| Assay ID | Title | Year | Journal | Article |
|---|
| AID1219957 | Induction of apoptosis in human HCT116 cells assessed as apoptotic cells at 40 uM after 24 hrs by TUNEL assay | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4
| Metabolism of [6]-shogaol in mice and in cancer cells. |
| AID1442905 | Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using bupropion as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442963 | Inhibition of CYP2A6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using coumarin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis r | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442912 | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using paclitaxel as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443013 | Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442979 | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using diclofenac as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysi | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442999 | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1219993 | Drug level in human HT-29 cells treated with 10 uM [6]-shogaol by HPLC-ECD analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4
| Metabolism of [6]-shogaol in mice and in cancer cells. |
| AID1442960 | Inhibition of CYP2A6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using coumarin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis re | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442946 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using testosterone as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442974 | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using paclitaxel as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443010 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using testosterone as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysi | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443014 | Inhibition of human CYP1A2 using phenacetin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442948 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using testosterone as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442978 | Inhibition of CYP2C8 in human liver microsomes using paclitaxel as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442937 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using midazolam as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442985 | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442929 | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme-mediated metabolite formation using (S)-mephenytoin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676748 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as reduction in isoniazid bromide MIC presence of test compound at 16 mg/L | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1219958 | Induction of apoptosis in human H1299 cells assessed as apoptotic cells at 40 uM after 24 hrs by TUNEL assay | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4
| Metabolism of [6]-shogaol in mice and in cancer cells. |
| AID1442927 | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using (S)-mephenytoin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442938 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using midazolam as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1220000 | Cytotoxicity against human HCT116 cells assessed as growth inhibition after 24 hrs by MTT assay | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4
| Metabolism of [6]-shogaol in mice and in cancer cells. |
| AID1442900 | Inhibition of CYP2A6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using coumarin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676736 | Antimicrobial activity against Mycobacterium smegmatis str. MC2 155 ATCC 700084 incubated for 72 hrs in 7H9 T medium supplemented with 10% Middlebrook ADC enrichment by MTT assay | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1443007 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using testosterone as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analy | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442915 | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation using paclitaxel as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442939 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using midazolam as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442944 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using testosterone as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442894 | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using phenacetin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442908 | Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation using bupropion as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443011 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using testosterone as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analys | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442911 | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using paclitaxel as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676756 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as increase in normalized ethidium bromide fluorescence efflux at 0.5 MIC level by fluorimetric assay (Rvb = 0.581 +/- 0.051 ratio) | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1442936 | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme-mediated metabolite formation using dextromethorphan as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442995 | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using dextromethorphan as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS ana | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443004 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using midazolam as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442973 | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using paclitaxel as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysi | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442890 | Inhibition of CYP2A6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using coumarin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442940 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using midazolam as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442925 | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using (S)-mephenytoin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442942 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using midazolam as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442943 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation using midazolam as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1220001 | Cytotoxicity against human H1299 cells assessed as growth inhibition after 24 hrs by MTT assay | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4
| Metabolism of [6]-shogaol in mice and in cancer cells. |
| AID1442895 | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation using phenacetin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1477268 | Antagonist activity at Pseudomonas aeruginosa LasR expressed in Escherichia coli DH5alpha assessed as inhibition of protein interaction with OdDHL at 1 to 10 uM after 1.5 hrs by beta-galactosidase reporter gene assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23
| Structure-Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents. |
| AID1442923 | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using (S)-mephenytoin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442976 | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using paclitaxel as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443012 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using testosterone as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analys | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442933 | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using dextromethorphan as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443015 | Inhibition of human CYP2B6 using bupropion as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442914 | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using paclitaxel as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442968 | Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using bupropion as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis r | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442972 | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using paclitaxel as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysi | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442930 | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using dextromethorphan as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1219960 | Induction of apoptosis in human H1299 cells assessed as apoptotic cells at 80 uM after 24 hrs by TUNEL assay | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4
| Metabolism of [6]-shogaol in mice and in cancer cells. |
| AID1442919 | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using diclofenac as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442910 | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using paclitaxel as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676738 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as reduction in ethidium bromide MIC presence of test compound at 16 mg/L | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1442986 | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using (S)-mephenytoin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS a | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442975 | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using paclitaxel as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442907 | Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using bupropion as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442970 | Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using bupropion as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442956 | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using phenacetin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443016 | Inhibition of human CYP2C8 using paclitaxel as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676737 | Antimicrobial activity against Mycobacterium smegmatis str. MC2 155 ATCC 700084 incubated for 72 hrs in Mueller-Hinton broth medium by MTT assay | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1442980 | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using diclofenac as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysi | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442971 | Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442961 | Inhibition of CYP2A6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using coumarin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis re | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442932 | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using dextromethorphan as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676744 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as fractional inhibitory concentration index in presence of ethidium bromide | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1442951 | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using phenacetin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysi | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442955 | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using phenacetin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442926 | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using (S)-mephenytoin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442935 | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using dextromethorphan as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442959 | Inhibition of CYP2A6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using coumarin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442903 | Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using bupropion as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1219996 | Drug level in human H1299 cells treated with 10 uM [6]-shogaol after 24 hrs by HPLC-ECD analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4
| Metabolism of [6]-shogaol in mice and in cancer cells. |
