| Assay ID | Title | Year | Journal | Article |
|---|
| AID233591 | Ratio of IC50 towards Tissue Plasminogen activator to thrombin | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Structure-activity study of tripeptide thrombin inhibitors using alpha-alkyl amino acids and other conformationally constrained amino acid substitutions. |
| AID321190 | Inhibition of human alpha-thrombin | 2008 | Bioorganic & medicinal chemistry, Feb-15, Volume: 16, Issue:4
| Inhibitors of proteases and amide hydrolases that employ an alpha-ketoheterocycle as a key enabling functionality. |
| AID211230 | Inhibition of human alpha-thrombin. | 1996 | Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
| Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group. |
| AID233457 | Selectivity ratio of IC50 of factor Xa relative to IC50 of human alpha thrombin | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. |
| AID242977 | Ki ratio of human alpha thrombin to activated protein C | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID51478 | Concentration required to inhibit Coagulation factor X was determined | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity. |
| AID210653 | Compound was tested for inhibition of gel-filtered platelet (GFP) aggregation induced by alpha-thrombin | 2004 | Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4
| Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G. |
| AID59843 | In vivo antithrombotic activity using canine thrombosis model | 2004 | Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4
| Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G. |
| AID232970 | Ratio between enzyme selectivity of trypsin inhibitor/thrombin inhibitor | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues. |
| AID232967 | Ratio between enzyme selectivity of factor Xa inhibitor/thrombin inhibitor | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues. |
| AID210922 | Concentration required to inhibit Tissue-type plasminogen activator (t-PA) was determined | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity. |
| AID242965 | Ki ratio of human alpha thrombin to streptokinase | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID215212 | Inhibition of bovine trypsin | 1996 | Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
| Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group. |
| AID249482 | Cardiovascular safety ratio ratiod (ED-25:ED50) estimation, which is based on a comparison of the hypotensive response in anesthetized guinea pigs to the anticoagulant / antithrombotic response in dogs | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID132400 | Efficacy required to inhibit thrombin was determined after 10 min of intravenous administration in the mouse thrombin challenge model | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity. |
| AID232968 | Ratio between enzyme selectivity of plasmin inhibitor/thrombin inhibitor | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues. |
| AID228477 | Anticoagulant activity for the compound by determining the concentration required to double the thrombin time. | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
| The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element. |
| AID242951 | Ki ratio of human alpha thrombin to plasmin | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID89963 | In vitro inhibition of thrombin catalytic activity using s-2238 substrate at 10 uM was measured at rt after 3 min incubation with compound | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues. |
| AID243048 | Ki ratio of human alpha thrombin to two chain urokinase type plasminogen activator | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID233221 | Compound was tested for inhibition of activated protein C. selectivity with respect to thrombin | 1996 | Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
| Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group. |
| AID130477 | ID50 is the dose required for 50% mice survival | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. |
| AID233225 | Inhibition of trypsin, selectivity with respect to thrombin | 1996 | Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
| Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group. |
| AID238527 | Binding affinity determined against human alpha thrombin | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID233459 | Selectivity ratio of IC50 of human trypsin relative to IC50 of human alpha thrombin | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. |
| AID215661 | Inhibitory activity against the human urokinase | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
| The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element. |
| AID215405 | Inhibitory activity against the human trypsin | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
| The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element. |
| AID210573 | Inhibitory activity against the human tissue plasminogen activator | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
| The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element. |
| AID112433 | In vivo potency for thrombin induced lethality model in anesthetized mice through peroral administration | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues. |
| AID241189 | Inhibitory concentration against human alpha thrombin | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID210851 | Inhibitory activity against the human alpha-thrombin | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
| The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element. |
| AID157968 | Inhibitory activity against the human plasmin | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
| The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element. |
| AID211774 | Binding inhibition against thrombin was measured by nonlinear regression analysis using Morrison's equation for tight-binding inhibition | 1999 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 9, Issue:5
| Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy. |
| AID248645 | Inhibitory concentration against gel filtered platelet aggregation induced by alpha thrombin | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID228476 | Anticoagulant activity for the compound by determining the concentration required to double the prothrombin time. | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
| The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element. |
| AID242972 | Ki ratio of human alpha thrombin to activated factor X | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID112432 | In vivo potency for thrombin induced lethality model in anesthetized mice through intraperitoneal administration | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues. |
| AID251305 | Percent change in blood pressure in guinea pig at 10 mg/kg dose | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID232969 | Ratio between enzyme selectivity of tissue plasminogen activator inhibitor/thrombin inhibitor | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| Thrombin active site inhibitors: chemical synthesis, in vitro and in vivo pharmacological profile of a novel and selective agent BMS-189090 and analogues. |
| AID132401 | Efficacy required to inhibit thrombin was determined after 1 hr of intravenous administration in the mouse thrombin challenge model | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity. |
| AID215026 | Concentration required to inhibit Trypsin was determined | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity. |
| AID213263 | In vitro Enzyme Inhibitory activity measured against Thrombin | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Structure-activity study of tripeptide thrombin inhibitors using alpha-alkyl amino acids and other conformationally constrained amino acid substitutions. |
| AID210648 | Compound was evaluated for the inhibition of thrombin using the synthetic substrate chromozym TH | 1998 | Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10
| 1,2-disubstituted cyclohexane derived tripeptide aldehydes as novel selective thrombin inhibitors. |
| AID132402 | Efficacy required to inhibit thrombin was determined after 1 hr of oral administration in the mouse thrombin challenge model | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity. |
| AID210843 | Binding to human thrombin was measured using the inhibition of thrombin hydrolysis of Bz-Phe-Val-Arg-pNA | 1999 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 9, Issue:5
| Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy. |
| AID247095 | In vivo effective intravenous dose for that reduces thrombus weight accumulation on a silk fiber by 50% was determined in Rabbit deep vein thrombosis model | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID89188 | Anticoagulant activity measured in human plasma through activated partial thromboplastin time (aPTT) assay | 1999 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 9, Issue:5
| Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy. |
| AID233590 | Ratio of IC50 towards Plasmin to thrombin | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Structure-activity study of tripeptide thrombin inhibitors using alpha-alkyl amino acids and other conformationally constrained amino acid substitutions. |
| AID210678 | Inhibitory activity against thrombin induced platelet aggregation | 1996 | Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
| Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group. |
| AID51331 | In vitro Enzyme Inhibitory activity measured against Coagulation factor X | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Structure-activity study of tripeptide thrombin inhibitors using alpha-alkyl amino acids and other conformationally constrained amino acid substitutions. |
| AID211215 | Inhibitory constant of thrombin catalytic activity was determined | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity. |
| AID157805 | In vitro Enzyme Inhibitory activity measured against Plasmin | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Structure-activity study of tripeptide thrombin inhibitors using alpha-alkyl amino acids and other conformationally constrained amino acid substitutions. |
| AID177704 | In vivo potency defined as the infusion dose that reduces the clot weight by 50% in rat arterial-venous shunt model of thrombosis | 1999 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 9, Issue:5
| Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy. |
| AID233458 | Selectivity ratio of IC50 of human plasmin relative to IC50 of human alpha thrombin | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. |
| AID238705 | Inhibition constant against human alpha thrombin | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID246819 | In vivo effective intravenous dose for eliciting a 25% decrease in blood pressure in anesthetized Guinea pig | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID233222 | Compound was tested for inhibition of plasmin, selectivity with respect to thrombin | 1996 | Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
| Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group. |
| AID157803 | Concentration required to inhibit Plasmin was determined | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity. |
| AID210656 | Concentration required to inhibit thrombin was determined | 2002 | Bioorganic & medicinal chemistry letters, Nov-04, Volume: 12, Issue:21
| Retro-binding thrombin active site inhibitors: identification of an orally active inhibitor of thrombin catalytic activity. |
| AID243040 | Ki ratio of human alpha thrombin to two chain tissue type plasminogen activator | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID233460 | Selectivity ratio of IC50 of tissue plasminogen activator relative to IC50 of human alpha thrombin | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. |
| AID233224 | Compound was tested for inhibition of tissue-type plasminogen activator (tissue plasminogen activator), selectivity with respect to thrombin | 1996 | Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
| Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group. |
| AID228475 | Anticoagulant activity for the compound by determining the concentration required to double the activated partial thromboplastin time. | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
| The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element. |
| AID249484 | Cardiovascular safety ratio ratiod (ED-25:ED50) estimation, which is based on a comparison of the hypotensive response in anesthetized guinea pigs to the anticoagulant / antithrombotic response in rabbit | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID210667 | In vitro inhibitory activity against hydrolysis of human alpha thrombin | 2002 | Bioorganic & medicinal chemistry letters, Jan-07, Volume: 12, Issue:1
| Molecular design and structure--activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664. |
| AID233057 | Compound was evaluated for IC50 ratio between human plasmin and thrombin | 1998 | Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10
| 1,2-disubstituted cyclohexane derived tripeptide aldehydes as novel selective thrombin inhibitors. |
| AID215719 | In vitro activity against trypsin was determined | 1994 | Journal of medicinal chemistry, Jul-08, Volume: 37, Issue:14
| Retro-binding tripeptide thrombin active-site inhibitors: discovery, synthesis, and molecular modeling. |
| AID167464 | In vivo antithrombotic activity using rabbit thrombosis model | 2004 | Journal of medicinal chemistry, Feb-12, Volume: 47, Issue:4
| Inhibitors of serine proteases as potential therapeutic agents: the road from thrombin to tryptase to cathepsin G. |
| AID89183 | Anticoagulant activity measured in human plasma through prothrombin time (PT) assay | 1999 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 9, Issue:5
| Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy. |
| AID233059 | Compound was evaluated for IC50 ratio between human trypsin and thrombin | 1998 | Bioorganic & medicinal chemistry letters, May-19, Volume: 8, Issue:10
| 1,2-disubstituted cyclohexane derived tripeptide aldehydes as novel selective thrombin inhibitors. |
| AID211543 | In vitro activity against thrombin was determined | 1994 | Journal of medicinal chemistry, Jul-08, Volume: 37, Issue:14
| Retro-binding tripeptide thrombin active-site inhibitors: discovery, synthesis, and molecular modeling. |
| AID238405 | Binding affinity against bovine trypsin | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID210737 | In vitro Enzyme Inhibitory activity against t-PA(Tissue plasminogen activator). | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Structure-activity study of tripeptide thrombin inhibitors using alpha-alkyl amino acids and other conformationally constrained amino acid substitutions. |
| AID89186 | Anticoagulant activity measured in human plasma through thrombin time (TT) assay | 1999 | Bioorganic & medicinal chemistry letters, Mar-08, Volume: 9, Issue:5
| Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 2. Sidechain optimization and demonstration of in vivo efficacy. |
| AID247088 | In vivo effective intravenous dose for that reduces thrombus weight accumulation on a silk fiber by 50% was determined in Dog arteriovenous shunt model | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID233223 | Compound was tested for inhibition of streptokinase (SK). selectivity with respect to thrombin | 1996 | Journal of medicinal chemistry, Aug-02, Volume: 39, Issue:16
| Potent thrombin inhibitors that probe the S1 subsite: tripeptide transition state analogues based on a heterocycle-activated carbonyl group. |
| AID158154 | In vitro activity against plasmid was determined | 1994 | Journal of medicinal chemistry, Jul-08, Volume: 37, Issue:14
| Retro-binding tripeptide thrombin active-site inhibitors: discovery, synthesis, and molecular modeling. |
| AID242952 | Ki ratio of human alpha thrombin to trypsin | 2005 | Journal of medicinal chemistry, Mar-24, Volume: 48, Issue:6
| In-depth study of tripeptide-based alpha-ketoheterocycles as inhibitors of thrombin. Effective utilization of the S1' subsite and its implications to structure-based drug design. |
| AID51826 | In vitro activity against Factor Xa was determined | 1994 | Journal of medicinal chemistry, Jul-08, Volume: 37, Issue:14
| Retro-binding tripeptide thrombin active-site inhibitors: discovery, synthesis, and molecular modeling. |
| AID30722 | Inhibitory activity against the activated human protein C | 1999 | Bioorganic & medicinal chemistry letters, Sep-20, Volume: 9, Issue:18
| The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element. |
| AID215027 | In vitro Enzyme Inhibitory activity measured against Trypsin | 1995 | Journal of medicinal chemistry, Oct-27, Volume: 38, Issue:22
| Structure-activity study of tripeptide thrombin inhibitors using alpha-alkyl amino acids and other conformationally constrained amino acid substitutions. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |