flutamide has been researched along with Bleeding in 10 studies
Flutamide: An antiandrogen with about the same potency as cyproterone in rodent and canine species.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although studies have shown that administration of testosterone receptor antagonist, flutamide, following trauma-hemorrhage, improves hepatic, cardiovascular, and immune functions, the precise cellular/molecular mechanisms responsible for producing these salutary effects remain largely unknown." | 7.74 | Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, CH; Kan, WH; Raju, R; Schwacha, MG, 2008) |
| "Flutamide, an androgen receptor antagonist, is thought to improve cardiovascular function by blocking the androgen receptor after trauma-hemorrhage (T-H)." | 7.73 | PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, YC; Rue, LW; Yang, S; Yu, HP, 2005) |
| "Although previous studies have shown that flutamide improves cardiovascular function after trauma-hemorrhage, the mechanisms responsible for the salutary effect remain unknown." | 7.73 | Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, YC; Schwacha, MG; Yang, S; Yu, HP, 2006) |
| "We hypothesized that administration of androgen receptors antagonist flutamide following trauma-hemorrhage (T-H) in metestrus females will maintain immune function and reduce remote organ damage under those conditions." | 7.73 | Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females. ( Chaudry, IH; Choudhry, MA; Hildebrand, F; Hubbard, WJ; Pape, HC; Thobe, BM, 2006) |
| " Because T-lymphocyte functions are altered following trauma-hemorrhage in male mice, we investigated whether (i) receptors for androgen (AR) and estrogen (ER) are present in splenic T lymphocytes, (ii) receptor expressions are altered following trauma-hemorrhage, and (iii) pretreatment of male mice with the AR antagonist, flutamide, alters receptor expressions and IL-6 release." | 7.70 | Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage. ( Bland, KI; Chaudry, IH; Cioffi, WG; Samy, TS; Schwacha, MG, 2000) |
| "Flutamide treatment increased intestinal HO-1 and ER-beta mRNA/protein levels as compared with vehicle-treated T-H rats." | 5.33 | Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1. ( Chaudry, IH; Choudhry, MA; Hsieh, YC; Schwacha, MG; Shimizu, T; Yang, S; Yu, HP, 2006) |
| "Although studies have shown that administration of testosterone receptor antagonist, flutamide, following trauma-hemorrhage, improves hepatic, cardiovascular, and immune functions, the precise cellular/molecular mechanisms responsible for producing these salutary effects remain largely unknown." | 3.74 | Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, CH; Kan, WH; Raju, R; Schwacha, MG, 2008) |
| "Flutamide, an androgen receptor antagonist, is thought to improve cardiovascular function by blocking the androgen receptor after trauma-hemorrhage (T-H)." | 3.73 | PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, YC; Rue, LW; Yang, S; Yu, HP, 2005) |
| "Although previous studies have shown that flutamide improves cardiovascular function after trauma-hemorrhage, the mechanisms responsible for the salutary effect remain unknown." | 3.73 | Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1. ( Bland, KI; Chaudry, IH; Choudhry, MA; Hsieh, YC; Schwacha, MG; Yang, S; Yu, HP, 2006) |
| "We hypothesized that administration of androgen receptors antagonist flutamide following trauma-hemorrhage (T-H) in metestrus females will maintain immune function and reduce remote organ damage under those conditions." | 3.73 | Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females. ( Chaudry, IH; Choudhry, MA; Hildebrand, F; Hubbard, WJ; Pape, HC; Thobe, BM, 2006) |
| " Because T-lymphocyte functions are altered following trauma-hemorrhage in male mice, we investigated whether (i) receptors for androgen (AR) and estrogen (ER) are present in splenic T lymphocytes, (ii) receptor expressions are altered following trauma-hemorrhage, and (iii) pretreatment of male mice with the AR antagonist, flutamide, alters receptor expressions and IL-6 release." | 3.70 | Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage. ( Bland, KI; Chaudry, IH; Cioffi, WG; Samy, TS; Schwacha, MG, 2000) |
