Page last updated: 2024-12-08

solidagenone

Description

solidagenone: RN given for (4R-(4alpha,4abeta,8aalpha))-isomer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID189066
CHEMBL ID3138675
MeSH IDM0360855

Synonyms (3)

Synonym
solidagenone
nsc 171083
CHEMBL3138675

Research Excerpts

Overview

Solidagenone (SOL) is a labdane-type diterpenoid found in Solidago chilensis. It is traditionally used to treat skin diseases, kidney pain and ovarian inflammation.

ExcerptReferenceRelevance
"Solidagenone (SOL) is a labdane-type diterpenoid found in Solidago chilensis, a plant traditionally used to treat skin diseases, kidney pain and ovarian inflammation. "( Solidagenone from Solidago chilensis Meyen inhibits skin inflammation in experimental models.
de Oliveira, TB; de Sousa, OV; Gonçalves, GC; Santos, BCS; Valverde, SS, 2021
)
3.51

Effects

ExcerptReferenceRelevance
"The solidagenone has a promissor antidepressant-like potential, which can result of its beneficial action in the neuroinflammation process and due its antioxidant capability at the central nervous system."( Antidepressant-like effects of solidagenone on mice with bacterial lipopolysaccharide (LPS)-induced depression.
Alievi, K; de Oliveira Alves, B; Ernetti, J; Locateli, G; Miorando, D; Mota da Silva, L; Müller, LG; Roman Junior, WA; Serpa, PZ; Vecchia, CAD; Zilli, GAL, 2020
)
1.4
"The solidagenone has a promissor antidepressant-like potential, which can result of its beneficial action in the neuroinflammation process and due its antioxidant capability at the central nervous system."( Antidepressant-like effects of solidagenone on mice with bacterial lipopolysaccharide (LPS)-induced depression.
Alievi, K; de Oliveira Alves, B; Ernetti, J; Locateli, G; Miorando, D; Mota da Silva, L; Müller, LG; Roman Junior, WA; Serpa, PZ; Vecchia, CAD; Zilli, GAL, 2020
)
1.4

Bioavailability

ExcerptReferenceRelevance
"In silico predictions showed good drug-likeness potential for SOL with high oral bioavailability and intestinal absorption."( Solidagenone acts on promastigotes of L. amazonensis by inducing apoptosis-like processes on intracellular amastigotes by IL-12p70/ROS/NO pathway activation.
Arakawa, NS; Bortoleti, BTDS; Carloto, AC; Conchon-Costa, I; Contato, VM; Costa, IN; de Matos, RLN; Detoni, MB; Gonçalves, MD; Lazarin, DB; Miranda-Sapla, MM; Pavanelli, WR; Rodrigues, ACJ; Silva, TF; Tomiotto-Pellissier, F; Wowk, PF, 2021
)
2.06
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1594145Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity 2019Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules.
AID977602Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
AID1594144Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme acti2019Bioorganic & medicinal chemistry letters, 05-01, Volume: 29, Issue:9
HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules.
AID977599Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM2013Molecular pharmacology, Jun, Volume: 83, Issue:6
Structure-based identification of OATP1B1/3 inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (38.46)29.6817
2010's3 (23.08)24.3611
2020's5 (38.46)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.41 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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