Compounds > 1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3-nitrophenylcarbamoyl)naphthalene
Page last updated: 2024-12-06

1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3-nitrophenylcarbamoyl)naphthalene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

The compound you described, **1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3-nitrophenylcarbamoyl)naphthalene**, is a complex organic molecule with a long and rather intimidating name. To understand its significance, let's break down its structure and potential applications.

**Structure and Properties:**

* **Azo dye:** The key feature is the **azo group (-N=N-)** connecting the 2-methoxy-5-nitrophenyl group to the naphthalene core. This azo linkage is characteristic of azo dyes, known for their vibrant colors.
* **Nitro groups:** The presence of multiple nitro groups (NO2) significantly influences the compound's properties. Nitro groups are electron-withdrawing, enhancing the compound's acidity and making it potentially explosive (though this requires specific conditions).
* **Hydroxy and carbamoyl groups:** The hydroxy group (-OH) contributes to the compound's potential for complexation, while the carbamoyl group (-CONH-) adds to its overall polarity.

**Potential Applications:**

This compound, with its complex structure and functionalities, could be relevant to various research areas:

* **Dyes and Pigments:** The azo group indicates potential use as a dye. The specific color and lightfastness would depend on the precise structure and its interaction with other molecules.
* **Materials Science:** The compound's combination of electron-withdrawing groups and potential for complexation could make it useful in material development. For example, it might be explored for use in:
* **Sensors:** The compound's color changes with pH or the presence of specific ions, suggesting potential application as a chemical sensor.
* **Polymers:** Incorporation into polymer chains could lead to new materials with specific optical or electrical properties.
* **Medicinal Chemistry:** The nitro groups and azo linkage, while not directly linked to drug action, might be modified to create derivatives with therapeutic potential. It's important to note that this application would require extensive research and testing due to the compound's complexity.

**Importance for Research:**

The specific importance of this compound hinges on its application. However, its complexity and unique combination of functional groups make it a potential starting point for various research avenues.

**Here's why it's important to research this type of compound:**

* **New materials:** Novel materials with specific properties are always in demand. This compound could potentially lead to materials with improved properties for various applications, from dyes to sensors to polymers.
* **Understanding structure-property relationships:** By investigating the effect of different functionalities on the compound's properties, researchers can gain insights into the behavior of complex molecules. This knowledge can be used to design and synthesize new materials with desired characteristics.
* **Developing new technologies:** The compound's potential applications in various fields, including sensors, dyes, and materials, highlight its potential role in advancing technology.

However, before any practical application can be considered, extensive research is needed to understand its properties, toxicity, and potential environmental impacts.

Cross-References

ID SourceID
PubMed CID22979
SCHEMBL ID16323799
SCHEMBL ID5421220
MeSH IDM0493503

Synonyms (46)

Synonym
6471-49-4
c.i. 12355
3-hydroxy-4-{(e)-[2-(methyloxy)-5-nitrophenyl]diazenyl}-n-(3-nitrophenyl)naphthalene-2-carboxamide
ccris 4896
3-hydroxy-4-((2-methoxy-5-nitrophenyl)azo)-n-(3-nitrophenyl)naphthalene-2-carboxamide
rubescence red mt-21
einecs 229-313-2
1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3-nitrophenylcarbamoyl)naphthalene
alkali resistant red dark
calcotone red 3b
ci 12355
textile red wd-263
naphthol red d toner 35-6001
2-naphthalenecarboxamide, 3-hydroxy-4-((2-methoxy-5-nitrophenyl)azo)-n-(3-nitrophenyl)-
naphthol red b 20-7575
hsdb 4356
congo red r-138
malta red x 2284
carnation red toner b
2-napthalenecarboxamide, 3-hydroxy-4-((2-methoxy-5-nitrophenyl)azo)-n-(3-nitrophenyl)-
naphthol red deep 10459
segnale light rubine rg
3-hydroxy-4-((2-methoxy-5-nitrophenyl)azo)-3'-nitro-2-naphthanilide
sapona red lake rl-6280
fenalac red fkb extra
nci-c60377
sanyo fast red 10b
2-naphthanilide, 3-hydroxy-4-((2-methoxy-5-nitrophenyl)azo)-3'-nitro-
red 23
unisperse red rbs-pi
2-naphthalenecarboxamide, 3-hydroxy-4-(2-(2-methoxy-5-nitrophenyl)diazenyl)-n-(3-nitrophenyl)-
082h78u257 ,
unii-082h78u257
3-hydroxy-4-((2-methoxy-5-nitrophenyl)azo)-3'-nitro-2- naphthanilide
3-hydroxy-4-((2-methoxy-5-nitrophenyl)azo)-n-(3- nitrophenyl)naphthalene-2-carboxamide
1-(2-methoxy-5-nitrophenylazo)-2-hydroxy-3-(3- nitrophenylcarbamoyl)naphthalene
2-naphthalenecarboxamide, 3-hydroxy-4-((2-methoxy-5- nitrophenyl)azo)-n-(3-nitrophenyl)-
AKOS025310990
SCHEMBL16323799
SCHEMBL5421220
W-110154
DTXSID3021227
mfcd00071991
2-naphthalenecarboxamide,3-hydroxy-4-[(2-methoxy-5-nitrophenyl)azo]-n-(3-nitrophenyl)-
Q27236350
3-hydroxy-4-[(2-methoxy-5-nitrophenyl)diazenyl]-n-(3-nitrophenyl)naphthalene-2-carboxamide
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (38.46)29.6817
2010's5 (38.46)24.3611
2020's3 (23.08)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.96

