Page last updated: 2024-10-23

azathioprine and Bleeding

azathioprine has been researched along with Bleeding in 57 studies

Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
azathioprine : A thiopurine that is 6-mercaptopurine in which the mercapto hydrogen is replaced by a 1-methyl-4-nitroimidazol-5-yl group. It is a prodrug for mercaptopurine and is used as an immunosuppressant, prescribed for the treatment of inflammatory conditions and after organ transplantation and also for treatment of Crohn's didease and MS.

Research Excerpts

ExcerptRelevanceReference
"Current guidelines support the use of corticosteroids and azathioprine as one possible treatment strategy for idiopathic pulmonary fibrosis (IPF)."3.74Azathioprine and diffuse alveolar haemorrhage: the pharmacogenetics of thiopurine methyltransferase. ( Adhikari, NK; Cole, DE; Friedman, O; Mintz, S; Perri, D; Piliotis, E, 2007)
" The intracystic hemorrhage in our case may have been related to a rapid tumor growth due to weakened antitumor immunity and azathioprine-induced pancreatitis."3.70Intracystic hemorrhage of pancreatic serous cystadenoma after renal transplantation: report of a case. ( Baba, S; Fujita, K; Harada, M; Ishikawa, A; Konno, H; Nakamura, S; Sakaguchi, T; Suzuki, K; Suzuki, S; Ushiyama, T, 2000)
"We report a case of broncho-alveolar carcinoma (CBA) in a man of 64 who had been treated with azathioprine for severe myasthenia gravis."3.68[Bronchiolo-alveolar carcinoma complicating myasthenia treated by azathioprine]. ( Chatté, G; Langevin, B, 1993)
"Hematuria, arthralgias, and bleeding from subcutaneous and soft tissues developed in a 56-year-old man with an allergic background following a course of sulfisoxazole for urinary tract infection, Coagulation studies demonstrated the presence of an inhibitor to factor VIII in high titers."3.65Acquired circulating anticoagulant to factor VIII. Response to high doses of cryoprecipitate and immunosuppressive therapy. ( Brauer, MJ; Herzig, EG; Sise, HS; Vera, JC, 1975)
"Of these, alveolar hemorrhage is the most common and well-described hemorrhagic complication and is a prominent component of the pulmonary-renal syndrome."2.52Hemorrhagic complications associated with PR3-ANCA crescentic glomerulonephritis. ( Cao, Y; Li, W; Tian, Z; Wang, G; Yang, Y, 2015)
"If the vasculitis is secondary to an underlying disease, such as lymphoma, therapy should be directed at the primary disease."2.37Pulmonary vasculitis. ( Fauci, AS; Leavitt, RY, 1986)
"Diffuse alveolar hemorrhage is an uncommon and often fatal condition in children that is characterized by distinct histopathological etiologies."1.51Acute pulmonary embolism in a child with ANCA-negative Idiopathic Pulmonary Capillaritis. ( Asseri, AA; Daines, CL; Zeng, Y, 2019)
"Interstitial lung disease is a rare but recognised complication of rituximab but has been rarely reported in the setting of ITP."1.38Rituximab-induced interstitial lung disease in a patient with immune thrombocytopenia purpura. ( Berkahn, L; Child, N; O'Carroll, M, 2012)
"However, bleeding is rare in this syndrome."1.35Bleeding and thrombosis in a patient with secondary antiphospholipid syndrome. ( Abdallah, TB; Beji, S; El Younsi, F; Ezzine, S; Guermazi, S; Hamida, FB; Kaaroud, H; Kheder, A; Moussa, FB, 2008)
"Lupus anticoagulant hypoprothrombinemia syndrome (LAHPS) is a rare disorder characterized by a bleeding tendency due to factor II deficiency associated with the presence of lupus anticoagulant (LAC) autoantibodies."1.33Thromboembolism complicating the treatment of lupus anticoagulant hypoprothrombinemia syndrome. ( Rich, E; Senécal, JL; Vinet, E, 2006)
"Azathioprine was discontinued on day 26."1.29Azathioprine-induced pulmonary haemorrhage in a child after renal transplantation. ( Bensman, A; de Blic, J; Fauroux, B; Leroy, B; Refabert, L; Sinnassamy, P, 1995)
"Thus, differential diagnosis of Goodpasture's syndrome (and probably of any "pulmonary renal syndrome") should include azathioprine hypersensitivity."1.29Azathioprine hypersensitivity mimicking Goodpasture's syndrome. ( Krapf, R; Schmidl, M; Stetter, M, 1994)
"Rheumatoid arthritis was present in 8% of the cases, 7% occurred during pregnancy or the post-partum period, and in several there was an association with allergy to penicillin, asthma, "auto-immune" diseases, or malignancy."1.26A survey of 215 non-hemophilic patients with inhibitors to Factor VIII. ( Green, D; Lechner, K, 1981)
"A case of Goodpasture's syndrome is described in which bilateral nephrectomy was undertaken because of massive pulmonary hemorrhage."1.25Bilateral nephrectomy for massive pulmonary hemorrhage in Goodpasture's syndrome. ( Ackman, CF; Hawkins, D; Silverman, M, 1973)

