| Assay ID | Title | Year | Journal | Article |
|---|
| AID31293 | Diglutamyl homologue inhibition activity against the AICAR formyltransferase was determined against L cell | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID105289 | Antitumor activity on MOLT-4 T-cell acute lymphoblastic leukemia cell lines | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID105287 | Ability to inhibit [3H]methotrexate transport into MOLT-4 cells in vitro | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid. |
| AID153426 | Effect on P388 tumor cell growth in mice. The percentage of increased life span was determined administered 5 mg/kg schedule - t.i.d., days 1-4 | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID94568 | Evaluated for reversal of L cell inhibition, where reversal of toxicity was evaluated by the addition of Leucovorin (0.2 uM) | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID72876 | Ability to inhibit glycinamide ribonucleotide transformylase (GAR-Tfase) in vitro, using hog liver with (6R)-10-formyl-FH4 as cofactor | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid. |
| AID94566 | Evaluated in vitro for ability to inhibit the L cell lines. | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID72754 | Inhibition of GAR transformylase in hog liver | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues. |
| AID102785 | In vitro inhibition of growth of MCF-7 human breast adenocarcinoma using 72 hours continuous exposure | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents. |
| AID103898 | Antitumor activity on MCF-7 breast adenocarcinoma cell lines | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID71346 | Apparent Km in uM for its activation for Hog Liver Folyl-polyglutamate synthase was determined | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID31287 | Diglutamyl homologue inhibition activity against the AICAR formyltransferase was determined against MOLT-4; NT=Not tested | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID31302 | In vitro inhibitory activity against MOLT-4 T-cell leukemia cell AICAR transformylase | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents. |
| AID200371 | Evaluated for inhibitory activity on Serine hydroxymethyl transferase (Lcell) at folate substrate concentration of 160 uM | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID201678 | Antitumor activity on SW 480 colon adenocarcinoma cell lines | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID73656 | Inhibition activity against Glycinamide ribotide formyltransferase against L cell | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID31296 | Triglutamyl homologue inhibition activity against AICAR formyltransferase was determined against L cell | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID94706 | Evaluated for reversal of L cell inhibition, where reversal of toxicity was evaluated by the addition of Thymidine (20 uM) | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID231102 | Ratio of app Km to ral Vmax | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID102441 | Effective dose which is required to inhibit 50% of the cell growth of MCF-7 cells in culture. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues. |
| AID71347 | Compound was evaluated for the substrate activity for hog liver Folyl-polyglutamate synthase | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues. |
| AID73791 | Triglutamyl homologue inhibition activity against Glycinamide ribonucleotide transformylase (GAR-TFase)was determined against L cell | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID105644 | Inhibition of the uptake of [3H]MTX influx into MOLT-4 cells. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues. |
| AID153425 | Effect on P388 tumor cell growth in mice. The percentage of increased life span was determined administered 10 mg/kg schedule - t.i.d., days 1-4 | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID31289 | Inhibition activity against AICAR formyltransferase determined against MOLT-4 | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID71345 | Vmax of Hog Folyl-polyglutamate synthase relative to aminopterin | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid. |
| AID3139 | Inhibitory activity against 5,10-methylenetetrahydrofolate dehydrogenase from Escherichia coli at a concentration of 0.1 mM; NT=Not tested | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID71227 | Percent Vmax of Hog folyl-poly-glutamate synthase in presence relative to aminopterin | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents. |
| AID73789 | Inhibition activity against Glycinamide ribonucleotide transformylase (GAR-TFase) against L cell | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID73657 | Triglutamyl homologue inhibition activity against Glycinamide ribonucleotide transformylase (GAR-TFase)was determined against hog liver; NT=Not tested | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID31294 | Hexaglutamyl homologue inhibition activity against the AICAR formyltransferase was determined against L cell | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID31295 | Inhibition activity against AICAR formyltransferase determined against L cell | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID8816 | Antitumor activity on A-427 lung carcinoma cell lines | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID94567 | Evaluated for reversal of L cell inhibition, where reversal of toxicity was evaluated by the addition of Hypoxanthine (37 uM) | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID105508 | Compound was evaluated for inhibition of [3H]methotrexate uptake into MOLT-4 cells | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents. |
| AID43846 | Compound was evaluated for reversal of growth inhibition against human lymphoblastic leukemic CCRF-CEM cells at 0.46 uM concentration and with 300 uM of AICA | 1992 | Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
| Synthesis and biological activity of acyclic analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid. |
