| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
4-hydroxybenzoic acid hydrazide
4-hydroxybenzoic acid hydrazide: metabolite of nifuroxazide. 4-hydroxybenzohydrazide : A carbohydrazide obtained by formal condensation of the carboxy group of 4-hydroxybenzoic acid with hydrazine. | 2.45 | 2 | 0 | carbohydrazide;
phenols | |
iproniazid
[no description available] | 2.08 | 1 | 0 | carbohydrazide;
pyridines | |
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC). | 2.45 | 2 | 0 | carbohydrazide | antitubercular agent;
drug allergen |
hydrazine
diamine : Any polyamine that contains two amino groups. | 2.65 | 3 | 0 | azane;
hydrazines | EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor |
nicotinic acid hydrazide
nicotinic acid hydrazide: structural homolog of isoniazid; structure given in first source | 2.45 | 2 | 0 | | |
benzoylhydrazine
benzoylhydrazine: inhibits copper-depleted bovine serum amine oxidase | 2.45 | 2 | 0 | carbohydrazide | |
acetylhydrazine
acetylhydrazine: metabolite of isoniazid in animals and humans; RN given refers to parent cpd. acetohydrazide : A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group. | 2.08 | 1 | 0 | carbohydrazide;
carbohydrazonic acid | drug metabolite |
2-furoic acid hydrazide
2-furoylhydrazine: used for determination of carbohydrates | 2.45 | 2 | 0 | | |
4-aminobenzhydrazide
4-aminobenzhydrazide: a Russian synthetic drug of acylhydrazide group; decreased uterus wt in rats; RN given refers to cpd with specified locants for amino group | 2.42 | 2 | 0 | | |
hypochlorous acid
Hypochlorous Acid: An oxyacid of chlorine (HClO) containing monovalent chlorine that acts as an oxidizing or reducing agent.. hypochlorous acid : A chlorine oxoacid with formula HOCl; a weak, unstable acid, it is the active form of chlorine in water. | 1.98 | 1 | 0 | chlorine oxoacid;
reactive oxygen species | EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
human metabolite |
phenyl acetate
phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid. | 1.95 | 1 | 0 | benzenes;
phenyl acetates | |
acetylisoniazid
acetylisoniazid: Antitubercular Agent. N'-acetylisoniazid : A carbohydrazide resulting from the formal condensation of the carboxy group of isonicotinic acid with hydrazine and subsequent acetylation of the monosubstituted nitrogen atom. | 2.08 | 1 | 0 | carbohydrazide | metabolite |
succinic dihydrazide
succinic dihydrazide: structure given in first source | 2.08 | 1 | 0 | | |
n,n'-diacetylhydrazine
[no description available] | 2.08 | 1 | 0 | carbohydrazide | |
thiophene-2-carboxylic acid hydrazide
thiophene-2-carbohydrazide: structure in first source | 2.08 | 1 | 0 | | |
4-methoxybenzohydrazide
4-methoxybenzohydrazide: structure in first source | 2.08 | 1 | 0 | | |
mocetinostat
mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11). | 1.98 | 1 | 0 | aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline | antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent |