cortivazol profile

cortivazol: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	66249
CHEMBL ID	2105842
CHEBI ID	135820
SCHEMBL ID	4875
MeSH ID	M0047799

Synonym
nsc-80998
cortivazol
1110-40-3
D03594
cortivazol (usan)
cortivazolum [inn-latin]
cortivazol [usan:inn]
einecs 214-175-8
11beta,17alpha,21-trihydroxy-6,16alpha-dimethyl-2'-phenylpregna-2,4,6-trieno(3,2-c)pyrazol-20-one 21-acetate
2'h-pregna-2,4,6-trieno(3,2-c)pyrazol-20-one, 21-(acetyloxy)-11,17-dihydroxy-6,16-dimethyl-2'-phenyl-, (11beta,16alpha)-
nsc 80998
cortivasolo [dcit]
11beta,17,21-trihydroxy-6,16alpha-dimethyl-2'-phenyl-2'h-pregna-2,4,6-trieno(3,2-c)pyrazol-20-one 21-acetate
2'h-pregna-2,4,6-trieno(3,2-c)pyrazol-20-one, 11beta,17,21-trihydroxy-6,16alpha-dimethyl-2'-phenyl-, 21-acetate
corticoid
CHEBI:135820
ym183k0h63 ,
altim
unii-ym183k0h63
cortivasolo
CHEMBL2105842
cortivazol [mi]
2'h-pregna-2,4,6-trieno(3,2-c)pyrazol-20-one, 21-(acetyloxy)-11,17-dihydroxy-6,16-dimethyl-2'-phenyl-, (11.beta.,16.alpha.)-
cortivazol [who-dd]
cortivazol [mart.]
11.beta.,17,21-trihydroxy-6,16.alpha.-dimethyl-2'-phenyl-2'h-pregna-2,4,6-trieno(3,2-c)pyrazol-20-one 21-acetate
cortivazol [usan]
cortivazol [inn]
SCHEMBL4875
RKHQGWMMUURILY-UHRZLXHJSA-N
DTXSID40149442
11,17,21-trihydroxy-6,16-dimethyl-2-phenyl-2-pregna-2,4,6-trieno[3,2-c]pyrazol-20-one 21-acetate
DB13003
EX-A7287
Q2421270
[2-[(1s,2r,13s,14s,16r,17r,18s,20s)-17,20-dihydroxy-2,11,16,18-tetramethyl-7-phenyl-6,7-diazapentacyclo[11.7.0.02,10.04,8.014,18]icosa-4(8),5,9,11-tetraen-17-yl]-2-oxoethyl] acetate
AKOS040746721

Excerpt	Reference	Relevance
"Cortivazol is a phenylpyrazolo glucocorticoid of high potency and unusual structure. "	( Cortivazol mediated induction of glucocorticoid receptor messenger ribonucleic acid in wild-type and dexamethasone-resistant human leukemic (CEM) cells. Ashraf, J; Chilton, D; Kunapuli, S; Thompson, EB, 1991)	3.17
"Cortivazol (CVZ) is a unique, high potency synthetic glucocorticoid, which has a phenylpyrazol fused to the A-ring of the steroid nucleus and displays binding consistent with two or more sites in the cytosol from CEM C7 cells (a human acute lymphoblastic T-cell line)."	( Two glucocorticoid binding sites on the human glucocorticoid receptor. Srivastava, D; Thompson, EB, 1990)	1

Excerpt	Reference	Relevance
"Cortivazol has potent antileukemic activity in childhood ALL. "	( Cytotoxicity of cortivazol in childhood acute lymphoblastic leukemia. Kurylak, A; Styczynski, J; Wysocki, M, )	1.92

Class	Description
steroid	Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene which is a triterpene.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	8 (23.53)	18.7374
1990's	13 (38.24)	18.2507
2000's	10 (29.41)	29.6817
2010's	3 (8.82)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	6 (15.38%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	8 (20.51%)	4.05%
Observational	0 (0.00%)	0.25%
Other	25 (64.10%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Clinical Trials (3)