| AID3143 | Evaluated for inhibitory activity on 5,10-methylenetetrahydrofolate dehydrogenase(L cell) at folate substrate concentration of 100 uM | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID43845 | Compound was evaluated for reversal of growth inhibition against human lymphoblastic leukemic CCRF-CEM cells at 0.46 uM concentration and with 100 uM of hypoxanthine | 1992 | Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
| Synthesis and biological activity of acyclic analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid. |
| AID73787 | Diglutamyl homologue inhibition activity against the Glycinamide ribonucleotide transformylase (GAR-TFase)was determined against L cell | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID56808 | Inhibition of dihydrofolate reductase (DHFR) in WIL2 cells | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues. |
| AID72755 | In vitro inhibition of hog liver GAR transformylase with (6R)-10-formyl-FH4 as cofactor | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents. |
| AID23336 | Maximum drug concentration (Vmax), relative to a control of 50 uM aminopterin included in each experiment. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues. |
| AID212152 | Inhibition of thymidylate synthase (TS) in human | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues. |
| AID3083 | Evaluated for inhibitory activity on 10-formyltetrahydrofolate synthetase(L cell) at folate substrate concentration of 100 uM | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID216454 | Antitumor activity on WiDr colon adenocarcinoma cell lines | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID73788 | Hexaglutamyl homologue inhibition activity against the Glycinamide ribonucleotide transformylase (GAR-TFase) was determined against L cell | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID31288 | Hexaglutamyl homologue inhibition activity against the AICAR formyltransferase was determined against MOLT-4 | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID103887 | Ability to inhibit growth of MCF-7 human breast adenocarcinoma in vitro | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid. |
| AID153427 | Effect on P388 tumor cell growth in mice. The percentage of increased life span was determined administered 7.5 mg/kg schedule - b.i.d., days 1-3 | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID212147 | Evaluated for inhibitory activity on Thymidylate synthase(calf thymus) at folate substrate concentration of 200 uM | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID58005 | Evaluated for inhibitory activity on Dihydrofolate reductase(rat liver) at folate substrate concentration of 45 uM | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID56620 | Evaluated in vitro for ability to inhibit the Detroit 98 cell lines | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID153428 | Effect on P388 tumor cell growth in mice. The percentage of increased life span was determined administered 75 mg/kg schedule - QD,days1,5,9 | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID3138 | Evaluated for inhibitory activity on 5,10-Methenyl Tetrahydrofolate Cyclohydrolase(L cell) at folate substrate concentration of 100 uM | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID43705 | Cytotoxicity against human lymphoblastic leukemic CCRF-CEM cell line was evaluated as the concentration required for 50% inhibition of the growth of the control value | 1992 | Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
| Synthesis and biological activity of acyclic analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid. |
| AID43706 | In vitro antitumor activity was assessed from rate of cell growth of CCRF/CEM cell line | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid. |
| AID71223 | Km value of Hog folyl-poly-glutamate synthase in presence relative to aminopterin | 1992 | Journal of medicinal chemistry, Apr-17, Volume: 35, Issue:8
| Synthesis and biological activity of open-chain analogues of 5,6,7,8-tetrahydrofolic acid--potential antitumor agents. |
| AID75851 | Diglutamyl homologue inhibition activity against the Glycinamide ribonucleotide transformylase (GAR-TFase)was determined against hog liver; NT=Not tested | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID43847 | Compound was evaluated for reversal of growth inhibition against human lymphoblastic leukemic CCRF-CEM cells at 0.46 uM concentration and with 5 uM of Thymidine | 1992 | Journal of medicinal chemistry, Mar-20, Volume: 35, Issue:6
| Synthesis and biological activity of acyclic analogues of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid. |
| AID71349 | Relative Vmax for its activation for Hog Liver Folyl-polyglutamate synthase was determined | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID107929 | Evaluated for inhibitory activity on Methionine synthase(L cell) at folate substrate concentration of 100 uM | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID31286 | Inhibition of 5-aminoimidazole-4-carboxamide AICAR formyltransferase in MOLT-4 cells | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues. |
| AID43560 | Antitumor activity on CCRF-CEM T-cell acute lymphoblastic leukemia cell lines | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID94569 | Evaluated for reversal of L cell inhibition, where reversal of toxicity was evaluated by the addition of Thymidine Hypoxanthine | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID230506 | Ratio of relative Vmax values to that of apparent Km values. | 1991 | Journal of medicinal chemistry, Feb, Volume: 34, Issue:2
| Synthesis and biological evaluation of 5-deazaisofolic acid, 5-deaza-5,6,7,8-tetrahydroisofolic acid, and their N9-substituted analogues. |
| AID73660 | Hexaglutamyl homologue inhibition activity against the Glycinamide ribonucleotide transformylase (GAR-TFase) was determined against hog liver | 1990 | Journal of medicinal chemistry, Feb, Volume: 33, Issue:2
| Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. |
| AID71220 | Km of Hog Folyl-polyglutamate synthase relative to aminopterin | 1994 | Journal of medicinal chemistry, Jun-24, Volume: 37, Issue:13
| Thienyl and thiazolyl acyclic analogues of 5-deazatetrahydrofolic acid. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |