indoprofen has been researched along with Osteoarthritis in 22 studies
Indoprofen: A drug that has analgesic and anti-inflammatory properties. Following reports of adverse reactions including reports of carcinogenicity in animal studies it was withdrawn from the market worldwide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p21)
indoprofen : A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causing severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A comparison was made between indoprofen (800 mg/day), naproxen (500 mg/day) and placebo in 30 patients with well defined osteoarthritis of the hip." | 9.05 | Indoprofen. Short-term double-blind cross-over study in patients with osteoarthritis of the hip. ( Carion, J; Debelle, M; Van der Mijnsbrugge, J, 1981) |
| "This paper contains a detailed account of the results obtained in 1629 patients with osteoarthritis treated with indoprofen, a recently introduced non-steroidal anti-inflammatory drug." | 9.05 | Indoprofen in the treatment of osteoarthritis. Results of a phase IV multiclinic study in 1629 patients. ( Emanueli, A; Sacchetti, G, 1981) |
| "The effectiveness, safety and acceptability of indoprofen (IP) and acetylsalicylic acid (ASA) were assessed in patients with osteoarthritis, in a double-blind comparative trial." | 9.05 | Double-blind comparative trial of indoprofen and acetylsalicylic acid in osteoarthritis. ( Katona, G, 1981) |
| "Patients suffering from osteoarthritis of the large joints or spine randomly allocated to either of two dose levels of indoprofen (IP, 300 or 600 mg/day) or indomethacin (IM, 75 mg/day)." | 9.05 | Double-blind multicentre, between patients comparison of two different doses of indoprofen and one of indomethacin in osteoarthritis. ( Bahous, I, 1981) |
| "Each treatment (indoprofen 300 or 600 mg/day, ASA 1500 + diazepam 6 mg/day, and matching placebo) was administered for 7 days." | 6.65 | Double-blind cross-over investigation of the effectiveness and safety of two doses of indoprofen compared with an ASA preparation and placebo in patients suffering from osteoarthritis. ( Bergamini, N; Groppi, W; Mandelli, V; Valtonen, E, 1981) |
| " Indoprofen was administered for 1 week at a daily dosage of 1000 mg according to a treatment schedule used with success in acute gouty arthritis: a 400 mg i." | 5.05 | Indoprofen in rheumatic patients with acute episodes: a multicentre trial. ( Accardo, S; Ambanelli, U; Bassi, G; Bedendo, A; Bianchi, V; Carcassi, U; Caruso, I; Cervi, G; Chérié-Lignière, G; Ciompi, M; Colombo, B; Fumagalli, M; Giordano, N; Goretti, P; Lavezzari, M; Loizzi, P; Manganelli, P; Mansoldo, G; Marcolongo, R; Pasero, G; Pellegrini, P; Perpignano, G; Pipitone, V; Provvedi, D; Rossi, R; Rubegni, M; Todesco, S, 1982) |
| "A comparison was made between indoprofen (800 mg/day), naproxen (500 mg/day) and placebo in 30 patients with well defined osteoarthritis of the hip." | 5.05 | Indoprofen. Short-term double-blind cross-over study in patients with osteoarthritis of the hip. ( Carion, J; Debelle, M; Van der Mijnsbrugge, J, 1981) |
| "This paper contains a detailed account of the results obtained in 1629 patients with osteoarthritis treated with indoprofen, a recently introduced non-steroidal anti-inflammatory drug." | 5.05 | Indoprofen in the treatment of osteoarthritis. Results of a phase IV multiclinic study in 1629 patients. ( Emanueli, A; Sacchetti, G, 1981) |
| "The effectiveness, safety and acceptability of indoprofen (IP) and acetylsalicylic acid (ASA) were assessed in patients with osteoarthritis, in a double-blind comparative trial." | 5.05 | Double-blind comparative trial of indoprofen and acetylsalicylic acid in osteoarthritis. ( Katona, G, 1981) |
| "Patients suffering from osteoarthritis of the large joints or spine randomly allocated to either of two dose levels of indoprofen (IP, 300 or 600 mg/day) or indomethacin (IM, 75 mg/day)." | 5.05 | Double-blind multicentre, between patients comparison of two different doses of indoprofen and one of indomethacin in osteoarthritis. ( Bahous, I, 1981) |
