Page last updated: 2024-10-19

melatonin and Bleeding

melatonin has been researched along with Bleeding in 14 studies

Research Excerpts

ExcerptRelevanceReference
"Forty participants with severe dysmenorrhea were randomized to either melatonin or placebo, 20 in each group."9.51Adjuvant use of melatonin for pain management in dysmenorrhea - a randomized double-blinded, placebo-controlled trial. ( Böttiger, Y; Edlund, M; Marions, L; Söderman, L, 2022)
"D-ß-hydroxybutyrate (BHB) and melatonin (M) treatment improves survival in animal models of hemorrhagic shock."7.81Safety of D-ß-Hydroxybutyrate and Melatonin for the Treatment of Hemorrhagic Shock With Polytrauma. ( Asghar, JI; Beilman, GJ; Iyegha, UP; Mulier, KE; Wolf, A, 2015)
"Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase."7.78Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012)
"Melatonin is a well-known jet-lag compound, which helps in entrainment of sleep cycle."5.72Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage. ( Huang, ACW; Kaur, T; Shih, HC; Shyu, BC, 2022)
"Forty participants with severe dysmenorrhea were randomized to either melatonin or placebo, 20 in each group."5.51Adjuvant use of melatonin for pain management in dysmenorrhea - a randomized double-blinded, placebo-controlled trial. ( Böttiger, Y; Edlund, M; Marions, L; Söderman, L, 2022)
"Melatonin-treated mice received either short-term treatment on Days 1 and 2 after hemorrhage or continuous treatment throughout the study."5.29Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge. ( Ayala, A; Chaudry, IH; Haisken, JM; Wichmann, MW, 1996)
"Twenty-six patients undergoing ESS for chronic sinusitis and polyp removal were enrolled and randomly assigned to receive either oral clonidine or melatonin as preoperative premedication."5.19Improved quality of surgical field during endoscopic sinus surgery after clonidine premedication--a pilot study. ( Burduk, PK; Cywinski, JB; Kazmierczak, W; Kusza, K; Wawrzyniak, K, 2014)
"D-ß-hydroxybutyrate (BHB) and melatonin (M) treatment improves survival in animal models of hemorrhagic shock."3.81Safety of D-ß-Hydroxybutyrate and Melatonin for the Treatment of Hemorrhagic Shock With Polytrauma. ( Asghar, JI; Beilman, GJ; Iyegha, UP; Mulier, KE; Wolf, A, 2015)
" Based on this background, the present study evaluated the protective efficacy of melatonin in Echis carinatus (EC) venom-induced tissue necrosis, oxidative stress, and organ toxicity."3.80Melatonin alleviates Echis carinatus venom-induced toxicities by modulating inflammatory mediators and oxidative stress. ( Girish, KS; Hemshekhar, M; Katkar, GD; Kemparaju, K; Rangappa, KS; Santhosh, MS; Sharma, DR; Sundaram, MS; Sunitha, K, 2014)
"Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase."3.78Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012)
"Melatonin is a well-known jet-lag compound, which helps in entrainment of sleep cycle."1.72Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage. ( Huang, ACW; Kaur, T; Shih, HC; Shyu, BC, 2022)
"Melatonin pretreatment significantly reduced the haemorrhagic lesions and decreased esophageal lipid peroxidation aggravated by RE."1.35Melatonin protects against experimental reflux esophagitis. ( Lahiri, S; Palit, G; Pant, KK; Rasheed, N; Singh, P; Singh, S, 2009)
"Melatonin treatment (100 micrograms/100 g b."1.29Hypothalamic and neurohypophysial vasopressin and oxytocin content as influenced by haemorrhage in melatonin-treated male rats. ( Guzek, JW; Juszczak, M; K+opotowska, A; Stempniak, B, 1993)
"Melatonin-treated mice received either short-term treatment on Days 1 and 2 after hemorrhage or continuous treatment throughout the study."1.29Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge. ( Ayala, A; Chaudry, IH; Haisken, JM; Wichmann, MW, 1996)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (28.57)18.2507
2000's2 (14.29)29.6817
2010's6 (42.86)24.3611
2020's2 (14.29)2.80

Authors

AuthorsStudies
Söderman, L1
Edlund, M1
Böttiger, Y1
Marions, L1
Kaur, T1
Shih, HC1
Huang, ACW1
Shyu, BC1
Esrefoglu, M1
Cetin, A1
Taslidere, E1
Elbe, H1
Ates, B1
Tok, OE1
Aydin, MS1
Katkar, GD1
Sundaram, MS1
Hemshekhar, M1
Sharma, DR1
Santhosh, MS1
Sunitha, K1
Rangappa, KS1
Girish, KS1
Kemparaju, K1
Wawrzyniak, K1
Burduk, PK1
Cywinski, JB1
Kusza, K1
Kazmierczak, W1
Wolf, A1
Mulier, KE1
Iyegha, UP1
Asghar, JI1
Beilman, GJ1
Lahiri, S1
Singh, P1
Singh, S1
Rasheed, N1
Palit, G1
Pant, KK1
Huston, B1
Mills, K1
Froloff, V1
McGee, M1
Wu, WS1
Chou, MT1
Chao, CM1
Chang, CK1
Lin, MT1
Chang, CP1
Serel, TA1
Ozguner, F1
Soyupek, S1
Juszczak, M2
K+opotowska, A1
Stempniak, B1
Guzek, JW1
Wichmann, MW1
Haisken, JM1
Ayala, A1
Chaudry, IH1
Régrigny, O1
Delagrange, P1
Scalbert, E1
Atkinson, J1
Lartaud-Idjouadiene, I1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Melatonin on Reduction of Pelvic Pain[NCT03782740]Phase 280 participants (Actual)Interventional2019-03-15Completed
Effect of Pre-operative Oral Steroids on Blood Loss in Endoscopic Sinus Surgery for Chronic Rhinosinusitis Without Polyps[NCT05095961]Phase 2/Phase 30 participants (Actual)Interventional2023-03-31Withdrawn (stopped due to Technical difficulties encountered with recording intraoperative blood loss; unable to proceed with study.)
The Therapeutic Effect of Melatonin in Pediatric Patients With Functional Dyspepsia[NCT04684199]14 participants (Actual)Interventional2014-08-31Completed
A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754]Phase 20 participants (Actual)Interventional2021-04-01Withdrawn (stopped due to lack of subject enrollment)
A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483]Phase 28 participants (Actual)Interventional2020-11-06Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for melatonin and Bleeding

