Page last updated: 2024-12-05

chamazulene

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Chamazulene is a blue-colored sesquiterpene compound found naturally in essential oils of certain plants, most notably chamomile (Matricaria recutita). It is known for its anti-inflammatory, antioxidant, and anti-allergic properties. Chamazulene can be synthesized through various chemical processes involving the rearrangement of other sesquiterpenes, such as matricin. Its biological effects are attributed to its ability to inhibit the production of inflammatory mediators like prostaglandins and leukotrienes, as well as to its antioxidant activity in scavenging free radicals. The therapeutic potential of chamazulene has been investigated in various fields, including dermatology, wound healing, and pain management. Its anti-inflammatory properties make it a promising candidate for treating skin conditions like eczema and acne. Chamazulene's antioxidant activity may also play a role in protecting against oxidative stress and inflammation. Its widespread occurrence in essential oils, coupled with its biological activity, makes it an attractive target for research, particularly in the development of natural therapeutic agents.'

chamazulene: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10719
CHEMBL ID495665
CHEBI ID3573
MeSH IDM0061986

Synonyms (43)

Synonym
ba 2784
azulene, 7-ethyl-1,4-dimethyl-
7-ethyl-1,4-dimethylazulene
azulene, 1,4-dimethyl-7-ethyl-
camazulene
1,4-dimethyl-7-ethylazulene
dimethulen
einecs 208-449-6
dimethulene
brn 1306577
C09633
chamazulene
529-05-5
chamazulen
LMPR0103410002
gxgjiomuzagveh-uhfffaoysa-
inchi=1/c14h16/c1-4-12-7-5-10(2)13-8-6-11(3)14(13)9-12/h5-9h,4h2,1-3h3
chebi:3573 ,
CHEMBL495665
unii-z439uh6e5f
4-05-00-01736 (beilstein handbook reference)
z439uh6e5f ,
FT-0623581
chamazulene [inci]
ba-2784
chamazulene [mi]
chamazulene (constituent of chamomile) [dsc]
chamazulene [who-dd]
GXGJIOMUZAGVEH-UHFFFAOYSA-N
mfcd00800984
chamazulene, analytical standard
DTXSID70200939 ,
7-ethyl-1,4-dimethyl-azulene
1,4-dimethyl-7-ethyl-azulene
dimethwlen
lindazulene
7-ethyl-1,4-dimethylazulen
Q909088
dimethylene
HY-121038
chamazulene (constituent of chamomile)
dtxcid50123430
AKOS040744437

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
sesquiterpenoidAny terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (1)

Assay IDTitleYearJournalArticle
AID378070Inhibition of spontaneous contraction in guinea pig ileum2006Journal of natural products, Aug, Volume: 69, Issue:8
Qualitative and quantitative analysis of the active components of the essential oil from Brickellia veronicaefolia by nuclear magnetic resonance spectroscopy.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (36)

TimeframeStudies, This Drug (%)All Drugs %
pre-199011 (30.56)18.7374
1990's4 (11.11)18.2507
2000's6 (16.67)29.6817
2010's14 (38.89)24.3611
2020's1 (2.78)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 43.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index43.65 (24.57)
Research Supply Index3.64 (2.92)
Research Growth Index4.75 (4.65)
Search Engine Demand Index62.61 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (43.65)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (2.78%)5.53%
Reviews2 (5.56%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other33 (91.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]