| " All of them had maturity-onset diabetes mellitus and were on sulfonylurea drugs (tolbutamide or glipizide)." | 5.05 | A study of the possible interaction of indoprofen with hypoglycemic sulfonylureas in diabetic patients. ( Bommartini, F; Emanueli, A; Freddo, J; Pedrazzi, F, 1981) |
| " administration of indoprofen on template bleeding time and other haemostatic parameters was investigated in ten elderly subjects with osteoarthritis." | 3.66 | Effects of intravenous indoprofen on bleeding time and other haemostatic parameters. ( Bandinelli, C; Bruni, G; De Mauro, G; Provvedi, D; Rubegni, M; Sacchetti, G, 1982) |
| "Safety data on indoprofen are presented, deriving from three sources: the first was a phase 4 multicentre clinical study based on 4042 patients suffering from osteoarthritis and treated with 400-800 mg daily by mouth for about 4 weeks; the second was a survey based on a heterogeneous series of 2722 subjects belonging to phase 1, 2 and 3 investigations, and treated with 200 to 1200 mg daily by the oral and/or parenteral route for from 1 to more than 180 days; the third was a safety laboratory study conducted in 472 patients, most of whom had participated in the first study, while the remainder were included in the second." | 3.66 | Adverse reactions to indoprofen: a survey based on a total of 6764 patients. ( Battaglia, A; Bruni, G; Emanueli, A; Lavezzari, M; Perbellini, A, 1982) |
| "Diclofenac was preferred to naproxen, aspirin and indomethacin, while piroxicam and placebo were preferred only to aspirin." | 2.66 | Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment. ( Bassi, GP; Borghi, C; Camarri, E; Cocco, F; Francucci, BM; Giannini, R; Giordano, N; Marcolongo, R; Mordini, M; Neri, D, 1985) |
| "Each treatment (indoprofen 300 or 600 mg/day, ASA 1500 + diazepam 6 mg/day, and matching placebo) was administered for 7 days." | 2.65 | Double-blind cross-over investigation of the effectiveness and safety of two doses of indoprofen compared with an ASA preparation and placebo in patients suffering from osteoarthritis. ( Bergamini, N; Groppi, W; Mandelli, V; Valtonen, E, 1981) |
| "Multiple dosing four times daily for 7 days of indoprofen 200 mg, a non-steroidal anti-inflammatory drug with a short half-life (t1/2), revealed drug accumulation in eight elderly subjects." | 1.27 | Pharmacokinetic profile of indoprofen in elderly subjects. ( Andersen, RB; Egsmose, C; Knudsen, O; Lund, B, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ambanelli, U | 2 |
| Bassi, G | 1 |
| Bianchi, V | 1 |
| Carcassi, U | 1 |
| Caruso, I | 1 |
| Colombo, B | 1 |
| Goretti, P | 1 |
| Mansoldo, G | 1 |
| Marcolongo, R | 3 |
| Pasero, G | 1 |
| Pellegrini, P | 1 |
| Pipitone, V | 1 |
| Rubegni, M | 4 |
| Todesco, S | 1 |
| Accardo, S | 1 |
| Bedendo, A | 1 |
| Cervi, G | 1 |
| Chérié-Lignière, G | 1 |
| Ciompi, M | 1 |
| Fumagalli, M | 1 |
| Giordano, N | 3 |
| Lavezzari, M | 3 |
| Loizzi, P | 1 |
| Manganelli, P | 1 |
| Perpignano, G | 1 |
| Provvedi, D | 3 |
| Rossi, R | 1 |
| Mattara, L | 2 |
| Leardini, G | 1 |
| Gruni, G | 1 |
| Mandelli, V | 3 |
| Egsmose, C | 2 |
| Lund, B | 2 |
| Bach Andersen, R | 1 |
| Emanueli, A | 5 |
| Sacchetti, G | 5 |
| Debelle, M | 1 |
| Carion, J | 1 |
| Van der Mijnsbrugge, J | 1 |
| Katona, G | 1 |
| Bahous, I | 1 |
| Pedrazzi, F | 1 |
| Bommartini, F | 1 |
| Freddo, J | 1 |
| Bruni, G | 3 |
| De Mauro, G | 2 |
| Valtonen, E | 1 |
| Bergamini, N | 2 |
| Groppi, W | 1 |
| Bandinelli, C | 1 |
| Perbellini, A | 1 |
| Battaglia, A | 1 |
| Cagianelli, MA | 1 |
| Mioni, V | 1 |
| Ferraccioli, GF | 1 |
| Tedoldi, A | 1 |
| Berton, A | 1 |
| Ferrati, G | 2 |
| Bellini, PG | 1 |
| Giro, C | 1 |
| Lo Presti, R | 1 |
| Mascellani, G | 1 |
| Knudsen, O | 1 |
| Andersen, RB | 1 |
| Bassi, GP | 1 |
| Giannini, R | 1 |
| Borghi, C | 1 |
| Francucci, BM | 1 |
| Camarri, E | 1 |
| Mordini, M | 1 |
| Cocco, F | 1 |
| Neri, D | 1 |
| Fornasari, PA | 1 |
13 trials available for indoprofen and Osteoarthritis
| Article | Year |
|---|---|
Indoprofen in rheumatic patients with acute episodes: a multicentre trial.
