Page last updated: 2024-12-09

2-thioxanthene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID1268185
CHEMBL ID218762
SCHEMBL ID94917
SCHEMBL ID19690932
MeSH IDM0167749

Synonyms (66)

Synonym
AC-17210
BB 0259635
AKOS003407172
6h-purin-6-one, 1,2,3,7-tetrahydro-2-thioxo-
2-thioxanthine
6-hydroxy-2-mercaptopurine
6h-purin-6-one,2,3,7-tetrahydro-2-thioxo-
nsc36822
6-hydroxypurine-2-thiol
nsc-36822
xanthine, 2-thio-
1,2,3,7-tetrahydro-2-thioxo-6h-purin-6-one
nsc 680828
2-thioxanthene
xanthine, 2-thio- (van)
nsc 36822
ai3-52144
2-thio-6-oxypurine
einecs 219-636-7
nsc-680828
nsc680828
2-mercapto-6-hydroxypurine
2487-40-3
2-sulfanyl-9h-purin-6-ol
2-thiohypoxanthine
2-thioxo-3,9-dihydropurin-6-one
2-thioxo-1,2,3,9-tetrahydro-purin-6-one
NCGC00161977-01
AKOS000275395
CHEMBL218762
2-mercaptohypoxanthine
T0225
2-thio-6-oxopurine
AKOS005457824
2-sulfanylidene-3,7-dihydropurin-6-one
2-mercapto-9h-purin-6-ol
pl0ppi1u9a ,
6h-purin-6-one, 1,2,3,9-tetrahydro-2-thioxo-
unii-pl0ppi1u9a
2-sulfanylhydropurin-6-one
2-thioxo-1,2,3,7-tetrahydro-6h-purin-6-one
STK520671
AKOS006230668
GEO-01523
FT-0621159
2-mercapto-1,9-dihydro-6h-purin-6-one
SCHEMBL94917
DTXSID7062459
hypoxanthine, 2-mercapto-
2-thioxo-2,3-dihydro-1h-purin-6(7h)-one
2on ,
2-sulfanyl-1,9-dihydro-6h-purin-6-one
mfcd00142991
2-sulfanylidene-2,3,6,9-tetrahydro-1h-purin-6-one
AS-66208
SCHEMBL19690932
2-thioxo-2,3-dihydro-1h-purin-6(9h)-one
CS-0063941
2-mercapto-9h-purin-6-ol;6-hydroxy-2-mercaptopurine
BCP30961
Q27286605
T72157
EN300-173305
2-sulfanylidene-2,3,6,7-tetrahydro-1h-purin-6-one
Z1198151179
PD194602
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (2)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency39.81070.631035.7641100.0000AID504339
thioredoxin reductaseRattus norvegicus (Norway rat)Potency1.77830.100020.879379.4328AID588453
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID274552Inhibition of [3H]hypoxanthine uptake into Plasmodium falciparum 3D7 at 125 uM2006Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases.
AID274555Antimalarial activity against Plasmodium falciparum 3D7 at 125 uM2006Journal of medicinal chemistry, Dec-14, Volume: 49, Issue:25
Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (12.50)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's4 (50.00)24.3611
2020's1 (12.50)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.70 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]