suramin and Bleeding
suramin has been researched along with Bleeding in 4 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "This experience suggests the avoidance of elective procedures during the first month after suramin therapy and a heightened awareness of the potential for bleeding and wound healing problems in patients receiving suramin who do require an emergent procedure." | 7.69 | Postoperative complications in patients receiving suramin therapy. ( Cole, DJ; Cooper, MR; Danforth, DN; Ettinghausen, SE; Linehan, MW; Myers, CW; Pass, HI; Sindelar, WF, 1994) |
| "Suramin-resistant DC-3F/SU 1,000 Chinese hamster fibrosarcoma cells were obtained by continuous exposure of parental DC-3F cells to increasing concentrations of suramin (1 mg/ml final concentration)." | 7.69 | Development and characterization of suramin-resistant Chinese hamster fibrosarcoma cells: drug-dependent formation of multicellular spheroids and a greatly enhanced metastatic potential. ( Larsen, AK; Lelièvre, S, 1994) |
| "This experience suggests the avoidance of elective procedures during the first month after suramin therapy and a heightened awareness of the potential for bleeding and wound healing problems in patients receiving suramin who do require an emergent procedure." | 3.69 | Postoperative complications in patients receiving suramin therapy. ( Cole, DJ; Cooper, MR; Danforth, DN; Ettinghausen, SE; Linehan, MW; Myers, CW; Pass, HI; Sindelar, WF, 1994) |
| "Suramin-resistant DC-3F/SU 1,000 Chinese hamster fibrosarcoma cells were obtained by continuous exposure of parental DC-3F cells to increasing concentrations of suramin (1 mg/ml final concentration)." | 3.69 | Development and characterization of suramin-resistant Chinese hamster fibrosarcoma cells: drug-dependent formation of multicellular spheroids and a greatly enhanced metastatic potential. ( Larsen, AK; Lelièvre, S, 1994) |
| " Heparin and other polyanions can neutralize histones but challenges with dosing or side effects such as bleeding limit clinical application." | 1.91 | The Polyanionic Drug Suramin Neutralizes Histones and Prevents Endotheliopathy. ( Bouchard, BA; Boyson, JE; Chen, YL; Freeman, K; Haines, L; Lawson, MA; Li, J; Ma, YT; Majumdar, D; Nelson, MT; Poynter, ME; Sackheim, AM; Sonkusare, SK; Villalba, N, 2023) |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Villalba, N | 1 |
| Sackheim, AM | 1 |
| Lawson, MA | 1 |
| Haines, L | 1 |
| Chen, YL | 1 |
| Sonkusare, SK | 1 |
| Ma, YT | 1 |
| Li, J | 1 |
| Majumdar, D | 1 |
| Bouchard, BA | 1 |
| Boyson, JE | 1 |
| Poynter, ME | 1 |
| Nelson, MT | 1 |
| Freeman, K | 1 |
| Cole, DJ | 1 |
| Ettinghausen, SE | 1 |
| Pass, HI | 1 |
| Danforth, DN | 1 |
| Linehan, MW | 1 |
| Myers, CW | 1 |
| Cooper, MR | 1 |
| Sindelar, WF | 1 |
| Lelièvre, S | 1 |
| Larsen, AK | 1 |
| Buller, KM | 1 |
| Khanna, S | 1 |
| Sibbald, JR | 1 |
| Day, TA | 1 |
Other Studies
4 other studies available for suramin and Bleeding
| Article | Year |
|---|---|
The Polyanionic Drug Suramin Neutralizes Histones and Prevents Endotheliopathy.
Topics: Animals; Endothelial Cells; Endothelium; Hemorrhage; Histones; Mice; Suramin | 2023 |
Postoperative complications in patients receiving suramin therapy.
Topics: Adult; Aged; Aged, 80 and over; Drug Evaluation; Female; Hemorrhage; Humans; Infusions, Intravenous; | 1994 |
Development and characterization of suramin-resistant Chinese hamster fibrosarcoma cells: drug-dependent formation of multicellular spheroids and a greatly enhanced metastatic potential.
Topics: Animals; Cell Adhesion; Cell Count; Cell Division; Cricetinae; Cricetulus; Drug Resistance; Fibrosar | 1994 |
Central noradrenergic neurons signal via ATP to elicit vasopressin responses to haemorrhage.
Topics: Adenosine Triphosphate; Adrenergic Fibers; Animals; Blood Pressure; Hemorrhage; Hypothalamus; Proto- | 1996 |