Topics: Adolescent; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Back Pain; Clinical Trials as Topic; Fema | 1982 |
A short-term, double-blind comparison between indoprofen and diclofenac in osteoarthritis.
Topics: Adult; Aged; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Female; Humans; Indoprofen; | 1983 |
Hip joint distension in osteoarthrosis. A triple-blind controlled study comparing the effect of intra-articular indoprofen with placebo.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Hip Joint; Humans; Indoprofen; Injections, Intra-Arti | 1984 |
Indoprofen. Short-term double-blind cross-over study in patients with osteoarthritis of the hip.
Topics: Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic | 1981 |
Indoprofen in the treatment of osteoarthritis. Results of a phase IV multiclinic study in 1629 patients.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Female; Humans; Indoprofen; Italy | 1981 |
Double-blind comparative trial of indoprofen and acetylsalicylic acid in osteoarthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Clinical Trials as Topic; Double-Blin | 1981 |
Double-blind multicentre, between patients comparison of two different doses of indoprofen and one of indomethacin in osteoarthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Dose-Response Relati | 1981 |
A study of the possible interaction of indoprofen with hypoglycemic sulfonylureas in diabetic patients.
Topics: Aged; Blood Glucose; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Double-Bli | 1981 |
A double-blind evaluation of oral indoprofen versus ASA in osteoarthritic patients: influence on haemostatic parameters and clinical effects.
Topics: Adult; Aged; Aspirin; Bleeding Time; Clinical Trials as Topic; Double-Blind Method; Female; Heartbur | 1981 |
Double-blind cross-over investigation of the effectiveness and safety of two doses of indoprofen compared with an ASA preparation and placebo in patients suffering from osteoarthritis.
Topics: Aged; Aspirin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Fema | 1981 |
[Therapeutic research on osteoarthrosis in the aged: controlled trial of indoprofen and ibuprofen].
Topics: Age Factors; Aged; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Ibuprofen; Indoprofen; | 1978 |
[Double-blind comparative study of indoprofen and ibuprofen in patients with osteoarthrosis].
Topics: Administration, Oral; Adult; Aged; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Ibupro | 1979 |
Double-blind preference and compliance multicentre study in osteoarthritis: once-a-day treatment.
Topics: Adult; Aged; Aspirin; Clinical Trials as Topic; Diclofenac; Double-Blind Method; Drug Administration | 1985 |
9 other studies available for indoprofen and Osteoarthritis
| Article | Year |
|---|---|
An algorithm for the classification of untoward events in large scale clinical trials.
Topics: Clinical Trials as Topic; Humans; Indoprofen; Mathematics; Osteoarthritis; Phenylpropionates | 1980 |
Effects of intravenous indoprofen on bleeding time and other haemostatic parameters.
Topics: Aged; Bleeding Time; Blood Coagulation; Female; Humans; Indoprofen; Kinetics; Male; Middle Aged; Ost | 1982 |
Adverse reactions to indoprofen: a survey based on a total of 6764 patients.
Topics: Adult; Age Factors; Aged; Body Height; Body Weight; Cardiovascular Diseases; Female; Gastrointestina | 1982 |
Evaluation of the long-term efficacy and safety of indoprofen in rheumatoid arthritis and osteoarthritis patients.
Topics: Aged; Arthritis, Rheumatoid; Female; Hematologic Tests; Humans; Indoprofen; Kidney Function Tests; L | 1981 |
Evaluation of the activity of anti-inflammatory agents by means of skin tests (M.S.U., SK-SD): comparison with clinical results.
Topics: Anti-Inflammatory Agents; Antigens; Arthritis, Rheumatoid; Drug Evaluation; Humans; Immunity, Cellul | 1981 |
[Indoprofen in the treatment of osteoarthrosis of the knee: comparison with indomethacin].
Topics: Aged; Drug Evaluation; Female; Humans; Indomethacin; Indoprofen; Knee Joint; Male; Middle Aged; Oste | 1980 |
Indoprofen, a new non-steroidal anti-inflammatory drug, in the treatment of osteoarthrosis: report on a multi-centre study in 1629 patients.
Topics: Adult; Aged; Constipation; Diarrhea; Digestive System; Drug Evaluation; Drug Tolerance; Female; Hear | 1979 |
Pharmacokinetic profile of indoprofen in elderly subjects.
Topics: Aged; Female; Half-Life; Humans; Indoprofen; Kinetics; Male; Middle Aged; Osteoarthritis; Phenylprop | 1986 |
[Efficacy and tolerance of dexindoprofen compared with diclofenac sodium in the treatment of osteoarthrosis patients].
Topics: Adult; Aged; Anti-Inflammatory Agents; Diclofenac; Drug Tolerance; Female; Humans; Indoprofen; Male; | 1985 |