Page last updated: 2024-12-11

fusarin c

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

fusarin C: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6435894
CHEBI ID82329
MeSH IDM0122790

Synonyms (14)

Synonym
fusarin c
hsdb 7078
3,5,7,9-undecatetraenoic acid, 2-ethylidene-11-(4-hydroxy-4-(2-hydroxyethyl)-2-oxo-6-oxa-3-azabicyclo(3.1.0)hex-1-yl)-4,6,10-trimethyl-11-oxo-, methyl ester, (1r-(1-alpha(2e,3e,5e,7e,9e),4-alpha,5-alpha))-
ccris 4320
79748-81-5
C19243
unii-c3f3z00lm3
c3f3z00lm3 ,
CHEBI:82329
fusarinc
3,5,7,9-undecatetraenoic acid, 2-ethylidene-11-((1r,4s,5r)-4-hydroxy-4-(2-hydroxyethyl)-2-oxo-6-oxa-3-azabicyclo(3.1.0)hex-1-yl)-4,6,10-trimethyl-11-oxo-, methyl ester, (2e,3e,5e,7e,9e)-
3,5,7,9-undecatetraenoic acid, 2-ethylidene-11-(4-hydroxy-4-(2-hydroxyethyl)-2-oxo-6-oxa-3-azabicyclo(3.1.0)hex-1-yl)-4,6,10-trimethyl-11-oxo-, methyl ester, (1r-(1.alpha.(2e,3e,5e,7e,9e),4.alpha.,5.alpha.))-
Q27155879
DTXSID501020204

Research Excerpts

Overview

Fusarin C is a mycotoxin that is produced by a variety of Fusarium species. It has been associated with esophageal cancer due to its carcinogenic effects.

ExcerptReferenceRelevance
"Fusarin C is a mycotoxin produced by several Fusarium species and has been associated with esophageal cancer due to its carcinogenic effects. "( Fusarin C acts like an estrogenic agonist and stimulates breast cancer cells in vitro.
Bonefeld-Jørgensen, EC; Giese, H; Hansen, FT; Nielsen, AK; Purup, S; Sondergaard, TE; Sørensen, JL, 2011
)
3.25
"Fusarin C is a mycotoxin that is produced by a variety of Fusarium species and is therefore a possible contaminant in food and feed. "( A new high-performance liquid chromatography-tandem mass spectrometry method based on dispersive solid phase extraction for the determination of the mycotoxin fusarin C in corn ears and processed corn samples.
Humpf, HU; Kleigrewe, K; Söhnel, AC, 2011
)
2.01
"Fusarin C is a Fusarium mycotoxin that rearranges under reversed phase chromatographic conditions. "( Structure elucidation of new fusarins revealing insights in the rearrangement mechanisms of the Fusarium mycotoxin fusarin C.
Aydin, F; Bergander, K; Hogrefe, K; Humpf, HU; Kleigrewe, K; Piecuch, P; Würthwein, EU, 2012
)
2.03
"Fusarin C is a Fusarium mycotoxin, which is mutagenic after metabolic activation."( New approach via gene knockout and single-step chemical reaction for the synthesis of isotopically labeled fusarin c as an internal standard for the analysis of this fusarium mycotoxin in food and feed samples.
Humpf, HU; Kleigrewe, K; Niehaus, EM; Tudzynski, B; Wiemann, P, 2012
)
1.31
"Fusarin C (FC) is a naturally occurring mutagen found on Fusarium moniliforme-contaminated corn. "( Stability of fusarin C: effects of the normal cooking procedure used in China and pH.
Jeffrey, AM; Zhu, B, 1992
)
2.1
"Fusarin C (FC) is a mutagenic and carcinogenic mycotoxin which was isolated from Fusarium moniliforme culture extracts. "( In vitro transformation of rat esophageal epithelial cells by fusarin C.
Cheng, SJ; Li, MX; Lu, FX, 1991
)
1.96
"Fusarin C (FC) is a potent mutagen present on Fusarium moniliforme contaminated corn. "( Metabolism of fusarin C by rat liver microsomes. Role of esterase and cytochrome P-450 enzymes with respect to the mutagenicity of fusarin C in Salmonella typhimurium.
Gelboin, HV; Jeffrey, AM; Li, MH; Lu, SJ; Park, SS, 1989
)
2.08
"Fusarin C (FC) is a potent mutagen which has been isolated from Fusarium moniliforme culture extracts (FME). "( Fusarium moniliforme metabolites: genotoxicity of culture extracts.
Jeffrey, AM; Li, MH; Lu, SJ; Ronai, ZA, 1988
)
1.72

Treatment

ExcerptReferenceRelevance
"Fusarin C treated rat esophageal epithelial cell line showed several characteristics of malignant transformations including the growth in nude mice."( [Fusarin C induced esophageal and forestomach carcinoma in mice and rats].
Li, MX, 1992
)
1.92

Toxicity

ExcerptReferenceRelevance
" However the toxic effects could not be accounted for by the content of the two toxins measured."( Differential cytotoxicity and mycotoxin content among isolates of Fusarium moniliforme.
Bacon, CW; Norred, WP; Plattner, RD; Vesonder, RF, 1991
)
0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
sesquiterpenoidAny terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (47)

TimeframeStudies, This Drug (%)All Drugs %
pre-199018 (38.30)18.7374
1990's15 (31.91)18.2507
2000's6 (12.77)29.6817
2010's8 (17.02)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.20

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.20 (24.57)
Research Supply Index3.91 (2.92)
Research Growth Index4.53 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.20)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (4.08%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other47 (95.92%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]