chlorambucil has been researched along with Bleeding in 14 studies
Chlorambucil: A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
chlorambucil : A monocarboxylic acid that is butanoic acid substituted at position 4 by a 4-[bis(2-chloroethyl)amino]phenyl group. A chemotherapy drug that can be used in combination with the antibody obinutuzumab for the treatment of chronic lymphocytic leukemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The relationship between treatments of chronic lymphocytic leukemia (CLL) with cladribine (2-CdA) or chlorambucil and immune thrombocytopenia (IT) has not been yet determined." | 9.17 | Immune thrombocytopenia in patients with chronic lymphocytic leukemia treated with cladribine-based regiments or chlorambucil--follow-up of PALG-CLL randomized trials. ( Blonski, JZ; Calbecka, M; Ceglarek, B; Chojnowski, K; Dmoszynska, A; Dwilewicz-Trojaczek, J; Gora-Tybor, J; Hellmann, A; Kloczko, J; Kostyra, A; Kowal, M; Kuliczkowski, K; Lewandowski, K; Mital, A; Nowak, W; Potoczek, S; Robak, T; Seferynska, I; Skotnicki, A; Stella-Holowiecka, B; Sulek, K; Trelinski, J; Warzocha, K; Wiater, E; Zawilska, K, 2013) |
| "The relationship between treatments of chronic lymphocytic leukemia (CLL) with cladribine (2-CdA) or chlorambucil and immune thrombocytopenia (IT) has not been yet determined." | 5.17 | Immune thrombocytopenia in patients with chronic lymphocytic leukemia treated with cladribine-based regiments or chlorambucil--follow-up of PALG-CLL randomized trials. ( Blonski, JZ; Calbecka, M; Ceglarek, B; Chojnowski, K; Dmoszynska, A; Dwilewicz-Trojaczek, J; Gora-Tybor, J; Hellmann, A; Kloczko, J; Kostyra, A; Kowal, M; Kuliczkowski, K; Lewandowski, K; Mital, A; Nowak, W; Potoczek, S; Robak, T; Seferynska, I; Skotnicki, A; Stella-Holowiecka, B; Sulek, K; Trelinski, J; Warzocha, K; Wiater, E; Zawilska, K, 2013) |
| " Randomized studies have shown that the risk of thrombosis was significantly reduced in ET with the use of hydroxyurea (HU) and in PV with the use of chlorambucil or 32P." | 4.80 | Treatment of polycythaemia vera and essential thrombocythaemia. ( Silverstein, MN; Tefferi, A, 1998) |
| "If the vasculitis is secondary to an underlying disease, such as lymphoma, therapy should be directed at the primary disease." | 2.37 | Pulmonary vasculitis. ( Fauci, AS; Leavitt, RY, 1986) |
| "Treatment with prednisone and chlorambucil was initiated, and the dog had a good response." | 1.37 | Waldenström's macroglobulinemia in a dog with a bleeding diathesis. ( Fournel-Fleury, C; Jaillardon, L, 2011) |
| "Behcet's syndrome, or Behcet's disease (BD), is a multisystem pathology, and survival is related to pulmonary involvement." | 1.35 | [Pulmonary involvement in Behcet's disease: a positive single-center experience with the use of immunosuppressive therapy]. ( Antunes, T; Barbas, CS; Barros, JM; Carvalho, CR; Kairalla, RA; Santana, AN, 2008) |
| "Bleeding tendency was seen in 17%, infections in 17%, hyperviscosity syndrome in 12%, and cardiac failure in 25% of the patients." | 1.31 | Waldenström's macroglobulinemia: clinical course and prognostic factors in 60 patients. Experience from a single hematology unit. ( Angelopoulou, MK; Boussiotis, V; Dimopoulou, MN; Fessas, P; Gribabis, A; Kittas, C; Konstantopoulos, K; Kontopidou, FN; Kyrtsonis, MC; Pangalis, GA; Siakantaris, P; Vaiopoulos, GA; Vassilakopoulos, TP, 2001) |
| "One characteristic of experimental allergic encephalomyelitis (EAE) in all species is the presence of a considerable leukocyte infiltrate in the central nervous system (CNS)." | 1.27 | Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system. ( Brostoff, S; Mason, D; Sedgwick, J, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (57.14) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blonski, JZ | 1 |
| Robak, T | 1 |
| Chojnowski, K | 1 |
| Gora-Tybor, J | 1 |
| Warzocha, K | 1 |
| Ceglarek, B | 1 |
| Seferynska, I | 1 |
| Calbecka, M | 1 |
| Kostyra, A | 1 |
| Stella-Holowiecka, B | 1 |
| Kloczko, J | 1 |
| Dmoszynska, A | 1 |
