glycine has been researched along with Osteoarthritis in 17 studies
Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A multicentered study was carried out, under double-blind conditions, on 160 elderly patients afflicted with differently localized symptomatic osteoarthritis, for the purpose of evaluating the therapeutical efficacy and tolerability of ST-679 (per-os at a dose of 1200 mg pro die in 80 patients) and to compare them with those of tolmetin (per os at a dose of 1200 mg pro die in 80 patients)." | 9.07 | [An evaluation of the therapeutic activity and tolerance of ST-679 in patients with osteoarthritis at different sites. A controlled double-blind study vs tolmetin]. ( Ciarimboli, M; Donati, G; Garzya, G; Imparato, L; Lingetti, M; Nolfe, G; Porfido, FA; Saraceni, G; Sorrentino, GP, 1993) |
| "A multicentered study was carried out, under double-blind conditions, on 160 elderly patients afflicted with differently localized symptomatic osteoarthritis, for the purpose of evaluating the therapeutical efficacy and tolerability of ST-679 (per-os at a dose of 1200 mg pro die in 80 patients) and to compare them with those of tolmetin (per os at a dose of 1200 mg pro die in 80 patients)." | 5.07 | [An evaluation of the therapeutic activity and tolerance of ST-679 in patients with osteoarthritis at different sites. A controlled double-blind study vs tolmetin]. ( Ciarimboli, M; Donati, G; Garzya, G; Imparato, L; Lingetti, M; Nolfe, G; Porfido, FA; Saraceni, G; Sorrentino, GP, 1993) |
| " All patients were asked to keep a daily diary to evaluate gastric tolerability, whereas overall tolerability was evaluated by recording adverse effects and determining the common laboratory parameters." | 2.70 | [Efficacy and safety of amtolmetin guacyl in the treatment of acute osteoarthritis]. ( Biasi, G; Marcolongo, R, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (58.82) | 18.7374 |
| 1990's | 2 (11.76) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 2 (11.76) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| de Paz-Lugo, P | 2 |
| Lupiáñez, JA | 2 |
| Sicilia, J | 1 |
| Meléndez-Hevia, E | 2 |
| Muley, MM | 1 |
| Krustev, E | 1 |
| Reid, AR | 1 |
| McDougall, JJ | 1 |
| Salter, DM | 1 |
| Wright, MO | 1 |
| Millward-Sadler, SJ | 1 |
| Mankin, HJ | 3 |
| Laing, PG | 1 |
| Moskowitz, RW | 2 |
| Goldberg, VM | 1 |
| Malemud, CJ | 1 |
| Mitrovic, D | 1 |
| Gruson, M | 1 |
| Demignon, J | 1 |
| Mercier, P | 1 |
| Aprile, F | 1 |
| De Seze, S | 1 |
| Lingetti, M | 1 |
| Ciarimboli, M | 1 |
| Porfido, FA | 1 |
| Imparato, L | 1 |
| Sorrentino, GP | 1 |
| Garzya, G | 1 |
| Saraceni, G | 1 |
| Donati, G | 1 |
| Nolfe, G | 1 |
| Tavella, A | 1 |
| Ursini, G | 1 |
| Biasi, G | 1 |
| Marcolongo, R | 1 |
| Raivio, KO | 1 |
| Becker, 7A | 1 |
| Meyer, LJ | 1 |
| Greene, ML | 1 |
| Nuki, G | 1 |
| Seegmiller, JE | 1 |
| Gold, EW | 1 |
| Anderson, LB | 1 |
| Miller, CW | 1 |
| Schwartz, ER | 1 |
| Ehrlich, MG | 1 |
| Jones, H | 1 |
| Grossman, A | 1 |
| Crispen, C | 1 |
| Ancona, D | 1 |
| Cashin, CH | 1 |
| Lippiello, L | 1 |
| Mayor, MB | 1 |
| Bottici, R | 1 |
| Ferrucci, A | 1 |
| Taddeucci, E | 1 |
4 trials available for glycine and Osteoarthritis
| Article | Year |
|---|---|
[An evaluation of the therapeutic activity and tolerance of ST-679 in patients with osteoarthritis at different sites. A controlled double-blind study vs tolmetin].
