Compounds > Echinocystic acid 3-glucoside
Page last updated: 2024-12-08

Echinocystic acid 3-glucoside

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ecliptasaponin A: has anti-fibrotic activity; isolated from Ecliptae Herba extract; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID476537
CHEMBL ID3343916
CHEBI ID184046

Synonyms (26)

Synonym
(4ar,5r,6ar,6as,6br,8ar,10s,12ar,14bs)-5-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-10-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
echinocystic acid 3-o-.beta.-d-glucopyranoside
78285-90-2
echinocystic acid 3-glucoside
(4ar,5r,6ar,6as,6br,8ar,10s,12ar,14bs)-5-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-10-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
CHEBI:184046
A839703
(4ar,5r,6ar,6as,6br,8ar,10s,12ar,14bs)-10-[(2r,3r,4s,5s,6r)-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-2,2,6a,6b,9,9,12a-heptamethyl-5-oxidanyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
(4ar,5r,6ar,6as,6br,8ar,10s,12ar,14bs)-5-hydroxy-2,2,6a,6b,9,9,12a-heptamethyl-10-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
S9403
echinocystic acid-3-o-glucoside
AC-34295
eclalbasaponin ii
ecliptasaponin a
mfcd00017386
CHEMBL3343916
eclalbasaponin ii, analytical standard
gleditsoside b
gleditschoside b
CS-0017051
HY-N1508
CCG-270299
DTXSID10999638
olean-12-en-28-oic acid, 3-(b-d-glucopyranosyloxy)-16-hydroxy-,(3b,16a)-
echinocysticacid-3-glucoside
AKOS040750442
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
triterpenoid saponinA terpene glycoside in which the terpene moiety is a triterpenoid.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (4)

Assay IDTitleYearJournalArticle
AID1172861Inhibition of NFkappaB (unknown origin) expressed in in LPS-stimulated HEK293-NF-kappaB-luc cells assessed as luminescence signals measured by relative light units at 500 ug/mL pre-treated for 4 hrs before LPS challenge for 24 hrs by luciferase assay2014Bioorganic & medicinal chemistry, Nov-15, Volume: 22, Issue:22
Thiophenes, polyacetylenes and terpenes from the aerial parts of Eclipata prostrate.
AID1172858Inhibition of NFkappaB (unknown origin) expressed in in LPS-stimulated HEK293-NF-kappaB-luc cells assessed as luminescence signals measured by relative light units at 1 ug/mL pre-treated for 4 hrs before LPS challenge for 24 hrs by luciferase assay2014Bioorganic & medicinal chemistry, Nov-15, Volume: 22, Issue:22
Thiophenes, polyacetylenes and terpenes from the aerial parts of Eclipata prostrate.
AID1172860Inhibition of NFkappaB (unknown origin) expressed in in LPS-stimulated HEK293-NF-kappaB-luc cells assessed as luminescence signals measured by relative light units at 100 ug/mL pre-treated for 4 hrs before LPS challenge for 24 hrs by luciferase assay2014Bioorganic & medicinal chemistry, Nov-15, Volume: 22, Issue:22
Thiophenes, polyacetylenes and terpenes from the aerial parts of Eclipata prostrate.
AID1172859Inhibition of NFkappaB (unknown origin) expressed in in LPS-stimulated HEK293-NF-kappaB-luc cells assessed as luminescence signals measured by relative light units at 10 ug/mL pre-treated for 4 hrs before LPS challenge for 24 hrs by luciferase assay2014Bioorganic & medicinal chemistry, Nov-15, Volume: 22, Issue:22
Thiophenes, polyacetylenes and terpenes from the aerial parts of Eclipata prostrate.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's6 (85.71)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.25 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index5.33 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
hydroxyproline
Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.. hydroxyproline : A proline derivative that is proline substituted by at least one hydroxy group.		2.11104-hydroxyproline;
L-alpha-amino acid zwitterion		human metabolite;
mouse metabolite;
plant metabolite
oleanolic acid
[no description available]		2.1310hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.		2.1110dialdehydebiomarker
glucose, (beta-d)-isomer
beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.		2.1710D-glucopyranoseepitope;
mouse metabolite
diprotin a
[no description available]		2.110peptide
beta-escin
[no description available]		3.3760
echinocystic acid
echinocystic acid: aglycone moiety of saponin chrysantellin		2.1310
eclalbasaponin i
eclalbasaponin I: has antineoplastic activity; isolated from Eclipta prostrata; structure in first source		2.7730
scopolamine hydrobromide
[no description available]		2.1710
ConditionIndicatedRelationship StrengthStudiesTrials
Cognitive Decline
[description not available]		02.1710
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1710
Age-Related Memory Disorders
[description not available]		02.1710
Memory Disorders
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.		02.1710
Cognitive Dysfunction
Diminished or impaired mental and/or intellectual function.		02.1710
Cancer of Ovary
[description not available]		02.1310
Ovarian Neoplasms
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.		02.1310
Bone Cancer
[description not available]		02.1710
Arthritis, Degenerative
[description not available]		02.1710
Bone Neoplasms
Tumors or cancer located in bone tissue or specific BONES.		02.1710
Chondrosarcoma
A slowly growing malignant neoplasm derived from cartilage cells, occurring most frequently in pelvic bones or near the ends of long bones, in middle-aged and old people. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion or in patients with ENCHONDROMATOSIS. (Stedman, 25th ed)		02.1710
Osteoarthritis
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.		02.1710
Alveolitis, Fibrosing
[description not available]		02.1110
Pulmonary Fibrosis
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.		02.1110