chitosan has been researched along with Osteoarthritis in 47 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (2.13) | 29.6817 |
| 2010's | 24 (51.06) | 24.3611 |
| 2020's | 22 (46.81) | 2.80 |
| Authors | Studies |
|---|---|
| Jiao, W; Li, S; Liu, J; Liu, S; Wang, X | 1 |
| Cao, R; Du, Y; Guo, A; Hao, C; Jiao, S; Long, H; Ma, L; Shi, L; Wang, Z; Yu, H; Zhang, H | 1 |
| Hou, D; Huang, Z; Li, J; Liu, N; Wang, W | 1 |
| Cao, Y; Chen, J; Li, Z; Lin, T; Lu, R; Lu, Y; Wu, C; Zhang, J; Zhao, C; Zhao, Y | 1 |
| Bagheri, F; Eslaminejad, MB; Moghadam, NA | 1 |
| Palanisamy, P; Srinivasan, V | 1 |
| Hekmat, A; Naderi-Manesh, H; Tabarsa, M; Tajik, E; Vaezi, Z | 1 |
| Almirall, A; Campos, Y; Chan, A; Cruz, LJ; Eich, C; Fuentes, G; Kaijzel, E; Que, I; Quintanilla, L; Rodríguez-Cabello, JC; Sola, FJ; Tabata, Y | 1 |
| An, C; Bunpetch, V; Cai, D; Chen, Y; Hong, Y; Ouyang, H; Pan, Z; Sun, H; Wu, X; Yi-Chin, T; Yu, D; Yu, J; Yuan, C; Zhang, S; Zhang, X; Zhou, F; Zou, Y | 1 |
| Abdelkhalek, AA; Elkasabgy, NA; Salama, AH | 1 |
| Belluzzi, E; Benetti, A; Brun, P; Elia, R; Mattiuzzo, E; Ruggieri, P; Tarricone, E; Venerando, R; Vindigni, V | 1 |
| Borgogna, M; Donati, I; Marsich, E; Scognamiglio, F; Travan, A | 1 |
| Ahmad, NM; Ahmed, N; Haq, IU; Rehman, AU; Siddiqui, B | 1 |
| Cao, J; Gao, X; Liu, C; Ma, Y; Tang, F; Zhang, G; Zhang, J | 1 |
| Li, FL; Sun, HJ; Wu, CB; Zhou, Q | 1 |
| Hernandez, JHM; Tovar, CDG; Zapata, MEV | 1 |
| Al-Salmi, FA; El-Shenawy, NS; Hamza, RZ | 1 |
| Chen, C; Gong, X; Huang, Y; Li, R; Li, T; Liu, P; Meng, S; Weng, C; Yang, J; Yang, L | 1 |
| Li, X; Mou, D; Yang, X; Yu, Q; Zhang, J; Zhou, J; Zhuang, W | 1 |
| Andrade, KC; Coimbra, IB; Damas, II; Moraes, ÂM; Westin, CB; Zuliani, CC | 1 |
| Li, S; Lin, L; Liu, Z; Ma, F; Mo, X; Tang, B; Wu, G | 1 |
| Barry, F; Blanchemain, N; Chai, F; Chijcheapaza-Flores, H; Garcia-Fernandez, MJ; Nicot, R | 1 |
| Comblain, F; Gauthier, S; Henrotin, Y; Rocasalbas, G | 1 |
| Chen, P; Fan, S; Mei, S; Pang, Y; Shao, F; Wang, J; Xia, C; Zhang, J; Zhu, R | 1 |
| Deng, M; He, B; Li, Y; Liu, S; Ming, J; Zhou, Y | 1 |
| Chen, Q; Hu, GL; Li, YM; Liao, Q; Liu, SQ; Ming, JH; Zhang, C | 1 |
| Chen, L; Li, Y; Liang, Y; Liu, Y; Mei, Y; Zhang, Y | 1 |
| Deng, RH; Qiu, B; Shang, XF; Xia, GQ; Xu, XF; Zhou, PH | 1 |
| Bhat, S; Kumar, A; Lidgren, L | 1 |
| Chausson, M; Dubuc, JE; Henrotin, Y; Maquet, V; Oprenyeszk, F | 1 |
| Dai, Y; Lu, H; Lv, L; Zhao, H | 1 |
| Kanwar, JR; Kanwar, RK; Samarasinghe, RM | 1 |
| Im, GI; Kang, ML; Kim, JE; Ko, JY | 1 |
| Blanco, FJ; Deplaine, H; Gómez Ribelles, JL; Lebourg, M; Magalhães, J | 1 |
| Boulocher, C; Gurny, R; Jordan, O; Kaderli, S; Pillet, E; Roger, T; Rougemont, AL; Scapozza, L; Viguier, E; Watrelot-Virieux, D | 1 |
| He, B; Liu, SQ; Peng, H; Yu, L; Zhao, Q; Zhou, Y | 1 |
| Chen, P; Fan, S; Lin, X; Mei, S; Shan, Z; Wang, J; Xia, C | 1 |
| Arunkumar, P; Indulekha, S; Srivastava, R; Vijayalakshmi, S | 1 |
| Im, GI; Kang, ML; Kim, JE | 1 |
| Chatsudthipong, V; Kunanusornchai, W; Muanprasat, C; Pichyangkura, R; Tawonsawatruk, T; Witoonpanich, B | 1 |
| Chen, P; Fan, S; Lei, C; Ma, J; Mei, S; Ning, L; Wang, J; Xia, C; Zhang, J | 1 |
| Chang, HI; Chang, SF; Chen, CN; Cheng, CC; Huang, KC; Lee, KC; Su, YP | 1 |
| Cai, Y; Creemers, LB; Howard, KA; López-Ruiz, E; Wengel, J | 1 |
| He, Z; Hu, C; Wang, B; Zhao, J | 1 |
| Lu, HD; Lv, LL; Wang, K; Zhao, HQ | 1 |
| Cai, BC; Cai, H; Chen, HX; Chen, J; Chen, ZP; Li, W; Liu, D; Liu, W; Pan, J; Xiao, YY | 1 |
| Chen, LY; Du, YM; Liu, SQ; Peng, H; Qiu, B | 1 |
4 review(s) available for chitosan and Osteoarthritis
| Article | Year |
|---|---|
The Role of Chitosan and Graphene Oxide in Bioactive and Antibacterial Properties of Acrylic Bone Cements.
Topics: Anti-Bacterial Agents; Bacteria; Biocompatible Materials; Bone Cements; Carbohydrate Conformation; Chitosan; Graphite; Materials Testing; Microbial Sensitivity Tests; Osteoarthritis | 2020 |
Systematic review of studies on drug-delivery systems for management of temporomandibular-joint osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents; Chitosan; Drug Delivery Systems; Humans; Hyaluronic Acid; Hydrogels; Lipids; Micelles; Osteoarthritis; Poloxamer; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Temporomandibular Joint Disorders | 2022 |
Chitosan: A promising polymer for cartilage repair and viscosupplementation.
Topics: Animals; Cartilage, Articular; Chitosan; Chondrogenesis; Humans; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Osteoarthritis; Synovial Membrane; Tissue Engineering; Viscosupplementation | 2017 |
An overview of hydrogel-based intra-articular drug delivery for the treatment of osteoarthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chitosan; Chondroitin Sulfates; Drug Delivery Systems; Humans; Hyaluronic Acid; Hydrogels; Injections, Intra-Articular; Microspheres; Nanoparticles; Nanotechnology; Osteoarthritis; Steroids; Tissue Engineering | 2017 |
43 other study(ies) available for chitosan and Osteoarthritis
| Article | Year |
|---|---|
Chitosan oligosaccharides packaged into rat adipose mesenchymal stem cells-derived extracellular vesicles facilitating cartilage injury repair and alleviating osteoarthritis.
