| Substance | Description | Relationhip Strength | Studies | Trials | Classes | Roles |
|---|
| clonidine | [no description available] | medium | 7 | 0 | clonidine;
imidazoline | |
| xylonidine | [no description available] | medium | 1 | 0 | | |
| 7-hydroxy-2-n,n-dipropylaminotetralin | [no description available] | medium | 1 | 0 | tetralins | |
| brimonidine | [no description available] | medium | 2 | 0 | imidazoles;
quinoxaline derivative;
secondary amine | adrenergic agonist;
alpha-adrenergic agonist;
antihypertensive agent |
| cirazoline | [no description available] | medium | 1 | 0 | aromatic ether | |
| mianserin | [no description available] | medium | 1 | 0 | dibenzoazepine | adrenergic uptake inhibitor;
alpha-adrenergic antagonist;
antidepressant;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
geroprotector;
H1-receptor antagonist;
histamine agonist;
sedative;
serotonergic antagonist |
| naphazoline | [no description available] | medium | 5 | 0 | naphthalenes | |
| naphazoline | [no description available] | medium | 5 | 1 | naphthalenes | |
| oxymetazoline | [no description available] | medium | 2 | 0 | carboxamidine;
imidazolines;
phenols | alpha-adrenergic agonist;
nasal decongestant;
sympathomimetic agent;
vasoconstrictor agent |
| prazosin | [no description available] | medium | 4 | 0 | aromatic ether;
furans;
monocarboxylic acid amide;
piperazines;
quinazolines | alpha-adrenergic antagonist;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor |
| talipexole | [no description available] | medium | 2 | 0 | azepine | |
| tetrahydrozoline | [no description available] | medium | 3 | 0 | carboxamidine;
imidazolines | nasal decongestant;
sympathomimetic agent |
| tolazoline | [no description available] | medium | 2 | 0 | imidazoles | alpha-adrenergic antagonist;
antihypertensive agent;
vasodilator agent |
| xylazine | [no description available] | medium | 2 | 0 | 1,3-thiazine;
methylbenzene;
secondary amino compound | alpha-adrenergic agonist;
analgesic;
emetic;
muscle relaxant;
sedative |
| xylometazoline | [no description available] | medium | 3 | 0 | alkylbenzene | |
| phentolamine | [no description available] | medium | 4 | 0 | imidazoles;
phenols;
substituted aniline;
tertiary amino compound | alpha-adrenergic antagonist;
vasodilator agent |
| piperoxan | [no description available] | medium | 2 | 0 | | |
| phenylephrine | [no description available] | medium | 6 | 0 | phenols;
phenylethanolamines;
secondary amino compound | alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent |
| methoxamine | [no description available] | medium | 2 | 0 | amphetamines | alpha-adrenergic agonist;
antihypotensive agent |
| azapetine | [no description available] | medium | 1 | 0 | benzazepine | |
| yohimbine | [no description available] | medium | 5 | 0 | methyl 17-hydroxy-20xi-yohimban-16-carboxylate | alpha-adrenergic antagonist;
dopamine receptor D2 antagonist;
serotonergic antagonist |
| dihydroergotamine | [no description available] | medium | 1 | 0 | ergot alkaloid;
semisynthetic derivative | dopamine agonist;
non-narcotic analgesic;
serotonergic agonist;
sympatholytic agent;
vasoconstrictor agent |
| amidephrine | [no description available] | medium | 1 | 0 | sulfonamide | |
| lofexidine | [no description available] | medium | 2 | 0 | aromatic ether;
carboxamidine;
dichlorobenzene;
imidazoles | alpha-adrenergic agonist;
antihypertensive agent |
| 5,6-dihydroxy-2-dimethylaminotetralin | [no description available] | medium | 1 | 0 | tetralins | |
| tiamenidine | [no description available] | medium | 2 | 0 | organochlorine compound | |
| corynanthine | [no description available] | medium | 2 | 0 | yohimban alkaloid | |
| st 587 | [no description available] | medium | 1 | 0 | | |
| indanidine | [no description available] | medium | 1 | 0 | | |
| 2-(n,n-dipropyl)amino-5,6-dihydroxytetralin | [no description available] | medium | 1 | 0 | | |
| (3,4-dihydroxyphenylamino)-2-imidazoline | [no description available] | medium | 1 | 0 | | |
| 2-(n,n-dipropyl)amino-6,7-dihydroxytetralin | [no description available] | medium | 1 | 0 | | |
| 5-hydroxy-2-n,n-dipropylaminotetralin | [no description available] | medium | 1 | 0 | | |
| rauwolscine | [no description available] | medium | 2 | 0 | methyl 17-hydroxy-20xi-yohimban-16-carboxylate | |
| guanabenz | [no description available] | medium | 1 | 0 | dichlorobenzene | |
| clozapine | [no description available] | medium | 1 | 0 | benzodiazepine;
N-arylpiperazine;
N-methylpiperazine;
organochlorine compound | adrenergic antagonist;
dopaminergic antagonist;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
GABA antagonist;
histamine antagonist;
muscarinic antagonist;
second generation antipsychotic;
serotonergic antagonist;
xenobiotic |
| azepexole | [no description available] | medium | 1 | 0 | | |
| st 1913 | [no description available] | medium | 1 | 0 | | |
| wb 4101 | [no description available] | medium | 1 | 0 | aromatic ether;
benzodioxine;
secondary amino compound | alpha-adrenergic antagonist |
| corbadrine | [no description available] | medium | 1 | 0 | catecholamine | alpha-adrenergic agonist;
nasal decongestant;
vasoconstrictor agent |
| framycetin | [no description available] | medium | 2 | 1 | aminoglycoside | allergen;
antibacterial drug;
Escherichia coli metabolite |
| methacholine chloride | [no description available] | medium | 1 | 0 | quaternary ammonium salt | |
| histamine | [no description available] | medium | 1 | 0 | aralkylamino compound;
imidazoles | human metabolite;
mouse metabolite;
neurotransmitter |
| 1-naphthylamine | [no description available] | medium | 5 | 0 | naphthylamine | human xenobiotic metabolite |
| theophylline | [no description available] | medium | 1 | 0 | dimethylxanthine | adenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent |
| verapamil | [no description available] | medium | 1 | 0 | aromatic ether;
nitrile;
polyether;
tertiary amino compound | |
| albuterol | [no description available] | medium | 1 | 0 | phenols;
phenylethanolamines;
secondary amino compound | beta-adrenergic agonist;
bronchodilator agent;
environmental contaminant;
xenobiotic |
| angiotensin ii | [no description available] | medium | 2 | 0 | amino acid zwitterion;
angiotensin II | human metabolite |
| metoprolol | [no description available] | medium | 1 | 0 | aromatic ether;
propanolamine;
secondary alcohol;
secondary amino compound | antihypertensive agent;
beta-adrenergic antagonist;
environmental contaminant;
geroprotector;
xenobiotic |
| tyramine | [no description available] | medium | 1 | 0 | monoamine molecular messenger;
primary amino compound;
tyramines | EC 3.1.1.8 (cholinesterase) inhibitor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
neurotransmitter |
| propranolol | [no description available] | medium | 1 | 0 | naphthalenes;
propanolamine;
secondary amine | anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic |
| chlorisondamine | [no description available] | medium | 3 | 0 | isoindoles | |
| methoxyhydroxyphenylglycol | [no description available] | medium | 1 | 0 | methoxybenzenes;
phenols | |
| azelastine | [no description available] | medium | 1 | 1 | monochlorobenzenes;
phthalazines;
tertiary amino compound | anti-allergic agent;
anti-asthmatic drug;
bronchodilator agent;
EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor;
H1-receptor antagonist;
platelet aggregation inhibitor |
| fluticasone | [no description available] | medium | 1 | 1 | 11beta-hydroxy steroid;
17alpha-hydroxy steroid;
3-oxo-Delta(4) steroid;
corticosteroid;
fluorinated steroid;
