Page last updated: 2024-12-06

1,5-naphthylene di-isocyanate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

## 1,5-Naphthylene Di-isocyanate (NDI)

1,5-Naphthylene di-isocyanate (NDI) is an organic compound with the chemical formula C12H6N2O2. It is a **diisocyanate**, meaning it contains two isocyanate (-N=C=O) groups. These groups are attached to a naphthalene ring, which is a fused aromatic ring system consisting of two benzene rings.

**Importance in Research:**

NDI is an important compound in research for several reasons:

* **Monomer for High-Performance Polymers:** NDI is a key monomer used in the synthesis of various high-performance polymers, including polyimides, polyamides, and polyurethanes. These polymers exhibit excellent properties like high thermal stability, mechanical strength, and chemical resistance, making them suitable for applications in aerospace, electronics, and automotive industries.
* **Organic Electronics:** NDI-based polymers are employed in organic electronics due to their ability to transport charge carriers efficiently. They find use in transistors, solar cells, and organic light-emitting diodes (OLEDs).
* **Advanced Materials:** NDI can be incorporated into various materials to enhance their properties. For example, it can be used to create self-healing materials, stimuli-responsive materials, and materials with improved mechanical properties.
* **Catalysis:** NDI derivatives have been explored as catalysts for various organic reactions, particularly in the field of green chemistry.
* **Biomedical Applications:** NDI has been investigated for its potential use in biomaterials, drug delivery systems, and tissue engineering.

**Key Advantages of NDI:**

* **High Reactivity:** The isocyanate groups in NDI are highly reactive, enabling efficient polymerization and modification reactions.
* **Planar Structure:** The rigid planar structure of NDI promotes strong intermolecular interactions, contributing to the excellent mechanical and thermal properties of resulting polymers.
* **Electron-Deficient Nature:** NDI's electron-deficient nature makes it a good acceptor in charge-transfer complexes, which is crucial for its applications in organic electronics.

**Overall, 1,5-Naphthylene di-isocyanate is a versatile building block with vast potential for creating innovative materials with advanced properties.** Research efforts continue to explore its diverse applications in various fields, including materials science, chemistry, and engineering.

1,5-naphthylene di-isocyanate: implicated in occupational asthma [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID18503
CHEBI ID82496
SCHEMBL ID22210
MeSH IDM0080713

Synonyms (41)

Synonym
naphthalene, 1,5-diisocyanato-
1,5-naphthylene di-isocyanate
3173-72-6
isocyanic acid,5-naphthylene ester
1,5-naphthylene diisocyanate
nsc-240728
1,5-naphthalene diisocyanate ,
nsc240728
1,5-diisocyanatonaphthalene
naphthalene,5-diisocyanato-
nsc 240728
1,5-naphthyl diisocyanate
isocyanic acid, 1,5-naphthylene ester
brn 2212353
einecs 221-641-4
1,5-naphthalene diisocyanate [diisocyanates]
ccris 8920
N0168
naphthalene 1,5-diisocyanate
C19464
unii-0orb22st7m
4-13-00-00342 (beilstein handbook reference)
0orb22st7m ,
ec 221-641-4
1,5-diisocyanatonaphthalene;1,5-naphthylene diisocyanate
A820975
FT-0600668
AKOS015900717
SCHEMBL22210
CHEBI:82496
mfcd00039588
SBJCUZQNHOLYMD-UHFFFAOYSA-N
1,5-naphthalenediol, diisocyanate
1,5-naphthalene diisocyanate [iarc]
1,5-ndi
naphthalene diisocyanate, 1,5-
DTXSID8040145
GS-3153
1,5-naphthalenediisocyanate
Q2786152
D91652
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
naphthalenesAny benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (14.29)18.7374
1990's1 (14.29)18.2507
2000's3 (42.86)29.6817
2010's2 (28.57)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.27

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.27 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.27)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies4 (40.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (60.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]