ibuprofen has been researched along with Bleeding in 20 studies
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dalteparin is superior to the NSAID ibuprofen in preventing extension of superficial thrombophlebitis during the 14-day treatment period with similar relief of pain and no increase in bleeding." | 9.16 | A randomized trial of dalteparin compared with ibuprofen for the treatment of superficial thrombophlebitis. ( Aston, CE; Rathbun, SW; Whitsett, TL, 2012) |
| "Perioperative ketorolac alone is not associated with an increased risk of significant bleeding in children undergoing appendectomy for perforated appendicitis." | 8.12 | Ketorolac use and risk of bleeding after appendectomy in children with perforated appendicitis. ( Kelley-Quon, LI; Kim, E; Kingston, P; Lascano, D; Ourshalimian, S; Russell, CJ, 2022) |
| " We determined whether paracetamol or ibuprofen use is associated with major cardiovascular events (MACE) or major bleeding in 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin included in the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) trial." | 7.83 | Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke. ( Amarenco, P; Bousser, MG; Chamorro, A; Fisher, M; Ford, I; Fox, KM; Gonzalez-Valcarcel, J; Hennerici, MG; Labreuche, J; Mattle, HP; Rothwell, PM; Sissani, L; Steg, PG; Vicaut, E, 2016) |
| "Dalteparin is superior to the NSAID ibuprofen in preventing extension of superficial thrombophlebitis during the 14-day treatment period with similar relief of pain and no increase in bleeding." | 5.16 | A randomized trial of dalteparin compared with ibuprofen for the treatment of superficial thrombophlebitis. ( Aston, CE; Rathbun, SW; Whitsett, TL, 2012) |
| "Perioperative ketorolac alone is not associated with an increased risk of significant bleeding in children undergoing appendectomy for perforated appendicitis." | 4.12 | Ketorolac use and risk of bleeding after appendectomy in children with perforated appendicitis. ( Kelley-Quon, LI; Kim, E; Kingston, P; Lascano, D; Ourshalimian, S; Russell, CJ, 2022) |
| " We determined whether paracetamol or ibuprofen use is associated with major cardiovascular events (MACE) or major bleeding in 19 120 patients with recent ischemic stroke or transient ischemic attack of mainly atherothrombotic origin included in the Prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) trial." | 3.83 | Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke. ( Amarenco, P; Bousser, MG; Chamorro, A; Fisher, M; Ford, I; Fox, KM; Gonzalez-Valcarcel, J; Hennerici, MG; Labreuche, J; Mattle, HP; Rothwell, PM; Sissani, L; Steg, PG; Vicaut, E, 2016) |
| " In a cohort study comparing the risk of upper gastrointestinal complications in celecoxib or traditional NSAIDs (diclofenac, ibuprofen) initiators with rheumatoid arthritis and osteoarthritis, we (1) aggregated medications and International Classification of Diseases-9 (ICD-9) diagnoses into hierarchies of the Anatomical Therapeutic Chemical classification (ATC) and the Clinical Classification Software (CCS), respectively, and (2) sampled the full cohort using techniques validated by simulations to create 9,600 samples to compare 16 aggregation scenarios across 50% and 20% samples with varying outcome incidence and exposure prevalence." | 3.79 | Effects of aggregation of drug and diagnostic codes on the performance of the high-dimensional propensity score algorithm: an empirical example. ( Beach, KJ; Brookhart, MA; Layton, JB; Le, HV; Poole, C; Schoenbach, VJ; Stürmer, T, 2013) |
