Compounds > n,n,n',n'-tetramethylbenzidine
Page last updated: 2024-12-05

n,n,n',n'-tetramethylbenzidine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID9702
CHEMBL ID3823639
SCHEMBL ID124209
MeSH IDM0074273

Synonyms (44)

Synonym
[1,1'-biphenyl]-4,4'-diamine, n,n,n',n'-tetramethyl-
benzidine, n,n,n',n'-tetramethyl-
n,n,n',n'-tetramethylbenzidine
nsc 433
4,4'-bis(n,n-dimethylamino)biphenyl
(1,1'-biphenyl)-4,4'-diamine, n,n,n',n'-tetramethyl-
n,n,n',n'-tetramethyl-(1,1'-biphenyl)-4,4'-diamine
einecs 206-676-5
ccris 1000
ai3-61957
n,n,n',n'-tetramethyl-p,p'-benzidine
CHEMDIV2_000092 ,
benzidine,n,n',n'-tetramethyl-
nsc-433
nsc433
[1,4'-diamine, n,n,n',n'-tetramethyl-
366-29-0
n,n',n'-tetramethylbenzidine
n,n,n',n'-tetramethylbenzidine, >=95% (hplc)
AKOS001482346
HMS1369E04
T0141
4,4'-bis(dimethylamino)biphenyl
n-[4'-(dimethylamino)[1,1'-biphenyl]-4-yl]-n,n-dimethylamine
(1,1'-biphenyl)-4,4'-diamine, n4,n4,n4',n4'-tetramethyl-
CCG-103298
FT-0632049
AB01331573-02
SCHEMBL124209
[1,1'-biphenyl]-4,4'-diamine,n,n,n'',n'-tetramethyl-
n4,n4,n4',n4'-tetramethyl-[1,1'-biphenyl]-4,4'-diamine
CHEMBL3823639
DTXSID0036845
SR-01000390721-1
sr-01000390721
mfcd00008310
n,n,n,n-tetramethylbenzidine
4-[4-(dimethylamino)phenyl]-n,n-dimethylaniline
n4,n4,n4',n4'-tetramethylbiphenyl-4,4'-diamine
AMY33203
D92306
NCGC00338604-01
BS-23690
CS-0044367
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1310986Inhibition of ATGL in mouse 3T3L1 cells assessed as inhibition of isoproterenol-stimulated lipolysis by measuring reduction in glycerol release in media at 20 uM preincubated for 4 hrs followed by isoproterenol addition measured after 1 hr by colorimetric2016European journal of medicinal chemistry, Aug-08, Volume: 118New Atglistatin closely related analogues: Synthesis and structure-activity relationship towards adipose triglyceride lipase inhibition.
AID1310985Inhibition of ATGL in mouse 3T3L1 cells assessed as inhibition of isoproterenol-stimulated lipolysis by measuring reduction in non-esterified fatty acid release in media at 20 uM preincubated for 4 hrs followed by isoproterenol addition measured after 1 h2016European journal of medicinal chemistry, Aug-08, Volume: 118New Atglistatin closely related analogues: Synthesis and structure-activity relationship towards adipose triglyceride lipase inhibition.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19907 (43.75)18.7374
1990's6 (37.50)18.2507
2000's0 (0.00)29.6817
2010's3 (18.75)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.40

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.40 (24.57)
Research Supply Index2.89 (2.92)
Research Growth Index4.29 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.40)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		1.9610halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
niacin
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.. vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).. nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.		1.9710pyridine alkaloid;
pyridinemonocarboxylic acid;
vitamin B3		antidote;
antilipemic drug;
EC 3.5.1.19 (nicotinamidase) inhibitor;
Escherichia coli metabolite;
human urinary metabolite;
metabolite;
mouse metabolite;
plant metabolite;
vasodilator agent
nitrates
Nitrates: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.		1.9710monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		1.9910isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
cetyltrimethylammonium ion
Cetrimonium: Cetyltrimethylammonium compound whose salts and derivatives are used primarily as topical antiseptics.. cetyltrimethylammonium ion : A quaternary ammonium ion in which the substituents on nitrogen are one hexadecyl and three methyl groups.		1.9810quaternary ammonium ion
aminosalicylic acid
Aminosalicylic Acid: An antitubercular agent often administered in association with ISONIAZID. The sodium salt of the drug is better tolerated than the free acid.. 4-aminosalicylic acid : An aminobenzoic acid that is salicylic acid substituted by an amino group at position 4.		1.9710aminobenzoic acid;
phenols		antitubercular agent
sodium fluoride
[no description available]		1.9910fluoride saltmutagen
mannitol
[no description available]		1.9910mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent
histidine
Histidine: An essential amino acid that is required for the production of HISTAMINE.. L-histidine : The L-enantiomer of the amino acid histidine.. histidine : An alpha-amino acid that is propanoic acid bearing an amino substituent at position 2 and a 1H-imidazol-4-yl group at position 3.		1.9910amino acid zwitterion;
histidine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
tetramethylphenylenediamine
1,4-bis(dimethylamino)benzene: structure in first source		2.1310
diethanolamine
diethanolamine: RN given refers to parent cpd. diethanolamine : A member of the class of ethanolamines that is ethanolamine having a N-hydroxyethyl substituent.		1.9610ethanolamineshuman xenobiotic metabolite
molybdenum
Molybdenum: A metallic element with the atomic symbol Mo, atomic number 42, and atomic weight 95.95. It is an essential trace element, being a component of the enzymes xanthine oxidase, aldehyde oxidase, and nitrate reductase.		2.4120chromium group element atommicronutrient
monoammonium molybdate
ammonium molybdate: RN given refers to unspecified ammonium molybdate salt. ammonium molybdate : An ammonium salt composed of ammonium and molybdate ions in a 2:1 ratio.		1.9710ammonium saltpoison
masoprocol
Masoprocol: A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. The compound also inhibits formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase to a lesser extent. It also serves as an antioxidant in fats and oils.. masoprocol : The meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase.		1.9710nordihydroguaiaretic acidantineoplastic agent;
hypoglycemic agent;
lipoxygenase inhibitor;
metabolite
silicon
Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].		2.110carbon group element atom;
metalloid atom;
nonmetal atom
mocetinostat
mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).		1.9610aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent
atglistatin
atglistatin: inhibits adipose triglyceride lipase; structure in first source. atglistatin : A biphenyl that is 1,1'-biphenyl substituted by (dimethylcarbamoyl)amino and dimethylamino groups at positions 3 and 4', respectively. It is a potent inhibitor of adipose triglyceride lipase activity (IC50 = 700nM).		2.1310
ConditionIndicatedRelationship StrengthStudiesTrials