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cimetidine and Bleeding

cimetidine has been researched along with Bleeding in 9 studies

Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.

Research Excerpts

ExcerptRelevanceReference
"In this study, cimetidine was used to treat patients with hemophilia A and inhibitors to factor VIII who presented with acute hemorrhages (Group A) and those without hemorrhages (Group B)."9.08Treatment of patients with hemophilia A and inhibitors to factor FVIII with cimetidine. ( Ambriz Fernandez, R; Collazo Jaloma, J; Dominguez Garcia, V; Martinez Murillo, C; Quintana Gonzalez, S; Rodriguez Moyado, H, 1996)
"Gastroesophageal reflux (GER) is a common episode in pediatric patients with severe motor and intellectual disabilities (SMID) and occasionally leads to a severe clinical state accompanied with nausea, hematemesis, melena, wheezing, pneumonia, anemia and/or failure to thrive."5.32Treatment of gastric hemorrhage by pulverized omeprazole and antacid--concomitant administration via a nasogastric tube. ( Kinoshita, E; Mukai, S; Ohtani, H; Sawada, Y; Yamaguchi, T, 2004)
"In this study, cimetidine was used to treat patients with hemophilia A and inhibitors to factor VIII who presented with acute hemorrhages (Group A) and those without hemorrhages (Group B)."5.08Treatment of patients with hemophilia A and inhibitors to factor FVIII with cimetidine. ( Ambriz Fernandez, R; Collazo Jaloma, J; Dominguez Garcia, V; Martinez Murillo, C; Quintana Gonzalez, S; Rodriguez Moyado, H, 1996)
" In a thromboplastin-induced thromboembolism model, administration of 30 mg/kg YM-75466 or 3 mg/kg warfarin significantly improved the lethality ratio."3.70Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice. ( Hirayama, F; Iizumi, Y; Kawasaki, T; Koshio, H; Matsumoto, Y; Sato, K; Taniuchi, Y, 1998)
"We investigated the mechanisms by which 16,16-dimethyl prostaglandin E2 and histamine induced pancreatic hemorrhage in an experimental model of acute pancreatitis in cats."3.67Vasoactive drugs, microvascular permeability, and hemorrhagic pancreatitis in cats. ( Harvey, MH; Reber, HA; Wedgwood, KR, 1987)
", which doses do not inhibit the gastric basal secretion nor the maximal secretory response to pentagastrin stimulation, each prevented the gastric microbleeding produced by the oral application of indomethacin."3.67Evidence of the gastric cytoprotective effects of vitamin A, atropine and cimetidine on the development of gastric mucosal damage produced by administration of indomethacin in healthy subjects. ( Jávor, T; Morón, F; Mózsik, G; Nagy, L; Ruzsa, CS; Tárnok, F, 1986)
"Gastroesophageal reflux (GER) is a common episode in pediatric patients with severe motor and intellectual disabilities (SMID) and occasionally leads to a severe clinical state accompanied with nausea, hematemesis, melena, wheezing, pneumonia, anemia and/or failure to thrive."1.32Treatment of gastric hemorrhage by pulverized omeprazole and antacid--concomitant administration via a nasogastric tube. ( Kinoshita, E; Mukai, S; Ohtani, H; Sawada, Y; Yamaguchi, T, 2004)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19905 (55.56)18.7374
1990's3 (33.33)18.2507
2000's1 (11.11)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yamaguchi, T1
Mukai, S1
Kinoshita, E1
Ohtani, H1
Sawada, Y1
Masciariello, S1
Santini, M1
Casucci, R1
Sodo, M1
Aprea, G1
Sainz Samitier, R1
Bajador Andréu, E1
Villarón Rico, C1
Giménez Martínez, A1
Bueno Gómez, J1
Ewe, K1
Ambriz Fernandez, R1
Quintana Gonzalez, S1
Martinez Murillo, C1
Dominguez Garcia, V1
Rodriguez Moyado, H1
Collazo Jaloma, J1
Sato, K1
Taniuchi, Y1
Kawasaki, T1
Hirayama, F1
Koshio, H1
Matsumoto, Y1
Iizumi, Y1
Launbjerg, J1
Egeblad, H1
Heaf, J1
Nielsen, NH1
Fugleholm, AM1
Ladefoged, K1
Harvey, MH1
Wedgwood, KR1
Reber, HA1
Mózsik, G1
Morón, F1
Nagy, L1
Ruzsa, CS1
Tárnok, F1
Jávor, T1

Trials

1 trial available for cimetidine and Bleeding

ArticleYear
Treatment of patients with hemophilia A and inhibitors to factor FVIII with cimetidine.
    Archives of medical research, 1996,Spring, Volume: 27, Issue:1

    Topics: Adjuvants, Immunologic; Adolescent; Adult; Antibodies; Child; Cimetidine; Factor VIII; Hemophilia A;

1996

Other Studies

8 other studies available for cimetidine and Bleeding

ArticleYear
Treatment of gastric hemorrhage by pulverized omeprazole and antacid--concomitant administration via a nasogastric tube.
    International journal of clinical pharmacology and therapeutics, 2004, Volume: 42, Issue:11

    Topics: Adolescent; Antacids; Anti-Ulcer Agents; Cimetidine; Drug Therapy, Combination; Gastroesophageal Ref

2004
[Recent developments in the medical treatment of emergency cirrhotic hemorrhage. Vasopressin and glipressin, prostaglandins, somatostatin, propranolol, cimetidine and ranitidine].
    Minerva medica, 1983, Oct-06, Volume: 74, Issue:38

    Topics: Cimetidine; Emergencies; Hemorrhage; Humans; Liver Cirrhosis; Lypressin; Propranolol; Prostaglandins

1983
[Development of upper digestive hemorrhage and cimetidine: prospective study].
    Revista espanola de las enfermedades del aparato digestivo, 1982, Volume: 62, Issue:4

    Topics: Adolescent; Adult; Aged; Antacids; Cimetidine; Drug Therapy, Combination; Esophageal Diseases; Femal

1982
[Preventive measures in gastroenterology].
    Der Internist, 1981, Volume: 22, Issue:2

    Topics: Cimetidine; Colonic Neoplasms; Diarrhea; Doxycycline; Esophageal and Gastric Varices; Gastrointestin

1981
Comparison of the anticoagulant and antithrombotic effects of YM-75466, a novel orally-active factor Xa inhibitor, and warfarin in mice.
    Japanese journal of pharmacology, 1998, Volume: 78, Issue:2

    Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Anticoagulants; Anti

1998
Bleeding complications to oral anticoagulant therapy: multivariate analysis of 1010 treatment years in 551 outpatients.
    Journal of internal medicine, 1991, Volume: 229, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Ambulatory Care; Anticoagulants; Cimetidine

1991
Vasoactive drugs, microvascular permeability, and hemorrhagic pancreatitis in cats.
    Gastroenterology, 1987, Volume: 93, Issue:6

    Topics: Animals; Capillary Permeability; Cats; Cimetidine; Drug Synergism; Female; Hemorrhage; Histamine; In

1987
Evidence of the gastric cytoprotective effects of vitamin A, atropine and cimetidine on the development of gastric mucosal damage produced by administration of indomethacin in healthy subjects.
    International journal of tissue reactions, 1986, Volume: 8, Issue:1

    Topics: Atropine; Cimetidine; Dose-Response Relationship, Drug; Gastric Juice; Gastric Mucosa; Hemorrhage; H

1986