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flutamide and Bleeding

flutamide has been researched along with Bleeding in 10 studies

Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Research Excerpts

ExcerptRelevanceReference
"Although studies have shown that administration of testosterone receptor antagonist, flutamide, following trauma-hemorrhage, improves hepatic, cardiovascular, and immune functions, the precise cellular/molecular mechanisms responsible for producing these salutary effects remain largely unknown."7.74Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, CH; Kan, WH; Raju, R; Schwacha, MG, 2008)
"Flutamide, an androgen receptor antagonist, is thought to improve cardiovascular function by blocking the androgen receptor after trauma-hemorrhage (T-H)."7.73PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, YC; Rue, LW; Yang, S; Yu, HP, 2005)
"Although previous studies have shown that flutamide improves cardiovascular function after trauma-hemorrhage, the mechanisms responsible for the salutary effect remain unknown."7.73Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, YC; Schwacha, MG; Yang, S; Yu, HP, 2006)
"We hypothesized that administration of androgen receptors antagonist flutamide following trauma-hemorrhage (T-H) in metestrus females will maintain immune function and reduce remote organ damage under those conditions."7.73Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females. ( Chaudry, IH; Choudhry, MA; Hildebrand, F; Hubbard, WJ; Pape, HC; Thobe, BM, 2006)
" Because T-lymphocyte functions are altered following trauma-hemorrhage in male mice, we investigated whether (i) receptors for androgen (AR) and estrogen (ER) are present in splenic T lymphocytes, (ii) receptor expressions are altered following trauma-hemorrhage, and (iii) pretreatment of male mice with the AR antagonist, flutamide, alters receptor expressions and IL-6 release."7.70Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage. ( Bland, KI; Chaudry, IH; Cioffi, WG; Samy, TS; Schwacha, MG, 2000)
"Flutamide treatment increased intestinal HO-1 and ER-beta mRNA/protein levels as compared with vehicle-treated T-H rats."5.33Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1. ( Chaudry, IH; Choudhry, MA; Hsieh, YC; Schwacha, MG; Shimizu, T; Yang, S; Yu, HP, 2006)
"Although studies have shown that administration of testosterone receptor antagonist, flutamide, following trauma-hemorrhage, improves hepatic, cardiovascular, and immune functions, the precise cellular/molecular mechanisms responsible for producing these salutary effects remain largely unknown."3.74Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, CH; Kan, WH; Raju, R; Schwacha, MG, 2008)
"Flutamide, an androgen receptor antagonist, is thought to improve cardiovascular function by blocking the androgen receptor after trauma-hemorrhage (T-H)."3.73PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, YC; Rue, LW; Yang, S; Yu, HP, 2005)
"Although previous studies have shown that flutamide improves cardiovascular function after trauma-hemorrhage, the mechanisms responsible for the salutary effect remain unknown."3.73Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, YC; Schwacha, MG; Yang, S; Yu, HP, 2006)
"We hypothesized that administration of androgen receptors antagonist flutamide following trauma-hemorrhage (T-H) in metestrus females will maintain immune function and reduce remote organ damage under those conditions."3.73Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females. ( Chaudry, IH; Choudhry, MA; Hildebrand, F; Hubbard, WJ; Pape, HC; Thobe, BM, 2006)
" Because T-lymphocyte functions are altered following trauma-hemorrhage in male mice, we investigated whether (i) receptors for androgen (AR) and estrogen (ER) are present in splenic T lymphocytes, (ii) receptor expressions are altered following trauma-hemorrhage, and (iii) pretreatment of male mice with the AR antagonist, flutamide, alters receptor expressions and IL-6 release."3.70Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage. ( Bland, KI; Chaudry, IH; Cioffi, WG; Samy, TS; Schwacha, MG, 2000)
"Although the testosterone receptor antagonist flutamide restores the depressed immune function in males after trauma and hemorrhage, it remains unknown whether this agent has any salutary effects on adrenal function."3.70Testosterone receptor blockade after trauma and hemorrhage attenuates depressed adrenal function. ( Ba, ZF; Bland, KI; Chaudry, IH; Cioffi, WG; Koo, DJ; Wang, P; Zhou, M, 2000)
"To determine whether treatment with an androgen receptor blocker (eg, flutamide) after trauma-hemorrhage and sepsis has any salutary effects on cell-mediated immunity and on the survival of male animals under those conditions."3.69Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis. ( Angele, MK; Ayala, A; Chaudry, IH; Cioffi, WG; Wichmann, MW, 1997)
"Flutamide, a chemotherapeutic agent for prostate cancer, is known to enhance warfarin anticoagulation."1.51Extreme Elevation of the Prothrombin Time-International Normalized Ratio due to a Probable Interaction between Warfarin and Flutamide. ( Araki, Y; Kawaguchi, O; Konishi, Y; Terada, T, 2019)
"Flutamide treatment increased intestinal HO-1 and ER-beta mRNA/protein levels as compared with vehicle-treated T-H rats."1.33Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1. ( Chaudry, IH; Choudhry, MA; Hsieh, YC; Schwacha, MG; Shimizu, T; Yang, S; Yu, HP, 2006)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (10.00)18.2507
2000's8 (80.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Konishi, Y1
Terada, T1
Araki, Y1
Kawaguchi, O1
Kan, WH1
Hsieh, CH1
Schwacha, MG4
Choudhry, MA5
Raju, R1
Bland, KI5
Chaudry, IH9
Hsieh, YC3
Yang, S3
Yu, HP3
Rue, LW1
Shimizu, T1
Mayr, S1
Walz, CR1
Angele, P1
Hernandez-Richter, T1
Loehe, F1
Jauch, KW1
Angele, MK2
Hildebrand, F1
Hubbard, WJ1
Thobe, BM1
Pape, HC1
Wichmann, MW1
Ayala, A1
Cioffi, WG3
Samy, TS1
Ba, ZF1
Wang, P1
Koo, DJ1
Zhou, M1

