Page last updated: 2024-08-07 13:06:52

Insulin-like growth factor-binding protein 4

An insulin-like growth factor-binding protein 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22692]

Synonyms

IBP-4;
IGF-binding protein 4;
IGFBP-4

Research

Bioassay Publications (1)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Compounds (1)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
nbi 31772Homo sapiens (human)Ki0.001011

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
signaling receptor bindingmolecular functionBinding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
insulin-like growth factor I bindingmolecular functionBinding to insulin-like growth factor I. [GOC:mah]
insulin-like growth factor II bindingmolecular functionBinding to insulin-like growth factor II. [GOC:mah]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
endoplasmic reticulum lumencellular componentThe volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
extracellular spacecellular componentThat part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Involved In

This protein is involved in 10 target(s):

TargetCategoryDefinition
MAPK cascadebiological processAn intracellular protein kinase cascade containing at least a MAP kinase (MAPK). It starts with the activation of a MAP3K, and the consecutive activation of a MPK2K and a MAPK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell. [PMID:20811974, PMID:9561267]
regulation of cell growthbiological processAny process that modulates the frequency, rate, extent or direction of cell growth. [GOC:go_curators]
signal transductionbiological processThe cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
regulation of glucose metabolic processbiological processAny process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. [GOC:BHF, GOC:tb]
response to organic cyclic compoundbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:ef]
positive regulation of MAPK cascadebiological processAny process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators]
positive regulation of insulin-like growth factor receptor signaling pathwaybiological processAny process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling. [GOC:bf]
type B pancreatic cell proliferationbiological processThe multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin. [GOC:jl, GOC:yaf]
negative regulation of canonical Wnt signaling pathwaybiological processAny process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. [GOC:dph, GOC:tb]
regulation of insulin-like growth factor receptor signaling pathwaybiological processAny process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling. [GOC:bf]