Page last updated: 2024-10-31

miconazole and Bleeding

miconazole has been researched along with Bleeding in 9 studies

Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.
miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.

Research Excerpts

ExcerptRelevanceReference
"Increases in the INR and cases of bleeding have been reported during concomitant use of miconazole oral gel or mucoadhesive buccal tablets and a vitamin K antagonist (fluindione or warfarin)."7.81Miconazole and oral anticoagulants: bleeding. ( , 2015)
"Increases in the INR and cases of bleeding have been reported during concomitant use of miconazole oral gel or mucoadhesive buccal tablets and a vitamin K antagonist (fluindione or warfarin)."3.81Miconazole and oral anticoagulants: bleeding. ( , 2015)
"Miconazole oral gel and topically applied nystatin solution have equally strong effects on warfarin activity and can provoke major bleeding."3.78Miconazole and nystatin used as topical antifungal drugs interact equally strongly with warfarin. ( Kovac, M; Kovac, Z; Mitic, G, 2012)
"Miconazole is a strong inhibitor of CYP2C9, one of the main enzymes involved in the metabolism of warfarin."2.47Warfarin and miconazole oral gel interactions: analysis and therapy recommendations based on clinical data and a pharmacokinetic model. ( Miki, A; Ohtani, H; Sawada, Y, 2011)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's1 (11.11)18.2507
2000's3 (33.33)29.6817
2010's4 (44.44)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
De Pauw, A1
De Backer, T1
Miki, A1
Ohtani, H1
Sawada, Y1
Kovac, M1
Mitic, G1
Kovac, Z1
Paul, R1
Watson, PG1
Lochan, RG1
Redding, VJ1
Evans, J1
Orme, DS1
Sedgwick, ML1
Youngs, GR1
Silingardi, M1
Ghirarduzzi, A1
Tincani, E1
Iorio, A1
Iori, I1
Murty, M1

Reviews

2 reviews available for miconazole and Bleeding

ArticleYear
Warfarin and miconazole oral gel interactions: analysis and therapy recommendations based on clinical data and a pharmacokinetic model.
    Journal of clinical pharmacy and therapeutics, 2011, Volume: 36, Issue:6

    Topics: Administration, Oral; Anticoagulants; Antifungal Agents; Biological Availability; Drug Interactions;

2011
Miconazole oral gel potentiates warfarin anticoagulant activity.
    Thrombosis and haemostasis, 2000, Volume: 83, Issue:5

    Topics: Administration, Oral; Aged; Anticoagulants; Antifungal Agents; Drug Synergism; Female; Gels; Hemorrh

2000

Other Studies

7 other studies available for miconazole and Bleeding

ArticleYear
Miconazole buccal gel and risk for systemic bleeding: how certain topical formula can interfere with anticoagulants.
    Acta clinica Belgica, 2015, Volume: 70, Issue:2

    Topics: Administration, Oral; Administration, Topical; Aged; Aged, 80 and over; Anticoagulants; Antifungal A

2015
Miconazole and oral anticoagulants: bleeding.
    Prescrire international, 2015, Volume: 24, Issue:156

    Topics: Administration, Buccal; Anticoagulants; Antifungal Agents; Blood Coagulation; Drug Interactions; Hem

2015
Miconazole and nystatin used as topical antifungal drugs interact equally strongly with warfarin.
    Journal of clinical pharmacy and therapeutics, 2012, Volume: 37, Issue:1

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anticoagulants; Antifungal Agents; Dose-Respon

2012
[Bleeding problems of a patient with hypothyroidism].
    Duodecim; laaketieteellinen aikakauskirja, 2002, Volume: 118, Issue:13

    Topics: Aged; Anemia; Anticoagulants; Antifungal Agents; Atrial Fibrillation; Drug Interactions; Ecchymosis;

2002
Drug interactions with coumarin derivative anticoagulants.
    British medical journal (Clinical research ed.), 1982, Oct-09, Volume: 285, Issue:6347

    Topics: Drug Interactions; Female; Hemorrhage; Humans; Imidazoles; Male; Miconazole; Middle Aged; Warfarin

1982
Treating oral candidiasis: potentially fatal.
    British dental journal, 1997, Jun-28, Volume: 182, Issue:12

    Topics: Administration, Oral; Administration, Topical; Aged; Anticoagulants; Antifungal Agents; Candidiasis,

1997
Miconazole-warfarin interaction: increased INR.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2001, Jul-10, Volume: 165, Issue:1

    Topics: Anticoagulants; Antifungal Agents; Blood Coagulation; Drug Interactions; Hemorrhage; Humans; Interna

2001