Page last updated: 2024-11-04

suramin and Bleeding

suramin has been researched along with Bleeding in 4 studies

Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.

Research Excerpts

ExcerptRelevanceReference
"This experience suggests the avoidance of elective procedures during the first month after suramin therapy and a heightened awareness of the potential for bleeding and wound healing problems in patients receiving suramin who do require an emergent procedure."7.69Postoperative complications in patients receiving suramin therapy. ( Cole, DJ; Cooper, MR; Danforth, DN; Ettinghausen, SE; Linehan, MW; Myers, CW; Pass, HI; Sindelar, WF, 1994)
"Suramin-resistant DC-3F/SU 1,000 Chinese hamster fibrosarcoma cells were obtained by continuous exposure of parental DC-3F cells to increasing concentrations of suramin (1 mg/ml final concentration)."7.69Development and characterization of suramin-resistant Chinese hamster fibrosarcoma cells: drug-dependent formation of multicellular spheroids and a greatly enhanced metastatic potential. ( Larsen, AK; Lelièvre, S, 1994)
"This experience suggests the avoidance of elective procedures during the first month after suramin therapy and a heightened awareness of the potential for bleeding and wound healing problems in patients receiving suramin who do require an emergent procedure."3.69Postoperative complications in patients receiving suramin therapy. ( Cole, DJ; Cooper, MR; Danforth, DN; Ettinghausen, SE; Linehan, MW; Myers, CW; Pass, HI; Sindelar, WF, 1994)
"Suramin-resistant DC-3F/SU 1,000 Chinese hamster fibrosarcoma cells were obtained by continuous exposure of parental DC-3F cells to increasing concentrations of suramin (1 mg/ml final concentration)."3.69Development and characterization of suramin-resistant Chinese hamster fibrosarcoma cells: drug-dependent formation of multicellular spheroids and a greatly enhanced metastatic potential. ( Larsen, AK; Lelièvre, S, 1994)
" Heparin and other polyanions can neutralize histones but challenges with dosing or side effects such as bleeding limit clinical application."1.91The Polyanionic Drug Suramin Neutralizes Histones and Prevents Endotheliopathy. ( Bouchard, BA; Boyson, JE; Chen, YL; Freeman, K; Haines, L; Lawson, MA; Li, J; Ma, YT; Majumdar, D; Nelson, MT; Poynter, ME; Sackheim, AM; Sonkusare, SK; Villalba, N, 2023)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (75.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Villalba, N1
Sackheim, AM1
Lawson, MA1
Haines, L1
Chen, YL1
Sonkusare, SK1
Ma, YT1
Li, J1
Majumdar, D1
Bouchard, BA1
Boyson, JE1
Poynter, ME1
Nelson, MT1
Freeman, K1
Cole, DJ1
Ettinghausen, SE1
Pass, HI1
Danforth, DN1
Linehan, MW1
Myers, CW1
Cooper, MR1
Sindelar, WF1
Lelièvre, S1
Larsen, AK1
Buller, KM1
Khanna, S1
Sibbald, JR1
Day, TA1

Other Studies

4 other studies available for suramin and Bleeding

ArticleYear
The Polyanionic Drug Suramin Neutralizes Histones and Prevents Endotheliopathy.
    Journal of immunology (Baltimore, Md. : 1950), 2023, 08-15, Volume: 211, Issue:4

    Topics: Animals; Endothelial Cells; Endothelium; Hemorrhage; Histones; Mice; Suramin

2023
Postoperative complications in patients receiving suramin therapy.
    Surgery, 1994, Volume: 116, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Drug Evaluation; Female; Hemorrhage; Humans; Infusions, Intravenous;

1994
Development and characterization of suramin-resistant Chinese hamster fibrosarcoma cells: drug-dependent formation of multicellular spheroids and a greatly enhanced metastatic potential.
    Cancer research, 1994, Aug-01, Volume: 54, Issue:15

    Topics: Animals; Cell Adhesion; Cell Count; Cell Division; Cricetinae; Cricetulus; Drug Resistance; Fibrosar

1994
Central noradrenergic neurons signal via ATP to elicit vasopressin responses to haemorrhage.
    Neuroscience, 1996, Volume: 73, Issue:3

    Topics: Adenosine Triphosphate; Adrenergic Fibers; Animals; Blood Pressure; Hemorrhage; Hypothalamus; Proto-

1996