4	0	5	1	6
Muscarinic acetylcholine receptor M5	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Replicase polyprotein 1a	0	1	2	3
Replicase polyprotein 1ab	0	1	2	3
Spike glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
DNA ligase 1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	2	0	2
DNA ligase A	0	1	0	1
Potassium voltage-gated channel subfamily H member 2	0	3	0	3
Sigma intracellular receptor 2	0	1	0	1
Phosphoethanolamine N-methyltransferase	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Angiotensin-converting enzyme 2	0	1	2	3
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Chain A, Beta-lactamase	4	0	0	4
PAX8	0	0	0	3
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
peroxisome proliferator-activated receptor delta	10	0	0	10
vitamin D (1,25- dihydroxyvitamin D3) receptor	10	0	0	10
aryl hydrocarbon receptor	10	0	0	10
activating transcription factor 6	10	0	0	10
nuclear receptor subfamily 0 group B member 1	0	3	0	3
atrial natriuretic peptide receptor 2 precursor	2	0	0	2
steroidogenic factor 1	0	3	0	3
caspase-1 isoform alpha precursor	3	0	0	3
Solute carrier family 22 member 3	0	1	0	1
Tubulin alpha-1A chain	0	3	1	4
Tubulin beta chain	0	3	1	4
Plasma kallikrein	0	1	0	3
Tubulin beta-4A chain	0	3	3	7
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin beta chain	0	3	3	7
ATP-dependent translocase ABCB1	0	3	0	6
Tubulin alpha-3C chain	0	3	3	7
Serine/threonine-protein kinase pim-1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Tubulin alpha-1B chain	0	3	3	7
Tubulin alpha-4A chain	0	3	3	7
Tubulin beta-4B chain	0	3	3	7
Vesicular acetylcholine transporter	0	1	0	1
Tubulin beta-3 chain	0	3	3	7
Tubulin beta-2A chain	0	3	3	7
Tubulin polymerization-promoting protein	0	0	1	1
Tubulin beta-8 chain	0	3	3	7
Tubulin beta-2B chain	0	5	0	6
Tubulin alpha-3E chain	0	3	3	7
Tubulin alpha-1A chain	0	3	3	7
Similar to alpha-tubulin isoform 1	0	3	0	4
Similar to alpha-tubulin isoform 1	0	3	0	4
CREB-binding protein	2	0	0	2
Tubulin alpha-1C chain	0	3	3	7
Tubulin beta-6 chain	0	3	3	7
Tubulin beta-2B chain	0	3	3	7
Tubulin beta-1 chain	0	3	3	7
P53	1	0	0	1
RPL19A	0	0	1	1
Histone H2A.x	15	0	0	15
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
transactivating tegument protein VP16 [Human herpesvirus 1]	0	5	0	5
COUP transcription factor 2 isoform a	0	1	0	1
Glucose transporter	0	1	0	1
Hexose transporter 1	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	2
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Eukaryotic initiation factor 4A-I	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	0	2
Peptidyl-prolyl cis-trans isomerase FKBP3	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP4	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	3	1	4
Hypoxia-inducible factor 1-alpha	0	1	0	1
Endothelial PAS domain-containing protein 1	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP14	0	1	0	1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4	0	1	0	1
G	6	0	0	6
LMP1 [Human herpesvirus 4]	0	0	0	3
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	4	0	4
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
nuclear receptor coactivator 3 isoform a	0	4	0	4
Thymidine kinase 2, mitochondrial	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	6	0	0	6
Thymidine kinase	0	2	0	3
Thymidylate synthase	0	4	0	6
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	3
Probable deoxycytidylate deaminase	0	0	0	2
Cytidine deaminase	0	1	0	3
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Inositol hexakisphosphate kinase 1	6	0	0	6
Thymidine kinase	0	1	0	2
Deoxynucleoside kinase	0	1	0	1
cytochrome P450 2C9, partial	6	0	0	6
Deoxycytidine kinase	0	0	0	1
caspase 7, apoptosis-related cysteine protease	4	0	0	4
caspase-3	4	0	0	4
RAD51	0	1	0	1
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1	0	1	0	1
Caspase-7	2	0	0	2
Growth factor receptor-bound protein 2	0	1	0	1
Pantothenate synthetase	0	1	0	1
Discoidin domain-containing receptor 2	0	1	0	1
