fusarochromanone profile

Description

fusarochromanone: from Fusarium sp.; consists of an amino acid bearing chromone [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	107777
CHEBI ID	174090
SCHEMBL ID	4475170
MeSH ID	M0153910

Synonyms (22)

Synonym
5-amino-6-(3-amino-4-hydroxybutanoyl)-2,2-dimethyl-3h-chromen-4-one
104653-89-6
CHEBI:174090
nsc627608
fusarochromanone
5-amino-6-(3-amino-4-hydroxybutanoyl)-2,2-dimethyl-2,3-dihydro-4h-chromen-4-one
5-amino-6-(3-amino-4-hydroxy-butanoyl)-2,2-dimethyl-chroman-4-one
tdp 1
unii-fm54x8s89o
fm54x8s89o ,
tdp-1
fusarochromenone
4h-1-benzopyran-4-one, 5-amino-6-(3-amino-4-hydroxy-1-oxobutyl)-2,3-dihydro-2,2-dimethyl-
5-amino-6-(3-amino-4-hydroxy-1-oxobutyl)-2,3-dihydro-2,2-dimethyl-4h-1-benzopyran-4-one
SCHEMBL4475170
fusarochromanone, (+/-)-
5-amino-6-(3-amino-4-hydroxybutanoyl)-2,2-dimethyl-3,4-dihydro-2h-1-benzopyran-4-one
5-amino-6-(3-amino-4-hydroxy-1-oxobutyl)-2,3-dihydro-2,2-dimethyl-4h-1-benzopyran-4-one, 9ci
Q27278066
DTXSID20909102
AKOS040739323
compound np-008475

Research Excerpts

Overview

Excerpt	Reference
"Fusarochromanone (FC101) is a small molecule fungal metabolite with a host of interesting biological functions, including very potent anti-angiogenic and direct anti-cancer activity."	( Adelmund, S; Barzegar, M; Bhinge, KN; Clifford, JL; Furmanski, BD; Gu, Y; Huang, S; Kevil, CG; Kim, YJ; Kolluru, GK; Liu, YY; Mahdavian, E; Palyok, P; Quick, Q; Salvatore, BA; Williams-Hart, T; Wu, Y, 2014)
"Fusarochromanone is a toxic metabolite produced by Fusarium equiseti, a fungus present in decaying cereal plants in northern latitudes; it has been detected in various food grains. "	( Culberson, C; Dréau, D; Foster, M; Hogg, M; Nunes, P; Wuthier, RE, 2007)
"Fusarochromanone is a mycotoxin produced by Fusarium equiseti that is implicated in the poultry disease tibial dyschrondroplasia. "	( Mirocha, CJ; Pawlosky, RJ, 1991)

Effects

Excerpt	Reference
"Fusarochromanone has been shown to have both stimulatory and inhibitory effects on various mammalian cells, depending on the concentration used."	( Culberson, C; Dréau, D; Foster, M; Hogg, M; Nunes, P; Wuthier, RE, 2007)

Drug Classes (1)

