tiaprofenic acid has been researched along with Osteoarthritis in 38 studies
tiaprofenic acid: RN given refers to parent cpd; structure
tiaprofenic acid : An aromatic ketone that is thiophene substituted at C-2 by benzoyl and at C-4 by a 1-carboxyethyl group.
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a randomised double-blind, multicentre, crossover study, the short term efficacy and tolerance of a sustained action preparation of tiaprofenic acid 600 mg once daily was compared with sustained release indomethacin 75 mg once daily in 98 patients with osteoarthritis." | 9.06 | Multicentre double-blind comparison of sustained action formulations of tiaprofenic acid and indomethacin in osteoarthritis. ( Calin, A; Cawley, MI; Pal, B; Rosenberg, JN; Silas, AM; Williams, PI, 1988) |
| "A double-blind, parallel-group study was carried out to compare the clinical efficacy and tolerance of tiaprofenic acid and piroxicam in 80 patients suffering from osteoarthritis of the knee." | 9.06 | Comparative double-blind study of tiaprofenic acid versus piroxicam in the treatment of osteoarthritis of the knee. ( Di Giorgio, E; Maccagno, A; Sebastian, O, 1988) |
| "A double-blind trial was carried out in 60 elderly patients with osteoarthritis of the knee or hip to compare the efficacy and tolerability of treatment with tiaprofenic acid and indomethacin." | 9.05 | Treatment of osteoarthritis: a 3-month comparison between tiaprofenic acid and indomethacin. ( Meurice, J, 1983) |
| "Two multi-centre studies were carried out in general practice comparing tiaprofenic acid ('Surgam') with five other non-steroidal anti-inflammatory agents (ibuprofen, indomethacin, naproxen, piroxicam and benoxaprofen), one in rheumatoid arthritis and one in osteoarthritis." | 9.05 | A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice. ( Clarke, TK; Mungavin, JM, 1983) |
| "Two multi-centre, placebo-controlled, crossover trials of tiaprofenic acid were conducted to an identical design: one in 80 patients suffering from rheumatoid arthritis, the other in 60 patients suffering from osteoarthritis." | 9.05 | Short-term efficacy and tolerance of tiaprofenic acid ('Surgam') in rheumatoid arthritis and osteoarthritis: multi-centre, placebo-controlled trials. ( Daymond, TJ; Essigman, WK; Huskisson, EC; Thompson, M; Wojtulewski, JA, 1982) |
| "Tiaprofenic acid 200 mg three times a day was compared with indomethacin 25 mg three times a day in 36 patients suffering from osteoarthritis of the knee and hip." | 9.05 | Tiaprofenic acid (surgam) in the treatment of osteoarthritis of the knee and hip. ( Thornton, EJ; Walter, J; Wojtulewski, J, 1981) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, soft-tissue injuries and inflammatory conditions and acute pain of varying origin." | 8.77 | Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. ( Brogden, RN; Sorkin, EM, 1985) |
| "To compare the rate of radiographic progression in knee osteoarthritis (OA) comparing indomethacin with placebo and tiaprofenic acid with placebo." | 5.08 | Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee. LINK Study Group. Longitudinal Investigation of Nonsteroidal Antiinflammatory Drugs in Knee Osteoarthritis. ( Berry, H; Gishen, P; Huskisson, EC; Jubb, RW; Whitehead, J, 1995) |
| "In a randomised double-blind, multicentre, crossover study, the short term efficacy and tolerance of a sustained action preparation of tiaprofenic acid 600 mg once daily was compared with sustained release indomethacin 75 mg once daily in 98 patients with osteoarthritis." | 5.06 | Multicentre double-blind comparison of sustained action formulations of tiaprofenic acid and indomethacin in osteoarthritis. ( Calin, A; Cawley, MI; Pal, B; Rosenberg, JN; Silas, AM; Williams, PI, 1988) |
| "A double-blind, parallel-group study was carried out to compare the clinical efficacy and tolerance of tiaprofenic acid and piroxicam in 80 patients suffering from osteoarthritis of the knee." | 5.06 | Comparative double-blind study of tiaprofenic acid versus piroxicam in the treatment of osteoarthritis of the knee. ( Di Giorgio, E; Maccagno, A; Sebastian, O, 1988) |
| "A double-blind trial was carried out in 60 elderly patients with osteoarthritis of the knee or hip to compare the efficacy and tolerability of treatment with tiaprofenic acid and indomethacin." | 5.05 | Treatment of osteoarthritis: a 3-month comparison between tiaprofenic acid and indomethacin. ( Meurice, J, 1983) |
| "Two multi-centre studies were carried out in general practice comparing tiaprofenic acid ('Surgam') with five other non-steroidal anti-inflammatory agents (ibuprofen, indomethacin, naproxen, piroxicam and benoxaprofen), one in rheumatoid arthritis and one in osteoarthritis." | 5.05 | A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice. ( Clarke, TK; Mungavin, JM, 1983) |
| "Two multi-centre, placebo-controlled, crossover trials of tiaprofenic acid were conducted to an identical design: one in 80 patients suffering from rheumatoid arthritis, the other in 60 patients suffering from osteoarthritis." | 5.05 | Short-term efficacy and tolerance of tiaprofenic acid ('Surgam') in rheumatoid arthritis and osteoarthritis: multi-centre, placebo-controlled trials. ( Daymond, TJ; Essigman, WK; Huskisson, EC; Thompson, M; Wojtulewski, JA, 1982) |
| "Tiaprofenic acid 200 mg three times a day was compared with indomethacin 25 mg three times a day in 36 patients suffering from osteoarthritis of the knee and hip." | 5.05 | Tiaprofenic acid (surgam) in the treatment of osteoarthritis of the knee and hip. ( Thornton, EJ; Walter, J; Wojtulewski, J, 1981) |
| "Eleven patients with osteoarthritis and mild hypertension completed an 8-week, double-blind crossover study in which 200 mg tiaprofenic acid 3-times daily or placebo were substituted for their normal non-steroidal anti-inflammatory therapy." | 5.05 | The effect of tiaprofenic acid on blood pressure control in treated hypertensive patients. ( Brooks, PM; Henstridge, JD; Kupa, A; Smith, MD; Weatherall, M, 1985) |
| "Tiaprofenic acid is a new non-steroidal anti-inflammatory agent advocated for use in rheumatoid arthritis, osteoarthritis, musculoskeletal disorders, soft-tissue injuries and inflammatory conditions and acute pain of varying origin." | 4.77 | Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. ( Brogden, RN; Sorkin, EM, 1985) |
| "The effect of therapeutic and pharmacological concentrations of tiaprofenic acid, a non-steroidal anti-inflammatory drug (NSAID), on the synthesis of the plasminogen activators, urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA), and the plasminogen activator inhibitors 1 and 2 (PAI-1 and PAI-2), by human synovial membranes isolated from osteoarthritis (OA) and rheumatoid arthritis (RA) sufferers was evaluated." | 3.68 | Effects of tiaprofenic acid on plasminogen activators and inhibitors in human OA and RA synovium. ( Cloutier, JM; Martel-Pelletier, J; McCollum, R; Pelletier, JP, 1992) |
| "We examined the in vivo effects of prophylactic intraarticular corticosteroid injections and nonsteroidal antiinflammatory drugs (NSAID) (tiaprofenic acid) oral administration on cartilage lesions of osteoarthritis (OA) and osteophyte formation in 18 dogs in which the anterior cruciate ligament had been sectioned." | 3.68 | In vivo protective effects of prophylactic treatment with tiaprofenic acid or intraarticular corticosteroids on osteoarthritic lesions in the experimental dog model. ( Martel-Pelletier, J; Pelletier, JP, 1991) |
| "The efficacy of intramuscular tiaprofenic acid (TA) was investigated in 3 separate studies: a multicentre open study involving 487 patients with various rheumatic conditions: an open study of 31 patients with active osteoarthritis of the knee; and an open comparative study with ketoprofen involving 30 patients with acute gout." | 3.67 | Clinical experiences with the intramuscular injection of tiaprofenic acid in rheumatic diseases, with particular emphasis on time of onset and duration of the analgesic effect. ( Burgos-Vargas, R; Katona, G, 1988) |
| "Among them 23 patients suffered from gonarthrosis and 9 patients from coxarthrosis." | 2.66 | [Double-blind study of the effect of tiaprofenic acid in comparison with indomethacin in patients with degenerative joint diseases]. ( Jajić, I; Jajić, Z, 1989) |
| "Tiaprofenic acid is a propionic acid derivative with analgesic, anti-inflammatory and antipyretic properties." | 1.31 | Fixed drug eruption due to tiaprofenic acid. ( Bicer, A; Ikizoglu, G; Kaya, TI; Tursen, U, 2002) |
| "We have studied the single dose and steady-state pharmacokinetic of tiaprofenic acid in ten elderly arthritic patients living in the community (5 men and 5 women) taking 200 mg tid for 8 days." | 1.27 | The pharmacokinetics of single and multiple doses of tiaprofenic acid in elderly patients with arthritis. ( Hosie, GA; Hosie, J, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (63.16) | 18.7374 |
| 1990's | 12 (31.58) | 18.2507 |
| 2000's | 2 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tursen, U | 1 |
| Bicer, A | 1 |
| Kaya, TI | 1 |
| Ikizoglu, G | 1 |
| Meurice, J | 1 |
| Mungavin, JM | 1 |
| Clarke, TK | 1 |
| Poletto, B | 1 |
| Diffey, BL | 1 |
| Daymond, TJ | 2 |
| Fairgreaves, H | 1 |
| Thompson, M | 1 |
| Essigman, WK | 1 |
| Huskisson, EC | 4 |
| Wojtulewski, JA | 1 |
| Wojtulewski, J | 1 |
| Walter, J | 1 |
| Thornton, EJ | 1 |
| Høyeraal, HM | 1 |
| Fagertun, H | 1 |
| Ingemann-Hansen, T | 1 |
| Ersmark, H | 1 |
| Rönn, O | 1 |
| Pelletier, JP | 7 |
| Cloutier, JM | 3 |
| Martel-Pelletier, J | 7 |
| Berry, H | 2 |
| Gishen, P | 1 |
| Jubb, RW | 1 |
| Whitehead, J | 1 |
| Jamali, F | 1 |
| Scott, DL | 1 |
| Capell, H | 1 |
| Coppock, J | 1 |
| Daymond, T | 1 |
| Doyle, DV | 1 |
| Fernandes, L | 1 |
| Hazleman, B | 1 |
| Hunter, J | 1 |
| Jawad, A | 1 |
| Jubb, R | 1 |
| Kennedy, T | 1 |
| McGill, P | 1 |
| Nichol, F | 1 |
| Palit, J | 1 |
| Webley, M | 1 |
| Woolf, A | 1 |
| Wotjulewski, J | 1 |
| David, MJ | 1 |
| Vignon, E | 3 |
| Peschard, MJ | 1 |
| Broquet, P | 2 |
| Louisot, P | 3 |
| Richard, M | 3 |
| McCollum, R | 1 |
| Meyer-Carrive, I | 1 |
| Ghosh, P | 2 |
| Wells, C | 1 |
| Smith, M | 1 |
| Hutadilok, N | 1 |
| Howell, DS | 1 |
| Pita, JC | 1 |
| Muller, FJ | 1 |
| Manicourt, DH | 1 |
| Altman, RD | 1 |
| Mathieu, P | 2 |
| Jajić, I | 1 |
| Jajić, Z | 1 |
| Vilamitjana, J | 1 |
| Harmand, MF | 1 |
| Shinmei, M | 1 |
| Kikuchi, T | 1 |
| Masuda, K | 1 |
| Shimomura, Y | 1 |
| Longatti, S | 1 |
| Calin, A | 1 |
| Cawley, MI | 1 |