ArticleYear
Adjuvant use of melatonin for pain management in dysmenorrhea - a randomized double-blinded, placebo-controlled trial.
    European journal of clinical pharmacology, 2022, Volume: 78, Issue:2

    Topics: Absenteeism; Adult; Analgesics; Central Nervous System Depressants; Dysmenorrhea; Female; Hemorrhage

2022
Improved quality of surgical field during endoscopic sinus surgery after clonidine premedication--a pilot study.
    International forum of allergy & rhinology, 2014, Volume: 4, Issue:7

    Topics: Adult; Arterial Pressure; Chronic Disease; Clonidine; Endoscopy; Female; Heart Rate; Hemodynamics; H

2014

Other Studies

12 other studies available for melatonin and Bleeding

ArticleYear
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage.
    Molecular pain, 2022, Volume: 18

    Topics: Animals; Comorbidity; Disease Models, Animal; Hemorrhage; Humans; Melatonin; Pain; Sleep

2022
Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage.
    Bratislavske lekarske listy, 2017, Volume: 118, Issue:6

    Topics: Animals; Antioxidants; Carbon Tetrachloride; Female; Hemorrhage; Inflammation; Liver; Liver Cirrhosi

2017
Melatonin alleviates Echis carinatus venom-induced toxicities by modulating inflammatory mediators and oxidative stress.
    Journal of pineal research, 2014, Volume: 56, Issue:3

    Topics: Animals; Free Radicals; Hemorrhage; Inflammation Mediators; Kidney; Liver; Melatonin; Mice; Muscle,

2014
Safety of D-ß-Hydroxybutyrate and Melatonin for the Treatment of Hemorrhagic Shock With Polytrauma.
    Shock (Augusta, Ga.), 2015, Volume: 44 Suppl 1

    Topics: 3-Hydroxybutyric Acid; Alanine Transaminase; Animals; Arterial Pressure; Aspartate Aminotransferases

2015
Melatonin protects against experimental reflux esophagitis.
    Journal of pineal research, 2009, Volume: 46, Issue:2

    Topics: Animals; Antioxidants; Cytokines; Drug Antagonism; Esophagitis, Peptic; Hemorrhage; Humans; Inflamma

2009
Bladder rupture after intentional medication overdose.
    The American journal of forensic medicine and pathology, 2012, Volume: 33, Issue:2

    Topics: Carisoprodol; Central Nervous System Depressants; Clonazepam; Drug Overdose; Fatal Outcome; Female;

2012
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
    Acta pharmacologica Sinica, 2012, Volume: 33, Issue:6

    Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha

2012
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
    Acta pharmacologica Sinica, 2012, Volume: 33, Issue:6

    Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha

2012
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
    Acta pharmacologica Sinica, 2012, Volume: 33, Issue:6

    Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha

2012
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
    Acta pharmacologica Sinica, 2012, Volume: 33, Issue:6

    Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha

2012
Prevention of shock wave-induced renal oxidative stress by melatonin: an experimental study.
    Urological research, 2004, Volume: 32, Issue:1

    Topics: Animals; Free Radical Scavengers; Hemorrhage; Kidney; Kidney Diseases; Leukocyte Count; Lithotripsy;

2004
The effect of haemorrhage and melatonin on neurohypophysial vasopressin and oxytocin content in pinealectomized male rats.
    Patologia polska, 1993, Volume: 44, Issue:2

    Topics: Animals; Hemorrhage; Male; Melatonin; Oxytocin; Pineal Gland; Pituitary Gland, Posterior; Rats; Rats

1993
Hypothalamic and neurohypophysial vasopressin and oxytocin content as influenced by haemorrhage in melatonin-treated male rats.
    Patologia polska, 1993, Volume: 44, Issue:2

    Topics: Animals; Hemorrhage; Hypothalamus; Male; Melatonin; Oxytocin; Pituitary Gland, Posterior; Rats; Rats

1993
Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge.
    The Journal of surgical research, 1996, Volume: 65, Issue:2

    Topics: Animals; Body Weight; Cecum; Hemorrhage; Ligation; Male; Melatonin; Mice; Mice, Inbred C3H; Sepsis;

1996
Melatonin improves cerebral circulation security margin in rats.
    The American journal of physiology, 1998, Volume: 275, Issue:1

    Topics: Animals; Blood Pressure; Carbon Dioxide; Cerebrovascular Circulation; Frontal Lobe; Heart Rate; Hemo

1998