Page last updated: 2024-08-23

s-adenosylmethionine and Osteoarthritis

s-adenosylmethionine has been researched along with Osteoarthritis in 45 studies

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-199019 (42.22)18.7374
1990's9 (20.00)18.2507
2000's14 (31.11)29.6817
2010's3 (6.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
De Silva, V; El-Metwally, A; Ernst, E; Lewith, G; Macfarlane, GJ1
Evans, RB; Gordon-Evans, WJ; Griffon, DJ; Imhoff, DJ; Johnson, AL; Swanson, KS1
Lopez, HL1
Bottiglieri, T1
Lasek, R; Victor, N; Witte, S1
Basch, E; Shmerling, R; Ulbricht, C1
Morelli, V; Naquin, C; Weaver, V1
Chiappelli, F; Coulter, I; Favreau, J; Hardy, ML; Jungvig, LK; Morton, SC; Orshansky, G; Rossi, F; Roth, EA; Shekelle, P; Suttorp, MJ; Venuturupalli, S1
Clayton, JJ1
Gregory, PJ; Sperry, M; Wilson, AF1
Hosea Blewett, HJ1
Castino, E; Ceccato, S; Cucinotta, D; Mancini, M1
Pellegrini, P1
Caroli, A1
McCarty, MF1
Bradley, JD; Brandt, KD; Chambers, MA; Flusser, D; Katz, BP; Schumacher, HR; Zonay, LJ1
Gaby, AR1
McCarty, MF; Russell, AL1
Cerrato, PL; Rowell, N1
Ramos, L1
Boorstin, J1
Avila, JR; Fetrow, CW1
Agelli, M; Bausell, RB; Berman, BM; Lee, WL; Soeken, KL1
Ballabio, CB; Caruso, I1
Chériè Lignière, G; Cortellaro, M; Parrini, L; Polli, E; Tessari, L1
Setnikar, I1
Jansen, G; Kalbhen, DA1
Barceló, HA; Barreira, JC; Macías, M; Sagasta, CL; Wiemeyer, JC2
Domljan, Z; Dürrigl, T; Pucar, I; Vrhovac, B1
Stramentinoli, G1
di Padova, C1
Caruso, I; Pietrogrande, V1
Caston, OL; Di Giorgio, EE; Maccagno, A; Sagasta, CL1
Vetter, G1
Müller-Fassbender, H1
Berger, R; Nowak, H1
König, B1
Schumacher, HR1
Cherie-Ligniere, G; Colombo, B; Giordano, M; Glorioso, S; Leardini, G; Marcolongo, R; Mattara, L; Mazzi, A; Passeri, M; Todesco, S1
Boccassini, L; Caruso, I; Fumagalli, M; Locati, M; Montrone, F; Santandrea, S; Sarzi Puttini, P; Volpato, R1

Reviews

12 review(s) available for s-adenosylmethionine and Osteoarthritis

ArticleYear
Evidence for the efficacy of complementary and alternative medicines in the management of osteoarthritis: a systematic review.
    Rheumatology (Oxford, England), 2011, Volume: 50, Issue:5

    Topics: Administration, Oral; Administration, Topical; Antirheumatic Agents; Capsaicin; Complementary Therapies; Humans; Osteoarthritis; S-Adenosylmethionine; Treatment Outcome

2011
Nutritional interventions to prevent and treat osteoarthritis. Part II: focus on micronutrients and supportive nutraceuticals.
    PM & R : the journal of injury, function, and rehabilitation, 2012, Volume: 4, Issue:5 Suppl

    Topics: Animals; Catechin; Dietary Supplements; Disease Progression; Drug Combinations; Epigenesis, Genetic; Harpagophytum; Humans; Hyaluronic Acid; Micronutrients; Osteoarthritis; Oxidative Stress; Peptide Hydrolases; Proteomics; S-Adenosylmethionine; Viscosupplements; Vitamins

2012
S-Adenosyl-L-methionine (SAMe): from the bench to the bedside--molecular basis of a pleiotrophic molecule.
    The American journal of clinical nutrition, 2002, Volume: 76, Issue:5

    Topics: Animals; Depression; Diffusion of Innovation; Humans; Liver Diseases; Methylation; Nervous System Diseases; Osteoarthritis; S-Adenosylmethionine; Tissue Distribution

2002
[Meta-analysis of the efficacy of adenosylmethionine and oxaceprol in the treatment of osteoarthritis].
    Der Orthopade, 2002, Volume: 31, Issue:11

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Confidence Intervals; Data Interpretation, Statistical; Diclofenac; Humans; Hydroxyproline; Ibuprofen; Osteoarthritis; Placebos; Randomized Controlled Trials as Topic; S-Adenosylmethionine; Therapeutic Equivalency