Trial Overview

Trial	Phase	Enrollment	Study Type	Start Date	Status
Plantar Fasciitis Treatment: Double Blinded Randomized Control Study of the Efficacy of an Injection of Platelet Rich Plasma (PRP) Versus an Infiltration of Corticosteroids [NCT03857334]		50 participants (Actual)	Interventional	2016-07-01	Completed
A Double Blind Randomized Controlled Trial of Greater Occipital Nerve Infiltration in Cluster Headache [NCT00804895]	Phase 2/Phase 3	43 participants (Actual)	Interventional	2008-12-31	Completed
Clinical Results After Medical Therapy Alone or Medical Therapy Associated With Lumbar Traction in the Treatment of Nerve Root Pain of Lumbar Disc Herniation With Disco-radicular Conflict [NCT02793440]		412 participants (Anticipated)	Interventional	2013-12-02	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
verapamil Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.	4.37	1	1	aromatic ether; nitrile; polyether; tertiary amino compound
iodixanol iodixanol: dimeric contrast media; structure given in first source. iodixanol : A dimeric, non-ionic, water-soluble, radiographic contrast agent, used particularly in coronary angiography.	2.07	1	0	organoiodine compound	radioopaque medium
prednisolone Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.. prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.	2.92	4	0	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; drug metabolite; environmental contaminant; immunosuppressive agent; xenobiotic
prednisolone acetate prednisolone acetate: RN given refers to cpd with locant for acetate group in position 21 & (11 beta)-isomer	2.69	3	0	corticosteroid hormone
triamcinolone acetonide Triamcinolone Acetonide: An esterified form of TRIAMCINOLONE. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.. triamcinolone acetonide : A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.	1.98	1	0	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; cyclic ketal; fluorinated steroid; glucocorticoid; primary alpha-hydroxy ketone	anti-allergic agent; anti-inflammatory drug
methylprednisolone Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.. 6alpha-methylprednisolone : The 6alpha-stereoisomer of 6-methylprednisolone.	2.04	1	0	6-methylprednisolone; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antiemetic; environmental contaminant; neuroprotective agent; xenobiotic
betamethasone Betamethasone: A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)	1.99	1	0	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; fluorinated steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	anti-asthmatic agent; anti-inflammatory drug; immunosuppressive agent
promegestone Promegestone: A synthetic progestin which is useful for the study of progestin distribution and progestin tissue receptors, as it is not bound by transcortin and binds to progesterone receptors with a higher association constant than progesterone.. promegestone : A progestin consisting of 17beta-propionylestra-4,9-dien-3-one substituted at position 17 by a methyl group.	1.98	1	0	20-oxo steroid; 3-oxo-Delta(4) steroid	antineoplastic agent; progesterone receptor agonist; progestin
mifepristone Mifepristone: A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.	3.24	6	0	3-oxo-Delta(4) steroid; acetylenic compound; tertiary amino compound	abortifacient; contraceptive drug; hormone antagonist; synthetic oral contraceptive
dexamethasone 21-methanesulfonate dexamethasone 21-methanesulfonate: RN given refers to (11beta,16alpha)-isomer	1.97	1	0
deacylcortivazol deacylcortivazol: acts through glucocorticoid receptors; structure given in first source	1.96	1	0
pulmicort Budesonide: A glucocorticoid used in the management of ASTHMA, the treatment of various skin disorders, and allergic RHINITIS.. budesonide : A glucocorticoid steroid having a highly oxygenated pregna-1,4-diene structure. It is used mainly in the treatment of asthma and non-infectious rhinitis and for treatment and prevention of nasal polyposis.	1.99	1	0	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; cyclic acetal; glucocorticoid; primary alpha-hydroxy ketone	anti-inflammatory drug; bronchodilator agent; drug allergen
tipredane [no description available]	1.99	1	0	3-hydroxy steroid	androgen
nivazol nivazol: RN given refers to (17alpha)-isomer; structure given in first source	6.96	1	0	steroid
orabase Orabase: used in therapy of oral mucosal ulcers	1.98	1	0

