amsacrine has been researched along with Bleeding in 7 studies
Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty-seven adult patients with acute promyelocytic leukemia (APL) were treated between 1974 and 1984 with daunorubicin (DNR) or 4-(9-acridinylamino)methanesulfan-m-anisidide (AMSA) in combination with arabinosylcytosine (Ara-C) and 6-thioguanine (TG); they also received prophylactic heparin." | 5.06 | Acute promyelocytic leukemia: treatment results during a decade at Memorial Hospital. ( Clarkson, BD; Cunningham, I; Gee, TS; Kempin, SJ; Naval, AN; Reich, LM, 1989) |
| "Laboratory evidence of disseminated intravascular coagulation (DIC) and/or fibrinolysis is present in the majority of patients with acute promyelocytic leukemia (APL)." | 2.68 | Thrombosis in patients with acute promyelocytic leukemia treated with and without all-trans retinoic acid. ( Escudier, SM; Estey, EH; Kantarjian, HM, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hines, JD | 1 |
| Oken, MM | 1 |
| Mazza, JJ | 1 |
| Keller, AM | 1 |
| Streeter, RR | 1 |
| Glick, JH | 1 |
| Escudier, SM | 1 |
| Kantarjian, HM | 2 |
| Estey, EH | 2 |
| Maurer, LH | 1 |
| Herndon, JE | 1 |
| Hollis, DR | 1 |
| Aisner, J | 1 |
| Carey, RW | 1 |
| Skarin, AT | 1 |
| Perry, MC | 1 |
| Eaton, WL | 1 |
| Zacharski, LL | 1 |
| Hammond, S | 1 |
| Green, MR | 1 |
| Navarro, JT | 1 |
| Hernández, JA | 1 |
| Ribera, JM | 1 |
| Sancho, JM | 1 |
| Oriol, A | 1 |
| Pujol, M | 1 |
| Millá, F | 1 |
| Feliu, E | 1 |
| Cunningham, I | 1 |
| Gee, TS | 1 |
| Reich, LM | 1 |
| Kempin, SJ | 1 |
| Naval, AN | 1 |
| Clarkson, BD | 1 |
| Keating, MJ | 1 |
| Walters, RS | 1 |
| McCredie, KB | 1 |
| Smith, TL | 1 |
| Dalton, WT | 1 |
| Cork, A | 1 |
| Trujillo, JM | 1 |
| Freireich, EJ | 1 |
| Louie, AC | 1 |
| Issell, BF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot, Pharmacodynamic Correlate Trial of Sirolimus in Combination With Chemotherapy (Idarubicin, Cytarabine) for the Treatment of Newly Diagnosed Acute Myelogenous Leukemia[NCT01822015] | Early Phase 1 | 55 participants (Actual) | Interventional | 2013-03-15 | Completed | ||
| A Multi-Center Phase 2 Study of Daratumumab With Pomalidomide and Dexamethasone in Combination With All-Transretinoic Acid in Patients With Multiple Myeloma Previously Exposed to Daratumumab-Based Regimens[NCT04700176] | Phase 2 | 43 participants (Anticipated) | Interventional | 2022-05-02 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for amsacrine and Bleeding
| Article | Year |
|---|---|
Amsacrine (AMSA)--a clinical review.
Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 1985 |
4 trials available for amsacrine and Bleeding
| Article | Year |
|---|---|
Thrombosis in patients with acute promyelocytic leukemia treated with and without all-trans retinoic acid.
Topics: Adult; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemot | 1996 |
Randomized trial of chemotherapy and radiation therapy with or without warfarin for limited-stage small-cell lung cancer: a Cancer and Leukemia Group B study.
Topics: Adult; Aged; Amsacrine; Anticoagulants; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, S | 1997 |
Acute promyelocytic leukemia: treatment results during a decade at Memorial Hospital.
Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daun | 1989 |
Amsacrine (AMSA)--a clinical review.
Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc | 1985 |
3 other studies available for amsacrine and Bleeding
| Article | Year |
|---|---|
High-dose cytosine arabinoside and m-AMSA is effective therapy in relapsed acute nonlymphocytic leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Combined Chemother | 1984 |
Prophylactic platelet transfusion threshold during therapy for adult acute myeloid leukemia: 10,000/microL versus 20,000/microL.
Topics: Acute Disease; Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; C | 1998 |
Acute promyelocytic leukemia. M.D. Anderson Hospital experience.
Topics: Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Cytara | 1986 |