Topics: Animals; Cartilage; Cells, Cultured; Chitosan; Chondrocytes; Extracellular Vesicles; Female; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Oligosaccharides; Osteoarthritis; Rats; Rats, Wistar; Specific Pathogen-Free Organisms; Transcriptome; Wound Healing | 2021 |
Low deacetylation degree chitosan oligosaccharide protects against IL-1β induced inflammation and enhances autophagy activity in human chondrocytes.
Topics: Anti-Inflammatory Agents; Autophagy; Chitosan; Chondrocytes; Humans; Inflammation; Interleukin-1beta; Matrix Metalloproteinase 13; Oligosaccharides; Osteoarthritis; Quality of Life | 2022 |
Intra-articular injection of loaded sPL sustained-release microspheres inhibits osteoarthritis and promotes cartilaginous repairs.
Topics: Aggrecans; Animals; Biological Factors; Cartilage, Articular; Chitosan; Chondrocytes; Collagen Type II; Delayed-Action Preparations; Gelatin; Hydrogels; Injections, Intra-Articular; Microspheres; Necrosis; Osteoarthritis; Proteoglycans; Quality of Life; Rats | 2021 |
Carboxymethyl chitosan-assisted MnO
Topics: Animals; Cartilage; Chitosan; Chondrogenesis; Nanoparticles; Osteoarthritis; Rats | 2022 |
Chondroitin sulfate modified chitosan nanoparticles as an efficient and targeted gene delivery vehicle to chondrocytes.
Topics: Chitosan; Chondrocytes; Chondroitin Sulfates; Drug Carriers; Genetic Therapy; Humans; Matrix Metalloproteinase 13; Nanoparticles; Osteoarthritis; Particle Size | 2022 |
Design and development of keratin/chitosan/glucosamine sulfate composite loaded MWCNT intended for osteoarthritis drug delivery.
Topics: Chitosan; Glucosamine; Humans; Keratins; Molecular Docking Simulation; Nanotubes, Carbon; Osteoarthritis | 2023 |
Grafting of sinapic acid onto glucosamine nanoparticle as a potential therapeutic drug with enhanced anti-inflammatory activities in osteoarthritis treatment.
Topics: Anti-Inflammatory Agents; Chitosan; Escherichia coli; Glucosamine; Humans; Nanoparticles; Osteoarthritis; Staphylococcus aureus | 2023 |
Design, construction, and biological testing of an implantable porous trilayer scaffold for repairing osteoarthritic cartilage.
Topics: Animals; Cartilage, Articular; Cell Survival; Chitosan; Chondrocytes; Humans; Hydroxyapatites; Male; Mice; Mice, Inbred C57BL; Microscopy, Confocal; Microscopy, Electron, Scanning; Osteoarthritis; Polymers; Porosity; Prostheses and Implants; Prosthesis Design; Rheology; Tissue Engineering; Tissue Scaffolds; X-Ray Microtomography | 2020 |
Targeting downstream subcellular YAP activity as a function of matrix stiffness with Verteporfin-encapsulated chitosan microsphere attenuates osteoarthritis.
Topics: Animals; Cartilage, Articular; Chitosan; Chondrocytes; Mice; Microspheres; Osteoarthritis; Verteporfin | 2020 |
Etoricoxib-loaded bio-adhesive hybridized polylactic acid-based nanoparticles as an intra-articular injection for the treatment of osteoarthritis.
Topics: Adhesives; Alkaline Phosphatase; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Cell Line; Cell Survival; Chitosan; Drug Liberation; Etoricoxib; Humans; Injections, Intra-Articular; Nanoparticles; Osteoarthritis; Polyesters; Polysorbates | 2020 |
Anti-Inflammatory Performance of Lactose-Modified Chitosan and Hyaluronic Acid Mixtures in an In Vitro Macrophage-Mediated Inflammation Osteoarthritis Model.