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.96 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.96)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (7.14%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (92.86%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
methane
Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).		2.1110alkane;
gas molecular entity;
mononuclear parent hydride;
one-carbon compound		bacterial metabolite;
fossil fuel;
greenhouse gas
citric acid, anhydrous
Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.. citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.		2.0310tricarboxylic acidantimicrobial agent;
chelator;
food acidity regulator;
fundamental metabolite
oxazepam
Oxazepam: A benzodiazepine used in the treatment of anxiety, alcohol withdrawal, and insomnia.. oxazepam : A 1,4-benzodiazepinone that is 1,3-dihydro-2H-1,4-benzodiazepin-2-one substituted by a chloro group at position 7, a hydroxy group at position 3 and phenyl group at position 5.		3.12101,4-benzodiazepinone;
organochlorine compound		anxiolytic drug;
environmental contaminant;
xenobiotic
hexachloroethane
[no description available]		3.1210chlorocarbon;
chloroethanes		carcinogenic agent;
refrigerant
ethane
Ethane: A two carbon alkane with the formula H3C-CH3.. ethane : An alkane comprising of two carbon atoms.		3.1210alkane;
gas molecular entity		plant metabolite;
refrigerant
methyleugenol
methyleugenol: structure		3.1210phenylpropanoid
4,4'-thiobis(6-tert-butyl-3-cresol)
4,4'-thiobis(6-tert-butyl-3-cresol): structure given in first source		3.1210
diethanolamine
diethanolamine: RN given refers to parent cpd. diethanolamine : A member of the class of ethanolamines that is ethanolamine having a N-hydroxyethyl substituent.		3.1210ethanolamineshuman xenobiotic metabolite
n-butoxyethanol
n-butoxyethanol: RN given refers to parent cpd; structure. 2-butoxyethanol : A primary alcohol that is ethanol in which one of the methyl hydrogens is replaced by a butoxy group. A high-boiling (171degreeC) colourless liquid, it is used as a solvent for paints and inks, as well as in some dry cleaning solutions.		3.1210glycol ether;
primary alcohol		protic solvent
bis(2-chloroethoxy)methane
bis(2-chloroethoxy)methane: a solvent used in polysulfide elastomer production; structure in first source		3.1210
isobutylene
2-methylprop-1-ene : An alkene that is prop-1-ene substituted by a methyl group at position 2.		3.1210alkene;
gas molecular entity
dianisidine
Dianisidine: Highly toxic compound which can cause skin irritation and sensitization. It is used in manufacture of azo dyes.		3.1210biphenyls
1,3-diphenyl-1-triazene
1,3-diphenyl-1-triazene: structure in first source		3.1210
c.i. 42510
Rosaniline Dyes: Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta color and are used as COLORING AGENTS.. basic fuchsin : A four-component mixture of chemically related dyes comprising pararosanilin, rosanilin, magenta II and new fuchsin in varying amounts. rosanilin : A hydrochloride that is the monohydrochloride of 4-[(4-aminophenyl)(4-iminocyclohexa-2,5-dien-1-ylidene)methyl]-2-methylaniline. One of the major constituents of Basic fuchsin, together with pararosanilin, magenta II and new fuchsin.		2.4110
zinc oxide
Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.		2.4520zinc molecular entity
direct blue 15
direct blue 15: RN given refers to tetra-Na salt. Pontamine sky blue 5B : An organic sodium salt resulting from the formal condensation of Pontamine sky blue 5B (acid form) with four equivalents of sodium hydroxide.		3.1210
direct red 81
