iodoacetic acid and Osteoarthritis studies

Iodoacetic Acid: A derivative of ACETIC ACID that contains one IODINE atom attached to its methyl group.
iodoacetic acid : A haloacetic acid that is acetic acid in which one of the hydrogens of the methyl group is replaced by an iodine atom.

Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.

Research Excerpts

Excerpt	Relevance	Reference
" Coenzyme Q10 (CoQ10) exerts diverse biological effects on bone and cartilage; observational studies have suggested that CoQ10 may slow OA progression and inflammation."	8.12	Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death. ( Cho, KH; Cho, ML; Chung, SJ; Kim, GH; Kim, JH; Lee, JS; Na, HS; Park, SH; Um, IG; Woo, JS, 2022)
"Diacerein (DIA) is a slow-acting drug for osteoarthritis (OA)."	7.96	A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis. ( Choi, SJ; Jung, JH; Kim, HJ; Kim, SE; Park, K; Song, GG, 2020)
"The anti-inflammatory and anti-catabolic actions of Diclofenac were compared with apigenin-C-glycosides rich Clinacanthus nutans (CN) leaf extract in osteoporotic-osteoarthritis rats."	7.96	Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model. ( Hussin, P; Lau, SF; Mohamed, S; Tantowi, NACA, 2020)
"The present work aimed to assess the chondroprotective influence of chitosan and lecithin in a monoiodoacetate (MIA)-induced experimental osteoarthritis (OA) model."	7.96	Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model. ( Al-Salmi, FA; El-Shenawy, NS; Hamza, RZ, 2020)
"We established a monoiodoacetate (MIA)-induced rat OA model and evaluated the joint pain and cartilage damage with or without celastrol treatments."	7.88	Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats. ( Gong, M; Ha, C; Lin, T; Wang, D; Wang, W; Wang, Y, 2018)
" Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain."	7.85	Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. ( McDougall, JJ; O'Brien, M; Philpott, HT, 2017)
"The objectives of this study were (1) to fabricate ibuprofen-loaded porous microspheres (IBU/PMSs), (2) to evaluate the in vitro anti-inflammatory effects of the microspheres using LPS-induced inflammation in cultured synoviocytes, and (3) to evaluate the in vivo effect of the IBU/PMSs on the progression of monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in a rat model."	7.83	Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model. ( Kim, HJ; Kim, SE; Lee, JY; Park, JW; Park, K; Song, HR; Yun, YP, 2016)
"After induction of osteoarthritis by the intracapsular injection of 50 μL with 40 mg/mL MIA, we compared the anti-inflammatory efficacy and safety of a topical application of 1% indomethacin gel in a dose of 1 g/kg of the gel (equivalent to 10 mg/kg of the active substance) daily for 3 weeks versus three decremental dose levels of Cu-Indo gel: an equivalent dose, half the dose, and 25% of the dose of indomethacin."	7.81	Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015)
"Our study demonstrated that atorvastatin attenuates MIA-induced osteoarthritic pain and protect cartilage degradation through inhibition of oxidative stress suggesting its importance in osteoarthritic pain management."	7.81	Effect of atorvastatin, a HMG-CoA reductase inhibitor in monosodium iodoacetate-induced osteoarthritic pain: implication for osteoarthritis therapy. ( Balaganur, V; Kant, V; Kumar, D; Lingaraju, MC; Pathak, NN; Sharma, AK; Tandan, SK, 2015)
"Dexketoprofen and tramadol, alone or in combination, were evaluated after oral or intra-articular administration on knee osteoarthritis nociception induced by intra-articular (i."	7.79	Comparison between oral and intra-articular antinociceptive effect of dexketoprofen and tramadol combination in monosodium iodoacetate-induced osteoarthritis in rats. ( Cialdai, C; Giuliani, S; Maggi, CA; Tramontana, M; Valenti, C, 2013)
" This study was carried out to investigate the effect of SMN, Celecoxib (CLX) individually and in combination on monoiodoacetate (MIA)-induced osteoarthritis (OA) in rat."	7.78	Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats. ( Amniattalab, A; Ashkavand, Z; Malekinejad, H; Rezaei-Golmisheh, A; Vishwanath, BS, 2012)
"It has been widely used in the treatment of osteoarthritis (OA) but underlying molecular mechanisms remain unclear."	5.91	Shang-Ke-Huang-Shui and coptisine alleviate osteoarthritis in the knee of monosodium iodoacetate-induced rats through inhibiting CXCR4 signaling. ( Bai, X; Chen, J; Chen, L; Cheng, W; Hu, C; Liang, J; Liao, J; Liu, B; Liu, L; Liu, Q; Song, B; Wang, JD; Wang, Y; Xie, Q; Yang, K; Zhang, P; Zhao, N; Zheng, F, 2023)
"Osteoarthritis was induced by intra-articular injection of monosodium iodoacetate."	5.56	Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine. ( Artuzi, FE; Baraldi, CE; Ponzoni, D; Puricelli, E; Quevedo, AS, 2020)
"Paw edema and thermal hyperalgesia were measured up to 6 h post-injection, when also myeloperoxidase activity and histological inflammation score were assessed."	5.51	Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain. ( Cordaro, M; Crupi, R; Cuzzocrea, S; D' Amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Schievano, C; Siracusa, R, 2019)
" The aim of this study was to evaluate the effect of adelmidrol, a synthetic palmitoylethanolamide analogue, combined with hyaluronic acid on pain severity and modulation of the inflammatory response in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis."	5.43	Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats. ( Britti, D; Cordaro, M; Cuzzocrea, S; Di Paola, R; Evangelista, M; Fusco, R; Impellizzeri, D; Morittu, VM, 2016)
" Both 27 and 48 demonstrated robust activity in the acute rat monoiodoacetate-induced osteoarthritis model of pain, and subchronic dosing of 48 showed a shift to a lower EC50 over 7 days."	5.43	Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain. ( Daanen, JF; DeGoey, DA; El-Kouhen, OF; Fricano, MM; Frost, JM; Ghoreishi-Haack, N; Gum, RJ; Hsieh, GC; Kort, ME; Lundgaard, GL; Matulenko, MA; Neelands, T; Pai, M; Shi, L; Zhan, C; Zhang, XF, 2016)
" Coenzyme Q10 (CoQ10) exerts diverse biological effects on bone and cartilage; observational studies have suggested that CoQ10 may slow OA progression and inflammation."	4.12	Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death. ( Cho, KH; Cho, ML; Chung, SJ; Kim, GH; Kim, JH; Lee, JS; Na, HS; Park, SH; Um, IG; Woo, JS, 2022)
" Osteoarthritis was induced in male adult control Wistar rats without any interventions and in Wisket rats after juvenile social isolation and ketamine treatment."	3.96	Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia. ( Banki, L; Büki, A; Horvath, G; Jancsó, G; Kekesi, G; Kis, G; Somogyvári, F; Tuboly, G; Varga, E; Vécsei, L, 2020)
"Diacerein (DIA) is a slow-acting drug for osteoarthritis (OA)."	3.96	A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis. ( Choi, SJ; Jung, JH; Kim, HJ; Kim, SE; Park, K; Song, GG, 2020)
"The anti-inflammatory and anti-catabolic actions of Diclofenac were compared with apigenin-C-glycosides rich Clinacanthus nutans (CN) leaf extract in osteoporotic-osteoarthritis rats."	3.96	Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model. ( Hussin, P; Lau, SF; Mohamed, S; Tantowi, NACA, 2020)
"The present work aimed to assess the chondroprotective influence of chitosan and lecithin in a monoiodoacetate (MIA)-induced experimental osteoarthritis (OA) model."	3.96	Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model. ( Al-Salmi, FA; El-Shenawy, NS; Hamza, RZ, 2020)
"We established a monoiodoacetate (MIA)-induced rat OA model and evaluated the joint pain and cartilage damage with or without celastrol treatments."	3.88	Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats. ( Gong, M; Ha, C; Lin, T; Wang, D; Wang, W; Wang, Y, 2018)
" longa (PCL) against monosodium iodoacetate (MIA) induced osteoarthritis in rat and to compare with curcuminoids, which are contemporarily believed to be the only active phytochemicals of C."	3.85	Antiarthritic Effect of Polar Extract of Curcuma longa on Monosodium Iodoacetate Induced Osteoarthritis in Rats. ( Bethapudi, B; Chandrasekaran, PR; Murugan, S; Purusothaman, D; Velusami, CC, 2017)
" Cannabidiol (CBD) is a noneuphoria producing constituent of cannabis that has the potential to relieve pain."	3.85	Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. ( McDougall, JJ; O'Brien, M; Philpott, HT, 2017)
"The objectives of this study were (1) to fabricate ibuprofen-loaded porous microspheres (IBU/PMSs), (2) to evaluate the in vitro anti-inflammatory effects of the microspheres using LPS-induced inflammation in cultured synoviocytes, and (3) to evaluate the in vivo effect of the IBU/PMSs on the progression of monosodium iodoacetate (MIA)-induced osteoarthritis (OA) in a rat model."	3.83	Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model. ( Kim, HJ; Kim, SE; Lee, JY; Park, JW; Park, K; Song, HR; Yun, YP, 2016)
"Although some evidence suggests that the prevalence of osteoarthritis (OA) is lower in smokers compared to nonsmokers, the mechanisms of nicotine-induced protection remain unclear."	3.81	Activation of α7 nicotinic acetylcholine receptors prevents monosodium iodoacetate-induced osteoarthritis in rats. ( Fan, W; Hu, J; Hui, Y; Liu, Y; Song, F; Wu, D; Wu, J; Zhu, C; Zhu, Q, 2015)
"After induction of osteoarthritis by the intracapsular injection of 50 μL with 40 mg/mL MIA, we compared the anti-inflammatory efficacy and safety of a topical application of 1% indomethacin gel in a dose of 1 g/kg of the gel (equivalent to 10 mg/kg of the active substance) daily for 3 weeks versus three decremental dose levels of Cu-Indo gel: an equivalent dose, half the dose, and 25% of the dose of indomethacin."	3.81	Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. ( Abdel-Rahman, RF; El-Shenawy, SM; Hassan, M; Helmy, S; Yakoot, M; Yassin, NZ, 2015)
"Our study demonstrated that atorvastatin attenuates MIA-induced osteoarthritic pain and protect cartilage degradation through inhibition of oxidative stress suggesting its importance in osteoarthritic pain management."	3.81	Effect of atorvastatin, a HMG-CoA reductase inhibitor in monosodium iodoacetate-induced osteoarthritic pain: implication for osteoarthritis therapy. ( Balaganur, V; Kant, V; Kumar, D; Lingaraju, MC; Pathak, NN; Sharma, AK; Tandan, SK, 2015)
"Dexketoprofen and tramadol, alone or in combination, were evaluated after oral or intra-articular administration on knee osteoarthritis nociception induced by intra-articular (i."	3.79	Comparison between oral and intra-articular antinociceptive effect of dexketoprofen and tramadol combination in monosodium iodoacetate-induced osteoarthritis in rats. ( Cialdai, C; Giuliani, S; Maggi, CA; Tramontana, M; Valenti, C, 2013)
" This study was carried out to investigate the effect of SMN, Celecoxib (CLX) individually and in combination on monoiodoacetate (MIA)-induced osteoarthritis (OA) in rat."	3.78	Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats. ( Amniattalab, A; Ashkavand, Z; Malekinejad, H; Rezaei-Golmisheh, A; Vishwanath, BS, 2012)
"It has been widely used in the treatment of osteoarthritis (OA) but underlying molecular mechanisms remain unclear."	1.91	Shang-Ke-Huang-Shui and coptisine alleviate osteoarthritis in the knee of monosodium iodoacetate-induced rats through inhibiting CXCR4 signaling. ( Bai, X; Chen, J; Chen, L; Cheng, W; Hu, C; Liang, J; Liao, J; Liu, B; Liu, L; Liu, Q; Song, B; Wang, JD; Wang, Y; Xie, Q; Yang, K; Zhang, P; Zhao, N; Zheng, F, 2023)
"Chronic joint pain is common in patients with osteoarthritis (OA)."	1.72	Analgesic dorsal root ganglion field stimulation blocks both afferent and efferent spontaneous activity in sensory neurons of rats with monosodium iodoacetate-induced osteoarthritis. ( Chao, D; Hogan, QH; Pan, B; Tran, H, 2022)
"Pain is the most common symptom of osteoarthritis, and spinal glia is known to contribute to this symptom."	1.72	Investigation of the effects of therapeutic ultrasound or photobiomodulation and the role of spinal glial cells in osteoarthritis-induced nociception in mice. ( Elisei, L; Galdino, G; Malta, I; Moraes, T; Novaes, R, 2022)
" This study determined the drug dosage and the mechanisms of GMGHT for OA."	1.56	Gumiganghwal-tang ameliorates cartilage destruction via inhibition of matrix metalloproteinase. ( Ahn, KS; Choi, Y; Hahm, DH; Kim, MH; Lee, SG; Um, JY; Yang, WM, 2020)
" Further fine tuning of alginate formulation and effective dosage for might be required in order to improve therapeutic efficacy depending on the target disease."	1.56	MSC encapsulation in alginate microcapsules prolongs survival after intra-articular injection, a longitudinal in vivo cell and bead integrity tracking study. ( Bernsen, M; Bos, PK; Haeck, J; Khatab, S; Kops, N; Leijs, MJ; Nieboer, M; van Buul, G; van Osch, GJVM; Verhaar, JAN, 2020)
"Osteoarthritis was induced by intra-articular injection of monosodium iodoacetate."	1.56	Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine. ( Artuzi, FE; Baraldi, CE; Ponzoni, D; Puricelli, E; Quevedo, AS, 2020)
"In contrast, we observed persistent joint pain after day 10 in the high-dose group."	1.51	Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint. ( Akiyama, M; Hoshino, T; Inomata, K; Katagiri, H; Koga, H; Miyatake, K; Muneta, T; Nakagawa, Y; Onuma, H; Sekiya, I; Tsuji, K; Udo, M, 2019)
"Bone pain is a prevalent issue in society today and also is one of the hardest types of pain to control."	1.51	Animal Models for the Study of Bone-Derived Pain. ( Largent-Milnes, TM; Thompson, AL; Vanderah, TW, 2019)
"Osteoarthritis was induced by injection of monoiodoacetate (MIA)."	1.51	Intraarticular injection of processed lipoaspirate cells has anti-inflammatory and analgesic effects but does not improve degenerative changes in murine monoiodoacetate-induced osteoarthritis. ( Honjoh, K; Kokubo, Y; Matsumine, A; Miyazaki, T; Nakajima, H; Oki, H; Sakamoto, T; Takahashi, A; Watanabe, S, 2019)
"Osteoarthritic pain is a chronic disabling condition lacking effective treatment."	1.51	Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain. ( Cabañero, D; Carcolé, M; Dickenson, AH; Fernández-Pastor, B; Gonçalves, L; Kummer, S; Maldonado, R; Merlos, M; Zamanillo, D, 2019)
"Paw edema and thermal hyperalgesia were measured up to 6 h post-injection, when also myeloperoxidase activity and histological inflammation score were assessed."	1.51	Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain. ( Cordaro, M; Crupi, R; Cuzzocrea, S; D' Amico, R; Di Paola, R; Fusco, R; Gugliandolo, E; Impellizzeri, D; Peritore, AF; Schievano, C; Siracusa, R, 2019)
" However, it is unknown whether the antalgic gait caused by MIA is associated with severity of degeneration from the high dosage or the whole-joint degeneration associated with glycolysis inhibition."	1.48	Quadrupedal rodent gait compensations in a low dose monoiodoacetate model of osteoarthritis. ( Allen, KD; Lakes, EH, 2018)
"Osteoarthritis was induced through a single intra-articular injection of monosodium iodoacetate in both knee joints."	1.48	Induction of osteoarthritis by injecting monosodium iodoacetate into the patellofemoral joint of an experimental rat model. ( Hoso, M; Kuroki, H; Matsuzaki, T; Takahashi, I, 2018)
"Preventive AR786 treatment inhibited pain behaviour development and therapeutic treatment attenuated established pain behaviour."	1.43	Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis. ( Chapman, V; Mapp, PI; Nwosu, LN; Walsh, DA, 2016)
" Both 27 and 48 demonstrated robust activity in the acute rat monoiodoacetate-induced osteoarthritis model of pain, and subchronic dosing of 48 showed a shift to a lower EC50 over 7 days."	1.43	Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain. ( Daanen, JF; DeGoey, DA; El-Kouhen, OF; Fricano, MM; Frost, JM; Ghoreishi-Haack, N; Gum, RJ; Hsieh, GC; Kort, ME; Lundgaard, GL; Matulenko, MA; Neelands, T; Pai, M; Shi, L; Zhan, C; Zhang, XF, 2016)
" The aim of this study was to evaluate the effect of adelmidrol, a synthetic palmitoylethanolamide analogue, combined with hyaluronic acid on pain severity and modulation of the inflammatory response in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis."	1.43	Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats. ( Britti, D; Cordaro, M; Cuzzocrea, S; Di Paola, R; Evangelista, M; Fusco, R; Impellizzeri, D; Morittu, VM, 2016)
" Unexpectedly, vitamin C's effects did not strengthen with the increasing dosage, while the 100 mg/kg dosage was more efficient than the 200 or 300 mg/kg dosages."	1.43	Vitamin C Protects Chondrocytes against Monosodium Iodoacetate-Induced Osteoarthritis by Multiple Pathways. ( Chang, KL; Cheng, HL; Chiu, PR; Hsieh, BS; Hu, YC; Huang, LW; Huang, TC; Yeh, JP, 2016)
"Although analgesic approaches targeting nerve growth factor (NGF) for the treatment of osteoarthritis (OA) pain remain of clinical interest, neurophysiological mechanisms by which NGF contribute to OA pain remain unclear."	1.42	Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat. ( Chapman, V; Nwosu, L; Sagar, DR; Walsh, DA, 2015)
"25mg) into rats and orally treated with 2g/ml d-Fuzi at a dosage of 7 ml/kg body weight for 28 days."	1.40	Chondroprotective activity of a detoxicated traditional Chinese medicine (Fuzi) of Aconitum carmichaeli Debx against severe-stage osteoarthritis model induced by mono-iodoacetate. ( Cao, G; Cheng, Y; Guo, Y; Jin, H; Jin, W; Shan, L; Tong, P; Xiao, L; Xu, S, 2014)
"Osteoarthritis was produced by single intra-articular injection of the MIA in the right knee joint on day 0."	1.39	Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy. ( Balaganur, V; Gupta, G; Kumar, D; Kumari, RR; Lingaraju, MC; More, AS; Pathak, NN; Sharma, AK; Tandan, SK, 2013)
"Osteoarthritis was induced by injection with a chemical (mono-iodoacetate), a surgical intervention (grooves applied in articular cartilage), and via exercise (strenuous running)."	1.37	Quantifying osteoarthritic cartilage changes accurately using in vivo microCT arthrography in three etiologically distinct rat models. ( Kops, N; Oei, EH; Piscaer, TM; Siebelt, M; Verhaar, JA; Waarsing, JH; Weinans, H, 2011)

Timeframe	Studies, this research(%)	All Research%
pre-1990	6 (3.53)	18.7374
1990's	10 (5.88)	18.2507
2000's	3 (1.76)	29.6817
2010's	81 (47.65)	24.3611
2020's	70 (41.18)	2.80

Trial	Phase	Enrollment	Study Type	Start Date	Status
The Use of Cannabinoid Patch for Knee Osteoarthritis[NCT04412837]	Phase 2	0 participants (Actual)	Interventional	2022-10-31	Withdrawn (stopped due to Inadequate funding)
Osteoarthritis of the Knee Pain Study Using CBD and THC in Rapidly Dissolvable Sublingual Tablet[NCT04195269]	Phase 2	30 participants (Anticipated)	Interventional	2020-04-20	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Pain Intensity and Trajectory Following Intra-Articular Injection of Mono-Iodoacetate in Experimental Osteoarthritis: A Meta-Analysis of Cartilage, 2023, Volume: 14, Issue:1 Topics: Animals; Injections, Intra-Articular; Iodoacetic Acid; Osteoarthritis; Pain; Pain Measurement; Rats	2023
Molecular Targets of Natural Products for Chondroprotection in Destructive Joint Diseases. International journal of molecular sciences, 2020, Jul-13, Volume: 21, Issue:14 Topics: Animals; Biological Products; Cartilage, Articular; Chondrocytes; Cytokines; Drug Evaluation, Precli	2020
[Experimental arthrosis]. Revue du rhumatisme et des maladies osteo-articulaires, 1982, Volume: 49, Issue:2 Topics: Adrenal Cortex Hormones; Animals; Disease Models, Animal; Enzyme Induction; Humans; Immobilization;	1982

Article	Year
Anti-inflammatory activity of palmitoylethanolamide ameliorates osteoarthritis induced by monosodium iodoacetate in Sprague-Dawley rats. Inflammopharmacology, 2021, Volume: 29, Issue:5 Topics: Administration, Oral; Amides; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Dose-Respo	2021
Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment. Journal of medicinal chemistry, 2021, 09-23, Volume: 64, Issue:18 Topics: Animals; Anti-Inflammatory Agents; Betulinic Acid; Bone and Bones; Cartilage, Articular; Cell Differ	2021
Investigation of the effects of therapeutic ultrasound or photobiomodulation and the role of spinal glial cells in osteoarthritis-induced nociception in mice. Lasers in medical science, 2022, Volume: 37, Issue:3 Topics: Animals; Disease Models, Animal; Iodoacetic Acid; Male; Mice; Neuroglia; Nociception; Osteoarthritis	2022
PTX-3 Secreted by Intra-Articular-Injected SMUP-Cells Reduces Pain in an Osteoarthritis Rat Model. Cells, 2021, 09-14, Volume: 10, Issue:9 Topics: Animals; C-Reactive Protein; Cytokines; Disease Models, Animal; Inflammation; Injections, Intra-Arti	2021
The Xiaogu San Attenuates Pain and Cartilage Damage in Rats with Monosodium Iodoacetate Induced Osteoarthritis. Combinatorial chemistry & high throughput screening, 2022, Volume: 25, Issue:11 Topics: Animals; Cartilage, Articular; Cytokines; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; P	2022
Inhibition of SYK and cSrc kinases can protect bone and cartilage in preclinical models of osteoarthritis and rheumatoid arthritis. Scientific reports, 2021, 11-30, Volume: 11, Issue:1 Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Cartilage;	2021
Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat. Behavioural pharmacology, 2022, 02-01, Volume: 33, Issue:1 Topics: Animals; Arthralgia; Behavior Observation Techniques; Behavior, Animal; Behavioral Symptoms; Disease	2022
Chondroprotection of fruit peels in a monosodium iodoacetate-induced osteoarthritis rat model via downregulation of Col1A1. Archiv der Pharmazie, 2022, Volume: 355, Issue:7 Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Down-Regulation; Fruit; Iodoacetic Acid; Osteoart	2022
Anti-Inflammatory and Analgesic Effects of Nutrients, 2022, Mar-24, Volume: 14, Issue:7 Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Iodoacetic Acid; Lipopolysaccharides; Mi	2022
ALPK1 Aggravates TMJOA Cartilage Degradation via NF-κB and ERK1/2 Signaling. Journal of dental research, 2022, Volume: 101, Issue:12 Topics: Aggrecans; Animals; Cartilage, Articular; Chondrocytes; Cyclooxygenase 2; Humans; Iodoacetic Acid; M	2022
Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death. PloS one, 2022, Volume: 17, Issue:6 Topics: Animals; Cartilage, Articular; Cell Death; Chondrocytes; Disease Models, Animal; Inflammation; Iodoa	2022
Analgesic dorsal root ganglion field stimulation blocks both afferent and efferent spontaneous activity in sensory neurons of rats with monosodium iodoacetate-induced osteoarthritis. Osteoarthritis and cartilage, 2022, Volume: 30, Issue:11 Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Ganglia, Spina	2022
Anti-arthritic effects of Schisandra chinensis extract in monosodium iodoacetate-induced osteoarthritis rats. Inflammopharmacology, 2022, Volume: 30, Issue:6 Topics: Animals; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; Plant Extracts; Rats; Schisandra	2022
Soluble CCR2 gene therapy controls joint inflammation, cartilage damage, and the progression of osteoarthritis by targeting MCP-1 in a monosodium iodoacetate (MIA)-induced OA rat model. Journal of translational medicine, 2022, 09-23, Volume: 20, Issue:1 Topics: Amino Acids; Animals; Anti-Inflammatory Agents; Cartilage; Cartilage, Articular; Chemokine CCL2; Dis	2022
[Therapeutic effects of alkaloids in Tibetan medicine Bangna (Aconiti Penduli et Aconiti Flavi Radix) on osteoarthritis rats and mechanisms]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2022, Volume: 47, Issue:17 Topics: Aconitine; Aconitum; Aggrecans; Alkaloids; Animals; Cells, Cultured; Cyclooxygenase 2; Fibroblast Gr	2022
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 108 Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats;	2023
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 108 Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats;	2023
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 108 Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats;	2023
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 108 Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats;	2023
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 108 Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats;	2023
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 108 Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats;	2023
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 108 Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats;	2023
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 108 Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats;	2023
Astragaloside IV as a novel CXCR4 antagonist alleviates osteoarthritis in the knee of monosodium iodoacetate-induced rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2023, Volume: 108 Topics: Animals; Astragalus propinquus; Cartilage, Articular; Humans; Iodoacetic Acid; Osteoarthritis; Rats;	2023
Rotator cuff muscle degeneration in a mouse model of glenohumeral osteoarthritis induced by monoiodoacetic acid. Journal of shoulder and elbow surgery, 2023, Volume: 32, Issue:3 Topics: Animals; Disease Models, Animal; Forelimb; Iodoacetic Acid; Mice; Mice, Inbred C57BL; Muscular Atrop	2023
Rotator cuff muscle degeneration in a mouse model of glenohumeral osteoarthritis induced by monoiodoacetic acid. Journal of shoulder and elbow surgery, 2023, Volume: 32, Issue:3 Topics: Animals; Disease Models, Animal; Forelimb; Iodoacetic Acid; Mice; Mice, Inbred C57BL; Muscular Atrop	2023
Rotator cuff muscle degeneration in a mouse model of glenohumeral osteoarthritis induced by monoiodoacetic acid. Journal of shoulder and elbow surgery, 2023, Volume: 32, Issue:3 Topics: Animals; Disease Models, Animal; Forelimb; Iodoacetic Acid; Mice; Mice, Inbred C57BL; Muscular Atrop	2023
Rotator cuff muscle degeneration in a mouse model of glenohumeral osteoarthritis induced by monoiodoacetic acid. Journal of shoulder and elbow surgery, 2023, Volume: 32, Issue:3 Topics: Animals; Disease Models, Animal; Forelimb; Iodoacetic Acid; Mice; Mice, Inbred C57BL; Muscular Atrop	2023
Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation. International immunopharmacology, 2023, Volume: 114 Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Interleukin-1beta; Iodoacetic Acid; Ma	2023
Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation. International immunopharmacology, 2023, Volume: 114 Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Interleukin-1beta; Iodoacetic Acid; Ma	2023
Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation. International immunopharmacology, 2023, Volume: 114 Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Interleukin-1beta; Iodoacetic Acid; Ma	2023
Transglutaminase 2 inhibitors attenuate osteoarthritic degeneration of TMJ-osteoarthritis by suppressing NF-κB activation. International immunopharmacology, 2023, Volume: 114 Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Interleukin-1beta; Iodoacetic Acid; Ma	2023
Effectiveness of losartan on infrapatellar fat pad/synovial fibrosis and pain behavior in the monoiodoacetate-induced rat model of osteoarthritis pain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 158 Topics: Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Iodoacetic Acid; Losarta	2023
Effectiveness of losartan on infrapatellar fat pad/synovial fibrosis and pain behavior in the monoiodoacetate-induced rat model of osteoarthritis pain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 158 Topics: Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Iodoacetic Acid; Losarta	2023
Effectiveness of losartan on infrapatellar fat pad/synovial fibrosis and pain behavior in the monoiodoacetate-induced rat model of osteoarthritis pain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 158 Topics: Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Iodoacetic Acid; Losarta	2023
Effectiveness of losartan on infrapatellar fat pad/synovial fibrosis and pain behavior in the monoiodoacetate-induced rat model of osteoarthritis pain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 158 Topics: Adipose Tissue; Angiotensin II Type 1 Receptor Blockers; Animals; Fibrosis; Iodoacetic Acid; Losarta	2023
Intra-articular injection of rAAV-hFGF-2 ameliorates monosodium iodoacetate-induced osteoarthritis in rats via inhibiting TLR-4 signaling and activating TIMP-1. Toxicology and applied pharmacology, 2023, 01-15, Volume: 459 Topics: Animals; Cartilage, Articular; Disease Models, Animal; Fibroblast Growth Factor 2; Humans; Injection	2023
Comparison of chemical-induced temporomandibular osteoarthritis rat models (monosodium iodoacetate versus collagenase type II) for the study of prolonged drug delivery systems. PloS one, 2023, Volume: 18, Issue:1 Topics: Animals; Arthralgia; Collagenases; Disease Models, Animal; Drug Delivery Systems; Injections, Intra-	2023
Protective effects of Pudilan Tablets against osteoarthritis in mice induced by monosodium iodoacetate. Scientific reports, 2023, 02-16, Volume: 13, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Cartilage, Articular; Disease Models, Animal; Drugs, Chinese Herb	2023
Pathological Characteristics of Monosodium Iodoacetate-Induced Osteoarthritis in Rats. Tissue engineering and regenerative medicine, 2023, Volume: 20, Issue:3 Topics: Animals; Arthritis, Experimental; Inflammation; Iodoacetic Acid; Male; Osteoarthritis; Pain; Rats; X	2023
Assessment of the Impact of Physical Activity on the Musculoskeletal System in Early Degenerative Knee Joint Lesions in an Animal Model. International journal of molecular sciences, 2023, Feb-10, Volume: 24, Issue:4 Topics: Animals; Disease Models, Animal; Iodoacetic Acid; Knee Joint; Male; Models, Animal; Muscular Atrophy	2023
Evaluation of articular changes using a rat mono-iodoacetate-induced shoulder arthritis model by histology and radiology. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2023, Volume: 41, Issue:11 Topics: Animals; Cartilage, Articular; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; Radiology; R	2023
Shang-Ke-Huang-Shui and coptisine alleviate osteoarthritis in the knee of monosodium iodoacetate-induced rats through inhibiting CXCR4 signaling. Journal of ethnopharmacology, 2023, Jul-15, Volume: 311 Topics: Animals; Cartilage, Articular; Chondrocytes; Iodoacetic Acid; Molecular Docking Simulation; Osteoart	2023
The effect of oral administration of undenatured type II collagen on monosodium iodoacetate-induced osteoarthritis in young and old rats. Scientific reports, 2023, 04-20, Volume: 13, Issue:1 Topics: Administration, Oral; Animals; Cartilage, Articular; Collagen Type II; Disease Models, Animal; Iodoa	2023
High intensity interval training attenuates osteoarthritis-associated hyperalgesia in rats. The journal of physiological sciences : JPS, 2023, Apr-28, Volume: 73, Issue:1 Topics: Animals; Disease Models, Animal; High-Intensity Interval Training; Hyperalgesia; Iodoacetic Acid; Os	2023
Effective Technical Protocol for Producing a Mono-Iodoacetate-Induced Temporomandibular Joint Osteoarthritis in a Rat Model. Tissue engineering. Part C, Methods, 2023, Volume: 29, Issue:9 Topics: Animals; Bone Remodeling; Disease Models, Animal; Iodoacetic Acid; Osteoarthritis; Pain; Rats; Tempo	2023
Bifidobacterium longum BORI inhibits pain behavior and chondrocyte death, and attenuates osteoarthritis progression. PloS one, 2023, Volume: 18, Issue:6 Topics: Animals; Cartilage, Articular; Chondrocytes; Cytokines; Inflammation; Iodoacetic Acid; Osteoarthriti	2023
Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2-mediated antioxidant signalling. British journal of pharmacology, 2023, Volume: 180, Issue:24 Topics: Animals; Antioxidants; Disease Models, Animal; Humans; Hyperalgesia; Iodoacetic Acid; Neuroinflammat	2023
Therapeutic effects of combining curcumin and swimming in osteoarthritis using a rat model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 166 Topics: Animals; Cartilage, Articular; Curcumin; Disease Models, Animal; Iodoacetic Acid; MicroRNAs; Osteoar	2023
Bixa orellana ethyl acetate fraction and its isolated compound ellagic acid attenuate the progression of MIA-induced osteoarthritis in rat knees. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023, Volume: 168 Topics: Animals; Bixaceae; Cartilage, Articular; Disease Models, Animal; Ellagic Acid; Iodoacetates; Iodoace	2023
Therapeutic Nanodiamonds Containing Icariin Ameliorate the Progression of Osteoarthritis in Rats. International journal of molecular sciences, 2023, Nov-05, Volume: 24, Issue:21 Topics: Animals; Anti-Inflammatory Agents; Cartilage, Articular; Disease Models, Animal; Interleukin-10; Int	2023
Transcranial Direct Current Stimulation Attenuates the Chronic Pain of Osteoarthritis in Rats via Reducing NMDAR2B Expressions in the Spinal Cord. Journal of musculoskeletal & neuronal interactions, 2023, Dec-01, Volume: 23, Issue:4 Topics: Analgesics; Animals; Chronic Pain; Hyperalgesia; Iodoacetic Acid; Osteoarthritis; Rats; Spinal Cord;	2023
Development of an ultrathin sheet plastination technique in rat humeral joints with osteoarthritis induced by monosodium iodoacetate for neovascularization study. Anatomical science international, 2020, Volume: 95, Issue:2 Topics: Animals; Cartilage, Articular; Humerus; Injections, Intra-Articular; Iodoacetic Acid; Joints; Neovas	2020
Comparative study of osteoarthritis induced by monoiodoacetate and papain in rabbit temporomandibular joints: macroscopic and microscopic analysis. Folia morphologica, 2020, Volume: 79, Issue:3 Topics: Animals; Cartilage, Articular; Iodoacetic Acid; Male; Osteoarthritis; Papain; Rabbits; Severity of I	2020
Comparison of the therapeutic effect of amniotic fluid stem cells and their exosomes on monoiodoacetate-induced animal model of osteoarthritis. BioFactors (Oxford, England), 2020, Volume: 46, Issue:1 Topics: Amniotic Fluid; Animals; Disease Models, Animal; Exosomes; Humans; Iodoacetic Acid; Osteoarthritis;	2020
Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia. Neuroscience letters, 2020, 01-01, Volume: 714 Topics: Analgesics, Opioid; Animals; Ankle Joint; Brain; Brain Stem; Chronic Pain; Diencephalon; Disease Mod	2020
Inhibition of miR-203 Ameliorates Osteoarthritis Cartilage Degradation in the Postmenopausal Rat Model: Involvement of Estrogen Receptor α. Human gene therapy. Clinical development, 2019, Volume: 30, Issue:4 Topics: 3' Untranslated Regions; Aggrecans; Animals; Antagomirs; Cartilage; Collagen Type II; Disease Models	2019
Cartilage protective and anti-analgesic effects of ALM16 on monosodium iodoacetate induced osteoarthritis in rats. BMC complementary and alternative medicine, 2019, Nov-21, Volume: 19, Issue:1 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Astragalus propinquus; Cartilage, Articular; Cell Lin	2019
Osthole ameliorates cartilage degradation by downregulation of NF-κB and HIF-2α pathways in an osteoarthritis murine model. European journal of pharmacology, 2020, Jan-15, Volume: 867 Topics: Administration, Oral; Animals; Arthritis, Experimental; Basic Helix-Loop-Helix Transcription Factors	2020
Thermoresponsive Hyalomer intra-articular hydrogels improve monoiodoacetate-induced osteoarthritis in rats. International journal of pharmaceutics, 2020, Jan-05, Volume: 573 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cartilage, Articular; Dic	2020
Safety and efficacy of a new micronized formulation of the ALIAmide palmitoylglucosamine in preclinical models of inflammation and osteoarthritis pain. Arthritis research & therapy, 2019, 11-28, Volume: 21, Issue:1 Topics: Analgesics; Animals; Carrageenan; Female; Glucosamine; Hyperalgesia; Inflammation; Iodoacetic Acid;	2019
Protectin DX attenuates IL-1β-induced inflammation via the AMPK/NF-κB pathway in chondrocytes and ameliorates osteoarthritis progression in a rat model. International immunopharmacology, 2020, Volume: 78 Topics: AMP-Activated Protein Kinases; Animals; Arthritis, Experimental; Cells, Cultured; Chondrocytes; Dise	2020
A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis. International journal of pharmaceutics, 2020, May-15, Volume: 581 Topics: Administration, Oral; Animals; Anthraquinones; Anti-Inflammatory Agents; Arthritis, Experimental; Ca	2020
Reduction of osteoarthritis severity in the temporomandibular joint of rabbits treated with chondroitin sulfate and glucosamine. PloS one, 2020, Volume: 15, Issue:4 Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Chondroitin Sulfates; Disease Models, Animal	2020
p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis. International journal of nanomedicine, 2020, Volume: 15 Topics: Animals; Cartilage, Articular; Chondrocytes; Cytokines; Disease Models, Animal; Humans; Iodoacetic A	2020
Contribution of salidroside to the relieve of symptom and sign in the early acute stage of osteoarthritis in rat model. Journal of ethnopharmacology, 2020, Sep-15, Volume: 259 Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cartilage, Articular; Chondrocytes; Cytokines; Fema	2020
Comparison of diclofenac with apigenin-glycosides rich Clinacanthus nutans extract for amending inflammation and catabolic protease regulations in osteoporotic-osteoarthritis rat model. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2020, Volume: 28, Issue:2 Topics: Administration, Oral; Animals; Apigenin; Cytokines; Diclofenac; Disease Models, Animal; Dose-Respons	2020
Interleukin-1-Interleukin-17 Signaling Axis Induces Cartilage Destruction and Promotes Experimental Osteoarthritis. Frontiers in immunology, 2020, Volume: 11 Topics: Animals; Arthralgia; Arthritis, Experimental; Cartilage, Articular; Cells, Cultured; Chondrocytes; H	2020
MSC encapsulation in alginate microcapsules prolongs survival after intra-articular injection, a longitudinal in vivo cell and bead integrity tracking study. Cell biology and toxicology, 2020, Volume: 36, Issue:6 Topics: Adult; Alginates; Animals; Cell Survival; Cell Tracking; Cells, Cultured; Disease Models, Animal; Fe	2020
Intra-Articular Route for the System of Molecules 14G1862 from Nutrients, 2020, May-31, Volume: 12, Issue:6 Topics: Analgesics; Animals; Arthritis, Experimental; Cell Survival; Centella; Disease Models, Animal; Hyper	2020
Osteoarthritis Pain Model Induced by Intra-Articular Injection of Mono-Iodoacetate in Rats. Journal of visualized experiments : JoVE, 2020, 05-20, Issue:159 Topics: Animals; Cartilage, Articular; Chondrocytes; Cytokines; Disease Models, Animal; Injections, Intra-Ar	2020
Gumiganghwal-tang ameliorates cartilage destruction via inhibition of matrix metalloproteinase. Journal of ethnopharmacology, 2020, Oct-28, Volume: 261 Topics: Animals; Arthritis, Experimental; Cartilage, Articular; Cell Line, Tumor; Chondrocytes; Collagen Typ	2020
Effect and mechanism of the CACNA2D1-CGRP pathway in osteoarthritis-induced ongoing pain. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020, Volume: 129 Topics: Adenylyl Cyclases; Animals; Arthralgia; Calcitonin Gene-Related Peptide; Calcium Channels, L-Type; C	2020
TissueGene-C promotes an anti-inflammatory micro-environment in a rat monoiodoacetate model of osteoarthritis via polarization of M2 macrophages leading to pain relief and structural improvement. Inflammopharmacology, 2020, Volume: 28, Issue:5 Topics: Animals; Arthritis, Experimental; Cell- and Tissue-Based Therapy; Chondrocytes; Genetic Therapy; Hum	2020
Synthesis of Human & experimental toxicology, 2021, Volume: 40, Issue:2 Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Bone and Bones; C-Reactive Protein; COVID	2021
Alterations in Anandamide Synthesis and Degradation during Osteoarthritis Progression in an Animal Model. International journal of molecular sciences, 2020, Oct-06, Volume: 21, Issue:19 Topics: Animals; Arachidonic Acids; Disease Models, Animal; Disease Progression; Endocannabinoids; Gene Expr	2020
Galactomannan of Delonix regia seeds reduces nociception and morphological damage in the rat model of osteoarthritis induced by sodium monoiodoacetate. Naunyn-Schmiedeberg's archives of pharmacology, 2021, Volume: 394, Issue:3 Topics: Analgesics; Animals; Disease Models, Animal; Fabaceae; Foot Joints; Galactose; Iodoacetic Acid; Male	2021
TAP2, a peptide antagonist of Toll-like receptor 4, attenuates pain and cartilage degradation in a monoiodoacetate-induced arthritis rat model. Scientific reports, 2020, 10-15, Volume: 10, Issue:1 Topics: Animals; Arthritis, Experimental; ATP Binding Cassette Transporter, Subfamily B, Member 3; Cartilage	2020
Antarctic Krill Oil Ameliorates Monosodium Iodoacetate-Induced Irregularities in Articular Cartilage and Inflammatory Response in the Rat Models of Osteoarthritis. Nutrients, 2020, Nov-20, Volume: 12, Issue:11 Topics: Animals; Antarctic Regions; Cartilage, Articular; Cytokines; Disease Models, Animal; Euphausiacea; I	2020
Herbal Composition LI73014F2 Alleviates Articular Cartilage Damage and Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats. Molecules (Basel, Switzerland), 2020, Nov-23, Volume: 25, Issue:22 Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Cartilage, Articular; Cytokines; Disease Models, Anim	2020
Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model. Molecules (Basel, Switzerland), 2020, Dec-04, Volume: 25, Issue:23 Topics: Adenosine Triphosphate; Animals; Antioxidants; Chitosan; Disease Models, Animal; Electron Transport	2020
d-Mannose suppresses osteoarthritis development in vivo and delays IL-1β-induced degeneration in vitro by enhancing autophagy activated via the AMPK pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 135 Topics: AMP-Activated Protein Kinases; Animals; Antirheumatic Agents; Apoptosis; Autophagy; Cells, Cultured;	2021
Inhibition effect of International journal of medical sciences, 2021, Volume: 18, Issue:4 Topics: Animals; Arthritis, Experimental; Caragana; Cells, Cultured; Chondrocytes; Humans; Inflammation Medi	2021
CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 136 Topics: Analgesics; Animals; Arthralgia; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal	2021
The anti-inflammatory effects of 15-HETE on osteoarthritis during treadmill exercise. Life sciences, 2021, May-15, Volume: 273 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Hydroxyeicosatetraenoic Acids; Inflammat	2021
Local Administration of Low-Dose Nerve Growth Factor Antibody Reduced Pain in a Rat Osteoarthritis Model. International journal of molecular sciences, 2021, Mar-04, Volume: 22, Issue:5 Topics: Animals; Antibodies, Monoclonal, Humanized; Arthritis, Experimental; Cartilage, Articular; Dose-Resp	2021
Biosynthesis of gold nanoparticles for the treatment of osteoarthritis alone or in combination with Diacerein Inflammopharmacology, 2021, Volume: 29, Issue:3 Topics: Animals; Anthraquinones; Anti-Inflammatory Agents; Chenopodium; Disease Models, Animal; Drug Therapy	2021
The active ingredients analysis of Herba Lysimachiae treating osteoarthritis based on the LC-MS/MS technology and public bioinformatics platforms. Journal of separation science, 2021, Volume: 44, Issue:20 Topics: Animals; Chromatography, Liquid; Computational Biology; Drugs, Chinese Herbal; Iodoacetic Acid; Male	2021
Spinal neuropeptide modulation, functional assessment and cartilage lesions in a monosodium iodoacetate rat model of osteoarthritis. Neuropeptides, 2017, Volume: 65 Topics: Animals; Bradykinin; Calcitonin Gene-Related Peptide; Cartilage Diseases; Disease Models, Animal; Fe	2017
Transient Receptor Potential Vanilloid 5 Mediates Ca2+ Influx and Inhibits Chondrocyte Autophagy in a Rat Osteoarthritis Model. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 42, Issue:1 Topics: Animals; Autophagy; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; C	2017
The intra-articular injection of RANKL-binding peptides inhibits cartilage degeneration in a murine model of osteoarthritis. Journal of pharmacological sciences, 2017, Volume: 134, Issue:2 Topics: Animals; Bone and Bones; Cartilage, Articular; Cell Differentiation; Cell Line; Cell Proliferation;	2017
Photobiomodulation therapy by NIR laser in persistent pain: an analytical study in the rat. Lasers in medical science, 2017, Volume: 32, Issue:8 Topics: Animals; Disease Models, Animal; Freund's Adjuvant; Inflammation; Infrared Rays; Injections, Intra-A	2017
Effects of Tribulus terrestris on monosodium iodoacetate‑induced osteoarthritis pain in rats. Molecular medicine reports, 2017, Volume: 16, Issue:4 Topics: Animals; Bone and Bones; Cartilage; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Female; Inf	2017
Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Pain, 2017, Volume: 158, Issue:12 Topics: Animals; Arthralgia; Cannabidiol; Disease Models, Animal; Inflammation; Iodoacetic Acid; Knee Joint;	2017
Celastrol attenuates pain and cartilage damage via SDF-1/CXCR4 signalling pathway in osteoarthritis rats. The Journal of pharmacy and pharmacology, 2018, Volume: 70, Issue:1 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cartilage, Articular; Chemokine CXCL12;	2018
Evaluation of oral multi-herbal preparation of Dashmoolarishta on mice model of osteoarthritis. Journal of basic and clinical physiology and pharmacology, 2017, Nov-27, Volume: 28, Issue:6 Topics: Animals; Arthritis, Experimental; Behavior, Animal; Female; Hyaluronic Acid; Iodoacetic Acid; Male;	2017
Low-intensity pulsed ultrasound stimulation for mandibular condyle osteoarthritis lesions in rats. Oral diseases, 2018, Volume: 24, Issue:4 Topics: Animals; Bone Density; Chondrocytes; Iodoacetic Acid; Male; Mandibular Condyle; Matrix Metalloprotei	2018
Cell-type-specific gene expression patterns in the knee cartilage in an osteoarthritis rat model. Functional & integrative genomics, 2018, Volume: 18, Issue:1 Topics: Animals; Arthritis, Experimental; Biomarkers; Cartilage, Articular; Gene Expression Regulation; Iodo	2018
Intraarticularly-Injected Mesenchymal Stem Cells Stimulate Anti-Inflammatory Molecules and Inhibit Pain Related Protein and Chondrolytic Enzymes in a Monoiodoacetate-Induced Rat Arthritis Model. International journal of molecular sciences, 2018, Jan-09, Volume: 19, Issue:1 Topics: ADAMTS5 Protein; Animals; Calcitonin Gene-Related Peptide; Cartilage, Articular; Cell Adhesion Molec	2018
Tabetri™ ( Mediators of inflammation, 2017, Volume: 2017 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Chondrocytes; Ethanol; Humans; Inflammat	2017
The Combination of Probiotic Complex, Rosavin, and Zinc Improves Pain and Cartilage Destruction in an Osteoarthritis Rat Model. Journal of medicinal food, 2018, Volume: 21, Issue:4 Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Cartilage, Articular; Chondrocytes; Cyto	2018
Antiarthritic Effect of Polar Extract of Curcuma longa on Monosodium Iodoacetate Induced Osteoarthritis in Rats. Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2017, Volume: 16, Issue:3 Topics: Animals; Collagen Type II; Curcuma; Disease Models, Animal; Female; Humans; Iodoacetic Acid; Male; M	2017
Sensitization of transient receptor potential vanilloid 4 and increasing its endogenous ligand 5,6-epoxyeicosatrienoic acid in rats with monoiodoacetate-induced osteoarthritis. Pain, 2018, Volume: 159, Issue:5 Topics: Animals; Arthritis, Experimental; Disease Models, Animal; Ganglia, Spinal; Hand Strength; Iodoacetic	2018
In Vitro and In Vivo Anti-Osteoarthritis Effects of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-Glucoside from Polygonum Multiflorum. Molecules (Basel, Switzerland), 2018, Mar-03, Volume: 23, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Chondrocytes; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dino	2018
Development and characterization of various osteoarthritis models for tissue engineering. PloS one, 2018, Volume: 13, Issue:3 Topics: Animals; Anterior Cruciate Ligament; Cartilage, Articular; Disease Models, Animal; Female; Guinea Pi	2018
Transient Receptor Potential Channel, Vanilloid 5, Induces Chondrocyte Apoptosis in a Rat Osteoarthritis Model Through the Mediation of Ca2+ Influx. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 46, Issue:2 Topics: Animals; Apoptosis; Calcium; Calcium Channels; Calcium Chelating Agents; Calmodulin; Cartilage, Arti	2018
Induction of osteoarthritis by injecting monosodium iodoacetate into the patellofemoral joint of an experimental rat model. PloS one, 2018, Volume: 13, Issue:4 Topics: Animals; Cartilage, Articular; Disease Models, Animal; Fibrosis; Iodoacetic Acid; Male; Osteoarthrit	2018
Quadrupedal rodent gait compensations in a low dose monoiodoacetate model of osteoarthritis. Gait & posture, 2018, Volume: 63 Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Enzyme Inhibitors; Gait; Iodoacetic Acid	2018
Differential contributions of peripheral and central mechanisms to pain in a rodent model of osteoarthritis. Scientific reports, 2018, 05-08, Volume: 8, Issue:1 Topics: Anesthetics, Local; Animals; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Gene Expre	2018
BST106 Protects against Cartilage Damage by Inhibition of Apoptosis and Enhancement of Autophagy in Osteoarthritic Rats. Biological & pharmaceutical bulletin, 2018, Aug-01, Volume: 41, Issue:8 Topics: Animals; Apoptosis; Autophagy; Cartilage, Articular; Chrysanthemum; Iodoacetic Acid; Knee Joint; Mal	2018
Protective Effects of Nutrients, 2018, Jun-11, Volume: 10, Issue:6 Topics: Animals; Anti-Inflammatory Agents; Apiaceae; Caspase 3; Caspase 7; Cytochrome P-450 CYP2D6; Disease	2018
Impaired chronic pain-like behaviour and altered opioidergic system in the TASTPM mouse model of Alzheimer's disease. European journal of pain (London, England), 2019, Volume: 23, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Analgesics; Analgesics, Opioid; Animals; Arthralg	2019
Lactobacillus acidophilus ameliorates pain and cartilage degradation in experimental osteoarthritis. Immunology letters, 2018, Volume: 203 Topics: Animals; Cartilage; Chondrocytes; Iodoacetic Acid; Lactobacillus acidophilus; Male; Osteoarthritis;	2018
Persistent synovial inflammation plays important roles in persistent pain development in the rat knee before cartilage degradation reaches the subchondral bone. BMC musculoskeletal disorders, 2018, Aug-16, Volume: 19, Issue:1 Topics: Animals; Arthralgia; Avoidance Learning; Behavior, Animal; Calcitonin Gene-Related Peptide; Cartilag	2018
Intra-articular effects of combined xenogenous serum rich in growth factors (SRGF) and vitamin C on histopathology grading and staging of osteoarthritis in rat model. Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine, 2019, Volume: 26, Issue:1 Topics: Animals; Ascorbic Acid; Cartilage, Articular; Chondrocytes; Disease Models, Animal; Injections, Intr	2019
Effect of Chondroitin Sulfate on Blood Serum Cytokine Profile during Carrageenan-induced Edema and Monoiodoacetate-induced Osteoarthritis in Rats. Reviews on recent clinical trials, 2019, Volume: 14, Issue:1 Topics: Animals; Arthritis, Experimental; Carrageenan; Chondroitin Sulfates; Cytokines; Disease Models, Anim	2019
An investigation into the noradrenergic and serotonergic contributions of diffuse noxious inhibitory controls in a monoiodoacetate model of osteoarthritis. Journal of neurophysiology, 2019, 01-01, Volume: 121, Issue:1 Topics: Action Potentials; Adrenergic alpha-2 Receptor Antagonists; Animals; Diffuse Noxious Inhibitory Cont	2019
Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondrocyte hypertrophy and apoptosis. Journal of ethnopharmacology, 2019, Mar-01, Volume: 231 Topics: Agkistrodon; Analgesics; Animals; Apoptosis; Cartilage, Articular; Chondrocytes; Complex Mixtures; H	2019
Time course analyses of structural changes in the infrapatellar fat pad and synovial membrane during inflammation-induced persistent pain development in rat knee joint. BMC musculoskeletal disorders, 2019, Jan-05, Volume: 20, Issue:1 Topics: Adipose Tissue; Animals; Arthralgia; Arthritis, Experimental; Behavior, Animal; Disease Progression;	2019
The Therapeutic Effect of STAT3 Signaling-Suppressed MSC on Pain and Articular Cartilage Damage in a Rat Model of Monosodium Iodoacetate-Induced Osteoarthritis. Frontiers in immunology, 2018, Volume: 9 Topics: Administration, Intravenous; Animals; Arthritis, Experimental; Cartilage, Articular; Cells, Cultured	2018
Animal Models for the Study of Bone-Derived Pain. Methods in molecular biology (Clifton, N.J.), 2019, Volume: 1914 Topics: Animals; Behavior, Animal; Bone and Bones; Bone Neoplasms; Cell Culture Techniques; Cell Line, Tumor	2019
Action of MK-7264 (gefapixant) at human P2X3 and P2X2/3 receptors and in vivo efficacy in models of sensitisation. British journal of pharmacology, 2019, Volume: 176, Issue:13 Topics: Animals; Carbolines; Cell Line, Tumor; Female; Freund's Adjuvant; Humans; Hyperalgesia; Iodoacetic A	2019
Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor α in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compound. Inflammopharmacology, 2019, Volume: 27, Issue:6 Topics: Amides; Analgesics; Animals; Cannabinoids; Dronabinol; Ethanolamines; Iodoacetic Acid; Male; Motor A	2019
Chondroprotective effects of platelet lysate towards monoiodoacetate-induced arthritis by suppression of TNF-α-induced activation of NF-ĸB pathway in chondrocytes. Aging, 2019, 05-14, Volume: 11, Issue:9 Topics: Analgesics; Animals; Arthritis; Blood Platelets; Cell Survival; Chondrocytes; Gene Expression Regula	2019
Vitamin E ameliorates alterations to the articular cartilage of knee joints induced by monoiodoacetate and diabetes mellitus in rats. Ultrastructural pathology, 2019, Volume: 43, Issue:2-3 Topics: Animals; Antioxidants; Cartilage, Articular; Chondrocytes; Diabetes Mellitus; Disease Models, Animal	2019
Dual regulatory roles of HMGB1 in inflammatory reaction of chondrocyte cells and mice. Cell cycle (Georgetown, Tex.), 2019, Volume: 18, Issue:18 Topics: Animals; Apoptosis; Autophagy; Cells, Cultured; Chondrocytes; Cytosol; Disease Models, Animal; Glycy	2019
Intraarticular injection of processed lipoaspirate cells has anti-inflammatory and analgesic effects but does not improve degenerative changes in murine monoiodoacetate-induced osteoarthritis. BMC musculoskeletal disorders, 2019, Jul-19, Volume: 20, Issue:1 Topics: Adipose Tissue; Animals; Arthralgia; Arthritis, Experimental; Biomarkers; Cartilage, Articular; Fema	2019
Sigma-1 receptor modulates neuroinflammation associated with mechanical hypersensitivity and opioid tolerance in a mouse model of osteoarthritis pain. British journal of pharmacology, 2019, Volume: 176, Issue:20 Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Toleranc	2019
Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis. Annals of the rheumatic diseases, 2014, Volume: 73, Issue:8 Topics: Animals; Arthralgia; Behavior, Animal; Bone Density Conservation Agents; Bone Remodeling; Diphosphon	2014
Comparison between oral and intra-articular antinociceptive effect of dexketoprofen and tramadol combination in monosodium iodoacetate-induced osteoarthritis in rats. European journal of pharmacology, 2013, Aug-15, Volume: 714, Issue:1-3 Topics: Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Combinations; Iodo	2013
Coenzyme Q10 ameliorates pain and cartilage degradation in a rat model of osteoarthritis by regulating nitric oxide and inflammatory cytokines. PloS one, 2013, Volume: 8, Issue:7 Topics: Analgesics; Animals; Cartilage; Cytokines; Disease Models, Animal; Gene Expression Regulation; Infla	2013
Estrogen aggravates iodoacetate-induced temporomandibular joint osteoarthritis. Journal of dental research, 2013, Volume: 92, Issue:10 Topics: Animals; Apoptosis; Cartilage, Articular; Caspase 3; Caspase 8; Chondrocytes; Estradiol; Fas Ligand	2013
Chondroprotective activity of a detoxicated traditional Chinese medicine (Fuzi) of Aconitum carmichaeli Debx against severe-stage osteoarthritis model induced by mono-iodoacetate. Journal of ethnopharmacology, 2014, Volume: 151, Issue:1 Topics: Animals; Diterpenes; Drugs, Chinese Herbal; Iodoacetic Acid; Male; Osteoarthritis; Plant Extracts; R	2014
Histology, glycosaminoglycan level and cartilage stiffness in monoiodoacetate-induced osteoarthritis: comparative analysis with anterior cruciate ligament transection in rat model and human osteoarthritis. International journal of medical sciences, 2014, Volume: 11, Issue:1 Topics: Animals; Anterior Cruciate Ligament; Cartilage, Articular; Disease Models, Animal; Glycosaminoglycan	2014
Effect of interval-training exercise on subchondral bone in a chemically-induced osteoarthritis model. Osteoarthritis and cartilage, 2014, Volume: 22, Issue:8 Topics: Absorptiometry, Photon; Animals; Arthritis, Experimental; Bone Density; Cartilage, Articular; Diseas	2014
Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis. European journal of pharmacology, 2014, Sep-05, Volume: 738 Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Duloxe	2014
Near infrared spectroscopy for rapid determination of Mankin score components: a potential tool for quantitative characterization of articular cartilage at surgery. Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association, 2014, Volume: 30, Issue:9 Topics: Animals; Anterior Cruciate Ligament; Anterior Cruciate Ligament Injuries; Cartilage Diseases; Cartil	2014
Effects of deer bone extract on the expression of pro-inflammatory cytokine and cartilage-related genes in monosodium iodoacetate-induced osteoarthritic rats. Bioscience, biotechnology, and biochemistry, 2014, Volume: 78, Issue:10 Topics: Animals; Body Weight; Bone and Bones; Cartilage, Articular; Cytokines; Deer; Eating; Gene Expression	2014
Activation of α7 nicotinic acetylcholine receptors prevents monosodium iodoacetate-induced osteoarthritis in rats. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 35, Issue:2 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cells, Cultured; Chondrocytes; Iodoacetic Acid; Ma	2015
Dissecting the contribution of knee joint NGF to spinal nociceptive sensitization in a model of OA pain in the rat. Osteoarthritis and cartilage, 2015, Volume: 23, Issue:6 Topics: Animals; Arthritis, Experimental; Behavior, Animal; Injections, Intra-Articular; Iodoacetic Acid; Ma	2015
Effect of a topical copper indomethacin gel on inflammatory parameters in a rat model of osteoarthritis. Drug design, development and therapy, 2015, Volume: 9 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Copper; Disease Models, A	2015
Effect of atorvastatin, a HMG-CoA reductase inhibitor in monosodium iodoacetate-induced osteoarthritic pain: implication for osteoarthritis therapy. Pharmacological reports : PR, 2015, Volume: 67, Issue:3 Topics: Animals; Atorvastatin; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibit	2015
Anti-Osteoarthritic Effects of the Litsea japonica Fruit in a Rat Model of Osteoarthritis Induced by Monosodium Iodoacetate. PloS one, 2015, Volume: 10, Issue:8 Topics: Animals; Body Weight; Cartilage, Articular; Cytokines; Disease Models, Animal; Enzyme-Linked Immunos	2015
Electrophysiological evidence for voltage-gated calcium channel 2 (Cav2) modulation of mechano- and thermosensitive spinal neuronal responses in a rat model of osteoarthritis. Neuroscience, 2015, Oct-01, Volume: 305 Topics: Animals; Calcium Channel Blockers; Caveolin 2; Disease Models, Animal; Evoked Potentials; Functional	2015
Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis. Annals of the rheumatic diseases, 2016, Volume: 75, Issue:6 Topics: Analgesics, Non-Narcotic; Animals; Arthritis, Experimental; Drug Evaluation, Preclinical; Iodoacetic	2016
Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis. Osteoarthritis and cartilage, 2015, Volume: 23, Issue:11 Topics: Animals; Arthralgia; Arthritis, Experimental; Blotting, Western; Cells, Cultured; Chondrocytes; Dise	2015
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain. Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7 Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Ev	2016
Concurrent validity of different functional and neuroproteomic pain assessment methods in the rat osteoarthritis monosodium iodoacetate (MIA) model. Arthritis research & therapy, 2016, 06-23, Volume: 18 Topics: Acclimatization; Animals; Arthritis, Experimental; Chromatography, High Pressure Liquid; Conditionin	2016
Ibuprofen-loaded porous microspheres suppressed the progression of monosodium iodoacetate-induced osteoarthritis in a rat model. Colloids and surfaces. B, Biointerfaces, 2016, Nov-01, Volume: 147 Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Proliferation; Chond	2016
Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models. Journal of neuroinflammation, 2016, 09-02, Volume: 13, Issue:1 Topics: Action Potentials; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; Chronic Pain; Disease Mo	2016
Lysophosphatidic acid provides a missing link between osteoarthritis and joint neuropathic pain. Osteoarthritis and cartilage, 2017, Volume: 25, Issue:6 Topics: Activating Transcription Factor 3; Adult; Aged; Aged, 80 and over; Animals; Arthralgia; Arthritis, E	2017
Novel role of CCN3 that maintains the differentiated phenotype of articular cartilage. Journal of bone and mineral metabolism, 2017, Volume: 35, Issue:6 Topics: Animals; Cartilage, Articular; Cell Differentiation; Cells, Cultured; DNA Transposable Elements; Ext	2017
Protective Effect of Deer Bone Oil on Cartilage Destruction in Rats with Monosodium Iodoacetate (MIA)-Induced Osteoarthritis. Biological & pharmaceutical bulletin, 2016, Volume: 39, Issue:12 Topics: Animals; Arthritis, Experimental; Bone and Bones; Cartilage, Articular; Cell Survival; Cells, Cultur	2016
Adelmidrol, in combination with hyaluronic acid, displays increased anti-inflammatory and analgesic effects against monosodium iodoacetate-induced osteoarthritis in rats. Arthritis research & therapy, 2016, 12-12, Volume: 18, Issue:1 Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Dicarboxylic Acids; Hyaluron	2016
Vitamin C Protects Chondrocytes against Monosodium Iodoacetate-Induced Osteoarthritis by Multiple Pathways. International journal of molecular sciences, 2016, Dec-27, Volume: 18, Issue:1 Topics: Animals; Apoptosis; Ascorbic Acid; Cell Line, Tumor; Chondrocytes; Cytokines; Humans; Iodoacetic Aci	2016
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models. Arthritis and rheumatism, 2009, Volume: 60, Issue:7 Topics: Animals; Cartilage, Articular; Cattle; Disease Models, Animal; Dose-Response Relationship, Drug; Enz	2009
Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis. Pain, 2011, Volume: 152, Issue:5 Topics: Action Potentials; Afferent Pathways; Age Factors; Animals; Arthralgia; Benzamides; Carbamates; Dicl	2011
Quantifying osteoarthritic cartilage changes accurately using in vivo microCT arthrography in three etiologically distinct rat models. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2011, Volume: 29, Issue:11 Topics: Animals; Apoptosis; Arthrography; Cartilage, Articular; Chondrocytes; Cumulative Trauma Disorders; D	2011
Determination of specific neuropeptides modulation time course in a rat model of osteoarthritis pain by liquid chromatography ion trap mass spectrometry. Neuropeptides, 2011, Volume: 45, Issue:6 Topics: Animals; Calcitonin Gene-Related Peptide; Chromatography, Liquid; Disease Models, Animal; Dynorphins	2011
Local ASIC3 modulates pain and disease progression in a rat model of osteoarthritis. Journal of biomedical science, 2012, Aug-21, Volume: 19 Topics: Acid Sensing Ion Channels; Animals; Behavior, Animal; Cnidarian Venoms; Gene Expression Regulation;	2012
Chondromodulating chimeric prodrugs of diacetylrhein: synthesis and evaluation in monoiodoacetate-induced hyperalgesia. Medicinal chemistry (Shariqah (United Arab Emirates)), 2013, Volume: 9, Issue:3 Topics: Animals; Anthraquinones; Chondrocytes; Disease Models, Animal; Hyperalgesia; Iodoacetic Acid; Osteoa	2013
Silymarin potentiates the anti-inflammatory effects of Celecoxib on chemically induced osteoarthritis in rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 2012, Oct-15, Volume: 19, Issue:13 Topics: Animals; Antioxidants; Cartilage, Articular; Celecoxib; Cyclooxygenase 2 Inhibitors; Drug Evaluation	2012
Antinociceptive effects of eugenol evaluated in a monoiodoacetate-induced osteoarthritis rat model. Phytotherapy research : PTR, 2012, Volume: 26, Issue:9 Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Clove Oil; Disease Models, Animal; Dynorphins;	2012
Pain-like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in C57Bl/6 mice. European journal of pain (London, England), 2013, Volume: 17, Issue:4 Topics: Animals; Arthritis, Experimental; Behavior, Animal; Calcitonin Gene-Related Peptide; Hyperalgesia; I	2013
Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: implication for osteoarthritis therapy. Pharmacology, biochemistry, and behavior, 2013, Volume: 103, Issue:4 Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intra-Articular; Iodo	2013
Augmented chondroprotective effect of coadministration of celecoxib and rebamipide in the monosodium iodoacetate rat model of osteoarthritis. Archives of pharmacal research, 2013, Volume: 36, Issue:1 Topics: Administration, Oral; Alanine; Animals; Arthritis, Experimental; Behavior, Animal; Cartilage; Celeco	2013
Intra-articular injection of xanthan gum reduces pain and cartilage damage in a rat osteoarthritis model. Carbohydrate polymers, 2013, Feb-15, Volume: 92, Issue:2 Topics: Animals; Cartilage, Articular; Disease Models, Animal; Injections, Intra-Articular; Iodoacetic Acid;	2013
Site specific changes in gene expression and cartilage metabolism during early experimental osteoarthritis. Osteoarthritis and cartilage, 2004, Volume: 12, Issue:4 Topics: Animals; Cartilage, Articular; Cyclooxygenase 2; Enzyme Inhibitors; Gelatinases; Gene Expression; Im	2004
Chemical arthrodesis of the distal tarsal joints using sodium monoiodoacetate in 104 horses. Australian veterinary journal, 2004, Volume: 82, Issue:5 Topics: Animals; Arthrodesis; Enzyme Inhibitors; Horse Diseases; Horses; Injections, Intra-Articular; Iodoac	2004
Immobilization ameliorates chemically-induced articular cartilage damage. Arthritis and rheumatism, 1984, Volume: 27, Issue:2 Topics: Animals; Cartilage, Articular; Femur; Guinea Pigs; Histocytochemistry; Immobilization; Injections, I	1984
Site-specific cartilage changes in murine degenerative knee joint disease induced by iodoacetate and collagenase. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 1994, Volume: 12, Issue:2 Topics: Animals; Cartilage, Articular; Collagenases; Iodoacetates; Iodoacetic Acid; Knee Joint; Male; Mice;	1994
Histomorphological studies on the effect of recombinant human superoxide dismutase in biochemically induced osteoarthritis. Pharmacology, 1993, Volume: 47, Issue:4 Topics: Animals; Cartilage, Articular; Chickens; Female; Humans; Injections, Intra-Articular; Iodoacetates;	1993
Prolonged effect of iodoacetate on articular cartilage and its modification by an anti-rheumatic drug. International journal of experimental pathology, 1993, Volume: 74, Issue:3 Topics: Animals; Cartilage, Articular; Diclofenac; Iodoacetates; Iodoacetic Acid; Knee Joint; Male; Osteoart	1993
In vivo quantification of proteoglycan synthesis in articular cartilage of different topographical areas in the murine knee joint. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 1993, Volume: 11, Issue:4 Topics: Animals; Autoradiography; Cartilage, Articular; Disease Models, Animal; Iodoacetates; Iodoacetic Aci	1993
Use of sodium monoiodoacetate to fuse the distal hock joints in horses. Australian veterinary journal, 1995, Volume: 72, Issue:1 Topics: Animals; Arthrodesis; Female; Hindlimb; Horse Diseases; Horses; Injections, Intra-Articular; Iodoace	1995
In vitro magnetic resonance microimaging of experimental osteoarthritis in the rat knee joint. The Journal of rheumatology, 1997, Volume: 24, Issue:1 Topics: Animals; Injections, Intra-Articular; Iodoacetates; Iodoacetic Acid; Knee Joint; Magnetic Resonance	1997
Cross-relaxation times of normal and biochemically induced osteoarthritic rabbit knee cartilages. The Japanese journal of physiology, 1997, Volume: 47, Issue:3 Topics: Animals; Body Water; Cartilage, Articular; Iodoacetates; Iodoacetic Acid; Knee Joint; Magnetic Reson	1997
Gait analysis in a rat model of osteoarthrosis. Physiology & behavior, 1997, Volume: 62, Issue:5 Topics: Animals; Disease Models, Animal; Gait; Injections, Intra-Articular; Iodoacetates; Iodoacetic Acid; K	1997
Evaluation of intra-articularly administered sodium monoiodoacetate-induced chemical injury to articular cartilage of horses. American journal of veterinary research, 1992, Volume: 53, Issue:7 Topics: Animals; Carpus, Animal; Cartilage, Articular; Disease Models, Animal; Histocytochemistry; Horse Dis	1992
Fusion of the distal intertarsal and tarsometatarsal joints in the horse using intraarticular sodium monoiodoacetate. Equine veterinary journal, 1991, Volume: 23, Issue:4 Topics: Animals; Arthrodesis; Cartilage, Articular; Horse Diseases; Horses; Iodoacetates; Iodoacetic Acid; L	1991
Development of osteoarthritic lesions in mice by "metabolic" and "mechanical" alterations in the knee joints. The American journal of pathology, 1989, Volume: 135, Issue:6 Topics: Animals; Biomechanical Phenomena; Glycosaminoglycans; Injections, Intra-Articular; Iodoacetates; Iod	1989
[Monoiodoacetic acid-induced arthropathy of the rabbit knee--a contribution to the pathogenesis of arthrosis]. Beitrage zur Orthopadie und Traumatologie, 1989, Volume: 36, Issue:5 Topics: Animals; Disease Models, Animal; Glycolysis; Injections, Intra-Articular; Iodoacetates; Iodoacetic A	1989
Chemical model of osteoarthritis--a pharmacological evaluation. The Journal of rheumatology, 1987, Volume: 14 Spec No Topics: Adrenal Cortex Hormones; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chickens; Disease Models,	1987
Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Arthritis and rheumatism, 1985, Volume: 28, Issue:11 Topics: Animals; Cartilage Diseases; Cartilage, Articular; Guinea Pigs; Histocytochemistry; Iodoacetates; Io	1985

iodoacetic acid and Osteoarthritis

Research Excerpts

Research

Studies (170)

Authors

Clinical Trials (2)

Trial Overview

Reviews

Other Studies

Authors	Studies
Jung, JI	1
Lee, HS	1
Jeon, YE	1
Kim, SM	3
Hong, SH	1
Moon, JM	1
Lim, CY	1
Kim, YH	1
Kim, EJ	1
Wang, J	1
Wei, W	1
Zhang, X	2
Cao, S	1
Hu, B	1
Ye, Y	1
Jiang, M	1
Wang, T	1
Zuo, J	1
He, S	1
Yang, C	1
Malta, I	1
Moraes, T	1
Elisei, L	1
Novaes, R	1
Galdino, G	1
Lee, M	2
Kim, GH	2
Kim, M	1
Seo, JM	1
Kim, YM	1
Seon, MR	1
Um, S	1
Choi, SJ	2
Oh, W	1
Song, BR	1
Jin, HJ	1
Chen, R	1
Liao, Z	1
Zhu, Y	1
Chen, Y	1
Liu, J	1
Chen, X	2
Novikov, FN	1
Panova, MV	1
Titov, IY	1
Stroylov, VS	1
Stroganov, OV	1
Chilov, GG	1
Han, FY	1
Brockman, DA	1
Nicholson, JR	1
Corradini, L	1
Smith, MT	1
Aborehab, NM	1
El Bishbishy, MH	1
Lee, YM	1
Son, E	1
Kim, SH	3
Kim, DS	1
Liu, X	4
Zhao, J	1
Jiang, H	3
Li, H	3
Feng, Y	1
Ke, J	1
Long, X	3
Na, HS	5
Woo, JS	2
Kim, JH	2
Lee, JS	2
Um, IG	2
Cho, KH	5
Cho, ML	9
Chung, SJ	1
Park, SH	9
Chao, D	1
Tran, H	1
Hogan, QH	1
Pan, B	1
Lee, YS	2
Park, EJ	1
Lee, HJ	2
Lee, SY	3
Lee, DH	1
Choi, SY	3
Kim, SA	2
Go, EJ	2
Lee, AR	1
Choi, JW	1
Kim, SJ	6
Wang, Q	1
Peng, J	1
Liu, Y	3
Tian, Y	3
Li, J	1
Ren, YY	1
Gu, J	1
Tan, R	1
Yang, K	4
Xie, Q	4
Tang, T	3
Zhao, N	4
Liang, J	4
Shen, Y	3
Li, Z	3
Liu, B	4
Chen, J	4
Cheng, W	4
Bai, X	4
Zhang, P	4
Liu, Q	5
Song, B	4
Hu, C	4
Liu, L	4
Wang, Y	8
Chen, C	3
Zhou, H	4
Yin, Y	5
Hu, H	3
Jiang, B	3
Zhang, K	3
Wu, S	3
Shen, M	3
Wang, Z	3
Li, Y	2
Sun, H	2
Hu, Z	3
Guo, H	2
Sriwatananukulkit, O	2
Desclaux, S	2
Tawonsawatruk, T	2
Srikuea, R	2
Himakhun, W	2
Likitnukul, S	2
Hemstapat, R	2
Rabie, MA	1
Sayed, RH	1
Venkatesan, JK	1
Madry, H	1
Cucchiarini, M	1
El Sayed, NS	1
Jin, H	2
Yang, Y	2
Lei, G	1
Zeng, C	1
He, K	1
Deng, C	1
Wei, J	1
Li, X	3
Barry, F	1
Chai, F	1
Chijcheapaza-Flores, H	1
Garcia-Fernandez, MJ	1
Blanchemain, N	1
Nicot, R	1
Fang, Z	1
Lei, S	1
Feng, S	1
Zhou, C	1
Tong, X	1
Han, R	1
Kwon, M	1
Nam, D	1
Kim, J	3
Jarecki, J	1
Polkowska, I	1
Kazimierczak, W	1
Wójciak, M	1
Sowa, I	1
Dresler, S	1
Blicharski, T	1
Ise, S	1
Ochiai, N	1
Hashimoto, E	1
Hirosawa, N	1
Kajiwara, D	1
Shimada, Y	1
Inagaki, K	1
Hiraoka, Y	1
Hattori, F	1
Ohtori, S	1
Liao, J	1
Wang, JD	1
Zheng, F	1
Chen, L	1
Sahin, E	1
Orhan, C	1
Erten, F	1
Saiyed, Z	1
Azari, EK	1
Durkee, S	1
Sahin, K	1
Wang, X	1
Song, J	1
Xia, P	1
Lin, Q	1
Chen, A	1
Cheng, K	1
Kong, F	1
Shi, Y	1
Yun, SY	1
Kim, Y	3
Kim, H	2
Lee, BK	1
Oh, DK	1
Jhun, JY	2
Park, MS	1
Sun, J	1
Wang, XH	1
Song, FH	1
Li, DY	1
Gao, SJ	1
Zhang, LQ	1
Wu, JY	1
Liu, DQ	1
Wang, LW	1
Zhou, YQ	1
Mei, W	1
Saber, MM	1
Mahmoud, MM	1
Amin, HM	1
Essam, RM	1
Santiago, LÂM	1
Ataíde, ACS	1
de Araújo Morais, D	1
da Silva Lima, A	1
Dos Santos Martins, N	1
Dourado, AVCA	1
Ribeiro, RM	1
Lima-Neto, LG	1
de Sá Sousa, JC	1
da Rocha, CQ	1
de Sousa Cartágenes, MDS	1
Carvalho, RC	1
de Sousa, EM	1
Yu, Y	1
Park, K	4
Kim, HJ	3
Kim, JG	1
Kim, SE	3
Liu, Z	1
Chen, P	1
Wang, L	1
Vargas, CA	1
Baptista, CAC	1
Del Sol, M	1
Sandoval, C	1
Vásquez, B	1
Veuthey, C	1
Ottone, NE	1
Molinet, M	1
Alves, N	1
Vasconcelos, A	1
Deana, NF	1
Zavatti, M	1
Beretti, F	1
Casciaro, F	1
Bertucci, E	1
Maraldi, T	1
Banki, L	1
Büki, A	1
Horvath, G	1
Kekesi, G	1
Kis, G	1
Somogyvári, F	1
Jancsó, G	1
Vécsei, L	1
Varga, E	1
Tuboly, G	1
Tian, L	1
Su, Z	1
Ma, X	1
Wang, F	2
Guo, Y	2
Choi, DJ	1
Choi, SI	1
Choi, BR	1
Lee, DY	1
Kim, GS	1
Chern, CM	1
Wang, YH	1
Chang, CL	1
Chiou, WF	1
Chang, WT	1
Yao, CH	1
Liou, KT	1
Shen, YC	1
Hanafy, AS	1
El-Ganainy, SO	1
Cordaro, M	2
Siracusa, R	1
Impellizzeri, D	2
D' Amico, R	1
Peritore, AF	1
Crupi, R	1
Gugliandolo, E	1
Fusco, R	2
Di Paola, R	2
Schievano, C	1
Cuzzocrea, S	2
Piao, S	1
Du, W	3
Wei, Y	3
Feng, X	1
Bai, L	5
Jung, JH	1
Song, GG	1
Artuzi, FE	1
Puricelli, E	1
Baraldi, CE	1
Quevedo, AS	1
Ponzoni, D	1
Shin, HJ	2
Park, H	2
Shin, N	2
Shin, J	2
Gwon, DH	1
Kwon, HH	2
Hwang, JA	1
Hong, J	2
Heo, JY	1
Kim, CS	2
Joo, Y	2
Beom, J	2
Kim, DW	2
Sa, L	1
Wei, X	1
Huang, Q	1
Cai, Y	1
Lu, D	1
Mei, R	1
Hu, X	1
Tantowi, NACA	1
Mohamed, S	1
Lau, SF	1
Hussin, P	1
Park, JS	2
Kwon, JY	4
Choi, J	2
Jhun, J	4
Khatab, S	1
Leijs, MJ	1
van Buul, G	1
Haeck, J	1
Kops, N	2
Nieboer, M	1
Bos, PK	1
Verhaar, JAN	1
Bernsen, M	1
van Osch, GJVM	1
Micheli, L	2
Di Cesare Mannelli, L	2
Mattoli, L	1
Tamimi, S	1
Flamini, E	1
Garetto, S	1
Lucci, J	1
Giovagnoni, E	1
Cinci, L	1
D'Ambrosio, M	1
Luceri, C	1
Ghelardini, C	2
Xu, J	1
Yan, L	3
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