Research

Studies (57)

TimeframeStudies, this research(%)All Research%
pre-199033 (57.89)18.7374
1990's3 (5.26)18.2507
2000's6 (10.53)29.6817
2010's13 (22.81)24.3611
2020's2 (3.51)2.80

Authors

AuthorsStudies
Saha, BK1
Osman, A1
Galiatsatos, P1
Bose, S1
Danoff, S1
Taşkıran, EZ1
Sönmez, HE1
Ayvaz, DÇ1
Koşukcu, C1
Batu, ED1
Esenboğa, S1
Topaloğlu, R1
Orhan, D1
Bilginer, Y1
Alikaşifoğlu, M1
Özen, S1
Tezcan, İ1
Degheili, JA1
El-Asmar, JM1
Bustros, GD1
Mansour, MM1
Nasr, RW1
Yachoui, R1
Sehgal, R1
Amlani, B1
Goldberg, JW1
Cao, Y1
Tian, Z1
Li, W1
Yang, Y1
Wang, G1
Hori, I1
Nakaseko, H1
Kamei, M1
Nomura, T1
Iwata, N1
Ito, Y1
Saitoh, S1
Freitas, A1
Senra, V1
Marinho, A1
Guedes, M1
Cabral, DA1
Canter, DL1
Muscal, E1
Nanda, K1
Wahezi, DM1
Spalding, SJ1
Twilt, M1
Benseler, SM1
Campillo, S1
Charuvanij, S1
Dancey, P1
Eberhard, BA1
Elder, ME1
Hersh, A1
Higgins, GC1
Huber, AM1
Khubchandani, R1
Kim, S1
Klein-Gitelman, M1
Kostik, MM1
Lawson, EF1
Lee, T1
Lubieniecka, JM1
McCurdy, D1
Moorthy, LN1
Morishita, KA1
Nielsen, SM1
O'Neil, KM1
Reiff, A1
Ristic, G1
Robinson, AB1
Sarmiento, A1
Shenoi, S1
Toth, MB1
Van Mater, HA1
Wagner-Weiner, L1
Weiss, JE1
White, AJ1
Yeung, RS1
Trapani, S1
Mariotti, P1
Resti, M1
Nappini, L1
de Martino, M1
Falcini, F1
Krumsiek, A1
Poggemann, V1
Wertzel, H1
Achenbach, HJ1
Lynch, JP1
Tazelaar, H1
Irioka, T1
Mizusawa, H1
Child, N1
O'Carroll, M1
Berkahn, L1
STEINER, B1
NABRADY, J1
STRAFFON, RA1
NAKAMOTO, S1
KOLFF, WJ1
Tsai, CL1
Lu, TC1
Chen, WJ1
Vinet, E1
Rich, E1
Senécal, JL1
Willms, H1
Gutjahr, K1
Juergens, UR1
Hammerschmidt, S1
Gessner, C1
Hoheisel, G1
Wirtz, H1
Gillissen, A1
Perri, D1
Cole, DE1
Friedman, O1
Piliotis, E1
Mintz, S1
Adhikari, NK1
Kaaroud, H1
Beji, S1
Guermazi, S1
Moussa, FB1
Hamida, FB1
Ezzine, S1
Abdallah, TB1
El Younsi, F1
Kheder, A1
Wahn, V1
Göbel, U1
Ebell, W1
Jürgens, H1
Green, D2
Lechner, K1
Refabert, L1
Sinnassamy, P1
Leroy, B1
Fauroux, B1
de Blic, J1
Bensman, A1
Stetter, M1
Schmidl, M1
Krapf, R1
Chatté, G1
Langevin, B1
Sakaguchi, T1
Nakamura, S1
Suzuki, S1
