strontium-radioisotopes and Osteoarthritis

Topics: Arthritis, Rheumatoid; Calcium Radioisotopes; Femur; Hip Joint; Humans; Methods; Osteoarthritis; Phosphorus Radioisotopes; Radionuclide Imaging; Strontium Radioisotopes

Topics: Bone and Bones; Female; Hip Joint; Humans; Male; Middle Aged; Osteoarthritis; Radionuclide Imaging; Strontium Radioisotopes

Topics: Aged; Diphosphates; Female; Hip Joint; Humans; Male; Middle Aged; Osteoarthritis; Radionuclide Imaging; Strontium Radioisotopes; Technetium; Technetium Tc 99m Pyrophosphate

Topics: Female; Humans; Kinetics; Knee Joint; Middle Aged; Minerals; Osteoarthritis; Radionuclide Imaging; Regional Blood Flow; Strontium Radioisotopes

The concentration of 99mTc-pyrophosphate was determined in the lower extremities of rabbits (normal, abacterial and bacterial affected soft tissues), in osteoarthritis of the hip joint (capsule and muscle) as well as in knee joint effusions. Compared with the 85Sr-concentration, reflecting the calcification capacity, concentrations of 99mTc-pyrophosphate in soft tissues were found to be lower 2 hours p.i., but were up to elevenfold higher 24 hours p.i. These findings should be due to a fixation of 99mTc-pyrophosphate in collagen containing tissues as in the soft tissue tumors (myosarcoma, synvialioma, breast cancer) presented. A mechanism of delayed equilibration could explain augmented uptake in lymph-edema, ascites and effusions in florid osteoarthritis of the knee joint. The possible dependence of 99mTc-pyrophosphate concentration in bone and soft tissue on collagenous contents is discussed.

Topics: Animals; Ascites; Bone and Bones; Breast Neoplasms; Diphosphates; Disease Models, Animal; Extremities; Freund's Adjuvant; Hip; Humans; Joint Diseases; Joint Prosthesis; Joints; Knee; Osteoarthritis; Phosphates; Rabbits; Rhabdomyosarcoma; Sarcoma, Synovial; Strontium; Strontium Radioisotopes; Technetium; Tibial Fractures; Time Factors; Tin

Topics: Aged; Arthritis, Rheumatoid; Autoradiography; Bone Cysts; Calcium; Diagnosis, Differential; Female; Femur Head; Hip; Hip Joint; Humans; Joint Diseases; Male; Osteoarthritis; Paget Disease, Extramammary; Radiography; Strontium; Strontium Radioisotopes

Topics: Evaluation Studies as Topic; Female; Femoral Fractures; Femur Head Necrosis; Fluorine; Hip Joint; Humans; Injections, Intravenous; Joint Diseases; Knee Joint; Middle Aged; Necrosis; Oscillometry; Osteoarthritis; Radionuclide Imaging; Strontium Radioisotopes; Time Factors

Topics: Adult; Arthritis, Rheumatoid; Autoradiography; Bone Cysts; Female; Femur Head; Femur Head Necrosis; Humans; In Vitro Techniques; Injections, Intravenous; Male; Middle Aged; Osteoarthritis; Strontium; Strontium Radioisotopes