| Kowal, M | 1 |
| Lewandowski, K | 1 |
| Dwilewicz-Trojaczek, J | 1 |
| Wiater, E | 1 |
| Kuliczkowski, K | 1 |
| Potoczek, S | 1 |
| Hellmann, A | 1 |
| Mital, A | 1 |
| Skotnicki, A | 1 |
| Nowak, W | 1 |
| Sulek, K | 1 |
| Zawilska, K | 1 |
| Trelinski, J | 1 |
| Santana, AN | 1 |
| Antunes, T | 1 |
| Barros, JM | 1 |
| Kairalla, RA | 1 |
| Carvalho, CR | 1 |
| Barbas, CS | 1 |
| Jaillardon, L | 1 |
| Fournel-Fleury, C | 1 |
| MOLANDER, DW | 1 |
| LADUE, JS | 1 |
| Zeidman, A | 1 |
| Yarmolovsky, A | 1 |
| Djaldetti, M | 1 |
| Mittelman, M | 1 |
| Tefferi, A | 1 |
| Silverstein, MN | 1 |
| Kyrtsonis, MC | 1 |
| Vassilakopoulos, TP | 1 |
| Angelopoulou, MK | 1 |
| Siakantaris, P | 1 |
| Kontopidou, FN | 1 |
| Dimopoulou, MN | 1 |
| Boussiotis, V | 1 |
| Gribabis, A | 1 |
| Konstantopoulos, K | 1 |
| Vaiopoulos, GA | 1 |
| Fessas, P | 1 |
| Kittas, C | 1 |
| Pangalis, GA | 1 |
| Wiltshaw, E | 1 |
| Sedgwick, J | 1 |
| Brostoff, S | 1 |
| Mason, D | 1 |
| Leavitt, RY | 1 |
| Fauci, AS | 1 |
| Dunn, CD | 1 |
| Elson, LA | 1 |
| Afifi, AM | 1 |
| Tawfeek, S | 1 |
| Larbi, SO | 1 |
| Philp, RB | 1 |
| Gowdey, CW | 1 |
| Owen, LN | 1 |
| Kelly, DF | 1 |
| Porter, P | 1 |
3 reviews available for chlorambucil and Bleeding
| Article | Year |
|---|---|
Treatment of polycythaemia vera and essential thrombocythaemia.
Topics: Adult; Aged; Aspirin; Chlorambucil; Disease Progression; Female; Hemorrhage; Humans; Hydroxyurea; In | 1998 |
Chemotherapy in chronic lymphocytic leukaemia.
Topics: Adrenal Cortex Hormones; Bacterial Infections; Bone Marrow; Cell Transformation, Neoplastic; Chloram | 1977 |
Pulmonary vasculitis.
Topics: Adrenal Cortex Hormones; Azathioprine; Behcet Syndrome; Chlorambucil; Connective Tissue Diseases; Cy | 1986 |
1 trial available for chlorambucil and Bleeding
| Article | Year |
|---|---|
Immune thrombocytopenia in patients with chronic lymphocytic leukemia treated with cladribine-based regiments or chlorambucil--follow-up of PALG-CLL randomized trials.
Topics: Aged; Chlorambucil; Cladribine; Female; Follow-Up Studies; Hemorrhage; Humans; Leukemia, Lymphocytic | 2013 |
10 other studies available for chlorambucil and Bleeding
| Article | Year |
|---|---|
[Pulmonary involvement in Behcet's disease: a positive single-center experience with the use of immunosuppressive therapy].
Topics: Adult; Aneurysm; Anti-Inflammatory Agents; Behcet Syndrome; Chlorambucil; Female; Hemorrhage; Humans | 2008 |
Waldenström's macroglobulinemia in a dog with a bleeding diathesis.
Topics: Animals; Antineoplastic Agents; Blood Cell Count; Bone Marrow; Chlorambucil; Diarrhea; Disease Susce | 2011 |
CHRONIC LEUKEMIA.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Alkylating Agents; Anemia; Anemia, Hemolytic, | 1964 |
Hemorrhagic pleural effusion as a complication of chronic lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; Dyspnea; Fatal Outco | 1995 |
Waldenström's macroglobulinemia: clinical course and prognostic factors in 60 patients. Experience from a single hematology unit.
Topics: Adult; Aged; Aged, 80 and over; Blood Viscosity; Cardiac Output, Low; Chlorambucil; Fatigue; Female; | 2001 |
Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system.
Topics: Animals; Busulfan; Cells, Cultured; Central Nervous System; Cerebral Hemorrhage; Chlorambucil; Encep | 1987 |
Quantitative studies of haemopoietic spleen colonies in rats treated with cytotoxic chemicals.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Busulfan; Chlorambucil; Female | 1970 |
Deafness due to Waldenstrom macroglobulinaemia.
Topics: Audiometry; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Proteins; Chlorambucil; Deaf | 1971 |
The effects of alkoxyglycerols on haematopoiesis.
Topics: Anemia; Animals; Benzene; Blood Cell Count; Busulfan; Chlorambucil; Erythrocyte Count; Female; Hemat | 1968 |
The effect of N.N.-di-(2 chloroethyl)p-amino phenylbutyric acid (chlorambucil) on sheep.
Topics: Animals; Antibody Formation; Blood Cell Count; Blood Cells; Blood Protein Electrophoresis; Blood Pro | 1966 |