| "To study the role of the vasodilatory, antiaggregatory prostacyclin (PGI2) and its endogenous antagonist thromboxane A2 (TxA2) in acute pancreatitis, we measured serum thromboxane B2 (TxB2, which indicates platelet TxA2 production) and plasma 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha, which indicates systemic PGI2 production) from sequential blood samples in trypsin and taurocholate induced acute canine hemorrhagic pancreatitis (AHP)." | 3.67 | Prostacyclin and thromboxane in acute hemorrhagic pancreatitis in dogs. ( Jalovaara, P; Kairaluoma, M; Kiviniemi, H; Laitinen, S; Rämö, J; Ståhlberg, M; Viinikka, L, 1987) |
| "(1) hemorrhagic pancreatitis was associated with high levels of PGI2 in blood 15 times and in hemorrhagic ascitic fluid 25 times that of baseline; (2) steroids and ibuprofen blocked PGI2 production (p less than 0." | 3.67 | Effect of prostaglandin blockers on ascites fluid in pancreatitis. ( Farias, LR; Frey, CF; Gunther, R; Holcroft, JW, 1985) |
| "No studies have examined postoperative pain control following transsphenoidal surgery for pituitary lesions." | 2.87 | Randomized, double-blinded, placebo-controlled trial comparing two multimodal opioid-minimizing pain management regimens following transsphenoidal surgery. ( Jahnke, H; Little, AS; Shepherd, DM; White, WL, 2018) |
| " Data suggesting that conditions associated with chronic liver damage reduce the dosing threshold for induction of liver failure are of particular concern." | 2.61 | Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered? ( Fernandes, L; Kellstein, D, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 9 (45.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kingston, P | 1 |
| Lascano, D | 1 |
| Ourshalimian, S | 1 |
| Russell, CJ | 1 |
| Kim, E | 1 |
| Kelley-Quon, LI | 1 |
| Contorno, S | 1 |
| Cozzi, G | 1 |
| Berti, I | 1 |
| Barbi, E | 1 |
| Taddio, A | 1 |
| Cunningham, MJ | 1 |
| Kellstein, D | 1 |
| Fernandes, L | 1 |
| Le, HV | 1 |
| Poole, C | 1 |
| Brookhart, MA | 1 |
| Schoenbach, VJ | 1 |
| Beach, KJ | 1 |
| Layton, JB | 1 |
| Stürmer, T | 1 |
| Gonzalez-Valcarcel, J | 1 |
| Sissani, L | 1 |
| Labreuche, J | 1 |
| Bousser, MG | 1 |
| Chamorro, A | 1 |
| Fisher, M | 1 |
| Ford, I | 1 |
| Fox, KM | 1 |
| Hennerici, MG | 1 |
| Mattle, HP | 1 |
| Rothwell, PM | 1 |
| Steg, PG | 1 |
| Vicaut, E | 1 |
| Amarenco, P | 1 |
| Quiroga, B | 1 |
| Basterrechea, MÁ | 1 |
| Fernández-Francés, J | 1 |
| de Arriba, G | 1 |
| Iannuccelli, C | 1 |
| Di Franco, M | 1 |
| Pulcinelli, FM | 1 |
| Shepherd, DM | 1 |
| Jahnke, H | 1 |
| White, WL | 1 |
| Little, AS | 1 |
| Aranda, JV | 1 |
| Beharry, KD | 1 |
| Valencia, GB | 1 |
| Rathbun, SW | 1 |
| Aston, CE | 1 |
| Whitsett, TL | 1 |
| Woitzek, K | 1 |
| Sudheer Kumar, M | 1 |
| Sridhar Reddy, B | 1 |
| Kiran Babu, S | 1 |
| Bhilegaonkar, PM | 1 |
| Shirwaikar, A | 1 |
| Unnikrishnan, MK | 1 |
| Mielens, ZE | 1 |
| Bhandari, JC | 1 |
| Barbolt, TA | 1 |
| Stecher, VJ | 1 |
| Ertel, W | 3 |
| Morrison, MH | 2 |
| Meldrum, DR | 1 |
| Ayala, A | 3 |
| Chaudry, IH | 3 |
| Maunuksela, EL | 1 |
| Ryhänen, P | 1 |
| Janhunen, L | 1 |
| Perrin, MM | 1 |
| Wang, P | 1 |
| Kiviniemi, H | 1 |
| Rämö, J | 1 |
| Ståhlberg, M | 1 |
| Laitinen, S | 1 |
| Jalovaara, P | 1 |
| Viinikka, L | 1 |
| Kairaluoma, M | 1 |
| Farias, LR | 1 |
| Frey, CF | 1 |
| Holcroft, JW | 1 |
| Gunther, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Non-Steroidal Anti-inflammatory Drugs (NSAIDS) vs. Tramadol in Pain Management After Transnasal Transsphenoidal Surgery Among Patients With Pituitary Adenomas: A Prospective Randomized Controlled Trial[NCT04611685] | 202 participants (Anticipated) | Interventional | 2020-10-31 | Recruiting | |||
| Randomized, Double-Blind, Placebo-Controlled Trial Comparing Opioid-Sparing and Opioid-Containing Analgesia Regimens Following Trans-sphenoidal Surgery for Pituitary Tumors[NCT02351700] | Phase 4 | 62 participants (Actual) | Interventional | 2015-02-01 | Completed | ||
