girard's reagent t profile

Girard's reagent T is a reagent used in organic chemistry for the selective isolation and purification of carbonyl compounds, such as aldehydes and ketones. It is a hydrazide derivative of trimethylammonium chloride, with the chemical formula [(CH3)3NCH2C(=NH)NH2]Cl. The reagent was developed by Albert Girard and Jean-Claude Tcherniac in 1936. Girard's reagent T reacts with carbonyl compounds to form water-soluble derivatives known as Girard's T hydrazones, which can be easily separated from other non-carbonyl components by extraction with water. This technique is particularly useful for the separation of carbonyl compounds from mixtures containing other functional groups, such as alcohols, esters, or acids. The reaction of Girard's reagent T with carbonyl compounds is reversible, and the original carbonyl compound can be regenerated by treatment with dilute acid. The reaction is specific for carbonyl compounds, making Girard's reagent T a valuable tool in organic synthesis and analysis. '

Girard's reagent T: used for separating ketosteroids; RN given refers to chloride [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	67156
SCHEMBL ID	297019
MeSH ID	M0059289

Synonym
AKOS009031103
ethanaminium, 2-hydrazino-n,n,n-trimethyl-2-oxo-
einecs 204-629-3
nsc 9242
ai3-61529
(hydrazinocarbonylmethyl)trimethylammonium chloride
ammonium, (carboxymethyl)trimethyl-, chloride, hydrazide
ethanaminium, 2-hydrazino-n,n,n-trimethyl-2-oxo-, chloride
.beta.ine hydrazide hydrochloride
(carboxymethyl)trimethylammonium chloride hydrazide
girard's reagent t
girard reagent t
betaine hydrazide hydrochloride
wln: zmv1k1 & 1 & 1 & g
nsc-9242
trimethylacethydrazide ammonium chloride
ammonium, chloride, hydrazide
carbazoylmethyltrimethylammonium chloride
carbazoylmethyltrimetylammonium chloride
123-46-6
girards reagent t
girard t reagent
nsc9242
trimethylaminoacetohydrazide chloride
trimethylammonium acetyl hydrazide chloride
ethanaminium,n,n-trimethyl-2-oxo-, chloride
trimethylammonium chloride acethydrazide
(carboxymethyl)trimethylammonium chloride, hydrazide
(2-hydrazino-2-oxo-ethyl)-trimethyl-ammonium
B0457
trimethylacetohydrazideammonium chloride
trimethylacetylhydrazide ammonium chloride
ethanaminium, 2-hydrazinyl-n,n,n-trimethyl-2-oxo-, chloride (1:1)
unii-oo3mf0us46
oo3mf0us46 ,
FT-0626708
[(hydrazinecarbonyl)methyl]trimethylazanium chloride
SCHEMBL297019
girard-t reagent
reagents, girard's t
betaine hydrazide chloride
girard reagent t [mi]
(carbazoylmethyl)trimethylammonium chloride
(2-hydrazino-2-oxoethyl)trimethylammonium chloride
trimethylammonium chloride acetylhydrazid
girard's t reagent
YSULOORXQBDPCU-UHFFFAOYSA-N
Q-201157
mfcd00012009
2-hydrazineyl-n,n,n-trimethyl-2-oxoethan-1-aminium chloride
girard-t
2-hydrazinyl-n,n,n-trimethyl-2-oxoethanaminium chloride
(2-hydrazinyl-2-oxoethyl)-trimethylazanium;chloride
AS-13077
2-hydrazinyl-n,n,n-trimethyl-2-oxoethanaminiumchloride
EN300-21573
AMY742
CS-0109596
girard inverted exclamation mark s reagent t
Q27285753
DTXSID00883315
l-(-)-malicaciddiethylester
E81309
HY-W074541