Konno, H1
Fujita, K1
Suzuki, K1
Ushiyama, T1
Ishikawa, A1
Harada, M1
Baba, S1
Simons, SM1
Main, CA1
Yaish, HM1
Rutzky, J1
Kerstein, MD1
Grabman, JP1
Rubin, R1
Niemetz, J1
Estren, S1
Dickerman, RM1
Twiest, MW1
Crudup, JW1
Turcotte, JG1
Vera, JC1
Herzig, EG1
Sise, HS1
Brauer, MJ1
Leavitt, RY1
Fauci, AS1
d'Ardenne, AJ1
Dunnill, MS1
Thompson, JF1
McWhinnie, D1
Wood, RF1
Morris, PJ1
Clutterbuck, EJ1
Pusey, CD1
Lorber, MI1
Flechner, SM1
Van Buren, CT1
Kerman, RH1
Kahan, BD1
Calne, RY1
White, HJ1
Herbertson, BM1
Millard, PR1
Davis, DR1
Salaman, JR1
Samuel, JR1
Robson, GS1
Mackay, IR1
Onuora, CA1
Lindenbaum, J1
Nossel, HL1
Moreux, J1
Huguet, C1
Huguier, M1
Martin, E1
Bloch, P1
Khedroo, LG1
Arieff, AI1
Pinggera, WF1
Bell, MJ1
Martin, LW1
Gonzales, LL1
McEnery, PT1
West, CD1
Williams, GM1
Sterioff, S1
Bias, W1
Fiala, M1
Payne, JE1
Berne, TV1
Poolsawat, S1
Schieble, J1
Guze, LB1
Silverman, M1
Hawkins, D1
Ackman, CF1
Breslin, AB1
Morgan, JJ1
Seldon, WA1
Shanahan, MX1
Lower, RR1
Kosek, JC1
Kemp, VE1
Graham, WH1
Sewell, DH1
Lim, F1
Nowakowski, A1
Grove, RB1
King, LH1
Antonovych, TT1
Fortner, RW1
Knieser, MR1
Carter, CB1
Knepshield, JH1
Gondos, B1
White, P1
Benfield, JR1
Rizza, CR1
Edgcumbe, JO1
Pitney, WR1
Child, JA1
Rochon, M1
Neemeh, JA1
Gosselin, G1
Long, LA1
Soria, C1
Soria, J1
Girard, M1
Lejeay, A1
Kahn, MF1
Guérin, C1
de Sèze, S1
Prince, HN1
Grunberg, E1
Guisan, M1
Bircher, J1
Kistler, HJ1
Asseri, AA1
Zeng, Y1
Daines, CL1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Chronotherapy in Inflammatory Bowel Disease[NCT04304950]Phase 428 participants (Actual)Interventional2016-04-25Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

6-Methylmercaptopurine Levels in Blood

This is to examine if the intervention results in a lower level of 6-Methylmercaptopurine in the participants. If so, the participants are expected to have less symptom severity. Comparing baseline taken at visit one to visit two levels 10 weeks after intervention start. (NCT04304950)
Timeframe: 10 weeks post baseline visit.

