digitalin profile

digitalin: RN given refers to (3beta,5beta,16beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	441856
CHEMBL ID	505674
CHEBI ID	28143
SCHEMBL ID	310824
MeSH ID	M0106986

Synonym
gitoxigenin-glucodigitalosid
einecs 212-036-6
digitalum verum
digitalin (glycoside)
glucostrospeside
CHEBI:28143 ,
3beta-(6-deoxy-4-o-beta-d-glucopyranosyl-3-o-methyl-beta-d-galactopyranosyloxy)-14,16beta-dihydroxy-5beta-card-20(22)-enolide
752-61-4
C08862
gitoxigenin 3-o-glucosyldigitaloside
digitalin
CHEMBL505674
3-[(3s,5r,8r,9s,10s,13r,14s,16s,17r)-14,16-dihydroxy-3-[(2r,3r,4r,5s,6r)-3-hydroxy-4-methoxy-6-methyl-5-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta
diginorgin
unii-q15ece254b
q15ece254b ,
digitalinum true
schmiedebergs digitalin
digitalin [mi]
digitalin [mart.]
digitalinum
digitalinum [hpus]
digitalin [who-dd]
(3.beta.,5.beta.,16.beta.)-3-((6-deoxy-4-o-.beta.-d-glucopyranosyl-3-o-methyl-.beta.-d-galactopyranosyl)oxy)-14,16-dihydroxycard-20(22)-enolide
schmiedeberg's digitalin
SCHEMBL310824
digitalinum verum (glucostrospeside)
Q27103525
DTXSID801024550
digitalin (mart.)
(3beta,5beta,16beta)-3-((6-deoxy-4-o-beta-d-glucopyranosyl-3-o-methyl-beta-d-galactopyranosyl)oxy)-14,16-dihydroxycard-20(22)-enolide

Class	Description
cardenolide glycoside	Any member of the class of cardenolides with glycosyl residues attached to position 3.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Assay ID	Title	Year	Journal	Article
AID357577	Binding affinity to mouse Monoclonal antibody DIG 64.2B.5 by ELISA relative to digoxin
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	29 (96.67)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (3.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	2 (5.41%)	4.05%
Observational	0 (0.00%)	0.25%
Other	35 (94.59%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	1.93	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
amiodarone Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.. amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.	2.4	2	1-benzofurans; aromatic ketone; organoiodine compound; tertiary amino compound	cardiovascular drug
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	1.94	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
heptaminol Heptaminol: An amino alcohol that has been used as a myocardial stimulant and vasodilator and to relieve bronchospasm. Its most common therapeutic use is in orthostatic hypotension. The mechanism of heptaminol's therapeutic actions is not well understood although it has been suggested to affect catecholamine release or calcium metabolism.	6.93	1	tertiary alcohol
mechlorethamine nitrogen mustard : Compounds having two beta-haloalkyl groups bound to a nitrogen atom, as in (X-CH2-CH2)2NR.	1.94	1	nitrogen mustard; organochlorine compound	alkylating agent
thiotepa Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).	1.94	1	aziridines
rubidium chloride rubidium chloride : An inorganic chloride composed of rubidium and chloride ions in a 1:1 ratio.	6.93	1	inorganic chloride; rubidium molecular entity	antidepressant; biomarker
lanatosides Lanatosides: Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale, The Extra Pharmacopoeia, 30th ed, p670)	2.35	2
lithium chloride Lithium Chloride: A salt of lithium that has been used experimentally as an immunomodulator.. lithium chloride : A metal chloride salt with a Li(+) counterion.	6.93	1	inorganic chloride; lithium salt	antimanic drug; geroprotector
digitoxin Digitoxin: A cardiac glycoside sometimes used in place of DIGOXIN. It has a longer half-life than digoxin; toxic effects, which are similar to those of digoxin, are longer lasting. (From Martindale, The Extra Pharmacopoeia, 30th ed, p665). digitoxin : A cardenolide glycoside in which the 3beta-hydroxy group of digitoxigenin carries a 2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1->4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl trisaccharide chain.	2.63	3	cardenolide glycoside	EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor
glycosides [no description available]	6.93	1
lanatoside c lanatoside C: RN given refers to (3beta,5beta,12beta)-isomer	7.35	2
digoxin Digoxin: A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666). digoxin : A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.	1.97	1	cardenolide glycoside; steroid saponin	anti-arrhythmia drug; cardiotonic drug; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; epitope
lithium Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.	6.93	1	alkali metal atom
rubidium Rubidium: An element that is an alkali metal. It has an atomic symbol Rb, atomic number 37, and atomic weight 85.47. It is used as a chemical reagent and in the manufacture of photoelectric cells.	6.93	1	alkali metal atom

Condition	Relationship Strength	Studies
Chronic Illness [description not available]	1.93	1
Cardiac Failure [description not available]	3.03	5
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	1.93	1
Heart Failure A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.	8.03	5
Poisoning Used with drugs, chemicals, and industrial materials for human or animal poisoning, acute or chronic, whether the poisoning is accidental, occupational, suicidal, by medication error, or by environmental exposure.	6.93	1
Bleeding [description not available]	1.93	1
Hemorrhage Bleeding or escape of blood from a vessel.	6.93	1
Tachyarrhythmia [description not available]	2.34	2
Tachycardia Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.	2.34	2
Auricular Fibrillation [description not available]	2.66	3
Auricular Flutter [description not available]	1.94	1
Cardiac Complex, Premature [description not available]	1.94	1
A-V Dissociation [description not available]	2.34	2
Cardiovascular Stroke [description not available]	1.94	1
Paroxysmal Reciprocal Tachycardia [description not available]	1.94	1
Emesis [description not available]	2.34	2
Atrial Fibrillation Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.	2.66	3
Atrial Flutter Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).	1.94	1
Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).	1.94	1
Nausea An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.	2.34	2
Tachycardia, Paroxysmal Abnormally rapid heartbeats with sudden onset and cessation.	1.94	1
Vomiting The forcible expulsion of the contents of the STOMACH through the MOUTH.	2.34	2
Cardiac Diseases [description not available]	1.94	1
Heart Diseases Pathological conditions involving the HEART including its structural and functional abnormalities.	1.94	1
Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	2.33	2
Arteriosclerosis, Coronary [description not available]	2.03	1
Torsade de Pointes [description not available]	2.03	1
Coronary Artery Disease Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.	2.03	1
Arrhythmia [description not available]	1.96	1
Arrhythmias, Cardiac Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.	1.96	1
Plasma Cell Tumor [description not available]	1.96	1
Plasmacytoma Any discrete, presumably solitary, mass of neoplastic PLASMA CELLS either in BONE MARROW or various extramedullary sites.	1.96	1
Acute Disease Disease having a short and relatively severe course.	1.97	1

digitalin

Description

Cross-References

Synonyms (31)

Drug Classes (1)

Bioassays (1)

Research

Studies (30)

Market Indicators

Research Demand Index: 54.08

Study Types

digitalin

Description

Cross-References

Synonyms (31)

Drug Classes (1)

Bioassays (1)

Research

Studies (30)

Market Indicators

Research Demand Index: 54.08

Study Types

Related Drugs (15)

Related Conditions (33)