Class	Description
1-benzopyran
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (17)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (29.41)	18.7374
1990's	4 (23.53)	18.2507
2000's	3 (17.65)	29.6817
2010's	4 (23.53)	24.3611
2020's	1 (5.88)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	22 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Description	Relationhip Strength	Studies	Classes	Roles
chloroquine	[no description available]	medium	1	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	[no description available]	medium	1
pyrazolanthrone	[no description available]	medium	1	anthrapyrazole; aromatic ketone; cyclic ketone	antineoplastic agent; c-Jun N-terminal kinase inhibitor; geroprotector
acetylcysteine	[no description available]	medium	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
thymidine	[no description available]	medium	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
wortmannin	[no description available]	medium	1	acetate ester; cyclic ketone; delta-lactone; organic heteropentacyclic compound	anticoronaviral agent; antineoplastic agent; autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector; Penicillium metabolite; radiosensitizing agent
moniliformin	[no description available]	medium	1
3-acetyldeoxynivalenol	[no description available]	medium	1	trichothecene	epitope; mycotoxin
deoxynivalenol	[no description available]	medium	1	cyclic ketone; enone; primary alcohol; secondary alpha-hydroxy ketone; trichothecene; triol	mycotoxin
nivalenol	[no description available]	medium	1	trichothecene
enniatin b	[no description available]	medium	1	enniatin	antimicrobial agent
thiazolyl blue	[no description available]	medium	1	organic bromide salt	colorimetric reagent; dye
thiazoles	[no description available]	medium	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
zearalenone	[no description available]	medium	1	macrolide; resorcinols	fungal metabolite; mycoestrogen
fusarin c	[no description available]	medium	1	sesquiterpenoid
selenium	[no description available]	medium	1	chalcogen; nonmetal atom	micronutrient
acid phosphatase	[no description available]	medium	1
t-2 toxin	[no description available]	medium	1
sesquiterpenes	[no description available]	medium	1
ha14-1	[no description available]	low	0	1-benzopyran
cannabichromene	[no description available]	low	0	1-benzopyran
3'-carboxy-alpha-chromanol	[no description available]	low	0	1-benzopyran
levcromakalim	[no description available]	low	0	1-benzopyran
Eupatoriochromene	[no description available]	low	0	1-benzopyran
293b cpd	[no description available]	low	0	1-benzopyran
y 26763	[no description available]	low	0	1-benzopyran
sdz pco 400	[no description available]	low	0	1-benzopyran
brazilin	[no description available]	low	0	1-benzopyran
cromakalim	[no description available]	low	0	1-benzopyran
delta-8-tetrahydrocannabinol	[no description available]	low	0	1-benzopyran
LSM-28489	[no description available]	low	0	1-benzopyran
LSM-32980	[no description available]	low	0	1-benzopyran
3-(5-methoxy-2,2-dimethyl-1-benzopyran-8-yl)-3-oxopropanoic acid	[no description available]	low	0	1-benzopyran
8-fluoro-4H-thieno[3,2-c][1]benzopyran-2-carboxylic acid methyl ester	[no description available]	low	0	1-benzopyran
1,7,7-trimethyl-9-oxo-N-(2-oxolanylmethyl)-8H-furo[3,2-f][1]benzopyran-2-carboxamide	[no description available]	low	0	1-benzopyran
4-[[3-[(2-furanylmethylamino)-oxomethyl]-7-methoxy-1-benzopyran-2-ylidene]amino]benzoic acid	[no description available]	low	0	1-benzopyran
6-[2-(1-azepanyl)-2-oxoethoxy]-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-one	[no description available]	low	0	1-benzopyran
2-[(2,2-dimethyl-4-oxo-3,4-dihydro-2H-1-benzopyran-6-yl)oxy]-N-heptylacetamide	[no description available]	low	0	1-benzopyran
7-methoxy-2-phenylimino-1-benzopyran-3-carboxamide	[no description available]	low	0	1-benzopyran
2-[(6-methyl-4-spiro[3,4-dihydro-2H-1-benzopyran-2,1'-cyclopentane]yl)thio]-N-(2-phenylethyl)acetamide	[no description available]	low	0	1-benzopyran
l 759633	[no description available]	low	0	1-benzopyran
pd 128907	[no description available]	low	0	1-benzopyran
hu 210	[no description available]	low	0	1-benzopyran
rubriflordilactone a	[no description available]	low	0	1-benzopyran
avrainvillamide	[no description available]	low	0	1-benzopyran
[1-[(6-chloro-2H-1-benzopyran-3-yl)methyl]-4-(2-phenoxyethyl)-4-piperidinyl]methanol	[no description available]	low	0	1-benzopyran
N-(5-chloro-2-pyridinyl)-4H-thieno[3,2-c][1]benzopyran-2-carboxamide	[no description available]	low	0	1-benzopyran
11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid	[no description available]	low	0	1-benzopyran

Condition	Relationship Strength	Studies
Angiogenesis, Pathologic	low	1
Angiogenesis, Pathological	low	1
Astrocytoma, Grade IV	low	1
Benign Neoplasms	low	1
Benign Neoplasms, Brain	low	1
Bleeding	low	1
Brain Cancer	low	1
Brain Metastases	low	1
Brain Neoplasm, Primary	low	1
Brain Neoplasms	low	1
Brain Neoplasms, Benign	low	1
Brain Neoplasms, Malignant	low	1
Brain Neoplasms, Malignant, Primary	low	1
Brain Neoplasms, Primary Malignant	low	1
Brain Tumor, Primary	low	1
Brain Tumor, Recurrent	low	1
Brain Tumors	low	1
Cancer	low	1
Cancer of Brain	low	1
Cancer of the Brain	low	1
Chondrodystrophic Myotonia	low	2
Dyschondroplasia	low	2
Dyschondroplasias	low	2
Endosteal Hyperostosis, Autosomal Recessive	low	2
Gastric Diseases	low	1
Gastrointestinal Hemorrhage	low	1
Giant Cell Glioblastoma	low	1
Glioblastoma	low	1
Glioblastoma Multiforme	low	1
Hematochezia	low	1
Hematuria	low	1
Hemorrhage	low	1
Hemorrhage, Gastrointestinal	low	1
Hyperostosis Corticalis Generalisata	low	2
Hyperphosphatasemia Tarda	low	2
Intracranial Neoplasms	low	1
Late-Onset Spondyloepiphyseal Dysplasia	low	2
Lymphatic Diseases	low	1
Lymphatism	low	1
Malignancy	low	1
Malignant Melanoma	low	1
Malignant Neoplasms	low	1
Malignant Neoplasms, Brain	low	1
Malignant Primary Brain Neoplasms	low	1
Malignant Primary Brain Tumors	low	1
Melanoma	low	1
Melnick-Needles Osteodysplasty	low	2
Melnick-Needles Syndrome	low	2
Multiple Epiphyseal Dysplasia	low	2
Myotonic Chondrodystrophy	low	2
Myotonic Myopathy, Dwarfism, Chondrodystrophy, And Ocular And Facial Abnormalities	low	2
Neoplasia	low	1
Neoplasm	low	1
Neoplasms	low	1
Neoplasms, Benign	low	1
Neoplasms, Brain	low	1
Neoplasms, Brain, Benign	low	1
Neoplasms, Brain, Malignant	low	1
Neoplasms, Brain, Primary	low	1
Neoplasms, Intracranial	low	1
Neovascularization, Pathologic	low	1
Neovascularization, Pathological	low	1
Osteochondrodysplasias	low	2
Osteodysplasty of Melnick and Needles	low	2
Pathologic Angiogenesis	low	1
Pathologic Neovascularization	low	1
Poultry Diseases	low	2
Primary Brain Neoplasms	low	1
Primary Malignant Brain Neoplasms	low	1
Primary Malignant Brain Tumors	low	1
Schwartz Jampel Aberfeld syndrome	low	2
Schwartz-Jampel Syndrome	low	2
Schwartz-Jampel Syndrome, Type 1	low	2
Schwartz-Jampel-Aberfeld Syndrome	low	2
SED Tarda	low	2
SJA Syndrome	low	2
Sost Sclerosing Bone Dysplasia	low	2
Sost-Related Sclerosing Bone Dysplasia	low	2
Spondylo-Epimetaphyseal Dysplasia With Myotonia	low	2
Spondyloepiphyseal Dysplasia	low	2
Spondyloepiphyseal Dysplasia Tarda, X-Linked	low	2
Spondyloepiphyseal Dysplasia, Late	low	2
Status Lymphaticus	low	1
Stomach Diseases	low	1
Tumors	low	1
Van Buchem Disease	low	2
X-Linked SED	low	2
X-Linked SEDT	low	2
X-Linked Spondyloepiphyseal Dysplasia Tarda	low	2

Research Highlights

Safety/Toxicity (2)

Article	Year
Cytotoxicity of trichothecenes and fusarochromanone produced by Fusarium equiseti strains isolated from Norwegian cereals. Mycopathologia, Volume: 153, Issue: 1	2002
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (1)

Article	Year
Differential uptake and selective permeability of fusarochromanone (FC101), a novel membrane permeable anticancer naturally fluorescent compound in tumor and normal cells. Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada, Volume: 15, Issue: 6	2009
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

fusarochromanone

Description

Cross-References

Synonyms (22)

Research Excerpts

Overview

Effects

Drug Classes (1)

Research

Studies (17)

Study Types

Related Drugs (48)

Related Conditions (89)

Research Highlights

Safety/Toxicity (2)

Bioavailability (1)