Interventionpmol/8 x 10 ^8 RBC (Mean)
Evening Group Medication Administration2395.27
Morning Group Medication Administration825.15

Harvey Bradshaw Activity Index

Harvey Bradshaw Activity Index has 5 questions. The final score is totaled and will fall into the following categories, which are used to define the severity of the disease: >16 severe diseases, 8-16 moderate disease, 5-7 mild disease, <5 remission. Scores range from 0 ( lowest possible score) to 17. (NCT04304950)
Timeframe: 10 weeks post baseline visit.

Interventionunits on a scale (Mean)
Evening Group Medication Administration2.15
Morning Group Medication Administration3.09

Munich Chronotype Questionnaire ( MCTQ)

This questionnaire is used to collect primary sleep times, such as bed- and rise-times, including the time a person is fully awake, sleep latency and inertia, in addition to other time points. The MCTQ uses the midpoint of sleep between sleep onset and offset to assess chronotype. Chronotype is your body's natural time to be awake or asleep at certain times. Total scores can range from 16 to 86, with the lowest values representing extreme-late chronotype. For this study corrected midpoint of sleep (MSFc) was calculated. This information is combined to determine the mean time of day at which respondents were more likely to feel most alert. The numbers provided in the outcome measure data table represent time (hour and minute). The hour has been converted to military time and the minutes were converted to decimals. (NCT04304950)
Timeframe: 10 weeks post baseline visit.

Interventionhours (Mean)
Evening Group Medication Administration3.70
Morning Group Medication Administraion2.57

Short Inflammatory Bowel Disease Questionnaire

Quality of Life Measure Score:1-7 (The higher the number the greater the quality of life) (NCT04304950)
Timeframe: 10 weeks post baseline visit.

Interventionunits on a scale (Mean)
Evening Group Medication Administration5.83
Morning Group Medication Administration5.91

Thioguanine Levels in Blood (Morning Versus Evening Dosing)

This is to examine if the intervention results in a greater level of thioguanine in the participants. If so, the participants are expected to have less symptom severity. Comparing baseline taken at visit one to visit two levels 10 weeks after intervention start. (NCT04304950)
Timeframe: 10 weeks post baseline visit.

Interventionpmol/8 x 10^8 RBC (Mean)
Evening Group Medication Administration175.04
Morning Group Medication Administration225.65

Reviews

3 reviews available for azathioprine and Bleeding

ArticleYear
Hemorrhagic complications associated with PR3-ANCA crescentic glomerulonephritis.
    Renal failure, 2015, Volume: 37, Issue:5

    Topics: Aged; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutrophil Cytopla

2015
Severe hemorrhagic bullous lesions in Henoch Schonlein purpura: three pediatric cases and review of the literature.
    Rheumatology international, 2010, Volume: 30, Issue:10

    Topics: Azathioprine; Blister; Child; Female; Glucocorticoids; Hemorrhage; Humans; IgA Vasculitis; Immunosup

2010
Pulmonary vasculitis.
    The American review of respiratory disease, 1986, Volume: 134, Issue:1

    Topics: Adrenal Cortex Hormones; Azathioprine; Behcet Syndrome; Chlorambucil; Connective Tissue Diseases; Cy

1986

Other Studies

54 other studies available for azathioprine and Bleeding

ArticleYear
Determining the threshold for azathioprine use in recurrent diffuse alveolar hemorrhage in idiopathic pulmonary hemosiderosis.
    The American journal of the medical sciences, 2023, Volume: 366, Issue:2

    Topics: Azathioprine; Hemorrhage; Hemosiderosis; Humans; Lung Diseases

2023
Rheumatoid arthritis causing diffuse alveolar haemorrhage: a novel therapeutic approach.
    BMJ case reports, 2017, Jun-14, Volume: 2017

    Topics: Adult; Arthritis, Rheumatoid; Azathioprine; Diagnosis, Differential; Drug Administration Schedule; F

2017
Hypomorphic RAG1 defect in a child presented with pulmonary hemorrhage and digital necrosis.
    Clinical immunology (Orlando, Fla.), 2018, Volume: 187