thioester | anti-allergic agent;
anti-asthmatic drug |
| emedastine | [no description available] | medium | 1 | 1 | benzimidazoles | anti-allergic agent;
antipruritic drug;
H1-receptor antagonist |
| diclofenac | [no description available] | medium | 1 | 0 | amino acid;
aromatic amine;
dichlorobenzene;
monocarboxylic acid;
secondary amino compound | antipyretic;
drug allergen;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
xenobiotic |
| guanethidine | [no description available] | medium | 1 | 0 | azocanes;
guanidines | adrenergic antagonist;
antihypertensive agent;
sympatholytic agent |
| corticosterone | [no description available] | medium | 1 | 0 | 11beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone | human metabolite;
mouse metabolite |
| felodipine | [no description available] | medium | 1 | 0 | dichlorobenzene;
dihydropyridine;
ethyl ester;
methyl ester | anti-arrhythmia drug;
antihypertensive agent;
calcium channel blocker;
vasodilator agent |
| pentobarbital | [no description available] | medium | 1 | 0 | barbiturates | GABAA receptor agonist |
| nifedipine | [no description available] | medium | 1 | 0 | C-nitro compound;
dihydropyridine;
methyl ester | calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent |
| 8-hydroxy-2-(di-n-propylamino)tetralin | [no description available] | low | 0 | 0 | phenols;
tertiary amino compound;
tetralins | serotonergic antagonist |
| 2-(n-phenethyl-n-propyl)amino-5-hydroxytetralin | [no description available] | low | 0 | 0 | tetralins | |
| am 580 | [no description available] | low | 0 | 0 | amidobenzoic acid;
tetralins | antineoplastic agent;
retinoic acid receptor alpha/beta agonist |
| liranaftate | [no description available] | low | 0 | 0 | tetralins | |
| nadolol | [no description available] | low | 0 | 0 | tetralins | |
| tetralin | [no description available] | low | 0 | 0 | ortho-fused bicyclic hydrocarbon;
tetralins | |
| 6-Methoxy-1-tetralone | [no description available] | low | 0 | 0 | tetralins | |
| 2-aminotetralin | [no description available] | low | 0 | 0 | tetralins | |
| be 2254 | [no description available] | low | 0 | 0 | tetralins | |
| n 0437, (-)-isomer | [no description available] | low | 0 | 0 | tetralins | |
| mibefradil | [no description available] | low | 0 | 0 | tetralins | T-type calcium channel blocker |
| 5,6,7,8-tetrahydro-1-naphthol | [no description available] | low | 0 | 0 | tetralins | |
| sertraline | [no description available] | low | 0 | 0 | dichlorobenzene;
secondary amino compound;
tetralins | antidepressant;
serotonin uptake inhibitor |
| acetyl methyl tetramethyl tetralin | [no description available] | low | 0 | 0 | tetralins | |
| tamibarotene | [no description available] | low | 0 | 0 | dicarboxylic acid monoamide;
retinoid;
tetralins | antineoplastic agent;
retinoic acid receptor alpha/beta agonist |
| aj 76 | [no description available] | low | 0 | 0 | secondary amino compound;
tetralins | dopaminergic antagonist |
| oxoline | [no description available] | low | 0 | 0 | aromatic ketone;
tetralins | geroprotector |
| lasofoxifene | [no description available] | low | 0 | 0 | aromatic ether;
N-alkylpyrrolidine;
naphthols;
tetralins | antineoplastic agent;
bone density conservation agent;
cardioprotective agent;
estrogen receptor agonist;
estrogen receptor antagonist |
| isoshinanolone | [no description available] | low | 0 | 0 | tetralins | |
| 3-(4-chlorophenyl)-2-methyl-3,3a,4,5-tetrahydrobenzo[g]indazole | [no description available] | low | 0 | 0 | tetralins | |
| N1-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)acetamide | [no description available] | low | 0 | 0 | tetralins | |
| eptazocine | [no description available] | low | 0 | 0 | tetralins | |
