Page last updated: 2024-11-13

inotodiol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

inotodiol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	44422314
CHEMBL ID	449088
SCHEMBL ID	24065966
MeSH ID	M0506650

Synonyms (11)

Synonym
inotodiol
CHEMBL449088
Q15634152
MS-27970
DTXSID10957379
(22r)-5alpha-lanosta-8,24-diene-3beta,22-diol
HY-120149
CS-0077023
SCHEMBL24065966
E83702
AKOS040744638

Research Excerpts

Overview

Inotodiol is a lanostane triterpenoid isolated from Inonotus obliquus. It had been extensively reported to be an anti-inflammatory agent. Its effect on arthritis remains unknown.

Excerpt	Reference	Relevance
"Inotodiol is a lanostane triterpenoid that demonstrates antiviral, anticancer, and anti-inflammatory activities."	( Antiaging effect of inotodiol on oxidative stress in human dermal fibroblasts. Choi, SH; Kim, MY; Lee, SH; Oh, CH; Park, JI; Park, JT; Won, GW, 2022)	1.77
"Inotodiol is a lanostane triterpenoid isolated from Inonotus obliquus, which had been extensively reported to be an anti-inflammatory agent, but its effect on arthritis remains unknown."	( Inotodiol ameliorates the progression of osteoarthritis: An in vitro and in vivo study. Hu, W; Ji, R; Li, X; Pan, H; Qian, W; Ye, Q; Zhou, L, 2023)	3.07
"Inotodiol is a lanostane triterpenoid found only in Chaga mushroom. "	( Anti-allergic effect of inotodiol, a lanostane triterpenoid from Chaga mushroom, via selective inhibition of mast cell function. Hwang, I; Kim, YH; Le, BV; Le, HS; Nguyen, TMN, 2020)	2.31
"Inotodiol is a lanostane triterpenoid found in natural resources like edible mushroom Inonotus obliquus."	( Inotodiol suppresses proliferation of breast cancer in rat model of type 2 diabetes mellitus via downregulation of β-catenin signaling. Bao, C; Zhang, J; Zhang, X, 2018)	2.64

Effects

Excerpt	Reference	Relevance
"Inotodiol has been proven to have antitumor, antiviral, anti-inflammatory, and antiallergic properties. "	( Inotodiol suppresses allergic inflammation in allergic rhinitis mice. Choi, MR; Chung, EH; Chung, J; Kang, JY; Kim, YM; Park, JT; Park, SK, 2023)	3.8

Actions

Excerpt	Reference	Relevance
"Inotodiol can inhibit proliferation and induce the apoptosis of A549 cells, and its molecular mechanism may be associated with the up-regulating expression of p53 and bax proteins and down-regulating expression of Bcl-2 protein, which arrested A549 cells in S phase."	( Effects of inotodiol extracts from inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549. Sun, DZ; Wang, LB; Zhong, XH, 2011)	2.2

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay ID	Title	Year	Journal	Article
AID284049	Cell viability in Raji cells at 1000 mol ratio/TPA relative to control	2007	Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1	Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.
AID284048	Inhibition of TPA-induced EBV-EA activation in Raji cells at 10 mol ratio/TPA relative to control	2007	Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1	Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.
AID711411	Cytotoxicity against human COLO205 cells	2012	Journal of natural products, Nov-26, Volume: 75, Issue:11	Lanostanoids from fungi: a group of potential anticancer compounds.
AID711412	Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as increase in survival rate at 10 mg/kg	2012	Journal of natural products, Nov-26, Volume: 75, Issue:11	Lanostanoids from fungi: a group of potential anticancer compounds.
AID711414	Antitumor activity against mouse P388 cells allografted in CDF1 mouse assessed as increase in survival rate at 3 mg/kg	2012	Journal of natural products, Nov-26, Volume: 75, Issue:11	Lanostanoids from fungi: a group of potential anticancer compounds.
AID711416	Cytotoxicity against human HL60 cells	2012	Journal of natural products, Nov-26, Volume: 75, Issue:11	Lanostanoids from fungi: a group of potential anticancer compounds.
AID284045	Suppression of DMBA/TPA-induced papilloma-formation in ICR mouse within 10 week	2007	Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1	Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.
AID284044	Inhibition of TPA-induced EBV-EA activation in Raji cells at 500 mol ratio/TPA relative to control	2007	Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1	Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.
AID1063365	Hepatoprotective activity against D-galactosamine-induced toxicity in rat WB-F344 cells assessed as cell survival at 10 uM preincubated for 1 hr followed by D-galactosamine challenge measured after 24 hrs by MTT assay relative to normal cell	2014	Journal of natural products, Jan-24, Volume: 77, Issue:1	Chemical constituents from Inonotus obliquus and their biological activities.
AID284047	Inhibition of TPA-induced EBV-EA activation in Raji cells at 100 mol ratio/TPA relative to control	2007	Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1	Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.
AID284050	Toxicity in ICR mouse with DMBA/TPA-induced papilloma	2007	Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1	Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.
AID284043	Inhibition of TPA-induced EBV-EA activation in Raji cells at 1000 mol ratio/TPA relative to control	2007	Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1	Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus.
AID711410	Cytotoxicity against mouse L1210 cells	2012	Journal of natural products, Nov-26, Volume: 75, Issue:11	Lanostanoids from fungi: a group of potential anticancer compounds.
AID1063364	Hepatoprotective activity in rat WB-F344 cells assessed as inhibition of D-galactosamine-induced toxicity at 10 uM preincubated for 1 hr followed by D-galactosamine challenge measured after 24 hrs by MTT assay relative to control	2014	Journal of natural products, Jan-24, Volume: 77, Issue:1	Chemical constituents from Inonotus obliquus and their biological activities.
AID711413	Antiproliferative activity against mouse P388 cells	2012	Journal of natural products, Nov-26, Volume: 75, Issue:11	Lanostanoids from fungi: a group of potential anticancer compounds.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (21)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	2 (9.52)	29.6817
2010's	10 (47.62)	24.3611
2020's	9 (42.86)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 25.31

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	25.31 (24.57)
Research Supply Index	3.18 (2.92)
Research Growth Index	5.38 (4.65)
Search Engine Demand Index	39.34 (26.88)
Search Engine Supply Index	3.00 (0.95)

This Compound (25.31)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (4.35%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	22 (95.65%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.1	1	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
carbon tetrachloride Carbon Tetrachloride: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed). tetrachloromethane : A chlorocarbon that is methane in which all the hydrogens have been replaced by chloro groups.	2.07	1	chlorocarbon; chloromethanes	hepatotoxic agent; refrigerant
9,10-dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.	2.03	1	ortho-fused polycyclic arene; tetraphenes	carcinogenic agent
methylene chloride Methylene Chloride: A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.. dichloromethane : A member of the class of chloromethanes that is methane in which two of the hydrogens have been replaced by chlorine. A dense, non-flammible colourless liquid at room temperature (b.p. 40degreeC, d = 1.33) which is immiscible with water, it is widely used as a solvent, a paint stripper, and for the removal of caffeine from coffee and tea.	2.17	1	chloromethanes; volatile organic compound	carcinogenic agent; polar aprotic solvent; refrigerant
vanillic acid Vanillic Acid: A flavoring agent. It is the intermediate product in the two-step bioconversion of ferulic acid to vanillin. (J Biotechnol 1996;50(2-3):107-13).. vanillic acid : A monohydroxybenzoic acid that is 4-hydroxybenzoic acid substituted by a methoxy group at position 3.	2.1	1	methoxybenzoic acid; monohydroxybenzoic acid	plant metabolite
protocatechualdehyde protocatechualdehyde: found in wheat grains, wheat seedlings, & other plants; RN given refers to parent cpd; see also rancinamycins; structure	2.1	1	dihydroxybenzaldehyde
oleanolic acid [no description available]	2.03	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.07	1	dialdehyde	biomarker
silver nitrate Silver Nitrate: A silver salt with powerful germicidal activity. It has been used topically to prevent OPHTHALMIA NEONATORUM.	2.03	1	inorganic nitrate salt; silver salt	astringent
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.03	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
etoposide [no description available]	3.17	1	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor
eburicoic acid eburicoic acid: structure	3.17	1
10-hydroxycamptothecin [no description available]	3.17	1	pyranoindolizinoquinoline
lanosterol [no description available]	4.34	17	14alpha-methyl steroid; 3beta-sterol; tetracyclic triterpenoid	bacterial metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
ergosterol [no description available]	2.03	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; ergostanoid; phytosterols	fungal metabolite; Saccharomyces cerevisiae metabolite
oleic acid Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed). oleic acid : An octadec-9-enoic acid in which the double bond at C-9 has Z (cis) stereochemistry.	8.14	1	octadec-9-enoic acid	antioxidant; Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; Escherichia coli metabolite; mouse metabolite; plant metabolite; solvent
ganoderic acid a [no description available]	3.17	1	triterpenoid
ganoderiol f ganoderiol F: a ganoderma triterpene from Ganoderma amboinense; structure in first source	3.17	1	triterpenoid
Ganodermanontriol [no description available]	3.17	1	triterpenoid	metabolite
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.96	3
ergosta-7,22-dien-3-ol, (3beta,5alpha,6alpha,22e)-isomer 5alpha-ergosta-7,22-dien-3beta-ol : A 3beta-sterol consisting of an ergostane skeleton with double bonds at 7- and 22-positions.	2.1	1	3beta-sterol	anti-HSV-1 agent; antifungal agent; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor; metabolite
poricoic acid g poricoic acid G: from Poria cocos (Polyporaceae); structure in first source. poricoic acid G : A tricyclic triterpenoid isolated from Poria cocos.	3.17	1	dicarboxylic acid; secondary alcohol; tricyclic triterpenoid	fungal metabolite
polyporenic acid c [no description available]	3.17	1
bicyclol bicyclol: an antihepatitis drug, on the metabolism and hepatotoxicity of aflatoxin B1 (AFB1) in rats.	2.1	1
trametenolic acid b trametenolic acid B: from Trametes lactinea; structure in first source	4.1	4	triterpenoid
ganodermadiol ganodermadiol: isolated from Ganoderma lucidum; structure given in first source. ganoderol B : A tetracyclic triterpenoid that is lanosta-7,9(11),24-triene which is substituted by hydroxy groups at positions 3 and 27. It has been isolated from several Ganoderma species.	3.17	1	3beta-sterol; primary allylic alcohol; tetracyclic triterpenoid	antiviral agent; fungal metabolite; hepatoprotective agent
lucidenic acid a lucidenic acid A: isolated from fruiting bodies of Ganoderma lucidum; structure in first source	3.17	1	triterpenoid
ganoderic acid t ganoderic acid T: down-regulates expression of both MMP-2 and MMP-9; isolated from Ganoderma lucidum; structure in first source	3.17	1
ganoderic acid f ganoderic acid F: isolated from Ganoderma lucidum; structure in first source	3.17	1	triterpenoid
3,7-dioxolanosta-8,24-dien-26-oic acid [no description available]	3.17	1
ganoderic acid c2 ganoderic acid C2: from the fruiting body of Ganoderma; structure in first source	3.17	1	triterpenoid
ganoderic acid y ganoderic acid Y: has antiviral activity; isolated from Ganoderma lucidum; structure in first source	3.17	1	triterpenoid
7-oxo-ganoderic acid z 7-oxo-ganoderic acid Z: from the mushroom Ganoderma lucidum; structure in first source	3.17	1

Condition	Relationship Strength	Studies
Adenocarcinoma, Basal Cell [description not available]	2.45	2
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	7.45	2
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	3.54	6
Allergic Rhinitis [description not available]	7.6	1
Innate Inflammatory Response [description not available]	3.01	2
Sneezing The sudden, forceful, involuntary expulsion of air from the NOSE and MOUTH caused by irritation to the MUCOUS MEMBRANES of the upper RESPIRATORY TRACT.	2.6	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	8.01	2
Rhinitis, Allergic An inflammation of the NASAL MUCOSA triggered by ALLERGENS.	2.6	1
Asthma, Bronchial [description not available]	2.6	1
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	7.6	1
Arthritis, Degenerative [description not available]	2.6	1
Osteoarthritis A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	7.6	1
Allergy, Food [description not available]	2.61	2
Food Hypersensitivity Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.	2.61	2
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.17	1
Alloxan Diabetes [description not available]	2.17	1
Animal Mammary Carcinoma [description not available]	2.17	1
Cancer of Cervix [description not available]	2.54	2
Invasiveness, Neoplasm [description not available]	2.21	1
Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX.	2.54	2
Lung Adenocarcinoma [description not available]	7.06	1
Cancer of Lung [description not available]	2.06	1
Adenocarcinoma of Lung A carcinoma originating in the lung and the most common lung cancer type in never-smokers. Malignant cells exhibit distinct features such as glandular epithelial, or tubular morphology. Mutations in KRAS, EGFR, BRAF, and ERBB2 genes are associated with this cancer.	2.06	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.06	1

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