    Topics: Anemia, Hemolytic; Azathioprine; Child, Preschool; Consanguinity; Cyclophosphamide; Diagnostic Error

2018
Bleeding Scrotal Varicosity Secondary to Behçet Disease.
    Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases, 2020, Volume: 26, Issue:3

    Topics: Azathioprine; Behcet Syndrome; Colchicine; Hemorrhage; Humans; Male; Middle Aged; Platelet Aggregati

2020
Antiphospholipid antibodies-associated diffuse alveolar hemorrhage.
    Seminars in arthritis and rheumatism, 2015, Volume: 44, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Aged; Antibodies, Antiphospholipid; Antiphospholipid Syndrome; Azath

2015
Diffuse alveolar hemorrhage secondary to ANCA-associated vasculitis in a patient with Down syndrome.
    Pediatrics international : official journal of the Japan Pediatric Society, 2015, Volume: 57, Issue:2

    Topics: Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Azathioprine; Child, Preschool; Down Syn

2015
Chronic alveolar haemorrhage in a paediatric patient: a diagnostic and treatment challenge.
    BMJ case reports, 2015, Apr-21, Volume: 2015

    Topics: Adolescent; Adrenal Cortex Hormones; Antibodies, Antineutrophil Cytoplasmic; Azathioprine; Biopsy; C

2015
Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's): An ARChiVe Cohort Study.
    Arthritis & rheumatology (Hoboken, N.J.), 2016, Volume: 68, Issue:10

    Topics: Adolescent; Adrenal Cortex Hormones; Age Distribution; Antibodies, Antineutrophil Cytoplasmic; Asia;

2016
[Recurrent hemoptysis in a 29-year old woman].
    Der Internist, 2010, Volume: 51, Issue:12

    Topics: Adult; Anemia; Anti-Inflammatory Agents; Azathioprine; Biopsy; Bronchoscopy; Combined Modality Thera

2010
Wegener granulomatosis (granulomatosis with polyangiitis): evolving concepts in treatment.
    Seminars in respiratory and critical care medicine, 2011, Volume: 32, Issue:3

    Topics: Adrenal Cortex Hormones; Age Factors; Aged; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Cy

2011
Hemorrhagic bulla in Churg-Strauss syndrome.
    Internal medicine (Tokyo, Japan), 2011, Volume: 50, Issue:19

    Topics: Adrenal Cortex Hormones; Azathioprine; Churg-Strauss Syndrome; Hemorrhage; Humans; Leg; Male; Middle

2011
Rituximab-induced interstitial lung disease in a patient with immune thrombocytopenia purpura.
    Internal medicine journal, 2012, Volume: 42, Issue:3

    Topics: Aged, 80 and over; Antibodies, Monoclonal, Murine-Derived; Azathioprine; Combined Modality Therapy;

2012
[IMMUNOALLERGIC PULMONARY HEMORRHAGE TREATED WITH IMURAN. (PRELIMINARY REPORT)].
    Orvosi hetilap, 1964, Dec-06, Volume: 105

    Topics: Adolescent; Antineoplastic Agents; Azathioprine; Dexamethasone; Drug Therapy; Hemoptysis; Hemorrhage

1964
CLINICAL EXPERIENCE WITH RENAL TRANSPLANTATION.
    British journal of urology, 1965, Volume: 37

    Topics: Azathioprine; Cadaver; Dactinomycin; Drug Therapy; Hemorrhage; Humans; Hypertension; Immunosuppressi

1965
Spontaneous retroperitoneal bleeding in a patient with Evans syndrome.
    Annals of hematology, 2004, Volume: 83, Issue:12

    Topics: Adult; Anemia, Hemolytic; Angiography; Anti-Inflammatory Agents; Antimetabolites; Azathioprine; Fema

2004
Thromboembolism complicating the treatment of lupus anticoagulant hypoprothrombinemia syndrome.
    The Journal of rheumatology, 2006, Volume: 33, Issue:10

    Topics: Adrenal Cortex Hormones; Antiphospholipid Syndrome; Azathioprine; Central Nervous System Diseases; C

2006
[Diagnostics and therapy of idiopathic pulmonary hemosiderosis].
    Medizinische Klinik (Munich, Germany : 1983), 2007, Jun-15, Volume: 102, Issue:6

    Topics: Adult; Anemia, Iron-Deficiency; Azathioprine; Biopsy; Bronchoscopy; Diagnosis, Differential; Hemopty

2007
Azathioprine and diffuse alveolar haemorrhage: the pharmacogenetics of thiopurine methyltransferase.
    The European respiratory journal, 2007, Volume: 30, Issue:5

    Topics: Azathioprine; Female; Hemorrhage; Humans; Immunosuppressive Agents; Lung Diseases; Male; Methyltrans

2007
Bleeding and thrombosis in a patient with secondary antiphospholipid syndrome.
    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2008, Volume: 19, Issue:2

    Topics: Adrenal Cortex Hormones; Adult; Anticoagulants; Antiphospholipid Syndrome; Azathioprine; Female; Hem

2008
[Therapy of acute pulmonary hemorrhage in systemic lupus erythematosus].
    MMW, Munchener medizinische Wochenschrift, 1980, Mar-21, Volume: 122, Issue:12

    Topics: Azathioprine; Child; Hematuria; Hemorrhage; Humans; Lung; Lupus Erythematosus, Systemic; Male; Predn

1980
A survey of 215 non-hemophilic patients with inhibitors to Factor VIII.
    Thrombosis and haemostasis, 1981, Jun-30, Volume: 45, Issue:3

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Arthritis, Rheumatoid; Azathioprine; Child; Child, Presc

1981
Azathioprine-induced pulmonary haemorrhage in a child after renal transplantation.
    Pediatric nephrology (Berlin, Germany), 1995, Volume: 9, Issue:4

    Topics: Acute Disease; Adolescent; Azathioprine; Chemotaxis, Leukocyte; Hemorrhage; Humans; Immunosuppressiv

1995
Azathioprine hypersensitivity mimicking Goodpasture's syndrome.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1994, Volume: 23, Issue:6

    Topics: Adult; Anti-Glomerular Basement Membrane Disease; Azathioprine; Diagnosis, Differential; Drug Hypers

1994
[Bronchiolo-alveolar carcinoma complicating myasthenia treated by azathioprine].
    Revue des maladies respiratoires, 1993, Volume: 10, Issue:5

    Topics: Adenocarcinoma, Bronchiolo-Alveolar; Azathioprine; Hemorrhage; Humans; Lung Diseases; Lung Neoplasms

1993
Intracystic hemorrhage of pancreatic serous cystadenoma after renal transplantation: report of a case.
    Surgery today, 2000, Volume: 30, Issue:7

    Topics: Adult; Azathioprine; Cystadenoma, Serous; Disease Progression; Hemorrhage; Humans; Immunosuppressive

2000
Idiopathic thrombocytopenic purpura in children.
    The Journal of pediatrics, 1975, Volume: 87, Issue:1

    Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Age Factors; Azathioprine; Blood P

1975
Azathioprine as a treatment modality in acute hemorrhagic pancreatitis.
    Surgical forum, 1978, Volume: 29

    Topics: Acute Disease; Animals; Azathioprine; Dogs; Hemorrhage; Pancreatic Diseases; Pancreatitis; Survival

1978
Use of animal AHG concentrates (factor VIII) in the treatment of life-threatening hemorrhage in patients with factor VIII antibodies.
    Annals of the New York Academy of Sciences, 1975, Jan-20, Volume: 240

    Topics: Airway Obstruction; Animals; Antibodies; Anticoagulants; Azathioprine; Blood Transfusion; Cattle; Cy

1975
Transplantation of the pancreas into a retroperitoneal jejunal loop.
    American journal of surgery, 1975, Volume: 129, Issue:1