2002
Alternative therapies for traditional disease states: osteoarthritis.
    American family physician, 2003, Jan-15, Volume: 67, Issue:2

    Topics: Chondroitin Sulfates; Complementary Therapies; Drug Therapy, Combination; Glucosamine; Humans; Osteoarthritis; S-Adenosylmethionine

2003
S-adenosyl-L-methionine for treatment of depression, osteoarthritis, and liver disease.
    Evidence report/technology assessment (Summary), 2003, Issue:64

    Topics: Cholestasis, Intrahepatic; Depressive Disorder; Female; Humans; Liver Diseases; Osteoarthritis; Pregnancy; Pregnancy Complications; S-Adenosylmethionine

2003
Nutraceuticals in the management of osteoarthritis.
    Orthopedics, 2007, Volume: 30, Issue:8

    Topics: Aged; Amino Acids, Sulfur; Anthraquinones; Boswellia; Chondroitin; Dietary Supplements; Gelatin; Glucosamine; Humans; Hydroxyproline; Osteoarthritis; Persea; Phytotherapy; Plant Oils; Protein Hydrolysates; S-Adenosylmethionine; Soybean Oil

2007
Dietary supplements for osteoarthritis.
    American family physician, 2008, Jan-15, Volume: 77, Issue:2

    Topics: Anti-Inflammatory Agents; Chondroitin Sulfates; Curcuma; Dietary Supplements; Dimethyl Sulfoxide; Glucosamine; Harpagophytum; Humans; Osteoarthritis; Phytotherapy; Plant Preparations; S-Adenosylmethionine; Sulfones; Treatment Outcome; Zingiber officinale

2008
Natural treatments for osteoarthritis.
    Alternative medicine review : a journal of clinical therapeutic, 1999, Volume: 4, Issue:5

    Topics: Boron; Chondroitin Sulfates; Glucosamine; Humans; Manganese; Niacinamide; Osteoarthritis; Phytotherapy; S-Adenosylmethionine; Vitamins

1999
Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis.
    The Journal of family practice, 2002, Volume: 51, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Complementary Therapies; Dietary Supplements; Humans; Osteoarthritis; Randomized Controlled Trials as Topic; S-Adenosylmethionine

2002
Antireactive properties of "chondroprotective" drugs.
    International journal of tissue reactions, 1992, Volume: 14, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Glucosamine; Glycosaminoglycans; Osteoarthritis; S-Adenosylmethionine

1992
Pharmacologic aspects of S-adenosylmethionine. Pharmacokinetics and pharmacodynamics.
    The American journal of medicine, 1987, Nov-20, Volume: 83, Issue:5A

    Topics: Administration, Oral; Animals; Dogs; Female; Humans; Intestinal Absorption; Kinetics; Male; Osteoarthritis; Rats; S-Adenosylmethionine

1987

Trials

16 trial(s) available for s-adenosylmethionine and Osteoarthritis

ArticleYear
Evaluation of S-adenosyl l-methionine in a double-blinded, randomized, placebo-controlled, clinical trial for treatment of presumptive osteoarthritis in the dog.
    Veterinary surgery : VS, 2011, Volume: 40, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Dog Diseases; Dogs; Double-Blind Method; Gait; Osteoarthritis; Pain Measurement; S-Adenosylmethionine; Surveys and Questionnaires; Treatment Outcome

2011
[Controlled clinical study of SAMe (S-adenosylmethionine) administered orally in degenerative osteoarticular pathology].
    Giornale di clinica medica, 1980, Volume: 61, Issue:7

    Topics: Administration, Oral; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ibuprofen; Male; Middle Aged; Osteoarthritis; S-Adenosylmethionine; Time Factors

1980
[S-adenosylmethionine (SAMe) in osteoarthrosis; a double-blind crossover peroral study].
    Giornale di clinica medica, 1980, Volume: 61, Issue:8

    Topics: Administration, Oral; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Hip Joint; Humans; Knee Joint; Male; Middle Aged; Osteoarthritis; Research Design; S-Adenosylmethionine; Sulindac

1980
[Double-blind study of SAMe (capsules) and aspirin in osteoarthrosis].
    Giornale di clinica medica, 1980, Volume: 61, Issue:11

    Topics: Adult; Aged; Aspirin; Capsules; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Osteoarthritis; S-Adenosylmethionine

1980
A randomized, double blind, placebo controlled trial of intravenous loading with S-adenosylmethionine (SAM) followed by oral SAM therapy in patients with knee osteoarthritis.
    The Journal of rheumatology, 1994, Volume: 21, Issue:5

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Injections, Intravenous; Knee Joint; Male; Middle Aged; Osteoarthritis; S-Adenosylmethionine; Severity of Illness Index; Treatment Outcome

1994
[Pharmacological and clinical aspects of S-adenosylmethionine (SAMe) in primary degenerative arthropathy (osteoarthrosis)].
    Minerva medica, 1975, Dec-05, Volume: 66, Issue:83

    Topics: Adult; Aged; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; S-Adenosylmethionine

1975
A double-blind trial of ademetionine vs naproxen in activated gonarthrosis.
    International journal of clinical pharmacology, therapy, and toxicology, 1989, Volume: 27, Issue:7

    Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Naproxen; Osteoarthritis; Random Allocation; S-Adenosylmethionine

1989
S-adenosylmethionine in the treatment of osteoarthritis. Review of the clinical studies.
    The American journal of medicine, 1987, Nov-20, Volume: 83, Issue:5A

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Cartilage, Articular; Clinical Trials as Topic; Depression; Double-Blind Method; Humans; Osteoarthritis; Proteoglycans; S-Adenosylmethionine

1987
Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease.
    The American journal of medicine, 1987, Nov-20, Volume: 83, Issue:5A

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Naproxen; Osteoarthritis; Placebos; Random Allocation; S-Adenosylmethionine

1987
Double-blind controlled clinical trial of oral S-adenosylmethionine versus piroxicam in knee osteoarthritis.
    The American journal of medicine, 1987, Nov-20, Volume: 83, Issue:5A

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Knee Joint; Male; Middle Aged; Osteoarthritis; Piroxicam; Random Allocation; S-Adenosylmethionine

1987
Double-blind comparative clinical trial with S-adenosylmethionine and indomethacin in the treatment of osteoarthritis.
    The American journal of medicine, 1987, Nov-20, Volume: 83, Issue:5A

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Indomethacin; Male; Middle Aged; Osteoarthritis; Random Allocation; S-Adenosylmethionine

1987
Double-blind clinical trial of S-adenosylmethionine versus ibuprofen in the treatment of osteoarthritis.
    The American journal of medicine, 1987, Nov-20, Volume: 83, Issue:5A

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ibuprofen; Male; Middle Aged; Osteoarthritis; Random Allocation; S-Adenosylmethionine

1987
A new medical approach to the treatment of osteoarthritis. Report of an open phase IV study with ademetionine (Gumbaral).
    The American journal of medicine, 1987, Nov-20, Volume: 83, Issue:5A

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Osteoarthritis; S-Adenosylmethionine

1987
A long-term (two years) clinical trial with S-adenosylmethionine for the treatment of osteoarthritis.
    The American journal of medicine, 1987, Nov-20, Volume: 83, Issue:5A

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Depression; Female; Humans; Longitudinal Studies; Male; Middle Aged; Osteoarthritis; Psychological Tests; S-Adenosylmethionine

1987
Double-blind multicentre study of the activity of S-adenosylmethionine in hip and knee osteoarthritis.
    International journal of clinical pharmacology research, 1985, Volume: 5, Issue:1

    Topics: Aged; Clinical Trials as Topic; Double-Blind Method; Female; Hip Joint; Humans; Ibuprofen; Knee Joint; Male; Middle Aged; Osteoarthritis; S-Adenosylmethionine

1985
Double-blind study of S-adenosyl-methionine versus placebo in hip and knee arthrosis.
    Clinical rheumatology, 1985, Volume: 4, Issue:4

    Topics: Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Hip Joint; Histocompatibility Antigens Class II; HLA-B Antigens; Humans; Knee Joint; Middle Aged; Osteoarthritis; S-Adenosylmethionine

1985

Other Studies

17 other study(ies) available for s-adenosylmethionine and Osteoarthritis

ArticleYear
SAM-e on par with NSAIDs for osteoarthritis?
    Health news (Waltham, Mass.), 2002, Volume: 8, Issue:7

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Costs; Humans; Osteoarthritis; Pain; S-Adenosylmethionine

2002
Osteoarthritis. Options for arthritis pain.
    Newsweek, 2002, Dec-02, Volume: 140, Issue:23

    Topics: Acupuncture; Chondroitin Sulfates; Glucosamine; Humans; Osteoarthritis; Pain Management; Plants, Medicinal; S-Adenosylmethionine; United States

2002
A friend of mine has been taking something called SAM-e. She swears by it to relieve her joint pain, and it's nonprescription. What is SAM-e, and does it help joint pain?
    Mayo Clinic health letter (English ed.), 2007, Volume: 25, Issue:10

