melatonin has been researched along with Bleeding in 14 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Forty participants with severe dysmenorrhea were randomized to either melatonin or placebo, 20 in each group." | 9.51 | Adjuvant use of melatonin for pain management in dysmenorrhea - a randomized double-blinded, placebo-controlled trial. ( Böttiger, Y; Edlund, M; Marions, L; Söderman, L, 2022) |
| "D-ß-hydroxybutyrate (BHB) and melatonin (M) treatment improves survival in animal models of hemorrhagic shock." | 7.81 | Safety of D-ß-Hydroxybutyrate and Melatonin for the Treatment of Hemorrhagic Shock With Polytrauma. ( Asghar, JI; Beilman, GJ; Iyegha, UP; Mulier, KE; Wolf, A, 2015) |
| "Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase." | 7.78 | Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012) |
| "Melatonin is a well-known jet-lag compound, which helps in entrainment of sleep cycle." | 5.72 | Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage. ( Huang, ACW; Kaur, T; Shih, HC; Shyu, BC, 2022) |
| "Forty participants with severe dysmenorrhea were randomized to either melatonin or placebo, 20 in each group." | 5.51 | Adjuvant use of melatonin for pain management in dysmenorrhea - a randomized double-blinded, placebo-controlled trial. ( Böttiger, Y; Edlund, M; Marions, L; Söderman, L, 2022) |
| "Melatonin-treated mice received either short-term treatment on Days 1 and 2 after hemorrhage or continuous treatment throughout the study." | 5.29 | Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge. ( Ayala, A; Chaudry, IH; Haisken, JM; Wichmann, MW, 1996) |
| "Twenty-six patients undergoing ESS for chronic sinusitis and polyp removal were enrolled and randomly assigned to receive either oral clonidine or melatonin as preoperative premedication." | 5.19 | Improved quality of surgical field during endoscopic sinus surgery after clonidine premedication--a pilot study. ( Burduk, PK; Cywinski, JB; Kazmierczak, W; Kusza, K; Wawrzyniak, K, 2014) |
| "D-ß-hydroxybutyrate (BHB) and melatonin (M) treatment improves survival in animal models of hemorrhagic shock." | 3.81 | Safety of D-ß-Hydroxybutyrate and Melatonin for the Treatment of Hemorrhagic Shock With Polytrauma. ( Asghar, JI; Beilman, GJ; Iyegha, UP; Mulier, KE; Wolf, A, 2015) |
| " Based on this background, the present study evaluated the protective efficacy of melatonin in Echis carinatus (EC) venom-induced tissue necrosis, oxidative stress, and organ toxicity." | 3.80 | Melatonin alleviates Echis carinatus venom-induced toxicities by modulating inflammatory mediators and oxidative stress. ( Girish, KS; Hemshekhar, M; Katkar, GD; Kemparaju, K; Rangappa, KS; Santhosh, MS; Sharma, DR; Sundaram, MS; Sunitha, K, 2014) |
| "Melatonin (1 and 5 mg/kg) significantly (i) prolonged the survival time of heartstroke rats (117 and 186 min vs 59 min); (ii) attenuated heatstroke-induced hyperthermia and hypotension; (iii) attenuated acute lung injury, including edema, neutrophil infiltration, and hemorrhage scores; (iv) down-regulated exudate volume, BALF PMN cell number, and MPO activity; (v) decreased the BALF levels of lung inflammation response cytokines like TNF-alpha, interleukin (IL)-1β, and IL-6 but further increased the level of an anti-inflammatory cytokine IL-10; (vi) reduced BALF levels of glutamate, lactate-to-pyruvate ratio, NO, 2,3-DHBA, and lactate dehydrogenase." | 3.78 | Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats. ( Chang, CK; Chang, CP; Chao, CM; Chou, MT; Lin, MT; Wu, WS, 2012) |
