cryolite profile

cryolite: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

cryolite : A mineral originally discovered in Greenland (first described 1799). The name is derived from the Greek kapparhoupsilonomicronsigma (frost) and lambdaiotathetaomicronsigma (stone). [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	16693908
CHEMBL ID	3988899
CHEBI ID	39289
MeSH ID	M0050167

Synonym
cryolite
cryolite (alna3f6)
kryocide
ice spar
cryolite (na3(alf6))
13775-53-6
cryolite, synthetic, >=97.0% (from f)
sodium hexafluoroaluminate, 99.98% trace metals basis
sodium hexafluoroaluminate, 97%
15096-52-3
na3[alf6]
sodium hexafluoridoaluminate(3-)
CHEBI:39289
aluminum sodium fluoride
sodium aluminum hexafluoride
aluminum trisodium hexafluoride
trisodium hexafluoroaluminate(3-)
trisodium hexafluoridoaluminate
na3alf6
sodium hexafluoroaluminate
sodium hexafluoridoaluminate(iii)
trisodium (oc-6-11)-hexafluoroaluminate(3-)
trisodium hexafluoroaluminum(3-)
A809094
trisodium hexakis(fluoranyl)aluminum(3-)
C18816
5zis914rq9 ,
kryolith
FT-0624109
prokil cryolite-96
cryolite [mi]
cryocide
AKOS025310262
cryolite,naturallyoccurringmineral,grains,approximately0.06-19in
mfcd00003507
J-008762
sodium hexafluoroaluminate(iii)
DTXSID90872955
CHEMBL3988899
Q927885
chromium boride (cr2b) sputtering targets
trisodium;hexafluoroaluminum(3-)
sodiumhexafluoroaluminate(iii)

Class	Description
inorganic sodium salt
perfluorometallate salt	A salt where the anion is a perfluorometallate anion.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Carbonic anhydrase 1	Homo sapiens (human)	Ki	52,400.0000	0.0000	1.3726	10.0000	AID238090
Carbonic anhydrase 2	Homo sapiens (human)	Ki	300,000.0000	0.0000	0.7236	9.9200	AID238088
Carbonic anhydrase 4	Homo sapiens (human)	Ki	124,000.0000	0.0002	1.9720	9.9200	AID238091
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	Ki	43,600.0000	0.0000	1.2725	9.9000	AID238087
Carbonic anhydrase 9	Homo sapiens (human)	Ki	18,500.0000	0.0001	0.7874	9.9000	AID238089
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
one-carbon metabolic process	Carbonic anhydrase 1	Homo sapiens (human)
morphogenesis of an epithelium	Carbonic anhydrase 2	Homo sapiens (human)
positive regulation of synaptic transmission, GABAergic	Carbonic anhydrase 2	Homo sapiens (human)
positive regulation of cellular pH reduction	Carbonic anhydrase 2	Homo sapiens (human)
angiotensin-activated signaling pathway	Carbonic anhydrase 2	Homo sapiens (human)
regulation of monoatomic anion transport	Carbonic anhydrase 2	Homo sapiens (human)
secretion	Carbonic anhydrase 2	Homo sapiens (human)
regulation of intracellular pH	Carbonic anhydrase 2	Homo sapiens (human)
neuron cellular homeostasis	Carbonic anhydrase 2	Homo sapiens (human)
positive regulation of dipeptide transmembrane transport	Carbonic anhydrase 2	Homo sapiens (human)
regulation of chloride transport	Carbonic anhydrase 2	Homo sapiens (human)
carbon dioxide transport	Carbonic anhydrase 2	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 2	Homo sapiens (human)
bicarbonate transport	Carbonic anhydrase 4	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 4	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
response to hypoxia	Carbonic anhydrase 9	Homo sapiens (human)
morphogenesis of an epithelium	Carbonic anhydrase 9	Homo sapiens (human)
response to xenobiotic stimulus	Carbonic anhydrase 9	Homo sapiens (human)
response to testosterone	Carbonic anhydrase 9	Homo sapiens (human)
secretion	Carbonic anhydrase 9	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 9	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
arylesterase activity	Carbonic anhydrase 1	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 1	Homo sapiens (human)
protein binding	Carbonic anhydrase 1	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 1	Homo sapiens (human)
hydro-lyase activity	Carbonic anhydrase 1	Homo sapiens (human)
cyanamide hydratase activity	Carbonic anhydrase 1	Homo sapiens (human)
arylesterase activity	Carbonic anhydrase 2	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 2	Homo sapiens (human)
protein binding	Carbonic anhydrase 2	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 2	Homo sapiens (human)
cyanamide hydratase activity	Carbonic anhydrase 2	Homo sapiens (human)
protein binding	Carbonic anhydrase 4	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 4	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 4	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 9	Homo sapiens (human)
protein binding	Carbonic anhydrase 9	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 9	Homo sapiens (human)
molecular function activator activity	Carbonic anhydrase 9	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
cytosol	Carbonic anhydrase 1	Homo sapiens (human)
extracellular exosome	Carbonic anhydrase 1	Homo sapiens (human)
cytoplasm	Carbonic anhydrase 2	Homo sapiens (human)
cytosol	Carbonic anhydrase 2	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 2	Homo sapiens (human)
myelin sheath	Carbonic anhydrase 2	Homo sapiens (human)
apical part of cell	Carbonic anhydrase 2	Homo sapiens (human)
extracellular exosome	Carbonic anhydrase 2	Homo sapiens (human)
cytoplasm	Carbonic anhydrase 2	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 2	Homo sapiens (human)
apical part of cell	Carbonic anhydrase 2	Homo sapiens (human)
basolateral plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
rough endoplasmic reticulum	Carbonic anhydrase 4	Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartment	Carbonic anhydrase 4	Homo sapiens (human)
Golgi apparatus	Carbonic anhydrase 4	Homo sapiens (human)
trans-Golgi network	Carbonic anhydrase 4	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
external side of plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
cell surface	Carbonic anhydrase 4	Homo sapiens (human)
membrane	Carbonic anhydrase 4	Homo sapiens (human)
apical plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
transport vesicle membrane	Carbonic anhydrase 4	Homo sapiens (human)
secretory granule membrane	Carbonic anhydrase 4	Homo sapiens (human)
brush border membrane	Carbonic anhydrase 4	Homo sapiens (human)
perinuclear region of cytoplasm	Carbonic anhydrase 4	Homo sapiens (human)
extracellular exosome	Carbonic anhydrase 4	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
mitochondrial matrix	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
mitochondrion	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
cytoplasm	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
mitochondrion	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
nucleolus	Carbonic anhydrase 9	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 9	Homo sapiens (human)
membrane	Carbonic anhydrase 9	Homo sapiens (human)
basolateral plasma membrane	Carbonic anhydrase 9	Homo sapiens (human)
microvillus membrane	Carbonic anhydrase 9	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 9	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (5)