Growth factor receptor-bound protein 2	0	1	0	1
Reverse transcriptase/RNaseH	0	2	1	3
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Thymidine kinase 2	0	1	0	1
AAA family ATPase	0	0	0	1
AAA family ATPase	0	0	0	1
Sterol O-acyltransferase 1	0	2	0	2
Chain A, Cell division protein kinase 9	0	1	0	1
Chain A, Cell division protein kinase 2	0	1	0	1
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
Cyclin-T1	0	1	0	1
Casein kinase II subunit alpha'	0	1	0	1
Cyclin-A2	0	1	0	1
Cyclin-dependent kinase 2	0	1	1	2
Cyclin-dependent kinase 9	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit beta	0	1	0	1
Casein kinase II subunit alpha	0	1	0	1
Casein kinase II subunit alpha	0	2	0	2
Cyclin-A1	0	1	0	1
Eyes absent homolog 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
Estrogen receptor	0	5	0	5
Glucocorticoid receptor	0	6	2	13
Sex hormone-binding globulin	0	0	1	1
Glycine receptor subunit alpha-1	0	6	0	6
Corticosteroid-binding globulin	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	3	0	3
Androgen receptor	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
Sodium-dependent serotonin transporter	0	2	0	2
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Lanosterol 14-alpha demethylase	0	0	1	1
Olfactory receptor 51E2	0	0	1	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
SMAD family member 2	1	0	0	1
SMAD family member 3	1	0	0	1
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	3	0	0	3
Regulatory protein E2	0	0	1	1
DNA topoisomerase 2	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Caspase-3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	0	0	2
Glutamate receptor ionotropic, NMDA 2B	0	0	0	2
Glutamate receptor ionotropic, NMDA 2C	0	0	0	2
DNA topoisomerase 2-alpha	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	0	0	2
Glutamate receptor ionotropic, NMDA 3B	0	0	0	2
Solute carrier organic anion transporter family member 1B3	0	2	0	3
Glutamate receptor ionotropic, NMDA 3A	0	0	0	2
Trypanothione reductase	0	1	0	1
thioredoxin glutathione reductase	4	0	0	4
interferon gamma precursor	0	0	0	1
Sodium/nucleoside cotransporter 2	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
acetylcholinesterase	3	0	0	3
Skn7p	0	0	0	1
Solute carrier family 22 member 8	0	0	0	1
Epidermal growth factor receptor	0	1	0	1
Aromatase	0	1	0	1
Glutathione reductase	0	0	0	1
Multidrug resistance-associated protein 1	0	0	0	2
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
Histone-lysine N-methyltransferase EHMT1	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	2
Ricin	0	2	0	2
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	2	2
Purine nucleoside phosphorylase	0	0	2	4
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Carbonic anhydrase 12	0	0	0	1
Carbonic anhydrase 3	0	0	0	1
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 6	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	2
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 7	0	0	0	1
Carbonic anhydrase	0	0	0	1
Large neutral amino acids transporter small subunit 1	0	2	0	2
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	1	0	3
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 15	0	0	0	1
Carbonic anhydrase 13	0	0	0	1
Carbonic anhydrase 14	0	0	0	1
Carbonic anhydrase 5B, mitochondrial	0	0	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Stromelysin-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	0	1
Urease subunit alpha	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	0	1
Ribonucleoside-diphosphate reductase large subunit	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	0	1
Urease subunit beta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, Purine-nucleoside Phosphorylase	0	1	0	1
Chain C, Xanthine dehydrogenase/oxidase	0	0	1	1
Thymidine kinase, cytosolic	0	1	0	3
tumor necrosis factor	1	0	0	1
NEDD8-activating enzyme E1 regulatory subunit isoform a	0	1	0	1
NEDD8-conjugating enzyme Ubc12	0	1	0	1