Topics: Administration, Oral; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Interaction | 1993 |
[A clinical study on the anti-inflammatory activity and gastrointestinal tolerability of amtolmetin guacyl, a new NSAID, compared with diclofenac in aged patients with osteoarticular diseases].
Topics: Administration, Oral; Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Data Interpretatio | 1997 |
[Efficacy and safety of amtolmetin guacyl in the treatment of acute osteoarthritis].
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Female; Foll | 2001 |
[First results of the clinical use of injectable lysine acetylsalicylate].
Topics: Adult; Aged; Analgesics; Arthritis, Rheumatoid; Aspirin; Clinical Trials as Topic; Drug Combinations | 1972 |
13 other studies available for glycine and Osteoarthritis
| Article | Year |
|---|---|
Control analysis of collagen synthesis by glycine, proline and lysine in bovine chondrocytes in vitro - Its relevance for medicine and nutrition.
Topics: Animals; Cattle; Chondrocytes; Glycine; Lysine; Osteoarthritis; Procollagen; Proline | 2023 |
Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice.
Topics: Animals; Chronic Pain; Glycine; Leukocyte Elastase; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; | 2017 |
High glycine concentration increases collagen synthesis by articular chondrocytes in vitro: acute glycine deficiency could be an important cause of osteoarthritis.
Topics: Animals; Cartilage, Articular; Cattle; Cell Culture Techniques; Cell Proliferation; Cell Survival; C | 2018 |
NMDA receptor expression and roles in human articular chondrocyte mechanotransduction.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Cartilage, Articular; Cells, Cultured; Chondrocytes; Dizocilpi | 2004 |
Protein and ribonucleic acid synthesis in articular cartilage of osteoarthritic dogs.
Topics: Animals; Cartilage, Articular; DNA; Dog Diseases; Dogs; Glycine; Nucleosides; Osteoarthritis; Protei | 1967 |
Metabolic responses of cartilage in experimentally induced osteoarthritis.
Topics: Animals; Cartilage, Articular; DNA; Female; Glycine; Hindlimb; Osteoarthritis; Proteins; Rabbits; Su | 1981 |
Metabolism of human femoral head cartilage in osteoarthrosis and subcapital fracture.
Topics: Aged; Cartilage, Articular; Cell Count; Female; Femoral Fractures; Femur Head; Glycine; Humans; Male | 1981 |
Stimulation of human purine synthesis de novo by fructose infusion.
Topics: Adolescent; Adult; Creatinine; Erythrocytes; Fructose; Glycine; Gout; Humans; Male; Middle Aged; Ost | 1975 |
Effect of salicylate on the surgical inducement of joint degeneration in rabbit knees.
Topics: Animals; Cartilage, Articular; Glycine; Joint Diseases; Knee Joint; Lysosomes; Osteoarthritis; Rabbi | 1976 |
Biochemical confirmation of an experimental osteoarthritis model.
Topics: Acid Phosphatase; Animals; Cartilage, Articular; Disease Models, Animal; Femur; Glycine; Glycosamino | 1975 |
The induction of an erosive arthropathy in the guinea pig with copper II bisglycinate and its treatment with antirheumatic drugs.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Rheumatoid; Disease Models, Animal; Glycine | 1987 |
Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips.
Topics: Adult; Aged; Cartilage, Articular; DNA; Female; Femoral Neck Fractures; Femur Head; Glycine; Glycosa | 1970 |
Metabolic studies in experimentally-induced degenerative joint disease in the rabbit.
Topics: Animals; Autoradiography; Cartilage, Articular; Cell Division; Disease Models, Animal; Femur; Glycin | 1974 |