Assay ID	Title	Year	Journal	Article
AID238089	Inhibitory constant against human isozymes carbonic anhydrase IX for the CO2 hydration reaction at 20 C	2005	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 15, Issue:7	Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides.
AID238090	Inhibitory constant against human isozyme carbonic anhydrase I for the CO2 hydration reaction at 20 degree C	2005	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 15, Issue:7	Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides.
AID238087	Inhibitory constant against human isozymes carbonic anhydrase V for the CO2 hydration reaction at 20 C	2005	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 15, Issue:7	Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides.
AID238091	Inhibitory constant against human isozymes carbonic anhydrase IV for the CO2 hydration reaction at 20 degree C	2005	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 15, Issue:7	Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides.
AID238088	Inhibitory constant against human isozymes carbonic anhydrase II for the CO2 hydration reaction at 20 C	2005	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 15, Issue:7	Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V and IX with complex fluorides, chlorides and cyanides.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	8 (27.59)	18.7374
1990's	3 (10.34)	18.2507
2000's	4 (13.79)	29.6817
2010's	11 (37.93)	24.3611
2020's	3 (10.34)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	32 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
aluminum fluoride [no description available]	2.03	1	aluminium coordination entity
sodium fluoride [no description available]	4.66	28	fluoride salt	mutagen
phencyclidine Phencyclidine: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to KETAMINE in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (RECEPTORS, N-METHYL-D-ASPARTATE). As a drug of abuse, it is known as PCP and Angel Dust.. phencyclidine : A member of the class of piperidines that is piperidine in which the nitrogen is substituted with a 1-phenylcyclohexyl group. Formerly used as an anaesthetic agent, it exhibits both hallucinogenic and neurotoxic effects.	2.88	4	benzenes; piperidines	anaesthetic; neurotoxin; NMDA receptor antagonist; psychotropic drug
acrylic acid acrylic acid: RN given refers to parent cpd. acrylic acid : A alpha,beta-unsaturated monocarboxylic acid that is ethene substituted by a carboxy group.	1.98	1	alpha,beta-unsaturated monocarboxylic acid	metabolite
zinc oxide Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.	1.98	1	zinc molecular entity
lanthanum [no description available]	2.07	1	f-block element atom; lanthanoid atom; scandium group element atom
fluorine Fluorine: A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as fluoride (FLUORIDES) to prevent dental caries.	7.4	2	diatomic fluorine; gas molecular entity	NMR chemical shift reference compound
lead arsenate lead arsenate : An inorganic lead salt composed from lead(2+) and arsenate dianion. It was widely used in the United States in the 1950's as an insecticide to control pests in fruit orchards, specifically apples and cherries.	6.92	1	inorganic lead salt	insecticide; plant growth regulator; rodenticide
deuterium oxide Deuterium Oxide: The isotopic compound of hydrogen of mass 2 (deuterium) with oxygen. (From Grant & Hackh's Chemical Dictionary, 5th ed) It is used to study mechanisms and rates of chemical or nuclear reactions, as well as biological processes.	2.25	1	deuterated compound; water	NMR solvent
fluorosulfonic acid perfluorosulfonic acid: sulfonated tetrafluoroethylene-based fluoropolymer–copolymer	2.25	1	sulfur oxoacid	NMR solvent
fluorides [no description available]	7.88	4	halide anion; monoatomic fluorine
glutamic acid Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.. glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2.	1.98	1	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical
sodium hexafluorophosphate sodium hexafluorophosphate : An inorganic sodium salt having hexafluorophosphate(1-) as the counterion. It is an electrolyte used in sodium-ion batteries.	2.02	1	inorganic sodium salt
lead Lead: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.	7.33	2	carbon group element atom; elemental lead; metal atom	neurotoxin
cesium Cesium: A member of the alkali metals. It has an atomic symbol Cs, atomic number 50, and atomic weight 132.91. Cesium has many industrial applications, including the construction of atomic clocks based on its atomic vibrational frequency.	2.07	1	alkali metal atom
aluminum Aluminum: A metallic element that has the atomic number 13, atomic symbol Al, and atomic weight 26.98.	7.65	3	boron group element atom; elemental aluminium; metal atom
silicon Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].	2.72	2	carbon group element atom; metalloid atom; nonmetal atom
aluminum oxide Aluminum Oxide: An oxide of aluminum, occurring in nature as various minerals such as bauxite, corundum, etc. It is used as an adsorbent, desiccating agent, and catalyst, and in the manufacture of dental cements and refractories.	2.03	1