Queuine tRNA-ribosyltransferase	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Cationic amino acid transporter 3	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
dopamine D1 receptor	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
DNA polymerase eta isoform 1	1	0	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	1	1	2
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Delta-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Solute carrier family 22 member 6	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	2
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Solute carrier family 22 member 11	0	0	0	2
Protein-arginine deiminase type-4	0	2	0	2
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	2	0	2
Cytochrome P450 2D6	0	2	1	3
Integrin alpha-4	0	1	0	1
Cytochrome P450 2C19	0	2	1	3
Nuclear receptor corepressor 2	0	3	0	3
Formyl peptide receptor-related sequence 1	0	0	1	1
fMet-Leu-Phe receptor	0	2	2	4
N-formyl peptide receptor 2	0	0	2	2
FML2_HUMAN	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Plasminogen	0	1	0	1
Urokinase-type plasminogen activator	0	1	0	1
Trypsin-1	0	1	0	1
thyrotropin-releasing hormone receptor	2	0	0	2
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Cholesteryl ester transfer protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
D-amino-acid oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
Multidrug and toxin extrusion protein 1	0	1	0	1
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
nonstructural protein 1	0	1	0	1
Chain A, Glutathione-requiring prostaglandin D synthase	0	1	0	1
histone deacetylase 9 isoform 3	1	0	0	1
Sodium-dependent dopamine transporter	0	2	0	2
Photosystem I iron-sulfur center	0	0	0	1
GALC protein	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
luciferase	0	0	0	1
Fatty acid-binding protein, liver	0	1	0	1
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Histamine H1 receptor	0	1	1	2
Prostaglandin G/H synthase 2	0	1	0	1
Nociceptin receptor	0	0	1	1
Cytochrome P450 2J2	0	1	0	1
Estrogen receptor beta	0	3	0	3
30S ribosomal protein S6	0	2	0	3
30S ribosomal protein S7	0	2	0	3
50S ribosomal protein L15	0	2	0	3
50S ribosomal protein L10	0	2	0	3
50S ribosomal protein L11	0	2	0	3
50S ribosomal protein L7/L12	0	2	0	3
50S ribosomal protein L19	0	2	0	3
50S ribosomal protein L1	0	2	0	3
50S ribosomal protein L20	0	2	0	3
50S ribosomal protein L27	0	2	0	3
50S ribosomal protein L28	0	2	0	3
50S ribosomal protein L29	0	2	0	3
50S ribosomal protein L31	0	2	0	3
50S ribosomal protein L31 type B	0	2	0	3
50S ribosomal protein L32	0	2	0	3
50S ribosomal protein L33	0	2	0	3
50S ribosomal protein L34	0	2	0	3
50S ribosomal protein L35	0	2	0	3
50S ribosomal protein L36	0	2	0	3
30S ribosomal protein S10	0	2	0	3
30S ribosomal protein S11	0	2	0	3
30S ribosomal protein S12	0	2	0	3
30S ribosomal protein S13	0	2	0	3
30S ribosomal protein S16	0	2	0	3
30S ribosomal protein S18	0	2	0	3
30S ribosomal protein S19	0	2	0	3
30S ribosomal protein S20	0	2	0	3
30S ribosomal protein S2	0	2	0	3
30S ribosomal protein S3	0	2	0	3
30S ribosomal protein S4	0	2	0	3
30S ribosomal protein S5	0	2	0	3
30S ribosomal protein S8	0	2	0	3
30S ribosomal protein S9	0	2	0	3
50S ribosomal protein L13	0	2	0	3
50S ribosomal protein L14	0	2	0	3
50S ribosomal protein L16	0	2	0	3
50S ribosomal protein L23	0	2	0	3
30S ribosomal protein S15	0	2	0	3
50S ribosomal protein L17	0	2	0	3
50S ribosomal protein L21	0	2	0	3
50S ribosomal protein L30	0	2	0	3
50S ribosomal protein L6	0	2	0	3
30S ribosomal protein S14	0	2	0	3
30S ribosomal protein S17	0	2	0	3
30S ribosomal protein S1	0	2	0	3
50S ribosomal protein L18	0	2	0	3
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Puromycin-sensitive aminopeptidase	0	1	0	1
50S ribosomal protein L2	0	2	0	3
50S ribosomal protein L3	0	2	0	3
50S ribosomal protein L24	0	2	0	3
50S ribosomal protein L4	0	2	0	3
50S ribosomal protein L22	0	2	0	3
50S ribosomal protein L5	0	2	0	3
30S ribosomal protein S21	0	2	0	3
50S ribosomal protein L25	0	2	0	3
50S ribosomal protein L36 2	0	2	0	3