| "Although the testosterone receptor antagonist flutamide restores the depressed immune function in males after trauma and hemorrhage, it remains unknown whether this agent has any salutary effects on adrenal function." | 3.70 | Testosterone receptor blockade after trauma and hemorrhage attenuates depressed adrenal function. ( Ba, ZF; Bland, KI; Chaudry, IH; Cioffi, WG; Koo, DJ; Wang, P; Zhou, M, 2000) |
| "To determine whether treatment with an androgen receptor blocker (eg, flutamide) after trauma-hemorrhage and sepsis has any salutary effects on cell-mediated immunity and on the survival of male animals under those conditions." | 3.69 | Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis. ( Angele, MK; Ayala, A; Chaudry, IH; Cioffi, WG; Wichmann, MW, 1997) |
| "Flutamide, a chemotherapeutic agent for prostate cancer, is known to enhance warfarin anticoagulation." | 1.51 | Extreme Elevation of the Prothrombin Time-International Normalized Ratio due to a Probable Interaction between Warfarin and Flutamide. ( Araki, Y; Kawaguchi, O; Konishi, Y; Terada, T, 2019) |
| "Flutamide treatment increased intestinal HO-1 and ER-beta mRNA/protein levels as compared with vehicle-treated T-H rats." | 1.33 | Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1. ( Chaudry, IH; Choudhry, MA; Hsieh, YC; Schwacha, MG; Shimizu, T; Yang, S; Yu, HP, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 8 (80.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Konishi, Y | 1 |
| Terada, T | 1 |
| Araki, Y | 1 |
| Kawaguchi, O | 1 |
| Kan, WH | 1 |
| Hsieh, CH | 1 |
| Schwacha, MG | 4 |
| Choudhry, MA | 5 |
| Raju, R | 1 |
| Bland, KI | 5 |
| Chaudry, IH | 9 |
| Hsieh, YC | 3 |
| Yang, S | 3 |
| Yu, HP | 3 |
| Rue, LW | 1 |
| Shimizu, T | 1 |
| Mayr, S | 1 |
| Walz, CR | 1 |
| Angele, P | 1 |
| Hernandez-Richter, T | 1 |
| Loehe, F | 1 |
| Jauch, KW | 1 |
| Angele, MK | 2 |
| Hildebrand, F | 1 |
| Hubbard, WJ | 1 |
| Thobe, BM | 1 |
| Pape, HC | 1 |
| Wichmann, MW | 1 |
| Ayala, A | 1 |
| Cioffi, WG | 3 |
| Samy, TS | 1 |
| Ba, ZF | 1 |
| Wang, P | 1 |
| Koo, DJ | 1 |
| Zhou, M | 1 |
10 other studies available for flutamide and Bleeding
| Article | Year |
|---|---|
Extreme Elevation of the Prothrombin Time-International Normalized Ratio due to a Probable Interaction between Warfarin and Flutamide.
Topics: Aged, 80 and over; Anticoagulants; Atrial Fibrillation; Blood Coagulation; Blood Coagulation Factors | 2019 |
Flutamide protects against trauma-hemorrhage-induced liver injury via attenuation of the inflammatory response, oxidative stress, and apopotosis.
Topics: Androgen Antagonists; Animals; Apoptosis; Blotting, Western; Cell Separation; Chemokines; Cytokines; | 2008 |
PGC-1 upregulation via estrogen receptors: a common mechanism of salutary effects of estrogen and flutamide on heart function after trauma-hemorrhage.
Topics: Animals; Cardiotonic Agents; Estradiol; Flutamide; Heart; Hemorrhage; Male; Rats; Rats, Sprague-Dawl | 2005 |
Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1.
Topics: Abdominal Injuries; Animals; Aromatase; Dihydrotestosterone; Electron Transport Complex IV; Estradio | 2006 |
Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1.
Topics: Animals; Chemokine CXCL1; Chemokines, CXC; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogen | 2006 |
Castration prevents suppression of MHC class II (Ia) expression on macrophages after trauma-hemorrhage.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Animals; Antigen Presentation; CD11b Antigen; F | 2006 |
Effects of 17beta-estradiol and flutamide on inflammatory response and distant organ damage following trauma-hemorrhage in metestrus females.
Topics: Animals; Chemokine CCL2; Cytokines; Enzyme Activation; Estradiol; Female; Flow Cytometry; Flutamide; | 2006 |
Testosterone receptor blockade after hemorrhage in males. Restoration of the depressed immune functions and improved survival following subsequent sepsis.
Topics: Androgen Antagonists; Animals; Flutamide; Hemorrhage; Immunity, Cellular; Interleukins; Male; Mice; | 1997 |
Androgen and estrogen receptors in splenic T lymphocytes: effects of flutamide and trauma-hemorrhage.
Topics: Androgen Antagonists; Animals; DNA-Binding Proteins; Female; Flutamide; Hemorrhage; Interleukin-6; M | 2000 |
Testosterone receptor blockade after trauma and hemorrhage attenuates depressed adrenal function.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Androgen Antagonists; Androgen Receptor Antagonists; An | 2000 |