    Topics: Anti-Inflammatory Agents; Female; Humans; Osteoarthritis; S-Adenosylmethionine

2007
Exploring the mechanisms behind S-adenosylmethionine (SAMe) in the treatment of osteoarthritis.
    Critical reviews in food science and nutrition, 2008, Volume: 48, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Humans; Osteoarthritis; S-Adenosylmethionine

2008
The neglect of glucosamine as a treatment for osteoarthritis--a personal perspective.
    Medical hypotheses, 1994, Volume: 42, Issue:5

    Topics: Animals; Cartilage; Clinical Trials as Topic; Controlled Clinical Trials as Topic; Drug Tolerance; Glucosamine; Humans; Models, Biological; Osteoarthritis; Proteoglycans; S-Adenosylmethionine

1994
Arthritis relief: considering the alternatives.
    Harvard health letter, 1999, Volume: 24, Issue:9

    Topics: Chondroitin Sulfates; Dietary Supplements; Glucosamine; Humans; Osteoarthritis; S-Adenosylmethionine

1999
Niacinamide therapy for osteoarthritis--does it inhibit nitric oxide synthase induction by interleukin 1 in chondrocytes?
    Medical hypotheses, 1999, Volume: 53, Issue:4

    Topics: Antioxidants; Cartilage, Articular; Enzyme Inhibitors; Fish Oils; Glucosamine; Humans; Hyaluronic Acid; Interleukin-1; Niacinamide; Nitric Oxide Synthase; Osteoarthritis; S-Adenosylmethionine; Signal Transduction

1999
SAMe: a dietary remedy for mind and body?
    RN, 1999, Volume: 62, Issue:12

    Topics: Depression; Dietary Supplements; Food, Organic; Humans; Osteoarthritis; S-Adenosylmethionine; Treatment Outcome

1999
SAMe as a supplement: can it really help treat depression and arthritis?
    Journal of the American Dietetic Association, 2000, Volume: 100, Issue:4

    Topics: Depression; Dietary Supplements; Humans; Osteoarthritis; S-Adenosylmethionine

2000
Users say SAM-e is a wonder drug ... are they high?
    Fortune, 2000, Nov-13, Volume: 142, Issue:11

    Topics: Depression; Humans; Liver Diseases; Osteoarthritis; S-Adenosylmethionine; United States

2000
Efficacy of the dietary supplement S-adenosyl-L-methionine.
    The Annals of pharmacotherapy, 2001, Volume: 35, Issue:11

    Topics: Animals; Contraindications; Depressive Disorder; Diet; Dietary Supplements; Drug Interactions; Fibromyalgia; Humans; Osteoarthritis; S-Adenosylmethionine

2001
[Medical treatment of coxarthrosis].
    Minerva medica, 1978, Sep-08, Volume: 69, Issue:41

    Topics: Analgesics; Anti-Inflammatory Agents; Exercise Therapy; Hip Joint; Humans; Osteoarthritis; Physical Therapy Modalities; S-Adenosylmethionine; Sulindac

1978
[Pharmacologic studies on the antidegenerative effect of ademetionine in experimental arthritis in animals].
    Arzneimittel-Forschung, 1990, Volume: 40, Issue:9

    Topics: Animals; Bone and Bones; Cartilage; Chickens; Female; Iodoacetates; Osteoarthritis; Radiography; S-Adenosylmethionine

1990
[Experimental osteoarthritis and its course when treated with S-adenosyl-L-methionine].
    Revista clinica espanola, 1990, Volume: 187, Issue:2

    Topics: Animals; Female; Male; Osteoarthritis; Rabbits; S-Adenosylmethionine

1990
Osteoarthritis: the clinical picture, pathogenesis, and management with studies on a new therapeutic agent, S-adenosylmethionine. Proceedings of a symposium. April 29 to May 4, 1986, New York, New York.
    The American journal of medicine, 1987, Nov-20, Volume: 83, Issue:5A

    Topics: Animals; Humans; Osteoarthritis; S-Adenosylmethionine

1987
Osteoarthritis: the clinical picture, pathogenesis, and management with studies on a new therapeutic agent, S-adenosylmethionine.
    The American journal of medicine, 1987, Nov-20, Volume: 83, Issue:5A

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Humans; Osteoarthritis; S-Adenosylmethionine

1987
Effect of S-adenosylmethionine on experimental osteoarthritis in rabbits.
    The American journal of medicine, 1987, Nov-20, Volume: 83, Issue:5A

    Topics: Animals; Cartilage, Articular; Dose-Response Relationship, Drug; Knee Joint; Osteoarthritis; Rabbits; S-Adenosylmethionine

1987