| Pal, B | 1 |
| Rosenberg, JN | 1 |
| Silas, AM | 1 |
| Williams, PI | 1 |
| Maccagno, A | 1 |
| Sebastian, O | 1 |
| Di Giorgio, E | 1 |
| Ishioka, T | 1 |
| Platt, D | 1 |
| Eicher, H | 1 |
| Rieck, W | 1 |
| Hilgert, D | 1 |
| Katona, G | 1 |
| Burgos-Vargas, R | 1 |
| Hosie, J | 1 |
| Hosie, GA | 1 |
| Allison, N | 1 |
| Shantz, I | 1 |
| Smith, MD | 1 |
| Kupa, A | 1 |
| Weatherall, M | 1 |
| Henstridge, JD | 1 |
| Brooks, PM | 1 |
| Sorkin, EM | 1 |
| Brogden, RN | 1 |
| Lambert, JR | 1 |
| Cardoe, N | 1 |
| Simpson, NR | 1 |
| Oldham, P | 1 |
| Nichol, PE | 1 |
| Martin, L | 1 |
2 reviews available for tiaprofenic acid and Osteoarthritis
| Article | Year |
|---|---|
Tiaprofenic acid.
Topics: Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cartilage, Articular | 1984 |
Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Blood Platelets; Drug Evalu | 1985 |
13 trials available for tiaprofenic acid and Osteoarthritis
| Article | Year |
|---|---|
Treatment of osteoarthritis: a 3-month comparison between tiaprofenic acid and indomethacin.
Topics: Aged; Anti-Inflammatory Agents; Clinical Trials as Topic; Female; Humans; Indomethacin; Joints; Male | 1983 |
A multi-centre study of tiaprofenic acid ('Surgam') and five comparative drugs in rheumatoid arthritis and osteoarthritis in general practice.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthriti | 1983 |
Short-term efficacy and tolerance of tiaprofenic acid ('Surgam') in rheumatoid arthritis and osteoarthritis: multi-centre, placebo-controlled trials.
Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Digestive System; Drug Tolerance; Fema | 1982 |
Tiaprofenic acid (surgam) in the treatment of osteoarthritis of the knee and hip.
Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Hip Joint; Humans; Indomethacin; Knee Joint; Mi | 1981 |
Characterization of responders and nonresponders to tiaprofenic acid and naproxen in the treatment of patients with osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Discriminant Analysis; Doub | 1993 |
Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee. LINK Study Group. Longitudinal Investigation of Nonsteroidal Antiinflammatory Drugs in Knee Osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthrography; Disease Progr | 1995 |
The long-term effects of non-steroidal anti-inflammatory drugs in osteoarthritis of the knee: a randomized placebo-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Double- | 2000 |
[Double-blind study of the effect of tiaprofenic acid in comparison with indomethacin in patients with degenerative joint diseases].
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Female; Humans; Indometha | 1989 |
[Ambulatory multicenter study: efficiency and tolerance of tiaprofenic acid in 4166 osteoarthritic patients].
Topics: Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Drug Evaluation; | 1987 |
Multicentre double-blind comparison of sustained action formulations of tiaprofenic acid and indomethacin in osteoarthritis.
Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; D | 1988 |
Comparative double-blind study of tiaprofenic acid versus piroxicam in the treatment of osteoarthritis of the knee.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; | 1988 |
The effect of tiaprofenic acid on blood pressure control in treated hypertensive patients.
Topics: Aged; Anti-Inflammatory Agents; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Femal | 1985 |
A controlled comparison of tiaprofenic acid and ibuprofen in osteoarthritis.
Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; | 1985 |
23 other studies available for tiaprofenic acid and Osteoarthritis
| Article | Year |
|---|---|
Fixed drug eruption due to tiaprofenic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Eruptions; Female; Humans; Middle Aged; Osteoarthritis | 2002 |
Phototoxic reactions to piroxicam, naproxen and tiaprofenic acid.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Female; Humans; Male; Naproxen; Osteoarthritis; Pho | 1983 |
In vitro effects of NSAIDs and corticosteroids on the synthesis and secretion of interleukin 1 by human osteoarthritic synovial membranes.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Depression, Chemical; Enzyme-Linke | 1993 |
Lack of significant stereoselectivity in pharmacokinetics of tiaprofenic acid.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Chromatography, High Pressure Liquid; Humans; Os | 1997 |
Effect of non-steroidal anti-inflammatory drugs (NSAIDS) on glycosyltransferase activity from human osteoarthritic cartilage.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Chloroquine; Depression, Chemic | 1992 |
Effects of tiaprofenic acid on plasminogen activators and inhibitors in human OA and RA synovium.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Culture Techniques; Depression, Chem | 1992 |
Effects of tiaprofenic acid (Surgam) on cartilage proteoglycans in the rabbit joint immobilisation model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Chromatography, Gel; Drug Ad | 1992 |
Chondroprotection, myth or reality: an experimental approach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cartilage, Articular; Cells | 1990 |
In vivo protective effects of prophylactic treatment with tiaprofenic acid or intraarticular corticosteroids on osteoarthritic lesions in the experimental dog model.
Topics: Administration, Oral; Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents; Anti-Inflammatory | 1991 |
Treatment of osteoarthritis with tiaprofenic acid: biochemical and histological protection against cartilage breakdown in the Pond-Nuki canine model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Diseas | 1991 |
Cartilage degradative enzymes in human osteoarthritis: effect of a nonsteroidal antiinflammatory drug administered orally.
Topics: Acetaminophen; Administration, Oral; Aged; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Artic | 1990 |
Clinical aspects of chrondroprotection.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Humans; Indomethacin; Osteoarthritis; | 1990 |
Molecular basis for the action of tiaprofenic acid on human osteoarthritic cartilage degradation.
Topics: Cartilage, Articular; Cyclic AMP; Dinoprostone; Microscopy, Electron; Osteoarthritis; Propionates; P | 1989 |
Evidence for the involvement of interleukin 1 in human osteoarthritic cartilage degradation: protective effect of NSAID.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Culture Techniques; Cyclic AMP; Dinop | 1989 |
Phospholipase A2 activity in human osteoarthritic cartilage.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Endopeptidases; Female; Humans; | 1989 |
In vitro effects of tiaprofenic acid, sodium salicylate and hydrocortisone on the proteoglycan metabolism of human osteoarthritic cartilage.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Female; Huma | 1989 |
Effects of interleukin-1 and anti-inflammatory drugs on the degradation of human articular cartilage.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; Cartilage, Articular; Cel | 1988 |
In vitro effects of tiaprofenic acid, sodium salicylate and hydrocortisone on human osteoarthritic cartilage degradation and synovial collagenase synthesis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Humans; Hydrocortisone; Microbial Col | 1988 |
Is tiaprofenic acid different from other NSAIDs with regard to effects on renal function in the elderly?
Topics: Acetylglucosaminidase; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; beta | 1988 |
Pharmacokinetics of tiaprofenic acid in elderly multimorbid patients.
Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Female; Humans; Intestinal Absorpt | 1988 |
Clinical experiences with the intramuscular injection of tiaprofenic acid in rheumatic diseases, with particular emphasis on time of onset and duration of the analgesic effect.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheu | 1988 |
The pharmacokinetics of single and multiple doses of tiaprofenic acid in elderly patients with arthritis.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Female; Half-Life; Humans; Kinetics; Male; Osteoarthr | 1987 |
Delirium related to tiaprofenic acid.
Topics: Aged; Aged, 80 and over; Delirium; Female; Humans; Osteoarthritis; Propionates | 1987 |