| Management of Superficial Thrombophlebitis[NCT00264381] | Phase 4 | 72 participants (Actual) | Interventional | 2002-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Rescue narcotic in both groups will be recorded and compared using a standard equianalgesic oral morphine equivalent (OME) calculation (NCT02351700)
Timeframe: until discharge from hospital, an expected stay of 2 days
| Intervention | mg (Mean) |
|---|---|
| Opioid-sparing Group | 26.3 |
| Standard Treatment Group | 62.5 |
Comparison of pain scores between two arms using Visual Analog Scale (VAS) for Pain. Units of measure are 0=No Pain, 1=Annoying, 2=Mild Pain, 3=Troublesome, 4=Nagging Pain, Uncomfortable, 5=Distressing, 6=Miserable, 7=Horrible, 8=Intense, Dreadful, 9=Unbearable, 10=Worst Possible Pain. Higher values represent a worse outcome. There are no subscales. (NCT02351700)
Timeframe: mean pain score over 48 hours
| Intervention | 0-10 units on a scale (Mean) |
|---|---|
| Opioid-sparing Group | 1.7 |
| Standard Treatment Group | 2.8 |
Length of hospital stay from time of surgery to time of discharge. (NCT02351700)
Timeframe: until discharge from hospital, an expected stay of 2 days
| Intervention | hours (Mean) |
|---|---|
| Opioid-sparing Group | 71.3 |
| Standard Treatment Group | 51.7 |
Epistaxis, potentially related to IV ibuprofen, will be compared between two groups (NCT02351700)
Timeframe: until discharge from hospital, an expected stay of 2 days
| Intervention | participants (Number) |
|---|---|
| Opioid Sparing Group | 0 |
| Standard Treatment Group | 2 |
patients with one or more bowel movement(s) in the first 48 hours after surgery (NCT02351700)
Timeframe: until discharge from hospital, an expected stay of 2 days
| Intervention | participants (Number) |
|---|---|
| Opioid-sparing Group | 9 |
| Standard Treatment Group | 12 |
Use of antiemetics in first 48 hours after surgery (NCT02351700)
Timeframe: until discharge from hospital, an expected stay of 2 days
| Intervention | dose (Mean) |
|---|---|
| Opioid-sparing Group | 9.8 |
| Standard Treatment Group | 10.1 |
Change in pain at day 14 as measured by 11-point Box Pain Scale, 0 being the least amount of pain, and 10 the most amount of pain (NCT00264381)
Timeframe: Day 1, Day 14
| Intervention | units on a scale (Mean) |
|---|---|
| Ibuprofen 800 mg Tid | -2.28 |
| Dalteparin 200 U/kg Then 10,000 U Daily | -2.23 |
Number of participants with bleeding events related to treatment (NCT00264381)
Timeframe: 3 months
| Intervention | participants (Number) |
|---|---|
| Ibuprofen 800 mg Tid | 0 |
| Dalteparin 200 U/kg Then 10,000 U Daily | 0 |
Thrombosis progression and deep vein thrombosis at day 14 by ultrasound testing (NCT00264381)
Timeframe: Day 14
| Intervention | participants (Number) | |
|---|---|---|
| Thrombosis progression | VTE | |
| Dalteparin 200 U/kg Then 10,000 U Daily | 0 | 0 |
| Ibuprofen 800 mg Tid | 4 | 0 |
Symptomatic thrombosis extension (DVT) or pulmonary embolism at 3 months documented by radiologic testing. (NCT00264381)
Timeframe: 3 months
| Intervention | participants (Number) | |
|---|---|---|
| Thrombosis progression | VTE | |
| Dalteparin 200 U/kg Then 10,000 U Daily | 4 | 1 |
| Ibuprofen 800 mg Tid | 6 | 0 |
2 reviews available for ibuprofen and Bleeding
| Article | Year |
|---|---|
Symptomatic treatment of dengue: should the NSAID contraindication be reconsidered?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Contraindications, Drug; Dengue; Fever; Hemorrhage; Humans; | 2019 |
Nonsteroidal anti-inflammatory drugs (NSAIDs) in the newborn - which ones?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Ductus Arteriosus, Patent; Hemorrhage; Humans; Ibuprofen; I | 2009 |
4 trials available for ibuprofen and Bleeding
| Article | Year |
|---|---|
Randomized, double-blinded, placebo-controlled trial comparing two multimodal opioid-minimizing pain management regimens following transsphenoidal surgery.
