| Assay ID | Title | Year | Journal | Article |
|---|
| AID1443020 | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1477274 | Inhibition of dynamic biofilm formation of Pseudomonas aeruginosa PA14 assessed as biofilm volume up to 10 uM after 48 hrs by Ruby/ConA staining-based assay (Rvb = 23.1 +/- 1.8 um'3/um'2) | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23
| Structure-Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents. |
| AID480943 | Permeability in human Caco-2 cells assessed as passive diffusion after 3 hrs by HPLC | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
| Identification of serotonin 5-HT1A receptor partial agonists in ginger. |
| AID1477272 | Inhibition of static biofilm formation of Pseudomonas aeruginosa PA14 assessed as level of biofilm formation at 10 uM after 24 hrs by crystal violet staining-based assay relative to control | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23
| Structure-Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents. |
| AID1443028 | Inhibition of CYP2E1 in human liver microsomes using chlorzoxazone as substrate preincubated for 10 mins followed by NADPH addition measured after 20 mins | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676757 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as increase in normalized ethidium bromide fluorescence efflux at 0.5 MIC level by fluorimetric assay | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID480936 | Cytotoxicity against human Caco-2 cells at 50 ug/ml | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
| Identification of serotonin 5-HT1A receptor partial agonists in ginger. |
| AID676755 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as increase in relative ethidium bromide fluorescence accumulation at 0.5 MIC level by fluorimetric assay (Rvb = 6057.1 +/- 508.6 RFU) | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1443023 | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 10 mins followed by NADPH addition measured after 7 mins | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1477275 | Inhibition of dynamic biofilm formation of Pseudomonas aeruginosa PA14 assessed as biofilm thickness up to 10 uM after 48 hrs by Ruby/ConA staining-based assay (Rvb = 34.5 +/- 1.3 um) | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23
| Structure-Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents. |
| AID1443032 | Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid DBOMF substrate green measured every 30 sec for 30 mins by fluorescence assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443027 | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 10 mins followed by NADPH addition measured after 15 mins | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID480942 | Antagonist activity at 5HT1A receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced [S35]GTPgammaS binding by scintillation counting | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
| Identification of serotonin 5-HT1A receptor partial agonists in ginger. |
| AID1443026 | Inhibition of CYP2A6 in human liver microsomes using Coumarin as substrate preincubated for 10 mins followed by NADPH addition measured after 15 mins | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443024 | Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 10 mins followed by NADPH addition measured after 40 mins | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443033 | Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMR substrate red measured every 30 sec for 30 mins by fluorescence assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676743 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as reduction in ciprofloxacin bromide MIC presence of test compound at 32 mg/L | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID676737 | Antimicrobial activity against Mycobacterium smegmatis str. MC2 155 ATCC 700084 incubated for 72 hrs in Mueller-Hinton broth medium by MTT assay | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1477278 | Inhibition of dynamic biofilm formation of Pseudomonas aeruginosa PA14 at 10 uM after 48 hrs by Ruby/ConA staining-based confocal laser scanning microscopic method | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23
| Structure-Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents. |
| AID1477268 | Antagonist activity at Pseudomonas aeruginosa LasR expressed in Escherichia coli DH5alpha assessed as inhibition of protein interaction with OdDHL at 1 to 10 uM after 1.5 hrs by beta-galactosidase reporter gene assay | 2017 | Journal of medicinal chemistry, 12-14, Volume: 60, Issue:23
| Structure-Activity Relationships of 6- and 8-Gingerol Analogs as Anti-Biofilm Agents. |
| AID1443030 | Inhibition of recombinant human CYP2C9 expressed in baculosomes using Vivid OOMR substrate red measured every 30 sec for 30 mins by fluorescence assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID480937 | Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counting | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
| Identification of serotonin 5-HT1A receptor partial agonists in ginger. |
| AID480938 | Displacement of [3H]8-OH-DPAT from 5HT1A receptor expressed in HEK293 cells at 25 ug/ml after 2 hrs by liquid scintillation counting | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
| Identification of serotonin 5-HT1A receptor partial agonists in ginger. |
| AID676756 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as increase in normalized ethidium bromide fluorescence efflux at 0.5 MIC level by fluorimetric assay (Rvb = 0.581 +/- 0.051 ratio) | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1443022 | Inhibition of CYP2C8 in human liver microsomes using amodiaquin as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID480944 | Inhibition of human MDR1 expressed in MDCK cells assessed as fluorescence activity at 30 uM after 1.5 hrs by rhodamine 123 efflux test | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
| Identification of serotonin 5-HT1A receptor partial agonists in ginger. |
| AID676747 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as reduction in ethambutol bromide MIC presence of test compound at 32 mg/L | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID676744 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as fractional inhibitory concentration index in presence of ethidium bromide | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1443034 | Inhibition of recombinant human CYP3A4 expressed in baculosomes using Vivid BOMCC substrate blue measured every 30 sec for 30 mins by fluorescence assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID676754 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as fractional inhibitory concentration index in presence of rifampicin | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1443031 | Inhibition of recombinant human CYP2C19 expressed in baculosomes using Vivid EOMCC substrate blue measured every 30 sec for 30 mins by fluorescence assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443025 | Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 10 mins followed by NADPH addition measured after 10 mins | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID1443021 | Inhibition of CYP2B6 in human liver microsomes using bupropion as substrate preincubated for 10 mins followed by NADPH addition measured after 20 mins | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| AID480941 | Antagonist activity at 5HT1A receptor expressed in HEK293 cells assessed as inhibition of 8-OH-DPAT-induced [S35]GTPgammaS binding by scintillation counting | 2010 | Bioorganic & medicinal chemistry, May-01, Volume: 18, Issue:9
| Identification of serotonin 5-HT1A receptor partial agonists in ginger. |
| AID676753 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as reduction in rifampicin bromide MIC presence of test compound at 32 mg/L | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID676736 | Antimicrobial activity against Mycobacterium smegmatis str. MC2 155 ATCC 700084 incubated for 72 hrs in 7H9 T medium supplemented with 10% Middlebrook ADC enrichment by MTT assay | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID676739 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as reduction in ethidium bromide MIC presence of test compound at 32 mg/L | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID676750 | Inhibition of Multidrug resistance efflux pump in Mycobacterium smegmatis str. MC2 155 ATCC 700084 assessed as reduction in isoniazid bromide MIC presence of test compound at 32 mg/L | 2012 | Journal of natural products, Jul-27, Volume: 75, Issue:7
| Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. |
| AID1219968 | Antioxidant activity assessed as DPPH radical scavenging activity | 2012 | Drug metabolism and disposition: the biological fate of chemicals, Apr, Volume: 40, Issue:4
| Metabolism of [6]-shogaol in mice and in cancer cells. |
| AID1443035 | Inhibition of recombinant human CYP2D6 expressed in baculosomes using Vivid EOMCC substrate blue measured every 30 sec for 30 mins by fluorescence assay | 2017 | Bioorganic & medicinal chemistry letters, 04-15, Volume: 27, Issue:8
| Effects of 6-paradol, an unsaturated ketone from gingers, on cytochrome P450-mediated drug metabolism. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |