| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth. | 2.1 | 1 | 0 | nucleobase analogue;
organofluorine compound | antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic |
carbon tetrachloride
Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups. | 2.07 | 1 | 0 | chlorocarbon;
chloromethanes | hepatotoxic agent;
refrigerant |
9,10-dimethyl-1,2-benzanthracene
9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke. | 2.03 | 1 | 0 | ortho-fused polycyclic arene;
tetraphenes | carcinogenic agent |
methylene chloride
Methylene Chloride: A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.. dichloromethane : A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea. | 2.17 | 1 | 0 | chloromethanes;
volatile organic compound | carcinogenic agent;
polar aprotic solvent;
refrigerant |
vanillic acid
Vanillic Acid: A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).. vanillic acid : A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3. | 2.1 | 1 | 0 | methoxybenzoic acid;
monohydroxybenzoic acid | plant metabolite |
protocatechualdehyde
protocatechualdehyde: found in wheat grains, wheat seedlings, & other plants; RN given refers to parent cpd; see also rancinamycins; structure | 2.1 | 1 | 0 | dihydroxybenzaldehyde | |
oleanolic acid
[no description available] | 2.03 | 1 | 0 | hydroxy monocarboxylic acid;
pentacyclic triterpenoid | plant metabolite |
malondialdehyde
Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form. | 2.07 | 1 | 0 | dialdehyde | biomarker |
silver nitrate
Silver Nitrate: A silver salt with powerful germicidal activity. It has been used topically to prevent OPHTHALMIA NEONATORUM. | 2.03 | 1 | 0 | inorganic nitrate salt;
silver salt | astringent |
tetradecanoylphorbol acetate
Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types. | 2.03 | 1 | 0 | acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester | antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator |
etoposide
[no description available] | 3.17 | 1 | 0 | beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound | antineoplastic agent;
DNA synthesis inhibitor |
eburicoic acid
eburicoic acid: structure | 3.17 | 1 | 0 | | |
10-hydroxycamptothecin
[no description available] | 3.17 | 1 | 0 | pyranoindolizinoquinoline | |
lanosterol
[no description available] | 4.34 | 17 | 0 | 14alpha-methyl steroid;
3beta-sterol;
tetracyclic triterpenoid | bacterial metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite |
ergosterol
[no description available] | 2.03 | 1 | 0 | 3beta-hydroxy-Delta(5)-steroid;
3beta-sterol;
ergostanoid;
phytosterols | fungal metabolite;
Saccharomyces cerevisiae metabolite |
oleic acid
Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry. | 8.14 | 1 | 0 | octadec-9-enoic acid | antioxidant;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite;
solvent |
ganoderic acid a
[no description available] | 3.17 | 1 | 0 | triterpenoid | |
ganoderiol f
ganoderiol F: a ganoderma triterpene from Ganoderma amboinense; structure in first source | 3.17 | 1 | 0 | triterpenoid | |
Ganodermanontriol
[no description available] | 3.17 | 1 | 0 | triterpenoid | metabolite |
ovalbumin
Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily. | 2.96 | 3 | 0 | | |
ergosta-7,22-dien-3-ol, (3beta,5alpha,6alpha,22e)-isomer
5alpha-ergosta-7,22-dien-3beta-ol : A 3beta-sterol consisting of an ergostane skeleton with double bonds at 7- and 22-positions. | 2.1 | 1 | 0 | 3beta-sterol | anti-HSV-1 agent;
antifungal agent;
EC 3.2.1.18 (exo-alpha-sialidase) inhibitor;
metabolite |
poricoic acid g
poricoic acid G: from Poria cocos (Polyporaceae); structure in first source. poricoic acid G : A tricyclic triterpenoid isolated from Poria cocos. | 3.17 | 1 | 0 | dicarboxylic acid;
secondary alcohol;
tricyclic triterpenoid | fungal metabolite |
polyporenic acid c
[no description available] | 3.17 | 1 | 0 | | |
bicyclol
bicyclol: an antihepatitis drug, on the metabolism and hepatotoxicity of aflatoxin B1 (AFB1) in rats. | 2.1 | 1 | 0 | | |
trametenolic acid b
trametenolic acid B: from Trametes lactinea; structure in first source | 4.1 | 4 | 0 | triterpenoid | |
ganodermadiol
ganodermadiol: isolated from Ganoderma lucidum; structure given in first source. ganoderol B : A tetracyclic triterpenoid that is lanosta-7,9(11),24-triene which is substituted by hydroxy groups at positions 3 and 27. It has been isolated from several Ganoderma species. | 3.17 | 1 | 0 | 3beta-sterol;
primary allylic alcohol;
tetracyclic triterpenoid | antiviral agent;
fungal metabolite;
hepatoprotective agent |
lucidenic acid a
lucidenic acid A: isolated from fruiting bodies of Ganoderma lucidum; structure in first source | 3.17 | 1 | 0 | triterpenoid | |
ganoderic acid t
ganoderic acid T: down-regulates expression of both MMP-2 and MMP-9; isolated from Ganoderma lucidum; structure in first source | 3.17 | 1 | 0 | | |
ganoderic acid f
ganoderic acid F: isolated from Ganoderma lucidum; structure in first source | 3.17 | 1 | 0 | triterpenoid | |
3,7-dioxolanosta-8,24-dien-26-oic acid
[no description available] | 3.17 | 1 | 0 | | |
ganoderic acid c2
ganoderic acid C2: from the fruiting body of Ganoderma; structure in first source | 3.17 | 1 | 0 | triterpenoid | |
ganoderic acid y
ganoderic acid Y: has antiviral activity; isolated from Ganoderma lucidum; structure in first source | 3.17 | 1 | 0 | triterpenoid | |
7-oxo-ganoderic acid z
7-oxo-ganoderic acid Z: from the mushroom Ganoderma lucidum; structure in first source | 3.17 | 1 | 0 | | |