Topics: Acetaminophen; Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic | 2018 |
Randomized, double-blinded, placebo-controlled trial comparing two multimodal opioid-minimizing pain management regimens following transsphenoidal surgery.
Topics: Acetaminophen; Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic | 2018 |
Randomized, double-blinded, placebo-controlled trial comparing two multimodal opioid-minimizing pain management regimens following transsphenoidal surgery.
Topics: Acetaminophen; Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic | 2018 |
Randomized, double-blinded, placebo-controlled trial comparing two multimodal opioid-minimizing pain management regimens following transsphenoidal surgery.
Topics: Acetaminophen; Administration, Intravenous; Adult; Aged; Aged, 80 and over; Analgesics, Non-Narcotic | 2018 |
A randomized trial of dalteparin compared with ibuprofen for the treatment of superficial thrombophlebitis.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Dalte | 2012 |
[Ibuprofen/paracetamol combination therapy is more effective than monotherapy in knee pain, but increases bleeding risk].
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Chronic Pai | 2012 |
Efficacy of rectal ibuprofen in controlling postoperative pain in children.
Topics: Administration, Rectal; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; | 1992 |
14 other studies available for ibuprofen and Bleeding
| Article | Year |
|---|---|
Ketorolac use and risk of bleeding after appendectomy in children with perforated appendicitis.
Topics: Appendectomy; Appendicitis; Child; Hemorrhage; Humans; Ibuprofen; Ketorolac; Retrospective Studies | 2022 |
Young child with painful edema and purpura: a case report.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Diagnosis, Differential; Edema; Hemorrhage; | 2021 |
Posttonsillectomy Hemorrhage in the Ibuprofen Era: Not Just How Frequent but How Much.
Topics: Hemorrhage; Humans; Ibuprofen; Tonsillectomy | 2017 |
Effects of aggregation of drug and diagnostic codes on the performance of the high-dimensional propensity score algorithm: an empirical example.
Topics: Adolescent; Adult; Aged; Algorithms; Arthritis; Celecoxib; Confounding Factors, Epidemiologic; Cyclo | 2013 |
Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Brain Ischemia; Cardiovascular Diseases; Female; Hemo | 2016 |
Diffuse alveolar damage and acute kidney injury induced by abusive use of non-steroidal anti-inflammatory drugs: a new and atypical renopulmonary syndrome?
Topics: Acute Kidney Injury; Anti-Inflammatory Agents, Non-Steroidal; Drug Overdose; Hemorrhage; Humans; Ibu | 2016 |
Letter by Iannuccelli et al Regarding Article, "Paracetamol, Ibuprofen, and Recurrent Major Cardiovascular and Major Bleeding Events in 19 120 Patients With Recent Ischemic Stroke".
Topics: Acetaminophen; Brain Ischemia; Hemorrhage; Humans; Ibuprofen; Stroke | 2016 |
Antiinflammatory and antiulcer activities of phytic acid in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Cold Temperature; Ethanol; Famotidine; Gastric | 2004 |
Differential effects of pharmacologic agents on the reverse passive Arthus reaction in guinea pigs.
Topics: Aminophylline; Animals; Anti-Inflammatory Agents; Arthus Reaction; Colchicine; Edema; Guinea Pigs; H | 1984 |
Ibuprofen restores cellular immunity and decreases susceptibility to sepsis following hemorrhage.
Topics: Animals; Blood Pressure; Cells, Cultured; Concanavalin A; Cytokines; Disease Susceptibility; DNA Rep | 1992 |
Hemorrhage induces enhanced Kupffer cell cytotoxicity while decreasing peritoneal or splenic macrophage capacity. Involvement of cell-associated tumor necrosis factor and reactive nitrogen.
Topics: Animals; Cytotoxicity, Immunologic; Hemorrhage; Ibuprofen; Interferon-gamma; Interleukin-1; Kupffer | 1991 |
Eicosanoids regulate tumor necrosis factor synthesis after hemorrhage in vitro and in vivo.
Topics: Animals; Cytotoxicity Tests, Immunologic; Dinoprostone; Hemorrhage; Ibuprofen; Lipopolysaccharides; | 1991 |
Prostacyclin and thromboxane in acute hemorrhagic pancreatitis in dogs.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Blood Pressure; Dogs; Epoprostenol; Hemorrhage | 1987 |
Effect of prostaglandin blockers on ascites fluid in pancreatitis.
Topics: 6-Ketoprostaglandin F1 alpha; Acute Disease; Animals; Ascitic Fluid; Biological Assay; Electrolytes; | 1985 |