| 1-(1H-imidazol-5-ylsulfonyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-piperidinecarboxamide | [no description available] | low | 0 | 0 | tetralins | |
| 4-oxo-4-[5-(1,2,3,4-tetrahydronaphthalen-1-ylsulfamoyl)-2,3-dihydroindol-1-yl]butanoic acid | [no description available] | low | 0 | 0 | tetralins | |
| 2-phenoxy-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]acetamide | [no description available] | low | 0 | 0 | tetralins | |
| 1-(phenylmethyl)-3-(1,2,3,4-tetrahydronaphthalen-1-yl)thiourea | [no description available] | low | 0 | 0 | tetralins | |
| 4-phenyl-2-propionamidotetraline | [no description available] | low | 0 | 0 | tetralins | |
| a 61603 | [no description available] | low | 0 | 0 | tetralins | |
| N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]cyclohexanecarboxamide | [no description available] | low | 0 | 0 | tetralins | |
| 2-chloro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide | [no description available] | low | 0 | 0 | tetralins | |
| 2-(4-chlorophenoxy)-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]acetamide | [no description available] | low | 0 | 0 | tetralins | |
| 2,6-difluoro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide | [no description available] | low | 0 | 0 | tetralins | |
| 2,4-dichloro-N-[5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1,3,4-oxadiazol-2-yl]benzamide | [no description available] | low | 0 | 0 | tetralins | |
| 8-methoxy-2-propionamidotetralin | [no description available] | low | 0 | 0 | tetralins | |
| sr 59230a | [no description available] | low | 0 | 0 | tetralins | |
| 7-hydroxy-2-(n-n-propyl-n-(3-iodo-2'-propenyl)-amino)tetralin | [no description available] | low | 0 | 0 | organoiodine compound;
phenols;
tertiary amino compound;
tetralins | dopamine agonist |
| pseudopteroxazole | [no description available] | low | 0 | 0 | tetralins | metabolite |
| 8-hydroxy-2-(di-n-propylamino)tetralin, (r)-isomer | [no description available] | low | 0 | 0 | tetralins | |
| uh 232 | [no description available] | low | 0 | 0 | tetralins | |
| 4-[(2,1,3-benzothiadiazol-4-ylsulfonylamino)methyl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1-cyclohexanecarboxamide | [no description available] | low | 0 | 0 | tetralins | |
| nepicastat | [no description available] | low | 0 | 0 | 1,3-dihydroimidazole-2-thiones;
organofluorine compound;
primary amino compound;
tetralins | EC 1.14.17.1 (dopamine beta-monooxygenase) inhibitor |
| NNC 55-0396 (free base) | [no description available] | low | 0 | 0 | benzimidazoles;
cyclopropanecarboxylate ester;
organofluorine compound;
tertiary amino compound;
tetralins | angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
neuroprotective agent;
potassium channel blocker;
T-type calcium channel blocker |
| (S)-Isosclerone | [no description available] | low | 0 | 0 | tetralins | |
| PB28 | [no description available] | low | 0 | 0 | aromatic ether;
piperazines;
tetralins | anticoronaviral agent;
antineoplastic agent;
apoptosis inducer;
sigma-2 receptor agonist |
| (+)-lyoniresinol-3-alpha-O-beta-D-glucopyranoside | [no description available] | low | 0 | 0 | beta-D-glucoside;
dimethoxybenzene;
lignan;
monosaccharide derivative;
polyphenol;
primary alcohol;
tetralins | antibacterial agent;
antifungal agent;
metabolite |
| eptazocine hydrobromide | [no description available] | low | 0 | 0 | tetralins | |
| lyoniresinol | [no description available] | low | 0 | 0 | dimethoxybenzene;
lignan;
polyphenol;
primary alcohol;
tetralins | antineoplastic agent;
metabolite |
| N-[2-methyl-5-(2-thiazolo[5,4-b]pyridinyl)phenyl]-5,6,7,8-tetrahydronaphthalene-2-sulfonamide | [no description available] | low | 0 | 0 | tetralins | |
| N-methyl-N-(3-pyridinylmethyl)-5-(5,6,7,8-tetrahydronaphthalen-2-yloxymethyl)-3-isoxazolecarboxamide | [no description available] | low | 0 | 0 | tetralins | |