    Topics: Animals; Azathioprine; Blood Glucose; Diabetes Mellitus; Dogs; Graft Rejection; Hemorrhage; Immunosu

1975
Acquired circulating anticoagulant to factor VIII. Response to high doses of cryoprecipitate and immunosuppressive therapy.
    JAMA, 1975, Jun-09, Volume: 232, Issue:10

    Topics: Antibodies; Antibody Formation; Azathioprine; Blood Coagulation Tests; Cryoglobulins; Factor VIII; H

1975
Cyclosporin and renal graft histology.
    Journal of clinical pathology, 1986, Volume: 39, Issue:2

    Topics: Azathioprine; Creatinine; Cyclosporins; Graft Rejection; Hemorrhage; Humans; Kidney; Kidney Diseases

1986
Severe alveolar haemorrhage in Churg-Strauss syndrome.
    European journal of respiratory diseases, 1987, Volume: 71, Issue:3

    Topics: Adult; Asthma; Azathioprine; Cyclophosphamide; Female; Glucocorticoids; Hemorrhage; Humans; Lung Dis

1987
Cyclosporine, azathioprine, and prednisone as treatment for cyclosporine-induced nephrotoxicity in renal transplant recipients.
    Transplantation proceedings, 1985, Volume: 17, Issue:4 Suppl 1

    Topics: Adult; Azathioprine; Cyclosporins; Drug Therapy, Combination; Female; Hemorrhage; Humans; Immunosupp

1985
Pig-to-baboon liver xenografts.
    Lancet (London, England), 1968, Jun-01, Volume: 1, Issue:7553

    Topics: Animals; Azathioprine; Bronchopneumonia; Fibrinogen; Hemorrhage; Hominidae; Liver; Liver Transplanta

1968
Generalized cytomegalovirus infection in a patient with lupoid hepatitis.
    Australasian annals of medicine, 1969, Volume: 18, Issue:2

    Topics: Adult; Autoantibodies; Azathioprine; Cytomegalovirus Infections; Edema; Esophagus; Female; Hemorrhag

1969
Massive hemorrhage associated with circulating antibodies to factor V.
    The American journal of the medical sciences, 1973, Volume: 265, Issue:5

    Topics: Adult; Aged; Animals; Antibodies; Azathioprine; Blood Coagulation Disorders; Blood Coagulation Facto

1973
[Orthotopic transplantation of the liver in the dog. Report of 50 cases. Trial of an antilymphocyte serum].
    Journal de chirurgie, 1972, Volume: 103, Issue:4

    Topics: Animals; Antilymphocyte Serum; Azathioprine; Bilirubin; Blood Cell Count; Blood Coagulation Disorder

1972
Application of therapeutic agents to alter the course of acute hemorrhagic pancreatitis in dogs.
    International surgery, 1974, Volume: 59, Issue:5

    Topics: Acute Disease; Aminocaproates; Animals; Aprotinin; Azathioprine; Bile; Bile Ducts; Convalescence; Do

1974
Rapidly progressive glomerulonephritis treated with anticoagulants.
    Archives of internal medicine, 1972, Volume: 129, Issue:1

    Topics: Adult; Aged; Anticoagulants; Azathioprine; Blood Urea Nitrogen; Creatinine; Dipyridamole; Diuresis;

1972
Alternate-day single-dose prednisone therapy: a method of reducing steroid toxicity.
    Journal of pediatric surgery, 1972, Volume: 7, Issue:2

    Topics: Adolescent; Adult; Azathioprine; Bacterial Infections; Bone Diseases; Cataract; Child; Child, Presch

1972
Hyperacute and acute fulminating rejection of human renal allografts.
    Transplantation proceedings, 1972, Volume: 4, Issue:4

    Topics: Antibodies; Antilymphocyte Serum; Azathioprine; Cytotoxicity Tests, Immunologic; Graft Rejection; He

1972
Role of adenovirus type 11 in hemorrhagic cystitis secondary to immunosuppression.
    The Journal of urology, 1974, Volume: 112, Issue:5

    Topics: Adenoviridae; Antibodies, Viral; Azathioprine; Complement Fixation Tests; Cyclophosphamide; Cystitis

1974
Bilateral nephrectomy for massive pulmonary hemorrhage in Goodpasture's syndrome.
    Canadian Medical Association journal, 1973, Feb-03, Volume: 108, Issue:3

    Topics: Adolescent; Anti-Glomerular Basement Membrane Disease; Azathioprine; Female; Hematocrit; Hemorrhage;

1973
A heart transplantation. 5. Postoperative medical aspects.
    The Medical journal of Australia, 1969, Mar-29, Volume: 1, Issue:13

    Topics: Anti-Bacterial Agents; Antilymphocyte Serum; Arrhythmias, Cardiac; Australia; Azathioprine; Betameth

1969
Rejection of the cardiac transplant.
    The American journal of cardiology, 1969, Volume: 24, Issue:4

    Topics: Acute Disease; Adult; Animals; Arteries; Azathioprine; Chronic Disease; Coronary Vessels; Dogs; Edem

1969
Goodpasture's syndrome: recovery from severe pulmonary hemorrhage after bilateral nephrectomy.
    Annals of internal medicine, 1971, Volume: 75, Issue:2

    Topics: Adult; Anti-Glomerular Basement Membrane Disease; Autoantibodies; Azathioprine; Complement System Pr

1971
Histologic changes associated with rejection of canine lung transplants.
    The Journal of thoracic and cardiovascular surgery, 1971, Volume: 62, Issue:2

    Topics: Animals; Azathioprine; Biopsy; Dogs; Edema; Graft Rejection; Hemorrhage; Immunosuppression Therapy;

1971
The treatment of patients having spontaneously occurring antibodies to antihaemophilic factor (factor VIII).
    Thrombosis et diathesis haemorrhagica, 1972, Aug-31, Volume: 28, Issue:1

    Topics: Autoantibodies; Azathioprine; Blood Coagulation Disorders; Blood Coagulation Tests; Cryoglobulins; C

1972
[Cryptogenic anti-8 inhibitor].
    L'union medicale du Canada, 1971, Volume: 100, Issue:12

    Topics: Azathioprine; Blood Chemical Analysis; Blood Coagulation Disorders; Cholecystectomy; Ecchymosis; Fac

1971
Suppression of an antibody to factor VIII by a combination of factor VIII and cyclophosphamide.
    Blood, 1971, Volume: 37, Issue:4

    Topics: Antibodies; Antigen-Antibody Reactions; Antigens; Azathioprine; Blood Coagulation Disorders; Blood C

1971
[Rheumatoid arthritis and circulating antifactor 8 anticoagulant of immunoglobulin (IgG) nature. Apropos of a case treated with azathioprine].
    Revue du rhumatisme et des maladies osteo-articulaires, 1971, Volume: 38, Issue:3

    Topics: Aged; Antibodies; Anticoagulants; Arthritis, Rheumatoid; Autoimmune Diseases; Azathioprine; Factor V

1971
Leukemia L 1210 homograft in Swiss mice: immunologic, cellular and chemotherapeutic responses.
    Journal of immunology (Baltimore, Md. : 1950), 1969, Volume: 103, Issue:2

    Topics: Animals; Antibody Formation; Azathioprine; Complement System Proteins; Cortisone; Hemagglutination T

1969
[Apropos of differential diagnosis of pulmonary hemosiderosis].
    Schweizerische medizinische Wochenschrift, 1966, Oct-29, Volume: 96, Issue:43

    Topics: Adult; Anemia, Hypochromic; Anti-Glomerular Basement Membrane Disease; Azathioprine; Diagnosis, Diff

1966
Acute pulmonary embolism in a child with ANCA-negative Idiopathic Pulmonary Capillaritis.
    Saudi medical journal, 2019, Volume: 40, Issue:6

    Topics: Acute Disease; Antibodies, Antineutrophil Cytoplasmic; Capillaries; Chest Pain; Child; Female; Hemor

2019