Acetylcholinesterase	0	1	0	1
Pyruvate kinase PKM	0	0	1	1
Neutral amino acid transporter A	0	1	0	1
Cholinesterase	0	1	0	1
Neutral amino acid transporter B(0)	0	1	0	1
Amino acid transporter	0	1	0	1
GTPase HRas	0	1	0	1
Neutrophil elastase	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Alpha-1B adrenergic receptor	0	5	0	5
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Alpha-1A adrenergic receptor	0	5	0	5
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Serine/threonine-protein kinase D3	0	0	1	1
Protein kinase C gamma type	0	1	1	2
Protein kinase C beta type	0	1	1	2
Luciferin 4-monooxygenase	0	0	1	1
Protein kinase C alpha type	0	1	1	2
Beta-1 adrenergic receptor	0	1	0	1
Protein kinase C eta type	0	0	1	1
Protein kinase C iota type	0	0	1	1
Protein kinase C epsilon type	0	1	1	2
Protein kinase C theta type	0	0	1	1
Protein kinase C zeta type	0	0	1	1
Protein kinase C delta type	0	1	1	2
Serine/threonine-protein kinase D1	0	0	1	1
Ras guanyl-releasing protein 3	0	0	1	1
hypothetical protein, conserved	1	0	0	1
Apoptosis regulator Bcl-2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Mitogen-activated protein kinase 3	0	1	0	1
Bcl-2-like protein 1	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase	0	0	0	1
Thymidine phosphorylase	0	1	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Ornithine decarboxylase	0	0	0	1
Cytochrome P450 1A2	0	1	1	2
Ornithine decarboxylase	0	0	0	1
60 kDa chaperonin	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
60 kDa heat shock protein, mitochondrial	0	1	0	1
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor alpha	0	1	2	3
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor gamma	0	1	2	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor beta	0	1	2	3
Cellular retinoic acid-binding protein 2	0	0	1	1
Mitogen-activated protein kinase 1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	1	2	3
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-beta	0	1	2	3
Retinoic acid receptor RXR-gamma	0	1	2	3
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Cellular retinoic acid-binding protein 1	0	1	0	2
Retinoic acid receptor RXR-gamma	0	2	2	4
10 kDa heat shock protein, mitochondrial	0	1	0	1
Cellular retinoic acid-binding protein 1	0	0	1	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
Chain A, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)	0	1	0	1
Chain B, HDLP (HISTONE DEACETYLASE-LIKE PROTEIN)	0	1	0	1
Chain A, Histone deacetylase 7a	0	1	0	1
Chain A, Histone deacetylase 7a	0	1	0	1
Histone deacetylase 8	0	1	0	1
Histone deacetylase	0	1	0	1
Lysine-specific demethylase 4E	0	1	0	1
unnamed protein product	0	0	0	1
Histone deacetylase 1	0	2	0	2
5-hydroxytryptamine receptor 3A	0	1	0	1
Histone deacetylase 3	0	1	0	1
Coagulation factor VII	0	1	0	1
Vitamin D3 receptor	0	1	0	1
Tissue factor	0	1	0	1
Adenosine receptor A1	0	1	0	1
Histone deacetylase 2	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Histone deacetylase 1	0	1	0	1
Adenosine receptor A1	0	1	0	1
Histone deacetylase	0	1	0	1
Histone deacetylase 4	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 3	0	1	0	1
Histone deacetylase-like amidohydrolase	0	2	0	2
Histone deacetylase 7	0	1	0	1
NAD-dependent protein deacetylase sirtuin-6	0	1	1	2
Histone deacetylase 8	0	1	0	1
Histone deacetylase 11	0	1	0	1
HD2 type histone deacetylase HDA106	0	2	0	2
Histone deacetylase 9	0	1	0	1
Histone deacetylase 7	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase	0	1	0	1
Histone deacetylase 6	0	1	0	1
Histone deacetylase 5	0	1	0	1
Histone deacetylase	0	1	0	1
Chain A, Uracil-DNA Glycosylase	0	1	0	1
Protein cereblon	0	2	0	2
Calmodulin	0	1	1	2
Myosin light chain kinase, smooth muscle	0	1	0	1
Hsf1 protein	0	0	1	1
Aldo-keto reductase family 1 member B1	0	0	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (147)

Protein Targets (987)

Bloom Syndrome

Synonyms(4)

Research Excerpts

Overview

Treatment

Research

Studies (147)

Drugs Studied (107)

Protein Targets (987)