Condition	Relationship Strength	Studies	Trials
Disc, Herniated [description not available]	2.4	2	0
Nerve Root Avulsion [description not available]	2.04	1	0
Intervertebral Disc Displacement An INTERVERTEBRAL DISC in which the NUCLEUS PULPOSUS has protruded through surrounding ANNULUS FIBROSUS. This occurs most frequently in the lower lumbar region.	2.4	2	0
Radiculopathy Disease involving a spinal nerve root (see SPINAL NERVE ROOTS) which may result from compression related to INTERVERTEBRAL DISK DISPLACEMENT; SPINAL CORD INJURIES; SPINAL DISEASES; and other conditions. Clinical manifestations include radicular pain, weakness, and sensory loss referable to structures innervated by the involved nerve root.	2.04	1	0
Adhesive Capsulitis [description not available]	3.43	1	1
Bursitis Inflammation or irritation of a SYNOVIAL BURSA, the fibrous sac that acts as a cushion between moving structures of bones, muscles, tendons or skin.	3.43	1	1
Shoulder Pain Unilateral or bilateral pain of the shoulder. It is often caused by physical activities such as work or sports participation, but may also be pathologic in origin.	3.43	1	1
Calcification, Pathologic [description not available]	2.05	1	0
Spinal Diseases Diseases involving the SPINE.	2.42	2	0
Calcinosis Pathologic deposition of calcium salts in tissues.	2.05	1	0
Atypical Cluster Headache [description not available]	4.77	2	1
Low Back Ache [description not available]	2.07	1	0
Synovial Cyst Non-neoplastic tumor-like lesions at joints, developed from the SYNOVIAL MEMBRANE of a joint through the JOINT CAPSULE into the periarticular tissues. They are filled with SYNOVIAL FLUID with a smooth and translucent appearance. A synovial cyst can develop from any joint, but most commonly at the back of the knee, where it is known as POPLITEAL CYST.	2.43	2	0
Low Back Pain Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.	2.07	1	0
Acute Lymphoid Leukemia [description not available]	2.92	4	0
Precursor Cell Lymphoblastic Leukemia-Lymphoma A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.	2.92	4	0
Complications of Diabetes Mellitus [description not available]	4.34	1	1
Neuralgia, Sciatic [description not available]	5.55	3	2
Sciatica A condition characterized by pain radiating from the back into the buttock and posterior/lateral aspects of the leg. Sciatica may be a manifestation of SCIATIC NEUROPATHY; RADICULOPATHY (involving the SPINAL NERVE ROOTS; L4, L5, S1, or S2, often associated with INTERVERTEBRAL DISK DISPLACEMENT); or lesions of the CAUDA EQUINA.	5.55	3	2
Acute Myelogenous Leukemia [description not available]	2.04	1	0
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	2.04	1	0
Diffuse Mixed Small and Large Cell Lymphoma [description not available]	1.98	1	0
Lymphoma, Non-Hodgkin Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.	1.98	1	0
Ankylosing Vertebral Hyperostosis with Tylosis [description not available]	1.98	1	0
Experimental Hepatoma [description not available]	1.98	1	0
Adenocarcinoma, Basal Cell [description not available]	1.98	1	0
Cancer of Pancreas [description not available]	1.98	1	0
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	1.98	1	0
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	1.98	1	0
Polyarthritis [description not available]	1.98	1	0
Ankylosing Spondylarthritis [description not available]	1.98	1	0
Arthritis Acute or chronic inflammation of JOINTS.	1.98	1	0
Spondylitis, Ankylosing A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.	1.98	1	0
Arteriovenous Malformations Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas.	1.99	1	0
Angioma A vascular anomaly due to proliferation of blood or lymphatic vessels that forms a tumor-like mass. Vessels in the angioma may or may not be dilated.	1.99	1	0
Cancer of Skin [description not available]	1.99	1	0
Hemangioma A vascular anomaly due to proliferation of BLOOD VESSELS that forms a tumor-like mass. The common types involve CAPILLARIES and VEINS. It can occur anywhere in the body but is most frequently noticed in the SKIN and SUBCUTANEOUS TISSUE. (from Stedman, 27th ed, 2000)	1.99	1	0
Skin Neoplasms Tumors or cancer of the SKIN.	1.99	1	0
Arthritis, Degenerative [description not available]	3.38	1	1
Osteoarthritis A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	3.38	1	1
Entrapment Neuropathies [description not available]	2	1	0
Anasarca [description not available]	1.95	1	0
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	1.95	1	0
Anaphylactic Reaction [description not available]	1.98	1	0
Dermatitis Medicamentosa [description not available]	1.98	1	0
Allergy, Drug [description not available]	1.98	1	0
Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.	1.98	1	0
Drug Hypersensitivity Immunologically mediated adverse reactions to medicinal substances used legally or illegally.	1.98	1	0
Chromosome Deletion Actual loss of portion of a chromosome.	1.98	1	0
ATLL [description not available]	1.97	1	0
Leukemia-Lymphoma, Adult T-Cell Aggressive T-Cell malignancy with adult onset, caused by HUMAN T-LYMPHOTROPIC VIRUS 1. It is endemic in Japan, the Caribbean basin, Southeastern United States, Hawaii, and parts of Central and South America and sub-Saharan Africa.	1.97	1	0
Nerve Pain [description not available]	1.97	1	0
Neuralgia Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.	1.97	1	0
Leucocythaemia [description not available]	2.37	2	0
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	2.37	2	0
Circulatory Collapse [description not available]	1.96	1	0
Shock A pathological condition manifested by failure to perfuse or oxygenate vital organs.	6.96	1	0

cortivazol

Description

Cross-References

Synonyms (37)

Research Excerpts

Overview

Effects

Drug Classes (1)

Research

Studies (34)

Market Indicators

Research Demand Index: 34.35

Study Types

Clinical Trials (3)

Trial Overview

cortivazol

Description

Cross-References

Synonyms (37)

Research Excerpts

Overview

Effects

Drug Classes (1)

Research

Studies (34)

Market Indicators

Research Demand Index: 34.35

Study Types

Clinical Trials (3)

Trial Overview

Related Drugs (15)

Related Conditions (57)