Topics: Anti-Inflammatory Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell Survival; Chitosan; Chondrocytes; Culture Media, Conditioned; Down-Regulation; Gene Expression Regulation; Humans; Hyaluronic Acid; Inflammation; Inflammation Mediators; Interleukin-1beta; Lactose; Macrophages; Matrix Metalloproteinases; Models, Biological; Monocytes; Osteoarthritis; Reactive Oxygen Species; U937 Cells | 2020 |
A hydrogel system based on a lactose-modified chitosan for viscosupplementation in osteoarthritis.
Topics: Animals; Cells, Cultured; Chitosan; Cytokines; Humans; Hydrogels; Interleukin-10; Lactose; Macrophages; Osteoarthritis; Swine; Tumor Necrosis Factor-alpha; U937 Cells; Viscosupplementation; Viscosupplements | 2020 |
Development, optimisation, and evaluation of nanoencapsulated diacerein emulgel for potential use in osteoarthritis.
Topics: Administration, Oral; Animals; Anthraquinones; Anti-Inflammatory Agents; Biomimetics; Chitosan; Drug Delivery Systems; Drug Design; Gels; In Vitro Techniques; Male; Nanoparticles; Osteoarthritis; Particle Size; Polymers; Rats; Rats, Sprague-Dawley; Skin; Spectroscopy, Fourier Transform Infrared; Viscosity | 2020 |
Targeted elimination of intracellular reactive oxygen species using nanoparticle-like chitosan- superoxide dismutase conjugate for treatment of monoiodoacetate-induced osteoarthritis.
Topics: Animals; Chitosan; Nanoparticles; Osteoarthritis; Rats; Reactive Oxygen Species; Superoxide Dismutase | 2020 |
Comparison of Autologous Platelet-Rich Plasma and Chitosan in the Treatment of Temporomandibular Joint Osteoarthritis: A Retrospective Cohort Study.
Topics: China; Chitosan; Humans; Osteoarthritis; Platelet-Rich Plasma; Retrospective Studies; Temporomandibular Joint; Treatment Outcome | 2021 |
Chitosan and Lecithin Ameliorate Osteoarthritis Symptoms Induced by Monoiodoacetate in a Rat Model.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Chitosan; Disease Models, Animal; Electron Transport Complex IV; Glutathione; Interleukin-6; Iodoacetic Acid; Lecithins; Male; Matrix Metalloproteinases; Osteoarthritis; Rats; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2020 |
Intra-articular injection of anti-inflammatory peptide-loaded glycol chitosan/fucoidan nanogels to inhibit inflammation and attenuate osteoarthritis progression.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Chitosan; Chondrocytes; Collagen Type II; Cytokines; Disease Models, Animal; Inflammation; Injections, Intra-Articular; Interleukin-1beta; Interleukin-6; Male; Nanogels; Osteoarthritis; Polysaccharides; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2021 |
Intra-articular Injection of Chitosan-Based Supramolecular Hydrogel for Osteoarthritis Treatment.
Topics: Animals; Chitosan; Hyaluronic Acid; Hydrogels; Injections, Intra-Articular; Osteoarthritis; Rats | 2021 |
Chondrogenesis of human amniotic fluid stem cells in Chitosan-Xanthan scaffold for cartilage tissue engineering.
Topics: Adult Stem Cells; Amniotic Fluid; Cartilage, Articular; Cell Culture Techniques; Cell Differentiation; Chitosan; Chondrogenesis; Gene Expression Regulation, Developmental; Humans; Insulin-Like Growth Factor I; Microscopy, Electron, Scanning; Osteoarthritis; Polysaccharides, Bacterial; Proto-Oncogene Proteins c-kit; Tissue Engineering; Tissue Scaffolds | 2021 |
Synthesis of carboxymethyl chitosan-strontium complex and its therapeutic effects on relieving osteoarthritis.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chitosan; Chondrocytes; Humans; Male; Osteoarthritis; Polymers; Primary Cell Culture; Rats; Strontium | 2021 |
The amelioration of cartilage degeneration by photo-crosslinked GelHA hydrogel and crizotinib encapsulated chitosan microspheres.