| "Melatonin is a well-known jet-lag compound, which helps in entrainment of sleep cycle." | 1.72 | Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage. ( Huang, ACW; Kaur, T; Shih, HC; Shyu, BC, 2022) |
| "Melatonin pretreatment significantly reduced the haemorrhagic lesions and decreased esophageal lipid peroxidation aggravated by RE." | 1.35 | Melatonin protects against experimental reflux esophagitis. ( Lahiri, S; Palit, G; Pant, KK; Rasheed, N; Singh, P; Singh, S, 2009) |
| "Melatonin treatment (100 micrograms/100 g b." | 1.29 | Hypothalamic and neurohypophysial vasopressin and oxytocin content as influenced by haemorrhage in melatonin-treated male rats. ( Guzek, JW; Juszczak, M; K+opotowska, A; Stempniak, B, 1993) |
| "Melatonin-treated mice received either short-term treatment on Days 1 and 2 after hemorrhage or continuous treatment throughout the study." | 1.29 | Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge. ( Ayala, A; Chaudry, IH; Haisken, JM; Wichmann, MW, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 6 (42.86) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Söderman, L | 1 |
| Edlund, M | 1 |
| Böttiger, Y | 1 |
| Marions, L | 1 |
| Kaur, T | 1 |
| Shih, HC | 1 |
| Huang, ACW | 1 |
| Shyu, BC | 1 |
| Esrefoglu, M | 1 |
| Cetin, A | 1 |
| Taslidere, E | 1 |
| Elbe, H | 1 |
| Ates, B | 1 |
| Tok, OE | 1 |
| Aydin, MS | 1 |
| Katkar, GD | 1 |
| Sundaram, MS | 1 |
| Hemshekhar, M | 1 |
| Sharma, DR | 1 |
| Santhosh, MS | 1 |
| Sunitha, K | 1 |
| Rangappa, KS | 1 |
| Girish, KS | 1 |
| Kemparaju, K | 1 |
| Wawrzyniak, K | 1 |
| Burduk, PK | 1 |
| Cywinski, JB | 1 |
| Kusza, K | 1 |
| Kazmierczak, W | 1 |
| Wolf, A | 1 |
| Mulier, KE | 1 |
| Iyegha, UP | 1 |
| Asghar, JI | 1 |
| Beilman, GJ | 1 |
| Lahiri, S | 1 |
| Singh, P | 1 |
| Singh, S | 1 |
| Rasheed, N | 1 |
| Palit, G | 1 |
| Pant, KK | 1 |
| Huston, B | 1 |
| Mills, K | 1 |
| Froloff, V | 1 |
| McGee, M | 1 |
| Wu, WS | 1 |
| Chou, MT | 1 |
| Chao, CM | 1 |
| Chang, CK | 1 |
| Lin, MT | 1 |
| Chang, CP | 1 |
| Serel, TA | 1 |
| Ozguner, F | 1 |
| Soyupek, S | 1 |
| Juszczak, M | 2 |
| K+opotowska, A | 1 |
| Stempniak, B | 1 |
| Guzek, JW | 1 |
| Wichmann, MW | 1 |
| Haisken, JM | 1 |
| Ayala, A | 1 |
| Chaudry, IH | 1 |
| Régrigny, O | 1 |
| Delagrange, P | 1 |
| Scalbert, E | 1 |
| Atkinson, J | 1 |
| Lartaud-Idjouadiene, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Melatonin on Reduction of Pelvic Pain[NCT03782740] | Phase 2 | 80 participants (Actual) | Interventional | 2019-03-15 | Completed | ||
| Effect of Pre-operative Oral Steroids on Blood Loss in Endoscopic Sinus Surgery for Chronic Rhinosinusitis Without Polyps[NCT05095961] | Phase 2/Phase 3 | 0 participants (Actual) | Interventional | 2023-03-31 | Withdrawn (stopped due to Technical difficulties encountered with recording intraoperative blood loss; unable to proceed with study.) | ||
| The Therapeutic Effect of Melatonin in Pediatric Patients With Functional Dyspepsia[NCT04684199] | 14 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04784754] | Phase 2 | 0 participants (Actual) | Interventional | 2021-04-01 | Withdrawn (stopped due to lack of subject enrollment) | ||
| A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection[NCT04474483] | Phase 2 | 8 participants (Actual) | Interventional | 2020-11-06 | Terminated (stopped due to difficult recruitment and complete first visit in person during thne hight of tne pandemic and later not enough subjects) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for melatonin and Bleeding
| Article | Year |
|---|---|
Adjuvant use of melatonin for pain management in dysmenorrhea - a randomized double-blinded, placebo-controlled trial.
