pk 11195 has been researched along with Osteoarthritis in 4 studies
PK-11195 : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 1-(2-chlorophenyl)isoquinoline-3-carboxylic acid with the amino group of sec-butylmethylamine
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Romero-Sandoval, EA | 1 |
| Miltyk, W | 1 |
| Surazynski, A | 1 |
| Dondziło, J | 1 |
| Palka, J | 1 |
| Miller, TR | 1 |
| Wetter, JB | 1 |
| Jarvis, MF | 1 |
| Bitner, RS | 1 |
| Giusti, L | 1 |
| Betti, L | 1 |
| Giannaccini, G | 1 |
| Mascia, G | 1 |
| Bazzichi, L | 1 |
| Lucacchini, A | 1 |
1 review available for pk 11195 and Osteoarthritis
| Article | Year |
|---|---|
Peripheral benzodiazepine receptors: are they potential biomarkers for glial activation in pain states?
Topics: Animals; Isoquinolines; Male; Microglia; Neuralgia; Osteoarthritis; Pain; Spinal Cord | 2013 |
3 other studies available for pk 11195 and Osteoarthritis
| Article | Year |
|---|---|
4'-chlorodiazepam--agonist of peripheral benzodiazepine receptors as a protecting factor in IL-1 induced deregulation of collagen biosynthesis in cultured human chondrocytes.
Topics: Apoptosis; Benzodiazepinones; Cartilage; Cells, Cultured; Chondrocytes; Collagen; Convulsants; Extra | 2010 |
Spinal microglial activation in rat models of neuropathic and osteoarthritic pain: an autoradiographic study using [3H]PK11195.
Topics: Animals; Autoradiography; Disease Models, Animal; Isoquinolines; Male; Microglia; Neuralgia; Osteoar | 2013 |
[3H]PK11195 binding sites in human neutrophils: effect of fMLP stimulation and modulation in rheumatic diseases.
Topics: Aged; Arthritis, Psoriatic; Arthritis, Rheumatoid; Binding Sites; Cell Membrane; Female; Humans; Iso | 2004 |