Compounds > 3,7-diazabicyclo(3.3.1)nonane
Page last updated: 2024-12-08

3,7-diazabicyclo(3.3.1)nonane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3,7-diazabicyclo(3.3.1)nonane: 7-aza analog of azabicyclane; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID192720
CHEMBL ID3094064
SCHEMBL ID233307
SCHEMBL ID15996717
MeSH IDM0058294

Synonyms (18)

Synonym
3,7-diazabicyclo(3.3.1)nonane
AKOS005166853
3,7-diazabicyclo[3.3.1]nonane
280-74-0
EN300-90605
AKOS006330969
unii-ch6vdh22tl
ch6vdh22tl ,
SCHEMBL233307
PTPQJKANBKHDPM-UHFFFAOYSA-N
3.7-diazabicyclo[3.3.1]nonane
bispidine
CHEMBL3094064
SCHEMBL15996717
DTXSID90182283
CS-0267414
Q866620
bispidin

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The pharmacokinetics and bioavailability of a derivative of 3,7-diazabicyclo[3."( [Pharmacokinetic properties of an innovative nootropic agent based on a derivative of 3,7-diazabicyclo[3.3.1]nonane].
Beregovykh, VV; Brkich, GE; Filippova, OV; Nedorubov, AA; Pyatigorskaya, NV; Zyryanov, OA, 2020)		0.56

Dosage Studied

ExcerptRelevanceReference
"3%, thus suggesting the prospect of creating dosage forms for oral administration."( [Pharmacokinetic properties of an innovative nootropic agent based on a derivative of 3,7-diazabicyclo[3.3.1]nonane].
Beregovykh, VV; Brkich, GE; Filippova, OV; Nedorubov, AA; Pyatigorskaya, NV; Zyryanov, OA, 2020)		0.56
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (3)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)Ki0.60000.00000.12345.5000AID1057409
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)Ki0.60000.00000.10825.5000AID1057409
Neuronal acetylcholine receptor subunit alpha-7Rattus norvegicus (Norway rat)Ki1.00000.00000.73078.0000AID1057407
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID1057399Agonist activity at mouse alpha1beta1epsilondelta nAChR expressed in Xenopus laevis oocytes at 1 uM incubated for 8 secs followed by compound washout for 241 secs by Two-electrode voltage clamp assay2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.
AID1057402Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes at 10 uM incubated for 12 secs followed by compound washout for 181 secs by Two-electrode voltage clamp assay2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.
AID1057392Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes at 1 uM incubated for 12 secs followed by compound washout for 181 secs by Two-electrode voltage clamp assay2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.
AID1057409Displacement of [3H]epibatidine from alpha4beta2 nAChR in Sprague-Dawley rat forebrain P2 fraction after 90 mins by liquid scintillation counting analysis2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.
AID1057408Displacement of [3H]epibatidine from alpha3beta4 nAChR in calf adrenal membranes fraction after 90 mins by liquid scintillation counting analysis2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.
AID1057400Agonist activity at human alpha4beta2 nAChR expressed in Xenopus laevis oocytes at 1 uM incubated for 8 secs followed by compound washout for 241 secs by Two-electrode voltage clamp assay2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.
AID1057407Displacement of [3H]methyllycaconitine from alpha7 nAChR in Sprague-Dawley rat forebrain P2 fraction after 90 mins by liquid scintillation counting analysis2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.
AID1057406Displacement of [3H]epibatidine from (alpha1)2beta1gammadelta nAChR in Torpedo californica electroplax after 90 mins by liquid scintillation counting analysis2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.
AID1057401Agonist activity at human alpha3beta4 nAChR expressed in Xenopus laevis oocytes at 10 uM incubated for 8 secs followed by compound washout for 241 secs by Two-electrode voltage clamp assay2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.
AID1057391Agonist activity at human alpha3beta4 nAChR expressed in Xenopus laevis oocytes at 1 uM incubated for 8 secs followed by compound washout for 241 secs by Two-electrode voltage clamp assay2013Bioorganic & medicinal chemistry, Dec-01, Volume: 21, Issue:23
The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor (nAChR) ligands. Part 1: the influence of different hydrogen bond acceptor systems on alkyl and (hetero)aryl substituents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (63)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's17 (26.98)29.6817
2010's33 (52.38)24.3611
2020's13 (20.63)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.61

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.61 (24.57)
Research Supply Index4.16 (2.92)
Research Growth Index4.77 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.61)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (3.17%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other61 (96.83%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
1-octanol
1-Octanol: A colorless, slightly viscous liquid used as a defoaming or wetting agent. It is also used as a solvent for protective coatings, waxes, and oils, and as a raw material for plasticizers. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed). octan-1-ol : An octanol carrying the hydroxy group at position 1.		2.0810octanol;
primary alcohol		antifungal agent;
bacterial metabolite;
fuel additive;
kairomone;
plant metabolite
pyridine
azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.		2.4420azaarene;
mancude organic heteromonocyclic parent;
monocyclic heteroarene;
pyridines		environmental contaminant;
NMR chemical shift reference compound
oxyquinoline
Oxyquinoline: An antiseptic with mild fungistatic, bacteriostatic, anthelmintic, and amebicidal action. It is also used as a reagent and metal chelator, as a carrier for radio-indium for diagnostic purposes, and its halogenated derivatives are used in addition as topical anti-infective agents and oral antiamebics.. quinolin-8-ol : A monohydroxyquinoline that is quinoline substituted by a hydroxy group at position 8. Its fungicidal properties are used for the control of grey mould on vines and tomatoes.		2.2110monohydroxyquinolineantibacterial agent;
antifungal agrochemical;
antiseptic drug;
iron chelator
dibenzothiophene
dibenzothiophene : A mancude organic heterotricyclic parent that consists of a thiophene ring flanked by two benzene rings ortho-fused across the 2,3- and 4,5-positions.		2.1110dibenzothiophenes;
mancude organic heterotricyclic parent		keratolytic drug
tryptophan
Tryptophan: An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.. tryptophan : An alpha-amino acid that is alanine bearing an indol-3-yl substituent at position 3.		2.6320erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid zwitterion;
L-alpha-amino acid;
proteinogenic amino acid;
tryptophan zwitterion;
tryptophan		antidepressant;
Escherichia coli metabolite;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite
phthalimide
phthalimide: RN given refers to parent cpd. phthalimide : A dicarboximide that is 2,3-dihydro-1H-isoindole substituted by oxo groups at positions 1 and 3.		2.0710phthalimides
quinoxalines
quinoxaline : A naphthyridine in which the nitrogens are at positions 1 and 4.		2.0810mancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene
pyrrolidonecarboxylic acid
Pyrrolidonecarboxylic Acid: A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.. 5-oxo-L-proline : An optically active form of 5-oxoproline having L-configuration.		2.13105-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid		algal metabolite
methylphenylsulfide
thioanisole : An aryl sulfide that is thiophenol in which the hydrogen of the thiol group has been replaced by a methyl group.		2.5520aryl sulfide;
benzenes
methyl malonate
methyl malonate: do not confuse with methylmalonate, i.e., malonic acid substituted with a methyl group on C2; structure		2.0210
thiophenes
Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.		2.1110mancude organic heteromonocyclic parent;
monocyclic heteroarene;
thiophenes;
volatile organic compound		non-polar solvent
cyclohexane
Cyclohexane: C6H12. cyclohexane : An alicyclic hydrocarbon comprising a ring of six carbon atoms; the cyclic form of hexane, used as a raw material in the manufacture of nylon.		2.4520cycloalkane;
volatile organic compound		non-polar solvent
nonane
iotrochotin: toxin from the Caribbean sponge Iotrochota birotulata, which selectively permeabilizes synaptosomes. nonane : A straight chain alkane composed of 9 carbon atoms.		2.5720alkaneplant metabolite;
volatile oil component
thiazoles
[no description available]		2.1101,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
cytisine
[no description available]		2.7530alkaloid;
bridged compound;
lactam;
organic heterotricyclic compound;
secondary amino compound		nicotinic acetylcholine receptor agonist;
phytotoxin;
plant metabolite
sodium hydroxide
Sodium Hydroxide: A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)		2.1110alkali metal hydroxide
lutetium
Lutetium: An element of the rare earth family of metals. It has the atomic symbol Lu, atomic number 71, and atomic weight 175.		2.2110d-block element atom;
lanthanoid atom
manganese
Manganese: A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035). manganese(4+) : A manganese cation that is monoatomic and has a formal charge of +4.		2.1110elemental manganese;
manganese group element atom		Escherichia coli metabolite;
micronutrient
ruthenium
Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.		2.0610iron group element atom;
platinum group metal atom
pyrene
pyrene: structure in Merck Index, 9th ed, #7746. pyrene : An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.		2.1310ortho- and peri-fused polycyclic arenefluorescent probe;
persistent organic pollutant
alkenes
[no description available]		2.4420
thiazolyl blue
thiazolyl blue: RN & II refers to bromide. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide : The bromide salt of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium.		2.110organic bromide saltcolorimetric reagent;
dye
3,5-di-tert-butylcatechol
3,5-di-tert-butylcatechol: structure given in first source		2.0310
cobalt
Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27.		2.0310cobalt group element atom;
metal allergen		micronutrient
proline
Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.. proline : An alpha-amino acid that is pyrrolidine bearing a carboxy substituent at position 2.		2.0810amino acid zwitterion;
glutamine family amino acid;
L-alpha-amino acid;
proline;
proteinogenic amino acid		algal metabolite;
compatible osmolytes;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
varenicline
Varenicline: A benzazepine derivative that functions as an ALPHA4-BETA2 NICOTINIC RECEPTOR partial agonist. It is used for SMOKING CESSATION.. varenicline : An organic heterotetracyclic compound that acts as a partial agonist for nicotinic cholinergic receptors and is used (in the form of its tartate salt) as an aid to giving up smoking.		2.0810
organophosphonates
hydrogenphosphite : A divalent inorganic anion resulting from the removal of a proton from two of the hydroxy groups of phosphorous acid.		2.4110divalent inorganic anion;
phosphite ion
carboplatin
[no description available]		2.5220
betadex
beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.		2.4110cyclodextrin
phenyllithium
phenyllithium: structure in first source		2.0510
lithium
Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.		2.4420alkali metal atom
gallium
Gallium: A rare, metallic element designated by the symbol, Ga, atomic number 31, and atomic weight 69.72.. gallium atom : A metallic element predicted as eka-aluminium by Mendeleev in 1870 and discovered by Paul-Emile Lecoq de Boisbaudran in 1875. Named in honour of France (Latin Gallia) and perhaps also from the Latin gallus cock, a translation of Lecoq.		2.2510boron group element atom
indium
[no description available]		2.2110
ferryl iron
[no description available]		2.8220
piperidines
Piperidines: A family of hexahydropyridines.		2.4720
ConditionIndicatedRelationship StrengthStudiesTrials
Cancer of Cervix
[description not available]		02.1110
Uterine Cervical Neoplasms
Tumors or cancer of the UTERINE CERVIX.		02.1110
Benign Neoplasms
[description not available]		03.8330
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		03.8330
Amyloidosis
A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.		02.4110
Nicotine Addiction
[description not available]		02.0810
Tobacco Use Disorder
Tobacco used to the detriment of a person's health or social functioning. Tobacco dependence is included.		02.0810
Bleeding
[description not available]		02.1310
Embolism, Pulmonary
[description not available]		02.1310
Blood Clot
[description not available]		02.1310
Hemorrhage
Bleeding or escape of blood from a vessel.		02.1310
Pulmonary Embolism
Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.		02.1310
Thrombosis
Formation and development of a thrombus or blood clot in the blood vessel.		02.1310
Cancer of Prostate
[description not available]		02.0510
Prostatic Neoplasms
Tumors or cancer of the PROSTATE.		02.0510
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0310