Topics: Absenteeism; Adult; Analgesics; Central Nervous System Depressants; Dysmenorrhea; Female; Hemorrhage | 2022 |
Improved quality of surgical field during endoscopic sinus surgery after clonidine premedication--a pilot study.
Topics: Adult; Arterial Pressure; Chronic Disease; Clonidine; Endoscopy; Female; Heart Rate; Hemodynamics; H | 2014 |
12 other studies available for melatonin and Bleeding
| Article | Year |
|---|---|
Modulation of melatonin to the thalamic lesion-induced pain and comorbid sleep disturbance in the animal model of the central post-stroke hemorrhage.
Topics: Animals; Comorbidity; Disease Models, Animal; Hemorrhage; Humans; Melatonin; Pain; Sleep | 2022 |
Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage.
Topics: Animals; Antioxidants; Carbon Tetrachloride; Female; Hemorrhage; Inflammation; Liver; Liver Cirrhosi | 2017 |
Melatonin alleviates Echis carinatus venom-induced toxicities by modulating inflammatory mediators and oxidative stress.
Topics: Animals; Free Radicals; Hemorrhage; Inflammation Mediators; Kidney; Liver; Melatonin; Mice; Muscle, | 2014 |
Safety of D-ß-Hydroxybutyrate and Melatonin for the Treatment of Hemorrhagic Shock With Polytrauma.
Topics: 3-Hydroxybutyric Acid; Alanine Transaminase; Animals; Arterial Pressure; Aspartate Aminotransferases | 2015 |
Melatonin protects against experimental reflux esophagitis.
Topics: Animals; Antioxidants; Cytokines; Drug Antagonism; Esophagitis, Peptic; Hemorrhage; Humans; Inflamma | 2009 |
Bladder rupture after intentional medication overdose.
Topics: Carisoprodol; Central Nervous System Depressants; Clonazepam; Drug Overdose; Fatal Outcome; Female; | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Melatonin reduces acute lung inflammation, edema, and hemorrhage in heatstroke rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Bronchoalveolar Lavage Fluid; Fever; Heat Stroke; Hemorrha | 2012 |
Prevention of shock wave-induced renal oxidative stress by melatonin: an experimental study.
Topics: Animals; Free Radical Scavengers; Hemorrhage; Kidney; Kidney Diseases; Leukocyte Count; Lithotripsy; | 2004 |
The effect of haemorrhage and melatonin on neurohypophysial vasopressin and oxytocin content in pinealectomized male rats.
Topics: Animals; Hemorrhage; Male; Melatonin; Oxytocin; Pineal Gland; Pituitary Gland, Posterior; Rats; Rats | 1993 |
Hypothalamic and neurohypophysial vasopressin and oxytocin content as influenced by haemorrhage in melatonin-treated male rats.
Topics: Animals; Hemorrhage; Hypothalamus; Male; Melatonin; Oxytocin; Pituitary Gland, Posterior; Rats; Rats | 1993 |
Melatonin administration following hemorrhagic shock decreases mortality from subsequent septic challenge.
Topics: Animals; Body Weight; Cecum; Hemorrhage; Ligation; Male; Melatonin; Mice; Mice, Inbred C3H; Sepsis; | 1996 |
Melatonin improves cerebral circulation security margin in rats.
Topics: Animals; Blood Pressure; Carbon Dioxide; Cerebrovascular Circulation; Frontal Lobe; Heart Rate; Hemo | 1998 |