Condition	Relationship Strength	Studies
Anophthalmia [description not available]	2.59	2
Prosthesis Durability [description not available]	2.21	1
Pink Eye [description not available]	2.21	1
Conjunctivitis INFLAMMATION of the CONJUNCTIVA.	2.21	1
Poisoning, Lead [description not available]	2.33	2
Lead Poisoning Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.	2.33	2
Bladder Cancer [description not available]	2.02	1
Cancer of Lung [description not available]	2.39	2
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	2.02	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.39	2
Airway Obstruction Any hindrance to the passage of air into and out of the lungs.	2.03	1
Asthma, Bronchial [description not available]	2.03	1
Eosinophilia, Tropical [description not available]	2.03	1
Diseases, Occupational [description not available]	2.9	4
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	2.03	1
Eosinophilia Abnormal increase of EOSINOPHILS in the blood, tissues or organs.	2.03	1
Poisoning, Fluoride [description not available]	2.38	2
Fluoride Poisoning Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of FLUORIDE compounds.	2.38	2
Left Ventricular Hypertrophy [description not available]	2	1
Cardiac Remodeling, Ventricular [description not available]	2	1
Aortic Incompetence [description not available]	2	1
Aortic Stenosis [description not available]	2	1
Aortic Valve Insufficiency Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).	2	1
Aortic Valve Stenosis A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.	2	1
Hypertrophy, Left Ventricular Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.	2	1
Dental Fluoroses [description not available]	1.98	1
Arthritis, Degenerative [description not available]	1.98	1
Fluorosis, Dental A chronic endemic form of hypoplasia of the dental enamel caused by drinking water with a high fluorine content during the time of tooth formation, and characterized by defective calcification that gives a white chalky appearance to the enamel, which gradually undergoes brown discoloration. (Jablonski's Dictionary of Dentistry, 1992, p286)	1.98	1
Osteoarthritis A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	1.98	1
Benign Neoplasms [description not available]	1.96	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	1.96	1

cryolite

Description

Cross-References

Synonyms (43)

Drug Classes (2)

Protein Targets (5)

Inhibition Measurements

Biological Processes (16)

Molecular Functions (7)

Ceullar Components (23)

Bioassays (5)

Research

Studies (29)

Market Indicators

Research Demand Index: 74.07

Study Types

cryolite

Description

Cross-References

Synonyms (43)

Drug Classes (2)

Protein Targets (5)

Inhibition Measurements

Biological Processes (16)

Molecular Functions (7)

Ceullar Components (23)

Bioassays (5)

Research

Studies (29)

Market Indicators

Research Demand Index: 74.07

Study Types

Related Drugs (18)

Related Conditions (31)