lophyrotomin: isolated from the European Birch sawfly Arge pullata
ID Source | ID |
---|---|
PubMed CID | 5488869 |
MeSH ID | M0156407 |
Synonym |
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lophyrotomin |
brn 5230528 |
c6h5-co-ala-phe-val-ile-asp-asp-glu-gln |
85932-85-0 |
benzoyl-d-alanyl-d-phenylalanyl-l-valyl-l-isoleucyl-d-aspartyl-l-aspartyl-d-glutamyl-l-glutamine |
(2s)-5-amino-2-[[(2r)-2-[[(2s)-2-[[(2r)-2-[[(2s,3s)-2-[[(2s)-2-[[(2r)-2-[[(2r)-2-benzamidopropanoyl]amino]-3-phenylpropanoyl]amino]-3-methylbutanoyl]amino]-3-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amin |
Lophyrotomin is a toxic octapeptide, first isolated from larvae of the sawfly Lophyrotoma interrupta. It causes the death of cattle and sheep.
Excerpt | Reference | Relevance |
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"Lophyrotomin is a toxic octapeptide, first isolated from larvae of the sawfly Lophyrotoma interrupta, which causes the death of cattle and sheep. " | ( Solution structure of the toxic octapeptide, lophyrotomin. Atkins, AR; Daly, NL; Smith, R, 1993) | 1.99 |
Excerpt | Reference | Relevance |
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" Microcystin-LR, cylindrospermopsin and lophyrotomin all exhibited toxic effects on the primary rat hepatocytes with 72-h LC(50) of 8, 40 and 560 ng/ml, respectively." | ( Toxicity and uptake mechanism of cylindrospermopsin and lophyrotomin in primary rat hepatocytes. Chong, MW; Lam, PK; Seawright, AA; Shaw, GR; Wong, BS, 2002) | 0.83 |
Excerpt | Relevance | Reference |
---|---|---|
" Both compounds when dosed intraperitoneally to C57/Bl6 male mice were hepatotoxic with lowest lethal doses of 8 and 32 mg/kg, respectively." | ( Isolation and identification of the toxic peptides from Lophyrotoma zonalis (Pergidae) sawfly larvae. Grace, PB; MacLeod, JK; Oelrichs, PB; Seawright, AA, 2001) | 0.31 |
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 1 (16.67) | 18.7374 |
1990's | 2 (33.33) | 18.2507 |
2000's | 2 (33.33) | 29.6817 |
2010's | 1 (16.67) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.60) All Compounds (24.57) |
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 6 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |