Page last updated: 2024-10-22

amsacrine and Bleeding

amsacrine has been researched along with Bleeding in 7 studies

Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
amsacrine : A sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity.

Research Excerpts

ExcerptRelevanceReference
"Fifty-seven adult patients with acute promyelocytic leukemia (APL) were treated between 1974 and 1984 with daunorubicin (DNR) or 4-(9-acridinylamino)methanesulfan-m-anisidide (AMSA) in combination with arabinosylcytosine (Ara-C) and 6-thioguanine (TG); they also received prophylactic heparin."5.06Acute promyelocytic leukemia: treatment results during a decade at Memorial Hospital. ( Clarkson, BD; Cunningham, I; Gee, TS; Kempin, SJ; Naval, AN; Reich, LM, 1989)
"Laboratory evidence of disseminated intravascular coagulation (DIC) and/or fibrinolysis is present in the majority of patients with acute promyelocytic leukemia (APL)."2.68Thrombosis in patients with acute promyelocytic leukemia treated with and without all-trans retinoic acid. ( Escudier, SM; Estey, EH; Kantarjian, HM, 1996)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19904 (57.14)18.7374
1990's3 (42.86)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hines, JD1
Oken, MM1
Mazza, JJ1
Keller, AM1
Streeter, RR1
Glick, JH1
Escudier, SM1
Kantarjian, HM2
Estey, EH2
Maurer, LH1
Herndon, JE1
Hollis, DR1
Aisner, J1
Carey, RW1
Skarin, AT1
Perry, MC1
Eaton, WL1
Zacharski, LL1
Hammond, S1
Green, MR1
Navarro, JT1
Hernández, JA1
Ribera, JM1
Sancho, JM1
Oriol, A1
Pujol, M1
Millá, F1
Feliu, E1
Cunningham, I1
Gee, TS1
Reich, LM1
Kempin, SJ1
Naval, AN1
Clarkson, BD1
Keating, MJ1
Walters, RS1
McCredie, KB1
Smith, TL1
Dalton, WT1
Cork, A1
Trujillo, JM1
Freireich, EJ1
Louie, AC1
Issell, BF1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot, Pharmacodynamic Correlate Trial of Sirolimus in Combination With Chemotherapy (Idarubicin, Cytarabine) for the Treatment of Newly Diagnosed Acute Myelogenous Leukemia[NCT01822015]Early Phase 155 participants (Actual)Interventional2013-03-15Completed
A Multi-Center Phase 2 Study of Daratumumab With Pomalidomide and Dexamethasone in Combination With All-Transretinoic Acid in Patients With Multiple Myeloma Previously Exposed to Daratumumab-Based Regimens[NCT04700176]Phase 243 participants (Anticipated)Interventional2022-05-02Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for amsacrine and Bleeding

ArticleYear
Amsacrine (AMSA)--a clinical review.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:4

    Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc

1985

Trials

4 trials available for amsacrine and Bleeding

ArticleYear
Thrombosis in patients with acute promyelocytic leukemia treated with and without all-trans retinoic acid.
    Leukemia & lymphoma, 1996, Volume: 20, Issue:5-6

    Topics: Adult; Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemot

1996
Randomized trial of chemotherapy and radiation therapy with or without warfarin for limited-stage small-cell lung cancer: a Cancer and Leukemia Group B study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1997, Volume: 15, Issue:11

    Topics: Adult; Aged; Amsacrine; Anticoagulants; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, S

1997
Acute promyelocytic leukemia: treatment results during a decade at Memorial Hospital.
    Blood, 1989, Volume: 73, Issue:5

    Topics: Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Daun

1989
Amsacrine (AMSA)--a clinical review.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1985, Volume: 3, Issue:4

    Topics: Adult; Aminoacridines; Amsacrine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protoc

1985

Other Studies

3 other studies available for amsacrine and Bleeding

ArticleYear
High-dose cytosine arabinoside and m-AMSA is effective therapy in relapsed acute nonlymphocytic leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:6

    Topics: Acute Disease; Adolescent; Adult; Aged; Aminoacridines; Amsacrine; Antineoplastic Combined Chemother

1984
Prophylactic platelet transfusion threshold during therapy for adult acute myeloid leukemia: 10,000/microL versus 20,000/microL.
    Haematologica, 1998, Volume: 83, Issue:11

    Topics: Acute Disease; Adolescent; Adult; Aged; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; C

1998
Acute promyelocytic leukemia. M.D. Anderson Hospital experience.
    The American journal of medicine, 1986, Volume: 80, Issue:5

    Topics: Aminoacridines; Amsacrine; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Cytara

1986