cimetidine has been researched along with Osteoarthritis in 4 studies
Cimetidine: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
cimetidine : A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H2-receptor antagonist that inhibits the production of acid in stomach.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-three patients chronically ingesting plain aspirin or nonsteroidal antiinflammatory drugs, who had endoscopically proven solitary or multiple gastric ulcers, were treated for eight weeks with cimetidine and antacids." | 9.06 | Persistence of gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory agents in patients treated with a combination of cimetidine, antacids, and enteric-coated aspirin. ( Calzada, R; Dhar, R; Jaszewski, R, 1989) |
| "Steady state piroxicam plasma samples from 85 patients suffering from osteoarthritis of the hip and/or the knee, and treated with piroxicam 20 mg daily for at least four weeks, were obtained." | 7.68 | Free plasma concentrations of piroxicam in patients with osteoarthritis: relation to age, sex and efficacy. ( Hundal, O; Rugstad, HE, 1993) |
| "Twenty-three patients chronically ingesting plain aspirin or nonsteroidal antiinflammatory drugs, who had endoscopically proven solitary or multiple gastric ulcers, were treated for eight weeks with cimetidine and antacids." | 5.06 | Persistence of gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory agents in patients treated with a combination of cimetidine, antacids, and enteric-coated aspirin. ( Calzada, R; Dhar, R; Jaszewski, R, 1989) |
| "Steady state piroxicam plasma samples from 85 patients suffering from osteoarthritis of the hip and/or the knee, and treated with piroxicam 20 mg daily for at least four weeks, were obtained." | 3.68 | Free plasma concentrations of piroxicam in patients with osteoarthritis: relation to age, sex and efficacy. ( Hundal, O; Rugstad, HE, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rugstad, HE | 2 |
| Giercksky, KE | 1 |
| Husby, G | 1 |
| Holme, I | 1 |
| Hundal, O | 1 |
| Jaszewski, R | 1 |
| Calzada, R | 1 |
| Dhar, R | 1 |
| Roth, SH | 1 |
| Bennett, RE | 1 |
| Mitchell, CS | 1 |
| Hartman, RJ | 1 |
3 trials available for cimetidine and Osteoarthritis
| Article | Year |
|---|---|
Effect of cimetidine on gastrointestinal symptoms in patients taking nonsteroidal anti-inflammatory drugs. A large double-blind placebo controlled study.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Double-Blind Me | 1994 |
Persistence of gastric ulcers caused by plain aspirin or nonsteroidal antiinflammatory agents in patients treated with a combination of cimetidine, antacids, and enteric-coated aspirin.
Topics: Antacids; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cimetidine; Drug Therapy, Combination; G | 1989 |
Cimetidine therapy in nonsteroidal anti-inflammatory drug gastropathy. Double-blind long-term evaluation.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cimetidine; Clinical Tri | 1987 |
1 other study available for cimetidine and Osteoarthritis
| Article | Year |
|---|---|
Free plasma concentrations of piroxicam in patients with osteoarthritis: relation to age, sex and efficacy.
Topics: Aged; Aged, 80 and over; Aging; Cimetidine; Drug Therapy, Combination; Female; Humans; Male; Middle | 1993 |