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	7 (17.50)	18.7374
1990's	1 (2.50)	18.2507
2000's	9 (22.50)	29.6817
2010's	17 (42.50)	24.3611
2020's	6 (15.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	40 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
betaine glycine betaine : The amino acid betaine derived from glycine.	4.99	38	amino-acid betaine; glycine derivative	fundamental metabolite
bromide Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	2	1	halide anion; monoatomic bromine
phosphorylcholine Phosphorylcholine: Calcium and magnesium salts used therapeutically in hepatobiliary dysfunction.. phosphocholine : The phosphate of choline; and the parent compound of the phosphocholine family.	1.96	1	phosphocholines	allergen; epitope; hapten; human metabolite; mouse metabolite
potassium iodide Potassium Iodide: An inorganic compound that is used as a source of iodine in thyrotoxic crisis and in the preparation of thyrotoxic patients for thyroidectomy. (From Dorland, 27th ed). potassium iodide : A metal iodide salt with a K(+) counterion. It is a scavenger of hydroxyl radicals.	2	1	potassium salt	expectorant; radical scavenger
succinylacetone succinylacetone: inhibitor of heme biosynthesis. 4,6-dioxoheptanoic acid : A dioxo monocarboxylic acid that is heptanoic acid in which oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and a marker for type 1 tyrosinaemia.	2.03	1	beta-diketone; dioxo monocarboxylic acid	human metabolite
prednisolone Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.. prednisolone : A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.	1.95	1	11beta-hydroxy steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(1),Delta(4)-steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antineoplastic agent; drug metabolite; environmental contaminant; immunosuppressive agent; xenobiotic
aldosterone [no description available]	2.41	1	11beta-hydroxy steroid; 18-oxo steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid hormone; mineralocorticoid; primary alpha-hydroxy ketone; steroid aldehyde	human metabolite; mouse metabolite
androsterone [no description available]	2.31	1	17-oxo steroid; 3alpha-hydroxy steroid; androstanoid; C19-steroid	androgen; anticonvulsant; human blood serum metabolite; human metabolite; human urinary metabolite; mouse metabolite; pheromone
dehydroepiandrosterone Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.. dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.	1.99	1	17-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; androstanoid	androgen; human metabolite; mouse metabolite
androstenedione Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.. androst-4-ene-3,17-dione : A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.	1.99	1	17-oxo steroid; 3-oxo-Delta(4) steroid; androstanoid	androgen; Daphnia magna metabolite; human metabolite; mouse metabolite
norethindrone Norethindrone: A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for CONTRACEPTION.. norethisterone : A 17beta-hydroxy steroid that is testosterone in which the hydrogen at position 17 is replaced by an ethynyl group and in which the methyl group attached to position 10 is replaced by hydrogen.	1.99	1	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; terminal acetylenic compound; tertiary alcohol	progestin; synthetic oral contraceptive
triamcinolone acetonide Triamcinolone Acetonide: An esterified form of TRIAMCINOLONE. It is an anti-inflammatory glucocorticoid used topically in the treatment of various skin disorders. Intralesional, intramuscular, and intra-articular injections are also administered under certain conditions.. triamcinolone acetonide : A synthetic glucocorticoid that is the 16,17-acetonide of triamcinolone. Used to treat various skin infections.	2.13	1	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; cyclic ketal; fluorinated steroid; glucocorticoid; primary alpha-hydroxy ketone	anti-allergic agent; anti-inflammatory drug
furaldehyde Furaldehyde: A heterocyclic compound consisting of a furan where the hydrogen at position 2 is substituted by a formyl group.. furfural : An aldehyde that is furan with the hydrogen at position 2 substituted by a formyl group.	2.15	1	aldehyde; furans	Maillard reaction product; metabolite
glyoxal [no description available]	2.15	1	dialdehyde	agrochemical; allergen; pesticide; plant growth regulator
nandrolone Nandrolone: C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position.. nandrolone : A 3-oxo Delta(4)-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17.	1.99	1	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; anabolic androgenic steroid	human metabolite
deoxyuridine [no description available]	2.03	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
mesterolone Mesterolone: 17 beta-Hydroxy-1 alpha-methyl-5 alpha-androstan-3-one. A synthetic steroid with anabolic and androgenic activities.	7.82	2	3-oxo-5alpha-steroid
n-methylisatin N-methylisatin: structure given in first source	2.11	1
glycidyl trimethylammonium chloride glycidyl trimethylammonium: causes dermatitis on contact; structure given in first source; RN given refers to chloride	2.01	1
25-hydroxycholesterol [no description available]	2.15	1	25-hydroxy steroid; oxysterol	human metabolite
2,6-dihydroxyacetophenone 2,6-dihydroxyacetophenone: inhibits aminopyrine-N-demethylase in rat liver microsomal preparations	2.15	1	aromatic ketone
5-formyl-2'-deoxyuridine 5-formyl-2'-deoxyuridine: structure given in first source	2.03	1
deoxyglucose Deoxyglucose: 2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.. deoxyglucose : A deoxyhexose comprising glucose having at least one hydroxy group replaced by hydrogen.	2.15	1