| AID1442990 | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using (S)-mephenytoin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS an | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442899 | Inhibition of CYP2A6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using coumarin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443000 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using midazolam as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676745 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as reduction in ethambutol bromide MIC presence of test compound at 16 mg/L | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1442957 | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442982 | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using diclofenac as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676754 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as fractional inhibitory concentration index in presence of rifampicin | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1442965 | Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using bupropion as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443003 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using midazolam as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis r | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442996 | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using dextromethorphan as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS ana | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442947 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using testosterone as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442928 | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using (S)-mephenytoin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442952 | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using phenacetin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysi | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676751 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as reduction in rifampicin bromide MIC presence of test compound at 16 mg/L | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1442981 | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using diclofenac as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1219989 | Drug level in human HCT116 cells treated with 10 uM [6]-shogaol after 24 hrs by HPLC-ECD analysis | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4
| Metabolism of [6]-shogaol in mice and in cancer cells. |
| AID1442964 | Inhibition of CYP2A6 in human liver microsomes using coumarin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442953 | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using phenacetin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442909 | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using paclitaxel as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676757 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as increase in normalized ethidium bromide fluorescence efflux at 0.5 MIC level by fluorimetric assay | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1442993 | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using dextromethorphan as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS a | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676755 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as increase in relative ethidium bromide fluorescence accumulation at 0.5 MIC level by fluorimetric assay (Rvb = 6057.1 +/- 508.6 RFU) | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1443018 | Inhibition of human CYP2C19 using (S)-mephenytoin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442962 | Inhibition of CYP2A6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using coumarin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis r | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442892 | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using phenacetin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442977 | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using paclitaxel as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443006 | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442889 | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using phenacetin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442901 | Inhibition of CYP2A6 in human liver microsomes assessed as enzyme-mediated metabolite formation using coumarin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442984 | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using diclofenac as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1477267 | Inhibition of static biofilm formation of Pseudomonas aeruginosa PA14 at 10 uM after 24 hrs by crystal violet staining-based assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23
| Structure-Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents. |
| AID1442949 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using testosterone as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442904 | Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using bupropion as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443017 | Inhibition of human CYP2C9 using diclofenac as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442893 | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using phenacetin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442950 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation using testosterone as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442898 | Inhibition of CYP2A6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using coumarin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442987 | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using (S)-mephenytoin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS a | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442934 | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using dextromethorphan as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442994 | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using dextromethorphan as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS a | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442906 | Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using bupropion as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442896 | Inhibition of CYP2A6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using coumarin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442924 | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using (S)-mephenytoin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442891 | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using phenacetin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442989 | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using (S)-mephenytoin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS ana | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442997 | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using dextromethorphan as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS an | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442897 | Inhibition of CYP2A6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using coumarin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442917 | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using diclofenac as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442920 | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using diclofenac as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442902 | Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using bupropion as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1219981 | Drug level in C57BL/6J mouse feces treated with [6]-shogaol at 200 mg/kg, po by HPLC-ECD analysis relative to control | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4
| Metabolism of [6]-shogaol in mice and in cancer cells. |
| AID1442921 | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using diclofenac as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442941 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using midazolam as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442888 | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using phenacetin as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443009 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using testosterone as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysi | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443001 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using midazolam as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442945 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using testosterone as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442998 | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using dextromethorphan as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS an | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442991 | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using (S)-mephenytoin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS an | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442992 | Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443008 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using testosterone as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analy | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442954 | Inhibition of CYP1A2 in human liver microsomes assessed as enzyme-mediated metabolite formation at 3 uM using phenacetin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442958 | Inhibition of CYP2A6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using coumarin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442983 | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using diclofenac as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442966 | Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using bupropion as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442916 | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.1 uM using diclofenac as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442969 | Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using bupropion as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1219959 | Induction of apoptosis in human HCT116 cells assessed as apoptotic cells at 80 uM after 24 hrs by TUNEL assay | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4
| Metabolism of [6]-shogaol in mice and in cancer cells. |
| AID1442918 | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using diclofenac as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442931 | Inhibition of CYP2D6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 0.3 uM using dextromethorphan as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443002 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using midazolam as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis r | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676741 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as reduction in ciprofloxacin bromide MIC presence of test compound at 16 mg/L | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1443005 | Inhibition of CYP3A4 in human liver microsomes assessed as enzyme-mediated metabolite formation at 30 uM using midazolam as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442913 | Inhibition of CYP2C8 in human liver microsomes assessed as enzyme-mediated metabolite formation at 10 uM using paclitaxel as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis relative to control | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442967 | Inhibition of CYP2B6 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using bupropion as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS analysis r | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442988 | Inhibition of CYP2C19 in human liver microsomes assessed as enzyme-mediated metabolite formation at 1 uM using (S)-mephenytoin as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins in presence of NADPH by LC-MS/MS ana | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1442922 | Inhibition of CYP2C9 in human liver microsomes assessed as enzyme-mediated metabolite formation using diclofenac as substrate incubated for 5 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |