Page last updated: 2024-12-11

lophyrotomin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

lophyrotomin: isolated from the European Birch sawfly Arge pullata [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5488869
MeSH IDM0156407

Synonyms (6)

Synonym
lophyrotomin
brn 5230528
c6h5-co-ala-phe-val-ile-asp-asp-glu-gln
85932-85-0
benzoyl-d-alanyl-d-phenylalanyl-l-valyl-l-isoleucyl-d-aspartyl-l-aspartyl-d-glutamyl-l-glutamine
(2s)-5-amino-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-[[(2s,3s)-2-[[(2s)-2-[[(2r)-2-[[(2r)-2-benzamidopropanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amin

Research Excerpts

Overview

Lophyrotomin is a toxic octapeptide, first isolated from larvae of the sawfly Lophyrotoma interrupta. It causes the death of cattle and sheep.

ExcerptReferenceRelevance
"Lophyrotomin is a toxic octapeptide, first isolated from larvae of the sawfly Lophyrotoma interrupta, which causes the death of cattle and sheep. "( Solution structure of the toxic octapeptide, lophyrotomin.
Atkins, AR; Daly, NL; Smith, R, 1993
)
1.99

Toxicity

ExcerptReferenceRelevance
" Microcystin-LR, cylindrospermopsin and lophyrotomin all exhibited toxic effects on the primary rat hepatocytes with 72-h LC(50) of 8, 40 and 560 ng/ml, respectively."( Toxicity and uptake mechanism of cylindrospermopsin and lophyrotomin in primary rat hepatocytes.
Chong, MW; Lam, PK; Seawright, AA; Shaw, GR; Wong, BS, 2002
)
0.83

Dosage Studied

ExcerptRelevanceReference
" Both compounds when dosed intraperitoneally to C57/Bl6 male mice were hepatotoxic with lowest lethal doses of 8 and 32 mg/kg, respectively."( Isolation and identification of the toxic peptides from Lophyrotoma zonalis (Pergidae) sawfly larvae.
Grace, PB; MacLeod, JK; Oelrichs, PB; Seawright, AA, 2001
)
0.31
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (16.67)18.7374
1990's2 (33.33)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.60

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.60 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.55 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.60)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]