Direct Red 81: RN given refers to disodium salt; structure given in first source. Sirius red 4B : An organic sodium salt resulting from the formal condensation of Sirius red 4B (acid form) with two equivalents of sodium hydroxide. Used as the plasma stain in some trichrome staining methods.		2.0810
c.i. acid red 114, disodium salt
C.I. Acid Red 114: source gives many trade names; structure in first source		3.1210
titanium
Titanium: A dark-gray, metallic element of widespread distribution but occurring in small amounts with atomic number, 22, atomic weight, 47.867 and symbol, Ti; specific gravity, 4.5; used for fixation of fractures.		2.4620titanium group element atom
cadmium
Cadmium: An element with atomic symbol Cd, atomic number 48, and atomic weight 112.41. It is a metal and ingestion will lead to CADMIUM POISONING.. elemental cadmium : An element in the zinc group of the periodic table with atomic number 48, atomic mass 112, M.P. 321degreeC, and B.P. 765degreeC). An odourless, tasteless, and highly poisonous soft, ductile, lustrous metal with electropositive properties. It has eight stable isotopes: (106)Cd, (108)Cd,(110)Cd, (111)Cd, (112)Cd, (113)Cd, (114)Cd and (116)Cd, with (112)Cd and (114)Cd being the most common.		2.610cadmium molecular entity;
zinc group element atom
titanium dioxide
titanium dioxide: used medically as protectant against externally caused irritation & sunlight; high concentrations of dust may cause irritation to respiratory tract; RN given refers to titanium oxide (TiO2); structure. titanium dioxide : A titanium oxide with the formula TiO2. A naturally occurring oxide sourced from ilmenite, rutile and anatase, it has a wide range of applications.		2.4620titanium oxidesfood colouring
stannic oxide
tin dioxide : A tin oxide compound consisting of tin(IV) covalently bound to two oxygen atoms.		2.0410tin oxide
alkenes
[no description available]		3.1210
scarlet red
Scarlet Red: structure. Sudan IV : A bis(azo) compound that is 2-naphthol substituted at position 1 by a {2-methyl-4-[(2-methylphenyl)diazenyl]phenyl}diazenyl group. A fat-soluble dye predominantly used for demonstrating triglycerides in frozen sections, but which may also stain some protein bound lipids in paraffin sections.		2.4110azobenzenes;
bis(azo) compound;
naphthols		carcinogenic agent;
fluorochrome;
histological dye
c.i. direct red 80
Solophenyl red 3BL: structure in first source. Sirius red F3B : An organic sodium salt resulting from the formal condensation of Sirius red F3B (acid form) with six equivalents of sodium hydroxide. A polyazo dye used principally in staining methods for collagen and amyloid.		2.0810organic sodium saltfluorochrome;
histological dye
pectins
Pectins: High molecular weight polysaccharides present in the cell walls of all plants. Pectins cement cell walls together. They are used as emulsifiers and stabilizers in the food industry. They have been tried for a variety of therapeutic uses including as antidiarrheals, where they are now generally considered ineffective, and in the treatment of hypercholesterolemia.. alpha-D-galacturonic acid : The alpha-anomer of D-galacturonic acid.		2.2110D-galactopyranuronic acid
laccase
Laccase: A copper-containing oxidoreductase enzyme that catalyzes the oxidation of 4-benzenediol to 4-benzosemiquinone. It also has activity towards a variety of O-quinols and P-quinols. It primarily found in FUNGI and is involved in LIGNIN degradation, pigment biosynthesis and detoxification of lignin-derived products.		2.4110
mocetinostat
mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).		2.2110aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
ferrous citrate
ferrous citrate: iron fortificant		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials
Coronary Thrombosis
Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.		02.9410