androsterone glucuronide androsterone glucuronide: RN given refers to (3alpha,5alpha)-isomer. androsterone 3-glucosiduronic acid : A steroid glucosiduronic acid having androsterone as the steroid component.	2.31	1	beta-D-glucosiduronic acid; steroid glucosiduronic acid	human metabolite; metabolite; mouse metabolite
3-deoxyglucosone 3-deoxyglucosone: RN given refers to (D)-isomer. 3-deoxyglucosone : A deoxyketohexose comprising the open-chain form of D-glucose lacking the -OH group at the 3-position and having the keto group at the 2-position.	2.15	1	deoxyglucose; deoxyketohexose
androsterone sulfate androsterone sulfate: RN given refers to (3alpha,5alpha)-isomer. androsterone sulfate : A steroid sulfate that is the 3-sulfate of androsterone.	2.31	1	17-oxo steroid; androstanoid; steroid sulfate	human metabolite; mouse metabolite
cortisone [no description available]	2.07	1	11-oxo steroid; 17alpha-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	human metabolite; mouse metabolite
5-hydroxymethylfurfural 5-hydroxymethylfurfural: has antisickling activity; HMF is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo. 5-hydroxymethylfurfural : A member of the class of furans that is furan which is substituted at positions 2 and 5 by formyl and hydroxymethyl substituents, respectively. Virtually absent from fresh foods, it is naturally generated in sugar-containing foods during storage, and especially by drying or cooking. It is the causative component in honey that affects the presystemic metabolism and pharmacokinetics of GZ in-vivo.	2.15	1	arenecarbaldehyde; furans; primary alcohol	indicator; Maillard reaction product
potassium bromide potassium bromide : A metal bromide salt with a K(+) counterion.	2	1	potassium salt
n-acetylneuraminic acid N-Acetylneuraminic Acid: An N-acyl derivative of neuraminic acid. N-acetylneuraminic acid occurs in many polysaccharides, glycoproteins, and glycolipids in animals and bacteria. (From Dorland, 28th ed, p1518). N-acetylneuraminic acid : An N-acylneuraminic acid where the N-acyl group is specified as acetyl.	2.21	1	N-acetylneuraminic acids	antioxidant; bacterial metabolite; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor; human metabolite; mouse metabolite
thiosemicarbazide thiosemicarbazide: glutamate decarboxylase antagonist; structure given in first source. hydrazinecarbothioamide : A member of the class of thioureas that is thiourea in which a hydrogen of one of the amino groups is replaced by an amino group.	2.03	1	hydrazines; thiocarboxamide; thioureas
methenolone Methenolone: A synthetic steroid that has been used for its anabolic action.	7.6	1	3-hydroxy steroid	androgen
17-ketosteroids 17-Ketosteroids: Steroids that contain a ketone group at position 17.. 17-oxo steroid : Any oxo steroid carrying the oxo group at position 17.	2.05	1
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.1	1	prostaglandins E	human metabolite; mouse metabolite; oxytocic
12-oxophytodienoic acid 12-oxophytodienoic acid: structure given in first source; a jasmonate precursor that induces phytoalexin synthesis	2.17	1	carbocyclic fatty acid; olefinic fatty acid; oxo carboxylic acid
ethisterone Ethisterone: 17 alpha-Hydroxypregn-4-en-20-yn-3-one. A synthetic steroid hormone with progestational effects.. ethisterone : A 17beta-hydroxy steroid that is testosterone in which the 17beta hydrogen is replaced by an ethynyl group. Ethisterone was the first orally active progestin and is a metabolite of danazol.	1.99	1	17beta-hydroxy steroid; 3-oxo-Delta(4) steroid; terminal acetylenic compound; tertiary alcohol	drug metabolite; progestin
sulfur Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.	2.05	1	chalcogen; nonmetal atom	macronutrient
abscisic acid Abscisic Acid: Abscission-accelerating plant growth substance isolated from young cotton fruit, leaves of sycamore, birch, and other plants, and from potatoes, lemons, avocados, and other fruits.. (S)-2-trans-abscisic acid : A 2-trans-abscisic acid with (S)-configuration at the chiral centre.. (+)-abscisic acid : The naturally occurring (1'S)-(+) enantiomer of abscisic acid. It is an important sesquiterpenoid plant hormone which acts as a regulator of plant responses to environmental stresses such as drought and cold.	2.17	1	2-trans-abscisic acid
norgestrel Norgestrel: A synthetic progestational agent with actions similar to those of PROGESTERONE. This racemic or (+-)-form has about half the potency of the levo form (LEVONORGESTREL). Norgestrel is used as a contraceptive, ovulation inhibitor, and for the control of menstrual disorders and endometriosis.	1.99	1

Condition	Relationship Strength	Studies
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.99	4
Arthritis, Degenerative [description not available]	2.13	1
Osteoarthritis A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	2.13	1
4 Hydroxyphenylpyruvate Dioxygenase Deficiency Disease [description not available]	2.03	1
Tyrosinemias A group of disorders which have in common elevations of tyrosine in the blood and urine secondary to an enzyme deficiency. Type I tyrosinemia features episodic weakness, self-mutilation, hepatic necrosis, renal tubular injury, and seizures and is caused by a deficiency of the enzyme fumarylacetoacetase. Type II tyrosinemia features INTELLECTUAL DISABILITY, painful corneal ulcers, and keratoses of the palms and plantar surfaces and is caused by a deficiency of the enzyme TYROSINE TRANSAMINASE. Type III tyrosinemia features INTELLECTUAL DISABILITY and is caused by a deficiency of the enzyme 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE. (Menkes, Textbook of Child Neurology, 5th ed, pp42-3)	2.03	1

girard's reagent t

Description

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Research Demand Index: 32.22

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