Compounds > 1,5-naphthylene di-isocyanate
Page last updated: 2024-11-05

1,5-naphthylene di-isocyanate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

1,5-naphthylene di-isocyanate: implicated in occupational asthma [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID18503
CHEBI ID82496
SCHEMBL ID22210
MeSH IDM0080713

Synonyms (41)

Synonym
naphthalene, 1,5-diisocyanato-
1,5-naphthylene di-isocyanate
3173-72-6
isocyanic acid,5-naphthylene ester
1,5-naphthylene diisocyanate
nsc-240728
1,5-naphthalene diisocyanate ,
nsc240728
1,5-diisocyanatonaphthalene
naphthalene,5-diisocyanato-
nsc 240728
1,5-naphthyl diisocyanate
isocyanic acid, 1,5-naphthylene ester
brn 2212353
einecs 221-641-4
1,5-naphthalene diisocyanate [diisocyanates]
ccris 8920
N0168
naphthalene 1,5-diisocyanate
C19464
unii-0orb22st7m
4-13-00-00342 (beilstein handbook reference)
0orb22st7m ,
ec 221-641-4
1,5-diisocyanatonaphthalene;1,5-naphthylene diisocyanate
A820975
FT-0600668
AKOS015900717
SCHEMBL22210
CHEBI:82496
mfcd00039588
SBJCUZQNHOLYMD-UHFFFAOYSA-N
1,5-naphthalenediol, diisocyanate
1,5-naphthalene diisocyanate [iarc]
1,5-ndi
naphthalene diisocyanate, 1,5-
DTXSID8040145
GS-3153
1,5-naphthalenediisocyanate
Q2786152
D91652
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
naphthalenesAny benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's1 (14.29)18.2507
2000's3 (42.86)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.27

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.27 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.27)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies4 (40.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (60.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
4,4'-diphenylmethane diisocyanate
4,4'-diphenylmethane diisocyanate: used as a hardening agent incorporated in polyurethanes. diphenylmethane-4,4'-diisocyanate : A diisocyanate consisting of diphenylmethane with two isocyanate groups at the 4- and 4'-positions.		2.4620diisocyanateallergen;
hapten
1-naphthylamine
1-Naphthylamine: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.. naphthylamine : A primary arylamine that is naphthalene substituted by an amino group at unspecified position.. 1-naphthylamine : A naphthylamine that is naphthalene substituted by an amino group at position 1.		2.1510naphthylaminehuman xenobiotic metabolite
toluene 2,4-diisocyanate
Toluene 2,4-Diisocyanate: Skin irritant and allergen used in the manufacture of polyurethane foams and other elastomers.. toluene 2,4-diisocyanate : A toluene meta-diisocyanate in which the isocyanato groups are at positions 2 and 4 relative to the methyl group on the benzene ring.		2.110toluene meta-diisocyanateallergen;
hapten
1,5-naphthalenediamine
1,5-diaminonaphthalene: structure in first source. naphthalene-1,5-diamine : A naphthalenediamine compound having amino substituents in the 1- and 5-positions.		2.1510naphthalenediaminecarcinogenic agent
cyanates
Cyanates: Organic salts of cyanic acid containing the -OCN radical.. cyanates : Salts and esters of cyanic acid, HOC#N; compounds carrying the cyanate functional group -O-C#N.. isocyanates : Organonitrogen compounds that are derivatives of isocyanic acid; compounds containing the isocyanate functional group -N=C=O (as opposed to the cyanate group, -O-C#N).		3.470
ConditionIndicatedRelationship StrengthStudiesTrials
Asthma, Bronchial
[description not available]		02.3820
Diseases, Occupational
[description not available]		02.6730
Asthma
A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).		07.3820
Allergic Alveolitis, Extrinsic
[description not available]		02.0110
Bleeding
[description not available]		02.0110
Alveolitis, Extrinsic Allergic
A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.		02.0110
Hemorrhage
Bleeding or escape of blood from a vessel.		02.0110
Allergy, Drug
[description not available]		01.9510
Drug Hypersensitivity
Immunologically mediated adverse reactions to medicinal substances used legally or illegally.		01.9510