valproic acid has been researched along with Bleeding in 26 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| " As valproic acid (VPA) treatment has been shown to improve survival in animal models of lethal trauma, we hypothesized that it would also attenuate the degree of acute kidney injury." | 8.02 | Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma. ( Alam, HB; Biesterveld, BE; Kemp, MT; O'Connell, RL; Remmer, H; Shamshad, A; Siddiqui, AZ; Smith, WM; Wakam, GK; Williams, AM, 2021) |
| "BACKGROUND Valproic acid is utilized for the management of various disease states, but coagulation changes, such as thrombocytopenia, can limit use." | 7.96 | Valproic Acid-Induced Thrombocytopenia-Related Spontaneous Systemic Bleeding. ( Johnston, JP; Nerenberg, SF, 2020) |
| " In this study, we investigated whether valproic acid (VPA), a known mood stabilizer and anticonvulsant with HDAC-inhibiting activity, improves survival following otherwise lethal hemorrhage in rats." | 7.73 | Valproic acid prevents hemorrhage-associated lethality and affects the acetylation pattern of cardiac histones. ( Alam, HB; Britten-Webb, J; Burris, D; Chen, H; Gonzales, E; Koustova, E; Mehrani, T; Munuve, R; Nadel, A; Wherry, D, 2006) |
| "Valproic acid (VPA) has been extensively used for treatment of anxiety and seizure." | 5.72 | Valproic acid during hypotensive resuscitation in pigs with trauma and hemorrhagic shock does not improve survival. ( Bynum, J; Cap, AP; Martini, WZ; Ryan, KL; Xia, H, 2022) |
| "Acute pancreatitis is rarely seen in children, and it is often drug induced." | 5.35 | Acute hemorrhagic pancreatitis due to the use of valproic acid in a child. ( Köse, G; Ozaydin, E; Yükselgüngör, H, 2008) |
| " As valproic acid (VPA) treatment has been shown to improve survival in animal models of lethal trauma, we hypothesized that it would also attenuate the degree of acute kidney injury." | 4.02 | Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma. ( Alam, HB; Biesterveld, BE; Kemp, MT; O'Connell, RL; Remmer, H; Shamshad, A; Siddiqui, AZ; Smith, WM; Wakam, GK; Williams, AM, 2021) |
| "BACKGROUND Valproic acid is utilized for the management of various disease states, but coagulation changes, such as thrombocytopenia, can limit use." | 3.96 | Valproic Acid-Induced Thrombocytopenia-Related Spontaneous Systemic Bleeding. ( Johnston, JP; Nerenberg, SF, 2020) |
| " In this study, we investigated whether valproic acid (VPA), a known mood stabilizer and anticonvulsant with HDAC-inhibiting activity, improves survival following otherwise lethal hemorrhage in rats." | 3.73 | Valproic acid prevents hemorrhage-associated lethality and affects the acetylation pattern of cardiac histones. ( Alam, HB; Britten-Webb, J; Burris, D; Chen, H; Gonzales, E; Koustova, E; Mehrani, T; Munuve, R; Nadel, A; Wherry, D, 2006) |
| "Although the exact mechanism by which valproic acid acts on hemostasis is unknown, an association between the agent and defective blood clotting and spontaneous hemorrhage is evident." | 3.66 | Valproic acid: a new antiepileptic drug with potential side effects of dental concern. ( Hassell, TM; Jewson, LG; Peele, LC; White, GC, 1979) |
| "Valproic acid (VPA) has been extensively used for treatment of anxiety and seizure." | 1.72 | Valproic acid during hypotensive resuscitation in pigs with trauma and hemorrhagic shock does not improve survival. ( Bynum, J; Cap, AP; Martini, WZ; Ryan, KL; Xia, H, 2022) |
| "Hemorrhage is a major cause of morbidity and mortality among trauma patients." | 1.43 | Valproic acid-mediated myocardial protection of acute hemorrhagic rat via the BCL-2 pathway. ( He, M; He, Y; Kuai, Q; Li, W; Qiao, Z; Ren, S; Wang, C; Wang, X; Wang, Y; Yu, Q, 2016) |
| " Thus, this study shows that VPA can be dosed to selectively manipulate the fibrinolytic system in the vascular compartment and reduce thrombus formation in vivo." | 1.43 | Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse. ( Alwis, I; Bergh, N; Daglas, M; Fogelstrand, P; Glise, L; Jackson, SP; Jern, S; Larsson, P; Magnusson, M; Medcalf, RL; Niego, B; Sashindranath, M; Wu, MC, 2016) |
| "Valproic acid (VPA) is a histone deacetylase inhibitor that may decrease cellular metabolic needs following traumatic injury." | 1.39 | Beneficial effects of histone deacetylase inhibition with severe hemorrhage and ischemia-reperfusion injury. ( Alam, H; Causey, MW; Hempel, J; Hoffer, Z; Jin, G; Martin, M; Miller, S; Stallings, JD, 2013) |
| "Acute pancreatitis is rarely seen in children, and it is often drug induced." | 1.35 | Acute hemorrhagic pancreatitis due to the use of valproic acid in a child. ( Köse, G; Ozaydin, E; Yükselgüngör, H, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (19.23) | 18.7374 |
| 1990's | 2 (7.69) | 18.2507 |
| 2000's | 10 (38.46) | 29.6817 |
| 2010's | 5 (19.23) | 24.3611 |
| 2020's | 4 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Licon, DA | 1 |
| Xiang, L | 1 |
| Martini, WZ | 1 |
| Xia, H | 1 |
| Ryan, KL | 1 |
| Bynum, J | 1 |
| Cap, AP | 1 |
| Johnston, JP | 1 |
| Nerenberg, SF | 1 |
| Biesterveld, BE | 1 |
| Siddiqui, AZ | 1 |
| O'Connell, RL | 1 |
| Remmer, H | 1 |
| Williams, AM | 1 |
| Shamshad, A | 1 |
| Smith, WM | 1 |
| Kemp, MT | 1 |
| Wakam, GK | 1 |
| Alam, HB | 2 |
| Causey, MW | 1 |
| Miller, S | 1 |
| Hoffer, Z | 1 |
| Hempel, J | 1 |
| Stallings, JD | 1 |
| Jin, G | 1 |
| Alam, H | 1 |
| Martin, M | 1 |
| Wang, C | 2 |
| Wang, Y | 4 |
| Qiao, Z | 2 |
| Kuai, Q | 2 |
| Wang, X | 2 |
| He, M | 2 |
| Li, W | 2 |
| He, Y | 2 |
| Ren, S | 2 |
| Yu, Q | 2 |
| Larsson, P | 1 |
| Alwis, I | 1 |
| Niego, B | 1 |
| Sashindranath, M | 1 |
| Fogelstrand, P | 1 |
| Wu, MC | 1 |
| Glise, L | 1 |
| Magnusson, M | 1 |
| Daglas, M | 1 |
| Bergh, N | 1 |
| Jackson, SP | 1 |
| Medcalf, RL | 1 |
| Jern, S | 1 |
| Zhang, G | 1 |
| Jiang, X | 1 |
| Su, L | 1 |
| Psaras, T | 1 |
| Will, BE | 1 |
| Schoeber, W | 1 |
| Rona, S | 1 |
| Mittelbronn, M | 1 |
| Honegger, JB | 1 |
| Harden, CL | 1 |
| Sethi, NK | 1 |
| Besag, FM | 1 |
| Choi, KH | 1 |
| Nam, TS | 1 |
| Kim, JT | 1 |
| Choi, SM | 1 |
| Park, MS | 1 |
| Kim, BC | 1 |
| Kim, MK | 1 |
| Cho, KH | 1 |
| Inoue, Y | 1 |
| Suzuki, T | 1 |
| Takimoto, M | 1 |
| Irei, M | 1 |
| Yoshioka, S | 1 |
| Shibuya, Y | 1 |
| Kato, M | 1 |
| Koike, M | 1 |
| Takahashi, M | 1 |
| Kumar, S | 1 |
| Gonzales, E | 1 |
| Chen, H | 1 |
| Munuve, R | 1 |
| Mehrani, T | 1 |
| Britten-Webb, J | 1 |
| Nadel, A | 1 |
| Wherry, D | 1 |
| Burris, D | 1 |
| Koustova, E | 1 |
| Veinot, JP | 1 |
| Ruel, M | 1 |
| Ozaydin, E | 1 |
| Yükselgüngör, H | 1 |
| Köse, G | 1 |
| Williams, LH | 1 |
| Reynolds, RP | 1 |
| Emery, JL | 1 |
| Tam, DA | 1 |
| Myer, EC | 1 |
| Anderson, GD | 1 |
| Lin, YX | 1 |
| Berge, C | 1 |
| Ojemann, GA | 1 |
| Proulle, V | 1 |
| Masnou, P | 1 |
| Cartron, J | 1 |
| Kaplan, C | 1 |
| Ajzenberg, N | 1 |
| Tchernia, G | 1 |
| Dreyfus, M | 1 |
| Sleiman, C | 1 |
| Raffy, O | 1 |
| Roué, C | 1 |
| Mal, H | 1 |
| Hassell, TM | 1 |
| White, GC | 1 |
| Jewson, LG | 1 |
| Peele, LC | 1 |
| Sutor, AH | 1 |
| Jesdinsky-Buscher, C | 1 |
| Raghuveer, TS | 1 |
| Srinivasa, R | 1 |
| Chandrasekhara, MK | 1 |
| Rosenberg, HK | 1 |
| Ortega, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combined Scalp and Ear Acupuncture in Patients With Proton Pump Inhibitor- Dependent Gastroesophageal Reflux Disease[NCT04660019] | 43 participants (Actual) | Interventional | 2020-08-10 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for valproic acid and Bleeding
| Article | Year |
|---|---|
Epileptic disorders in pregnancy: an overview.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Folic Acid; Hemorrhag | 2008 |
25 other studies available for valproic acid and Bleeding
| Article | Year |
|---|---|
Letter Regarding: Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma.
Topics: Acute Kidney Injury; Hemorrhage; Humans; Valproic Acid | 2022 |
Valproic acid during hypotensive resuscitation in pigs with trauma and hemorrhagic shock does not improve survival.
Topics: Animals; Blood Coagulation; Disease Models, Animal; Hemorrhage; Resuscitation; Shock, Hemorrhagic; S | 2022 |
Valproic Acid-Induced Thrombocytopenia-Related Spontaneous Systemic Bleeding.
Topics: Anemia; Female; Hemorrhage; Humans; Middle Aged; Thrombocytopenia; Valproic Acid | 2020 |
Valproic Acid Protects Against Acute Kidney Injury in Hemorrhage and Trauma.
Topics: Acute Kidney Injury; Animals; Creatinine; Drug Evaluation, Preclinical; Hemorrhage; Histone Deacetyl | 2021 |
Beneficial effects of histone deacetylase inhibition with severe hemorrhage and ischemia-reperfusion injury.
Topics: Acidosis; Animals; Disease Models, Animal; Epinephrine; Hemorrhage; Histone Deacetylase Inhibitors; | 2013 |
Valproic acid-mediated myocardial protection of acute hemorrhagic rat via the BCL-2 pathway.
Topics: Acute Disease; Animals; Blotting, Western; Cell Hypoxia; Cells, Cultured; Disease Models, Animal; En | 2016 |
Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse.
Topics: Animals; Aorta; Blood Coagulation; Blood Platelets; Endothelium, Vascular; Enzyme Inhibitors; Fibrin | 2016 |
Energy metabolism regulated by HDAC inhibitor attenuates cardiac injury in hemorrhagic rat model.