Other Studies

10 other studies available for flutamide and Bleeding

ArticleYear
Extreme Elevation of the Prothrombin Time-International Normalized Ratio due to a Probable Interaction between Warfarin and Flutamide.
    Internal medicine (Tokyo, Japan), 2019, Nov-15, Volume: 58, Issue:22

    Topics: Aged, 80 and over; Anticoagulants; Atrial Fibrillation; Blood Coagulation; Blood Coagulation Factors

2019
Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis.
    Journal of applied physiology (Bethesda, Md. : 1985), 2008, Volume: 105, Issue:2

    Topics: Androgen Antagonists; Animals; Apoptosis; Blotting, Western; Cell Separation; Chemokines; Cytokines;

2008
PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage.
    American journal of physiology. Heart and circulatory physiology, 2005, Volume: 289, Issue:6

    Topics: Animals; Cardiotonic Agents; Estradiol; Flutamide; Heart; Hemorrhage; Male; Rats; Rats, Sprague-Dawl

2005
Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1.
    American journal of physiology. Heart and circulatory physiology, 2006, Volume: 290, Issue:1

    Topics: Abdominal Injuries; Animals; Aromatase; Dihydrotestosterone; Electron Transport Complex IV; Estradio

2006
Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1.
    Journal of leukocyte biology, 2006, Volume: 79, Issue:2

    Topics: Animals; Chemokine CXCL1; Chemokines, CXC; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogen

2006
Castration prevents suppression of MHC class II (Ia) expression on macrophages after trauma-hemorrhage.
    Journal of applied physiology (Bethesda, Md. : 1985), 2006, Volume: 101, Issue:2

    Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Antigen Presentation; CD11b Antigen; F

2006
Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females.
    Journal of leukocyte biology, 2006, Volume: 80, Issue:4

    Topics: Animals; Chemokine CCL2; Cytokines; Enzyme Activation; Estradiol; Female; Flow Cytometry; Flutamide;

2006
Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis.
    Archives of surgery (Chicago, Ill. : 1960), 1997, Volume: 132, Issue:11

    Topics: Androgen Antagonists; Animals; Flutamide; Hemorrhage; Immunity, Cellular; Interleukins; Male; Mice;

1997
Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage.
    Shock (Augusta, Ga.), 2000, Volume: 14, Issue:4

    Topics: Androgen Antagonists; Animals; DNA-Binding Proteins; Female; Flutamide; Hemorrhage; Interleukin-6; M

2000
Testosterone receptor blockade after trauma and hemorrhage attenuates depressed adrenal function.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:5

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Androgen Antagonists; Androgen Receptor Antagonists; An

2000