Topics: Animals; Biomarkers; Cartilage; Chitosan; Chondrocytes; Crizotinib; Disease Models, Animal; Drug Carriers; Drug Liberation; Gene Expression; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Interleukin-1beta; Mice; Microspheres; Neovascularization, Pathologic; Osteoarthritis; Protein Kinase Inhibitors; Pyrazoles; Pyridines; Vascular Endothelial Growth Factor A | 2017 |
Sustained release effects of berberine-loaded chitosan microspheres on in vitro chondrocyte culture.
Topics: Animals; Apoptosis; Berberine; Caspase 3; Chitosan; Chondrocytes; Delayed-Action Preparations; Half-Life; Microscopy, Electron, Scanning; Microspheres; Osteoarthritis; Rats; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction | 2017 |
The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model.
Topics: Animals; Cartilage, Articular; Chitosan; Disease Models, Animal; Gene Expression Regulation; Male; Oligosaccharides; Osteoarthritis; Osteoprotegerin; RANK Ligand; Rats; Rats, Sprague-Dawley | 2017 |
Anti-inflammatory effects in a mouse osteoarthritis model of a mixture of glucosamine and chitooligosaccharides produced by bi-enzyme single-step hydrolysis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Chitin; Chitosan; Disease Models, Animal; Glucosamine; Glycoside Hydrolases; Hexosaminidases; Hydrolysis; Male; Mice; Mice, Inbred C57BL; Oligosaccharides; Osteoarthritis | 2018 |
Hyaluronic acid-chitosan nanoparticles encoding CrmA attenuate interleukin-1β induced inflammation in synoviocytes in vitro.
Topics: Animals; Cell Survival; Chitosan; Chondrocytes; Gene Expression; Hyaluronic Acid; Interleukin-1beta; Male; Matrix Metalloproteinases; Nanoparticles; Osteoarthritis; Rats; Serpins; Synoviocytes; Transfection; Viral Proteins | 2019 |
In vitro neo-cartilage formation on a three-dimensional composite polymeric cryogel matrix.
Topics: Cartilage; Chitosan; Chondrocytes; Cryogels; Extracellular Matrix; Gelatin; Humans; Joints; Osteoarthritis; Polymers; Sepharose; Tissue Engineering; Tissue Scaffolds | 2013 |
Protective effect of a new biomaterial against the development of experimental osteoarthritis lesions in rabbit: a pilot study evaluating the intra-articular injection of alginate-chitosan beads dispersed in an hydrogel.
Topics: Alginates; Animals; Arthritis, Experimental; Biomarkers; C-Reactive Protein; Cartilage, Articular; Chitosan; Dinoprostone; Drug Evaluation, Preclinical; Glucuronic Acid; Hexuronic Acids; Hydrogel, Polyethylene Glycol Dimethacrylate; Inflammation Mediators; Injections, Intra-Articular; Microspheres; Osteoarthritis; Pilot Projects; Rabbits; Radiography; Synovial Membrane; Viscosupplementation; Viscosupplements | 2013 |
Chitosan-graft-polyethylenimine/DNA nanoparticles as novel non-viral gene delivery vectors targeting osteoarthritis.
Topics: Animals; Biological Transport; Cell Survival; Chitosan; Chondrocytes; DNA; Gene Expression; Genes, Reporter; Intracellular Space; Nanoparticles; Osteoarthritis; Polyethyleneimine; Rabbits; Synovial Membrane; Transfection | 2014 |
The effect of oral administration of iron saturated-bovine lactoferrin encapsulated chitosan-nanocarriers on osteoarthritis.
Topics: Administration, Oral; Alginates; Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Cattle; Chitosan; Drug Carriers; Gene Expression Regulation; Glucuronic Acid; Hexuronic Acids; Interleukin-1beta; Iron; Joints; Lactoferrin; Male; Mice; MicroRNAs; Nanostructures; Osteoarthritis; Oxidative Stress | 2014 |
Intra-articular delivery of kartogenin-conjugated chitosan nano/microparticles for cartilage regeneration.
Topics: Aged; Anilides; Animals; Cartilage; Cell Differentiation; Cells, Cultured; Chitosan; Chondrocytes; Chondrogenesis; Humans; Injections, Intra-Articular; Mesenchymal Stem Cells; Middle Aged; Nanoparticles; Osteoarthritis; Phthalic Acids; Rats; Rats, Sprague-Dawley; Regeneration | 2014 |
Effect of the physicochemical properties of pure or chitosan-coated poly(L-lactic acid)scaffolds on the chondrogenic differentiation of mesenchymal stem cells from osteoarthritic patients.
Topics: Adsorption; Cell Differentiation; Cell Proliferation; Cell Survival; Cellular Microenvironment; Chitosan; Chondrocytes; Chondrogenesis; Coated Materials, Biocompatible; Humans; Lactic Acid; Mesenchymal Stem Cells; Osteoarthritis; Polyesters; Polymers; Tissue Scaffolds | 2015 |
A novel biocompatible hyaluronic acid-chitosan hybrid hydrogel for osteoarthrosis therapy.
Topics: Aged; Animals; Biocompatible Materials; Cell Survival; Chitosan; Dose-Response Relationship, Drug; Fibroblasts; Humans; Hyaluronic Acid; Hydrogels; Injections, Intra-Articular; Injections, Subcutaneous; Male; Molecular Weight; Osteoarthritis; Rabbits; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Viscosity | 2015 |
In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis.
Topics: Animals; Apoptosis; Berberine; Cartilage, Articular; Chitosan; Chondrocytes; Cross-Linking Reagents; Cytokines; Drug Stability; Injections, Intra-Articular; Joints; Male; Nanoparticles; Osteoarthritis; Rats; Rats, Sprague-Dawley; Synovial Fluid | 2015 |
Intra-articular delivery of sinomenium encapsulated by chitosan microspheres and photo-crosslinked GelMA hydrogel ameliorates osteoarthritis by effectively regulating autophagy.
Topics: Animals; Autophagy; Cartilage; Chitosan; Chondrocytes; Cross-Linking Reagents; Extracellular Matrix; Gelatin; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Injections, Intra-Articular; Light; Methacrylates; Mice, Inbred C57BL; Microspheres; Microtubule-Associated Proteins; Osteoarthritis; Plant Extracts; Sinomenium; Sus scrofa | 2016 |
Poly (caprolactone) microparticles and chitosan thermogels based injectable formulation of etoricoxib for the potential treatment of osteoarthritis.
Topics: Animals; Cell Line; Chitosan; Delayed-Action Preparations; Etoricoxib; Gels; Humans; Male; Mice; Osteoarthritis; Polyesters; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Sulfones | 2016 |
Thermoresponsive nanospheres with independent dual drug release profiles for the treatment of osteoarthritis.
Topics: Anilides; Cell Differentiation; Chitosan; Chondrocytes; Diclofenac; Drug Carriers; Female; Humans; Macrophages; Male; Mesenchymal Stem Cells; Middle Aged; Nanospheres; Oligosaccharides; Osteoarthritis; Phthalic Acids; Poloxamer | 2016 |
Chitosan oligosaccharide suppresses synovial inflammation via AMPK activation: An in vitro and in vivo study.
Topics: Animals; Anterior Cruciate Ligament; Cells, Cultured; Chitosan; Cyclooxygenase 2; Epithelial Cells; Humans; Inflammation; Intestinal Mucosa; Intestines; Male; Mitogen-Activated Protein Kinases; Nitric Oxide Synthase Type II; Oligosaccharides; Osteoarthritis; Rabbits; Synoviocytes; Tumor Necrosis Factor-alpha | 2016 |
Photo-crosslinked HAMA hydrogel with cordycepin encapsulated chitosan microspheres for osteoarthritis treatment.
Topics: Animals; Antineoplastic Agents; Cartilage, Articular; Cell Survival; Chitosan; Chondrocytes; Deoxyadenosines; Drug Compounding; Drug Delivery Systems; Drug Liberation; Fluorescent Antibody Technique; Humans; Hyaluronic Acid; Hydrogel, Polyethylene Glycol Dimethacrylate; Immunohistochemistry; Male; Mice; Microspheres; Osteoarthritis | 2017 |
Glucose adsorption to chitosan membranes increases proliferation of human chondrocyte via mammalian target of rapamycin complex 1 and sterol regulatory element-binding protein-1 signaling.
Topics: Adaptor Proteins, Signal Transducing; Adsorption; Aged; Antirheumatic Agents; Cell Culture Techniques; Cell Line; Cell Proliferation; Chitosan; Chondrocytes; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Fatty Acid Synthase, Type I; Female; Glucose; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Membranes, Artificial; Middle Aged; mTOR Associated Protein, LST8 Homolog; Multiprotein Complexes; Osteoarthritis; Protein Kinase Inhibitors; Regulatory-Associated Protein of mTOR; RNA Interference; Signal Transduction; Sterol Regulatory Element Binding Protein 1; Time Factors; TOR Serine-Threonine Kinases; Transfection | 2017 |
A hyaluronic acid-based hydrogel enabling CD44-mediated chondrocyte binding and gapmer oligonucleotide release for modulation of gene expression in osteoarthritis.
Topics: Aldehydes; Chitosan; Chondrocytes; Cyclooxygenase 2; Gene Expression; Gene Silencing; Humans; Hyaluronan Receptors; Hyaluronic Acid; Hydrogels; MCF-7 Cells; Oligonucleotides; Osteoarthritis | 2017 |
Novel hyaluronic acid-chitosan nanoparticles as non-viral gene delivery vectors targeting osteoarthritis.
Topics: Animals; Cell Survival; Cells, Cultured; Chitosan; Chondrocytes; Fluorescent Dyes; Genetic Therapy; Green Fluorescent Proteins; Hyaluronic Acid; Hydrogen-Ion Concentration; Microscopy, Electron, Scanning; Molecular Weight; Nanoparticles; Osteoarthritis; Particle Size; Plasmids; Rabbits; Transfection | 2011 |
Development of brucine-loaded microsphere/thermally responsive hydrogel combination system for intra-articular administration.
Topics: Analgesics; Animals; Chitosan; Hydrogels; Injections, Intra-Articular; Interleukin-1beta; Male; Microspheres; Osteoarthritis; Particle Size; Rabbits; Rats; Rats, Sprague-Dawley; Spectroscopy, Fourier Transform Infrared; Strychnine; Surface Properties; Synovial Fluid; Temperature; Tumor Necrosis Factor-alpha; X-Ray Diffraction | 2012 |
The effects of carboxymethylated chitosan on metalloproteinase-1, -3 and tissue inhibitor of metalloproteinase-1 gene expression in cartilage of experimental osteoarthritis.
Topics: Acids; Animals; Antirheumatic Agents; Cartilage, Articular; Chitosan; Disease Models, Animal; Gene Expression; Injections, Intra-Articular; Matrix Metalloproteinase 1; Matrix Metalloproteinase 3; Methylation; Molecular Weight; Osteoarthritis; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1 | 2005 |