Topics: Animals; Cell Line; Disease Models, Animal; Energy Metabolism; Hemorrhage; Histone Deacetylase Inhib | 2016 |
Quantitative assessment of postoperative blood collection in brain tumor surgery under valproate medication.
Topics: Adult; Aged; Anticonvulsants; Blood Cell Count; Blood Chemical Analysis; Blood Volume; Brain Neoplas | 2008 |
Abnormal bleeding or bruising associated with antieplieptic treatment.
Topics: Anticonvulsants; Blood Platelets; Contusions; Epistaxis; Fructose; Hemorrhage; Humans; Neuroprotecti | 2009 |
Valproate associated diffuse alveolar hemorrhage.
Topics: Adolescent; Anticonvulsants; Hemorrhage; Humans; Lung Diseases; Male; Myoclonic Epilepsy, Juvenile; | 2011 |
Treatment with valproic acid for myelofibrosis with myeloid metaplasia.
Topics: Aged; Anticonvulsants; Blood Cell Count; Epilepsy; Female; Hemorrhage; Humans; Primary Myelofibrosis | 2005 |
Valproate-induced bleeding: report of two cases and review of literature.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy; Epilepsy, Absence; Factor XII Deficiency; Female; Hemo | 2005 |
Valproic acid prevents hemorrhage-associated lethality and affects the acetylation pattern of cardiac histones.
Topics: Acetylation; Animals; Disease Models, Animal; Heart; Hemorrhage; Histones; Male; Rats; Rats, Inbred | 2006 |
Valproic acid and bleeding: caution required.
Topics: Animals; Cardiac Surgical Procedures; Dogs; Hemorrhage; Neuroprotective Agents; Valproic Acid | 2007 |
Acute hemorrhagic pancreatitis due to the use of valproic acid in a child.
Topics: Acute Disease; Anticonvulsants; Child; Epilepsy, Generalized; Hemorrhage; Humans; Intellectual Disab | 2008 |
Pancreatitis during sodium valproate treatment.
Topics: Acute Disease; Female; Hemorrhage; Humans; Infant; Pancreatitis; Seizures, Febrile; Valproic Acid | 1983 |
Vitamin K-dependent coagulopathy in a child receiving anticonvulsant therapy.
Topics: Adolescent; Anticonvulsants; Blood Coagulation; Drug Combinations; Factor X Deficiency; Female; Ging | 1996 |
Absence of bleeding complications in patients undergoing cortical surgery while receiving valproate treatment.
Topics: Adult; Cerebral Cortex; Epilepsy; Female; Hemorrhage; Humans; Male; Prognosis; Retrospective Studies | 1997 |
GPIaIIa as a candidate target for anti-platelet autoantibody occurring during valproate therapy and associated with peroperative bleeding.
Topics: Adult; Anticonvulsants; Astrocytoma; Autoantibodies; Blood Platelets; Brain Neoplasms; Female; Hemor | 2000 |
Fatal pulmonary hemorrhage during high-dose valproate monotherapy.
Topics: Adult; Anticonvulsants; Epilepsy, Generalized; Fatal Outcome; Female; Hemorrhage; Humans; Lung Disea | 2000 |
Valproic acid: a new antiepileptic drug with potential side effects of dental concern.
Topics: Adult; Blood Coagulation; Blood Platelets; Chemical Phenomena; Chemistry; Female; Hemorrhage; Hemost | 1979 |
[Changes in hemostasis during epilespy treatment using dipropyl acetate. Extended study].
Topics: Adolescent; Blood Cell Count; Blood Platelets; Child; Child, Preschool; Epilepsy; Factor IX; Female; | 1976 |
Valproate induced bleeding.
Topics: Ecchymosis; Hemorrhage; Humans; Infant; Male; Meningitis; Spasms, Infantile; Valproic Acid | 1989 |
Hemorrhagic pancreatitis in a young child following valproic acid therapy. Clinical and ultrasonic assessment.
Topics: Acute Disease; Child, Preschool; Hemorrhage; Humans; Male; Pancreatitis; Seizures; Ultrasonography; | 1987 |